Fas (CD95) and bcl-2 expression in active skin lesions of Behcet's disease

Behçet’s disease (BD) is a chronic recurrent systemic inflammatory disorder of unknown etiology characterized by oral and genital ulcerations, skin lesions, and uveitis. The ocular involvement of BD, or Behçet’s uveitis (BU), is characterized by panuveitis or posterior uveitis with occlusive retinal vasculitis and tends to be more recurrent and sight threatening than other endogenous autoimmune uveitides, despite aggressive immunosuppression. Although pathogenesis of BD is unclear, researches have revealed that immunological aberrations may be the cornerstone of BD development. General hypothesis of BD pathogenesis is that inflammatory response is initiated by infectious agents or autoantigens in patients with predisposing genetic factors and perpetuated by both innate and acquired immunity. In addition, a network of immune mediators plays a substantial role in the inflammatory cascade. Recently, we found that the immunopathogenesis of BU is distinct from other autoimmune uveitides regarding intraocular effector cell profiles, maturation markers of dendritic cells, and the cytokine/chemokine environment. In addition, accumulating evidence indicates the involvement of Th17 cells in BD and BU. Recent studies on genetics and biologics therapies in refractory BU also support the immunological association with the pathogenesis of BU. In this review, we provide an overview of novel findings regarding the immunopathogenesis of BU.

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Detection of Herpes Virus Genomes in Skin Lesions from Patients with Behçet's Disease and Other Related Inflammatory Diseases

Acta Dermato Venereologica ◽

10.1080/00015550310007472 ◽

2003 ◽

Vol 83 (2) ◽

pp. 124-127 ◽

Cited By ~ 27

Author(s):

MICHIKO TOJO ◽

XUEYI ZHENG ◽

HIROKATSU YANAGIHORI ◽

NORITAKA OYAMA ◽

KAZUO TAKAHASHI ◽

...

Keyword(s):

Behçet’S Disease ◽

Herpes Virus ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Inflammatory Diseases ◽

Skin Lesions ◽

Behcet's Disease ◽

Herpès Virus ◽

Virus Genomes

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Characteristics of T cell lines established from skin lesions of Behcet's disease

Journal of Dermatological Science ◽

10.1016/s0923-1811(96)00588-9 ◽

1997 ◽

Vol 15 (1) ◽

pp. 9-13 ◽

Cited By ~ 15

Author(s):

Mitsuru Mochizuki ◽

Eishin Morita ◽

Shoso Yamamoto ◽

Seizo Yamana

Keyword(s):

T Cell ◽

Cell Lines ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Skin Lesions ◽

Behcet's Disease ◽

T Cell Lines

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Behcet’s Disease in an Adult Male From Nepal: A Case Report

10.22541/au.162824035.51750829/v1 ◽

2021 ◽

Author(s):

Madan Basnet ◽

Abisha Phudong ◽

Kamal Gautam ◽

Bishnu Pathak ◽

Suman Gaire ◽

...

Keyword(s):

Case Report ◽

Blood Vessels ◽

Behçet’S Disease ◽

Adult Male ◽

Acute Inflammation ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Skin Lesions ◽

Behcet's Disease

Behcet’s Disease is a rare systemic vasculitis characterized by recurrent episodes of acute inflammation affecting blood vessels of all sizes. Symptoms include orogenital apthosis, cutaneous skin lesions, and uveitis. We present the case of a 38-year-old Nepalese man with Behcet’s Disease. In Nepal, Behcet’s Disease may still be under-reported.

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Behçet's Disease from Rheumatology and Neurology Perspectives with Special Reference to Children

Journal of Pediatric Neurology ◽

10.1055/s-0039-1692451 ◽

2019 ◽

Vol 18 (04) ◽

pp. 175-181

Author(s):

Yaşar B. Turgut ◽

Ayşe F. Tosun ◽

Beste K. Yüzbaşı ◽

Hasan Tunca

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

International Study ◽

Skin Lesions ◽

Disease Classification ◽

Behcet's Disease ◽

Male Predominance ◽

Pediatric Age Group ◽

Pathergy Test

AbstractBehçet's disease (BD) is an idiopathic chronic relapsing multisystemic vascular inflammatory disease. Although it is generally seen in young adults with male predominance, the onset age of the disease is the pediatric age group in only 4 to 26% of all cases of BD. According to the International Study Group for Behçet's Disease Classification Criteria, a diagnosis of BD requires recurrent oral aphthous ulcerations with two of the following: genital ulcerations, skin lesions, eye lesions, or a positive pathergy test. In this article, we extensively reviewed the current literature with respect to the rheumatological and neurological findings of BD in childhood.

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Ethiopathogenesis of Behçet's Disease

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0113 ◽

2018 ◽

pp. 324-328

Keyword(s):

Behçet’S Disease ◽

Genetic Factors ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Skin Lesions ◽

Th2 Cells ◽

Innate And Adaptive Immunity ◽

Behcet's Disease ◽

Oral Ulcers ◽

Th 1

Behçet’s disease (BD) is a chronic multisystem inflammatory disease characterized mainly by recurrent oral ulcers, ocular inflammation, genital ulcers, and skin lesions, presenting with remission and exacerbations. The pathogenesis of BD has not been fully elucidated since it has a broad spectrum of phenotypic heterogeneity and complex immunopathogenesis. BD has been considered that both environmental and genetic factors contribute to its onset and development. Recent advances in molecular biology and genetics show us that particular genes encompass both innate and adaptive immunity, and confirm the importance of the predominant polarization towards helper T cell (Th)1 versus Th2 cells, and the involvement of Th17 cells in BD.

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Epidemiology, Prevalence, Incidence in Behçet's Disease

Güncel Retina Dergisi (Current Retina Journal) ◽

10.37783/crj-0112 ◽

2018 ◽

pp. 321-323

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Systemic Vasculitis ◽

Skin Lesions ◽

Medical Community ◽

Aphthous Ulcer ◽

Ocular Involvement ◽

Behcet's Disease ◽

Ancient Silk Road

Behçet’s disease (BD) was first brought to the attention of the modern medical community by Hulusi Behçet in 1937. The disease is a systemic vasculitis characterized by a recurrent aphthous ulcer, genital ulcer, uveitis, and skin lesions. It is observed more common and severe throughout the ancient Silk Road from East Asia to the Mediterranean. Ocular involvement is reported in 25-75% of patients with BD. In most cases, it may progress to blindness if left untreated. The aim of this review is to investigate the epidemiology, prevalence, and incidence of BD.

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Cyclosporine-induced pericarditis: an elusive cause of chest pain in Behçet’s disease

BMJ Case Reports ◽

10.1136/bcr-2019-229433 ◽

2019 ◽

Vol 12 (7) ◽

pp. e229433 ◽

Cited By ~ 2

Author(s):

Siddharth Jain ◽

Parminder Singh ◽

Shankar Naidu ◽

Aman Sharma

Keyword(s):

Chest Pain ◽

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Skin Lesions ◽

Sudden Onset ◽

Medical Emergency ◽

Behcet's Disease ◽

Coronary Syndrome ◽

Extensive Evaluation

Behçet’s disease (BD) is a variable-vessel vasculitis which commonly presents with recurrent orogenital ulceration, skin lesions, visual disturbances and neurodeficits. Arterial involvement is seen variably in 8%–18% cases of BD, with common affliction of the carotid, pulmonary, aortic and iliofemoral arteries. Cardiac involvement in the form of myocarditis, myocardial infarction, pericarditis, cardiac dysrhythmias or valvular disease is also known in BD, although rarely. Sudden-onset chest pain in BD is a medical emergency, with acute coronary syndrome, pulmonary thromboembolism and rupture of aortic or pulmonary artery aneurysms being the commonly implicated causes. Here, we report a rare case of BD who presented with sudden-onset severe chest pain, the cause of which remained elusive despite extensive evaluation for the abovementioned causes. To the best of our knowledge, this is the first reported case of cyclosporine-induced pericarditis in BD in available literature and should be considered in patients on cyclosporine presenting with chest pain.

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Pharmacological Inactivation of Src Family Kinases Inhibits LPS-Induced TNF-αProduction in PBMC of Patients with Behçet’s Disease

Mediators of Inflammation ◽

10.1155/2016/5414369 ◽

2016 ◽

Vol 2016 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Sevgi Irtegun ◽

Gulsum Pektanc ◽

Zeynep M. Akkurt ◽

Mehtap Bozkurt ◽

Fatih M. Turkcu ◽

...

Keyword(s):

Behçet’S Disease ◽

Proinflammatory Cytokines ◽

Behcet’S Disease ◽

Mononuclear Cells ◽

Behçet's Disease ◽

Skin Lesions ◽

Chronic Inflammatory Disease ◽

Src Family Kinases ◽

Peripheral Blood Mononuclear ◽

Behcet's Disease

Behçet’s disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-αproduction in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.

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Diagnosis/Classification Criteria for Behcet's Disease

Pathology Research International ◽

10.1155/2012/607921 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 30

Author(s):

Fereydoun Davatchi

Keyword(s):

Behçet’S Disease ◽

Behcet’S Disease ◽

Behçet's Disease ◽

Far East ◽

Skin Lesions ◽

Historical Background ◽

Vascular Lesions ◽

Behcet's Disease ◽

Pathergy Test ◽

Eye Lesions

Historical Background. The ISG criteria for Behcet's, created in 1990, have excellent specificity, but lack sensitivity. The International Criteria for Behcet's Disease (ICBD) was created in 2006, as replacement to ISG. The aim of this study was to compare their performance. ISG and ICBD Criteria. For ISG oral aphthosis is mandatory. The presence of any two of the following (genital aphthosis, skin lesions, eye lesions, and positive pathergy test) will diagnose/classify the patient as BD. For ICBD, vascular lesions were added, while oral aphthosis is no more mandatory. Getting 3 or more points diagnose/classify the patient as BD (genital aphthosis 2 points, eye lesions 2 points, and the remaining each one point). Performance and Comparison of ISG and ICBD. Their sensitivity, specificity, and accuracy (percent agreement), were tested in three independent cohort of patients from Far-East (China), Middle-East (Iran), and Europe (Germany). The sensitivity for ISG was respectively 65.4%, 78.1%, 83.7% and for ICBD 87%, 98.2%, and 96.5%. The specificity for ISG was 99.2%, 98.8%, 89.5% and for ICBD 94.1%, 95.6%, and 73.7%. The accuracy for ISG was 74.2%, 85.5%, 85.5% and for ICBD 88.9%, 97.3%, and 89.5%. Conclusion. ICBD has better sensitivity, and accuracy than ISG.

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