Factors Contributing to the Poor Myelination in the Brain of the Snell Dwarf Mouse

1982 ◽  
Vol 39 (6) ◽  
pp. 1693-1699 ◽  
Author(s):  
Tetsuya Noguchi ◽  
Tetsuro Sugisaki ◽  
Ken Takamatsu ◽  
Yasuzo Tsukada
Keyword(s):  
Dwarf Mouse ◽  
The Poor ◽  
Snell Dwarf ◽  
The Brain

Trail Making Test Performance in Relation to Certain Experimenter, Test and Subject Variables

1964 ◽  
Vol 19 (1) ◽  
pp. 199-206 ◽  
Author(s):  
Oscar A. Parsons ◽  
Harriet I. Maslow ◽  
Freda Morris ◽  
J. Peter Denny
Keyword(s):  
Test Performance ◽  
Screening Test ◽  
Poor Performance ◽  
Trail Making Test ◽  
Psychiatric Disturbance ◽  
The Poor ◽  
Subject Variables ◽  
Trail Making ◽  
The Brain ◽  
Order Of Administration

The Trail Making Test, previously reported highly effective in differentiating brain-damaged from non-brain-damaged Ss, was administered to 21 brain-damaged Ss and 63 non-brain-damaged Ss. Since the latter Ss performed at a level indistinguishable from that of the brain-damaged Ss, several studies were designed in an attempt to “explain” the poor performance of the non-brain-damaged Ss. The possible effects of behavioral agitation, anxiety, examiner differences, facility with letters of the alphabet, order of administration, and ego-involvement were investigated. Only anxiety was found to be significantly related to performance. However, in other analyses age, education, vocabulary, and degree of psychiatric disturbance were significantly related to performance. Until these variables are considered in the scoring system, it seems unlikely that the TMT will be effective as a general screening test for brain-damage.

Neutrophil affinity for PGP and HAIYPRH (T7) peptide dual-ligand functionalized nanoformulation enhances the brain delivery of tanshinone IIA and exerts neuroprotective effects against ischemic stroke by inhibiting proinflammatory signaling pathways

2018 ◽  
Vol 42 (23) ◽  
pp. 19043-19061
Author(s):  
Yutao Li ◽  
Chiying An ◽  
Danan Han ◽  
Yanxin Dang ◽  
Xin Liu ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Physicochemical Properties ◽  
Signaling Pathways ◽  
Blood Brain Barrier ◽  
Tanshinone Iia ◽  
Brain Barrier ◽  
Brain Delivery ◽  
Neuroprotective Effects ◽  
The Poor ◽  
The Brain

A great challenge to the therapy of ischemic stroke is the poor physicochemical properties and inability of the drug to cross the blood–brain barrier (BBB).

Growth Hormone Causes Rapid Induction of Lactogenic Receptor Activity in the Snell Dwarf Mouse Liver

Endocrinology ◽  
1978 ◽  
Vol 103 (5) ◽  
pp. 1590-1596 ◽  
Author(s):  
RICHARD A. KNAZEK ◽  
SUE C. LIU ◽  
ROBERT L. GRAETER ◽  
PHILIP C. WRIGHT ◽  
JANINE R. MAYER ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Mouse Liver ◽  
Receptor Activity ◽  
Dwarf Mouse ◽  
Rapid Induction ◽  
Snell Dwarf

scholarly journals Cerebrovascular events in COVID-19 patients

2020 ◽  
Vol 90 (2) ◽  
Author(s):  
Ajay Kumar Mishra ◽  
Kamal Kant Sahu ◽  
Anu Anna George ◽  
Jennifer Sargent ◽  
Amos Lal
Keyword(s):  
Computed Tomography ◽  
Vascular Injury ◽  
Neurological Deficits ◽  
Severe Illness ◽  
Cytokine Storm ◽  
Neurological Manifestations ◽  
The Poor ◽  
Cerebrovascular Events ◽  
Pubmed Database ◽  
The Brain

Neurological manifestations in patients with COVID–19 are more frequently being reported. Cerebrovascular events have been reported in around 3% of patients. In this review we summarize the published literature on cerebrovascular events in patients with COVID-19 as available on the PubMed database. So far, 3 studies have reported cerebrovascular events. Cerebrovascular events were identified on screening patients with decreased consciousness or in the presence of focal neurological deficits. These events were common in elderly, critically ill patients and in patients with prior cardio-cerebrovascular comorbidities. The diagnosis of cerebrovascular events was confirmed with computed tomography of the brain in most studies reporting neurological events. Multiple pathological mechanisms have been postulated regarding the process of neurological and vascular injury among which cytokine storm is shown to correlate with mortality. Patients with severe illness are found to have a higher cardio- cerebrovascular comorbidity. With an increasing number of cases and future prospective studies, the exact mechanism by which these cerebrovascular events occur and attribute to the poor outcome will be better understood.

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

2002 ◽  
Vol 123 (9) ◽  
pp. 1229-1244 ◽  
Author(s):  
Ching-Chyuan Hsieh ◽  
James H. DeFord ◽  
Kevin Flurkey ◽  
David E. Harrison ◽  
John Papaconstantinou
Keyword(s):  
Signaling Pathway ◽  
Insulin Signaling ◽  
Insulin Signaling Pathway ◽  
Dwarf Mouse ◽  
C Elegans ◽  
Snell Dwarf

Overexpression of human insulin-like growth factor-II in transgenic mice causes increased growth of the thymus

1995 ◽  
Vol 144 (3) ◽  
pp. 491-502 ◽  
Author(s):  
S C van Buul-Offers ◽  
K de Haan ◽  
M G Reijnen-Gresnigt ◽  
D Meinsma ◽  
M Jansen ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Mrna Expression ◽  
Body Length ◽  
Thymic Development ◽  
Transgenic Lines ◽  
Snell Dwarf ◽  
Liver And Kidney ◽  
The One ◽  
Dwarf Mice ◽  
The Brain

Abstract In order to determine the effects of IGF-II overexpression on growth of mice, transgenic mice were produced carrying one of three different H-2Kb human IGF-II minigenes in which different non-coding exons (exon 5, truncated exon 5 or exon 6) preceded the coding exons 7, 8 and 9. These were spaced by truncated introns and for proper polyadenylation an SV40 polyadenylation signal was incorporated. The highest levels of IGF-II minigene mRNA expression were found in lines containing the truncated exon 5 construct (II5′). Those containing exon 6 (II6) had less expression and 5 constructs (II5) gave only moderate levels of mRNA expression. In general mRNA expression was highest in thymus and spleen, low in liver and kidney and absent in the brain. In addition, one 115' line showed expression in the brain. Serum IGF-II levels at 8 weeks of age were increased 7- to 8-fold in homozygous transgenic lines with construct II5′ without brain expression and 2- to 3-fold in the one that showed expression in the brain; serum IGF-I levels were unchanged. Serum IGFs in the lines containing the constructs 115 and 116 were not different from those of the controls. In all cases body length and weight as well as the weight of several organs such as brain, liver, kidneys, heart and spleen when expressed as a function of age did not differ from controls. Only the thymus showed a significant increase in weight in the transgenics II5′. Inbreeding of 2 lines containing construct 115' with pituitary deficient Snell dwarf mice did not influence body length or weight despite increased serum IGF-II levels. Again the thymus showed a marked increase in growth. The biological activity of the IGF-II peptide was further demonstrated by increased serum IGF-binding protein-3 in the transgenic dwarf mice, as shown by Western ligand blotting. In summary, overexpression of IGF-II in transgenic normal and dwarf mice does not affect overall body growth, but causes increased growth of the thymus. This suggests a role for IGF-II in thymic development by paracrine/autocrine action. Journal of Endocrinology (1995) 144, 491–502

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