CONCENTRATIONS OF FREE FATTY ACIDS IN MATERNAL AND UMBILICAL CORD BLOOD DURING ELECTIVE CAESAREAN SECTION

1976 ◽  
Vol 83 (7) ◽  
pp. 539-544 ◽  
Author(s):  
M. C. Elphick ◽  
D. Hull ◽  
R. R. Sanders
Keyword(s):  
Fatty Acids ◽  
Caesarean Section ◽  
Free Fatty Acids ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Elective Caesarean Section

scholarly journals Does the Caesarean Section Impact on 11β HSD2 and Fetal Cortisol?

2020 ◽  
Vol 17 (15) ◽  
pp. 5566 ◽  
Author(s):  
Aneta Słabuszewska-Jóżwiak ◽  
Marta Włodarczyk ◽  
Krzysztof Kilian ◽  
Zbigniew Rogulski ◽  
Michał Ciebiera ◽  
...  
Keyword(s):  
Caesarean Section ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Cortisol Level ◽  
Umbilical Cord Blood ◽  
Elective Caesarean Section ◽  
Placental Tissue ◽  
Uterine Contractions ◽  
Vaginal Deliveries

Purpose: Comparison of the activity of 11beta-hydroxysteroid dehydrogenase type 2 in the placenta and the umbilical cord blood cortisol level between caesarean sections with or without uterine contraction and vaginal delivery groups. Cortisol is the main stress hormone responsible for the normal adaptation of the neonate to extrauterine life. The disorders resulting from a dysfunction of the 11β-HSD 2–cortisol system can explain the higher risk of developing diseases in children born by caesarean section. Methods: 111 healthy, pregnant women in singular pregnancy at term of delivery were included into the study. The study comprised 11β-HSD 2 in placental tissue from 49 pregnant women delivering by elective caesarean section and 46 pregnant women delivering by vagina. In 16 cases of the elective caesarean section, regular uterine contractions were declared. Cortisol level was estimated in umbilical cord blood directly after delivery. Results: We found no statistically significant differences in the activity of 11β-HSD 2 in placentas delivered via caesarean sections (29.61 on average in elective caesarean sections and 26.65 on average in intrapartum caesarean sections) compared to vaginal deliveries (31.94 on average, p = 0.381), while umbilical cord blood cortisol in the elective caesarean sections group was significantly lower (29.86 on average) compared to the vaginal deliveries (55.50 on average, p < 0.001) and intrapartum caesarean sections (52.27 on average, p < 0.001). Conclusions: The model of placental 11β-HSD 2 activity and umbilical cord blood cortisol concentration seems to be significant in conditions of stress associated with natural uterine contractions in labour.

Maternal adipose tissue, maternal and cord blood essential fatty acids and their long-chain polyunsaturated derivatives composition after elective caesarean section

2007 ◽  
Vol 83 (7) ◽  
pp. 459-464 ◽  
Author(s):  
Elżbieta Pankiewicz ◽  
Andrzej Cretti ◽  
Elżbieta Ronin-Walknowska ◽  
Maria-Beata Czeszyńska ◽  
Halina Konefał ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Caesarean Section ◽  
Cord Blood ◽  
Essential Fatty Acids ◽  
Elective Caesarean Section ◽  
Long Chain

scholarly journals Associations of maternal prenatal dietary intake of n-3 and n-6 fatty acids with maternal and umbilical cord blood levels

2009 ◽  
Vol 80 (5-6) ◽  
pp. 289-296 ◽  
Author(s):  
S.M.A. Donahue ◽  
S.L. Rifas-Shiman ◽  
S.F. Olsen ◽  
D.R. Gold ◽  
M.W. Gillman ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Dietary Intake ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Levels

Umbilical cord blood cytokines during spontaneous labor and caesarean section

2017 ◽  
Vol 4_2017 ◽  
pp. 68-72
Author(s):  
Tysyachnyi O.V. Tysyachnyi ◽  
Krechetova L.V. Krechetova ◽  
Baev O.R. Baev ◽  
Vtorushina V.V. Vtorushina ◽  
Keyword(s):  
Caesarean Section ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cytokines

DYNAMICS OF INDICES OF LINOLEIC AND ARACHIDONIC FATTY ACIDS IN CORD BLOOD OF NEWBORNS FROM MOTHERS WITH CYTOMEGALOVIRUS INFECTION

2016 ◽  
Vol 1 (60) ◽  
pp. 75-79
Author(s):  
Дорофиенко ◽  
Nikolay Dorofienko
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cytomegalovirus Infection ◽  
Umbilical Artery ◽  
Control Group ◽  
Gas Liquid Chromatography ◽  
Igg Antibodies

Due to the broad spectrum of influence of polyunsaturated fatty acids of ω-6 family on the development of the fetus and newborn child, the composition of arachidonic fatty acid and its predecessor linoleic fatty acid were studied in blood of the umbilical cord blood of newborns from mothers with chronic reactivation of cytomegalovirus infection. 82 newborns were examined; among them there were 42 infants (the main group) from mothers who had cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus was 1:1600) in the III trimester. The control group included 42 newborns from healthy women. In the umbilical cord blood of newborns the contents of arachidonic and linoleic fatty acids were identified with gas-liquid chromatography. The study found out that the reactivation of cytomegalovirus infection in the mother (titer of IgG antibodies to cytomegalovirus 1:1600) leads to an increase in the content of linoleic acid by 56% (p&#60;0.001) and of the predecessor of pro-inflammatory eicosanoids - arachidonic acid by 34% (p&#60;0.001) in the cord blood of newborns; it is one of the causes of disturbance of the structural and functional organization of the umbilical artery vessels. Identified changes in umbilical cord blood and umbilical artery endothelium can cause disturbances of the elastic properties of vessels, stagnation and thrombosis of blood vessels and, consequently, disturbances of blood flow between mother and fetus, which can then serve as a factor in the development of fetal hypoxia.

The influence of birth order and duration of farrowing on concentrations of metabolites in the umbilical cord blood of newborn piglets

2003 ◽  
Vol 2003 ◽  
pp. 85-85 ◽  
Author(s):  
S.E. Ilsley ◽  
H.M. Miller
Keyword(s):  
Fatty Acids ◽  
Cord Blood ◽  
Birth Order ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Newborn Piglets ◽  
Esterified Fatty Acids ◽  
Umbilical Cords

It was the purpose of this study to ascertain whether concentrations of glucose (GLU), urea and non-esterified fatty acids (NEFA) in blood collected from the umbilical cords of newborn piglets vary according to the position of the piglet in the birth order of a litter. Umbilical cord blood is representative of the piglets status at the time of birth. It would therefore be advantageous to know whether blood withdrawn from the umbilical cord of one piglet is representative of the litter in terms of these metabolites. This study was therefore designed to test the hypotheses that position in the birth order, and time of birth relative to delivery of the first piglet in a litter, will influence GLU, urea and NEFA concentrations in umbilical cord blood.

scholarly journals MOLECULAR EFFECTS OF ERYTHROPOIETIN ON THE LIPID COMPOSITION OF THE UMBILICAL CORD BLOOD ERYTHROCYTE MEMBRANES OF NEWBORNS AT CYTOMEGALOVIRUS INFECTION IN PREGNANCY

2019 ◽  
Vol 1 (71) ◽  
pp. 88-93
Author(s):  
Наталия Ишутина ◽  
Nataliya Ishutina ◽  
Ирина Андриевская ◽  
Irina Andrievskaya ◽  
Николай Дорофиенко ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Cord Blood ◽  
Red Blood Cells ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Cells ◽  
Thiobarbituric Acid ◽  
Third Trimester ◽  
The Third ◽  
Molecular Effects

In order to identify the molecular effects of erythropoietin on the lipid composition and properties of the membrane of red blood cells of the umbilical cord, 35 newborn children born from cytomegalovirus seropositive women with exacerbation of infection in the third trimester of pregnancy (main group) were examined. The control group consisted of 30 newborns born from cytomegalovirus seronegative women. Plasma and red blood cells of the umbilical cord became the material for the study. In the membrane of red blood cells of the umbilical cord by spectrophotometry there were studied the products that react with thiobarbituric acid; membrane microviscosity was studied by lateral diffusion of hydrophobic fluorescent probe of pyrenes; lysophosphatidylcholine content by a thin-layer chromatography; the content of arachidonic, oleic and α-linolenic fatty acids by gas chromatography; ionized calcium content by analyzer of blood gases and electrolytes; erythropoietin in umbilical cord blood plasma by enzyme immunoassay. The number of erythrocytes was determined by an automatic hematological analyzer. The assessment of erythrocytes morphology and echinocytes counting was performed by light microscopy with further cytophotometrical data processing. In the umbilical cord blood of newborns born from cytomegalovirus seropositive women with exacerbation of infection in the third trimester of pregnancy, there was found out an increase in the level of erythropoietin by 20% (p<0.05), the number of erythrocytes by 21% (p<0.01), of products reacting with thiobarbituric acid by 60% (p<0.001), of lysophosphatidylcholine by 42% (p<0.001), of arachidonic acid by 31% (p<0.001)<0.001), of ionized calcium by 14% (p<0.05), of the amount of echinocytes by 91% (p<0.001); with a decrease in the content of oleic and α-linolenic fatty acids by 40% (p<0.001), there was an increase in the ratio of fluorescence of excimers and monomers (Fe/Fm) by 30% (p<0.001), the number of red blood cells by 21% (p<0.01). The results obtained suggested in the newborns from seropositive women to cytomegalovirus with exacerbation of the infection in the third trimester of pregnancy the development of ineffective erythropoiesis, enhancing oxidative damage of red blood cells, leading to echinocytosis and eryptosis

scholarly journals Comparative Long-chain Polyunsaturated Fatty Acids Levels in Blood, Placenta and Cord Blood of Pregnant Women with or without Pre-eclampsia

BioMedica ◽  
2020 ◽  
Vol 36 (4) ◽  
pp. 379-389
Author(s):  
Zhang Weili
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Polyunsaturated Fatty Acids ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Maternal Blood ◽  
Umbilical Blood ◽  
Long Chain

Background and Objective: Long-chain polyunsaturated fatty acids (LCPUFA) play an important role in the regulation of fat metabolism in the placenta and fetus. Changes in placental function in pre-eclampsia affect the transport of fatty acids and affect fetal nutrition. The aim of the study was to compare LCPUFA levels in blood, placenta and cord blood of pregnant women with or without pre-eclampsia. Methods: The blood, placenta and umbilical cord blood of pregnant women (n = 30 each) who were normotensive and with pre-eclampsia were collected. The levels of fatty acids in maternal blood, placenta and umbilical cord blood were determined by the quartz capillary gas chromatography technique. Results: The average age of normal pregnant women was 27.0±4.5 years and that of pre-eclampsia pregnant women was 30±4.0 years (P > 0.05). The levels of total fatty acids, arachidonic acid (AA) and docosahexaenoic acid (DHA) were higher in pregnant women with pre-eclampsia than in normal women. The level of linoleic acid in cord blood and placenta was significantly higher in pre-eclampsia group than in the normal pregnant women while linoleic acid content in maternal blood being lower in pre-eclampsia group compared to the normal maternal group. Conclusion: The changes of LCPUFA in blood, placenta and umbilical blood of pre-eclampsia may be related to the changes of LCPUFA in placenta. These changes may be involved in the pathophysiological process of pre-eclampsia. Maternal supplement of LCPUFA, such as DHA, in early gestation may be helpful in improving morbidity associated with maternal eclampsia.

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