Self-Reported Alcohol Consumption and Falls in Older Adults: Cross-Sectional and Longitudinal Analyses of the Cardiovascular Health Study

2004 ◽  
Vol 52 (7) ◽  
pp. 1174-1179 ◽  
Author(s):  
Kenneth J. Mukamal ◽  
Murray A. Mittleman ◽  
W. T. Longstreth ◽  
Anne B. Newman ◽  
Linda P. Fried ◽  
...  
2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 185-185
Author(s):  
Junta Takahashi ◽  
Shuichi Obuchi ◽  
Hisashi Kawai ◽  
Kaori Ishii ◽  
Koichiro Oka ◽  
...  

Abstract In addition to intensity and quality, diversity of activity will be an important factor to explain health outcomes among older adults. Few studies, though, examined an association between activity diversity and health outcomes. This study aimed to examine the association between activity diversity and frailty among community-dwelling older Japanese. Participants were community-dwelling older adults who participated in a cohort study, the “Otassya-Kenshin” in 2018 . The participants were asked frequency of 20 daily activities, inside/outside chores, leisure activities with/without physically, direct/indirect contact with friends and so on, in a week and activity diversity score were calculated using the formula of Shannon’s entropy. Frailty was defined by the Japanese version of the Cardiovascular Health Study criteria. The difference in diversity score between frail and non frail were examined by t-test. Logistic regression analysis with covariates, age, sex, economic status, living alone, BMI, Mini-Mental State Examination, and IADL was adopted to find association between activity diversity score and presence of frailty. Of 652 participants (age: 72.8±6.3, women: 60.6%) analyzed, 27 (4.1%) were defined as frail. Frailty group revealed significantly lower activity diversity score than non-frailty group (0.66±0.11 vs 0.75±0.08, P<0.01). 0.2 point of decrease in diversity score increase 5 times chance of frailty after controlling covariates. We found significant relationship between activity diversity and health outcome among older subjects. The activity diversity may provide additional information to number or intensity of activity.


2018 ◽  
Vol 1 (8) ◽  
pp. e186383 ◽  
Author(s):  
Justin S. Sadhu ◽  
Eric Novak ◽  
Kenneth J. Mukamal ◽  
Jorge R. Kizer ◽  
Bruce M. Psaty ◽  
...  

2007 ◽  
Vol 153 (2) ◽  
pp. 260-266 ◽  
Author(s):  
Kenneth J. Mukamal ◽  
Bruce M. Psaty ◽  
Pentti M. Rautaharju ◽  
Curt D. Furberg ◽  
Lewis H. Kuller ◽  
...  

2004 ◽  
Vol 173 (1) ◽  
pp. 79-87 ◽  
Author(s):  
Kenneth J Mukamal ◽  
Mary Cushman ◽  
Murray A Mittleman ◽  
Russell P Tracy ◽  
David S Siscovick

2021 ◽  
Author(s):  
Claire C Meunier ◽  
Ellen Smit ◽  
Annette L Fitzpatrick ◽  
Michelle C Odden

Abstract Background Previous studies have demonstrated an association between gait speed and cognitive function. However, the relationship between balance and cognition remains less well explored. This study examined the cross-sectional and longitudinal relationship of balance and cognitive decline in older adults. Methods A cohort of 4,811 adults, aged ≥65 years, participating in the Cardiovascular Health Study was followed for 6 years. Modified Mini-Mental State Examination (3MSE) and Digit Symbol Substitution Test (DSST) were used to measure cognition. Tandem balance measures were used to evaluate balance. Regression models were adjusted for demographics, behavioural and disease factors. Results Worse balance was independently associated with worse cognition in cross-sectional analysis. Longitudinally, participants aged ≥76 years with poorer balance had a faster rate of decline after adjustment for co-variates: −0.97 points faster decline in 3MSE per year (95% confidence interval (CI): −1.32, −0.63) compared to the participants with good balance. There was no association of balance and change in 3MSE among adults aged <76 years (P value for balance and age interaction < 0.0001). DSST scores reflected −0.21 (95% CI: −0.37, −0.05) points greater decline when adjusted for co-variates. In Cox proportional hazard models, participants with worse balance had a higher risk of being cognitively impaired over the 6 years of follow-up visits (adjusted HR:1.72, 95% CI: 1.30, 2.29). Conclusions Future studies should evaluate standing balance as a potential screening technique to identify individuals at risk of cognitive decline. Furthermore, a better understanding of the pathophysiological link between balance and cognition may inform strategies to prevent cognitive decline.


2007 ◽  
Vol 18 (5) ◽  
pp. 593-602 ◽  
Author(s):  
K. J. Mukamal ◽  
J. A. Robbins ◽  
J. A. Cauley ◽  
L. M. Kern ◽  
D. S. Siscovick

Obesity ◽  
2007 ◽  
Vol 15 (7) ◽  
pp. 1758-1765 ◽  
Author(s):  
Luc Djoussé ◽  
Mary L. Biggs ◽  
Kenneth J. Mukamal ◽  
David S. Siscovick

2006 ◽  
Vol 54 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Kenneth J. Mukamal ◽  
Hyoju Chung ◽  
Nancy S. Jenny ◽  
Lewis H. Kuller ◽  
W.T. Longstreth ◽  
...  

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jihye Lim ◽  
Hyungchul Park ◽  
Heayon Lee ◽  
Eunju Lee ◽  
Danbi Lee ◽  
...  

Abstract Background Despite constipation being a common clinical condition in older adults, the clinical relevance of constipation related to frailty is less studied. Hence, we aimed to investigate the association between chronic constipation (CC) and frailty in older adults. Methods This is a cross-sectional analysis of a population-based, prospective cohort study of 1278 community-dwelling older adults in South Korea. We used the Rome criteria to identify patients with irritable bowel syndrome with predominant constipation (IBS-C) and functional constipation (FC). We investigated whether participants consistent with the criteria for IBS-C and FC had CC. Frailty was assessed using the Cardiovascular Health Study (CHS) frailty phenotype. Results In the study population with a mean age of 75.3 ± 6.3 years, 136 (10.7%) had CC. The participants with CC were older, had higher medication burdens, and had worse physical performances compared to those without CC (All P < .05). By association analysis, the prevalence of CC was associated with frailty by the CHS criteria (P < .001). The CHS frailty score was associated with the presence of CC by the univariate logistic regression analysis and the multivariate analysis adjusted for age, sex, and multimorbidity. Conclusions Frailty was associated with CC in community-dwelling older people, suggesting that constipation should be considered as an important geriatric syndrome in clinical practice concerning frail older adults.


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