Determination of urine thiocyanate in patients with amyotrophic lateral sclerosis

1989 ◽  
Vol 80 (5) ◽  
pp. 444-450
Author(s):  
Y. Yoshida ◽  
R. Hamada ◽  
H. Kamitsuchibashi ◽  
K. Yamamoto ◽  
M. Nakagawa ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Lateral Sclerosis

Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis

2019 ◽  
Vol 59 (5) ◽  
pp. 567-576 ◽  
Author(s):  
Stefanie Schreiber ◽  
Frank Schreiber ◽  
Cornelia Garz ◽  
Grazyna Debska‐Vielhaber ◽  
Anne Assmann ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Nervous System ◽  
Peripheral Nervous System ◽  
Immune Activity ◽  
Lateral Sclerosis

scholarly journals An miRNA fingerprint using neural-enriched extracellular vesicles from blood plasma: towards a biomarker for amyotrophic lateral sclerosis/motor neuron disease

Open Biology ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 200116 ◽  
Author(s):  
Sandra Anne Banack ◽  
Rachael Anne Dunlop ◽  
Paul Alan Cox
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Blood Plasma ◽  
Motor Neuron ◽  
Motor Neuron Disease ◽  
Extracellular Vesicles ◽  
Disease Diagnosis ◽  
Extracellular Vesicle ◽  
Improve Patient ◽  
Lateral Sclerosis

Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We hypothesized that neural-enriched extracellular vesicles could provide microRNA (miRNA) fingerprints with unequivocal signatures of neurodegeneration. Using blood plasma from ALS/MND patients and controls, we extracted neural-enriched extracellular vesicle fractions and conducted next-generation sequencing and qPCR of miRNA components of the transcriptome. We here report eight miRNA sequences which significantly distinguish ALS/MND patients from controls in a replicated experiment using a second cohort of patients and controls. miRNA sequences from patient blood samples using neural-enriched extracellular vesicles may yield unique insights into mechanisms of neurodegeneration and assist in early diagnosis of ALS/MND.

scholarly journals Capillary electrophoresis tandem mass spectrometry determination of glutamic acid and homocysteine’s metabolites: Potential biomarkers of amyotrophic lateral sclerosis

Talanta ◽  
2017 ◽  
Vol 170 ◽  
pp. 63-68 ◽  
Author(s):  
Zuzana Cieslarova ◽  
Fernando Silva Lopes ◽  
Claudimir Lucio do Lago ◽  
Marcondes Cavalcante França ◽  
Ana Valéria Colnaghi Simionato
Keyword(s):  
Mass Spectrometry ◽  
Amyotrophic Lateral Sclerosis ◽  
Capillary Electrophoresis ◽  
Tandem Mass Spectrometry ◽  
Glutamic Acid ◽  
Tandem Mass ◽  
Lateral Sclerosis ◽  
Potential Biomarkers

Dynamic markers of altered gait rhythm in amyotrophic lateral sclerosis

2000 ◽  
Vol 88 (6) ◽  
pp. 2045-2053 ◽  
Author(s):  
Jeffrey M. Hausdorff ◽  
Apinya Lertratanakul ◽  
Merit E. Cudkowicz ◽  
Amie L. Peterson ◽  
David Kaliton ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Motor Control ◽  
Therapeutic Interventions ◽  
Healthy Controls ◽  
Gait Dynamics ◽  
Fluctuation Dynamics ◽  
Distinct Features ◽  
Normal Controls ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a disorder marked by loss of motoneurons. We hypothesized that subjects with ALS would have an altered gait rhythm, with an increase in both the magnitude of the stride-to-stride fluctuations and perturbations in the fluctuation dynamics. To test for this locomotor instability, we quantitatively compared the gait rhythm of subjects with ALS with that of normal controls and with that of subjects with Parkinson's disease (PD) and Huntington's disease (HD), pathologies of the basal ganglia. Subjects walked for 5 min at their usual pace wearing an ankle-worn recorder that enabled determination of the duration of each stride and of stride-to-stride fluctuations. We found that the gait of patients with ALS is less steady and more temporally disorganized compared with that of healthy controls. In addition, advanced ALS, HD, and PD were associated with certain common, as well as apparently distinct, features of altered stride dynamics. Thus stride-to-stride control of gait rhythm is apparently compromised with ALS. Moreover, a matrix of markers based on gait dynamics may be useful in characterizing certain pathologies of motor control and, possibly, in quantitatively monitoring disease progression and evaluating therapeutic interventions.

Genetic aspects of amyotrophic lateral sclerosis and progressive bulbar paralysis

1959 ◽  
Vol 8 (3) ◽  
pp. 369-374 ◽  
Author(s):  
Walter F. Haberlandt
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Preliminary Report ◽  
Family Study ◽  
Psychiatric Patients ◽  
The Family ◽  
Bulbar Paralysis ◽  
Sporadic Cases ◽  
Index Cases ◽  
Lateral Sclerosis

SUMMARYIn this preliminary report the question of the inheritance of amyotrophic lateral sclerosis is discussed. Through systematic search within the province of Westphalia and especially in the District of Münster, we found 251 index cases out of a population of about 250.000 neuro-psychiatric patients observed during the last 30 years. This material is being analysed from a clinical as well as from a genetic standpoint. The family study will be a basis for determination of the mode of inheritance. As for the sporadic cases of Charcot's disease, the effect of mutations must be taken into consideration.

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