Long-term exposure to duodenal levodopa/carbidopa infusion therapy improves quality of life in relation especially to mobility, activities of daily living, and emotional well-being

e17559 Background: A single institution prospective clinical trial was conducted to examine the safety and efficacy of concurrent cetuximab and definitive thoracic radiotherapy followed by docetaxel plus cetuximab. Quality of life (QOL) was assessed as a secondary endpoint. Survival and toxicity data are presented separately. Methods: Eligible pts with unresectable stage IIA or IIIB LA-NSCLC, who also had ECOG PS 2 OR weight loss ≥5% in 3 months OR age >70, completed QOL measures at baseline, after concurrent cetuximab/radiotherapy (recovery), and after docetaxol/cetuximab (consolidation). Scores were calculated for Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL), Fatigue Symptom Inventory (FSI) worst fatigue, FSI fatigue interference, and Functional Assessment of Cancer Therapy – Lung Trial Outcome Index (FACT-L TOI). FACT-L TOI assessed physical (e.g., nausea) and functional (e.g., difficulty sleeping) well-being as well as lung cancer specific symptoms (e.g., shortness of breath, cough). Descriptive and t-test results are presented. Results: Pts (N = 27) were primarily male (67%) and non-Hispanic Caucasian (96%) with mean age of 73 years. High attrition between recovery (N = 22) and consolidation (N = 10) occurred. Compared to baseline, pts reported higher levels of worst fatigue (p < .03) and fatigue interference (p = .01) at recovery. There was a decline in IADLs (p = .01) but no significant difference in ADLs or FACT-L TOI. Further examination of FACT subscales revealed declines in physical (p < .0001) and functional (p = .02) well-being but improvement in lung cancer specific symptoms (p < .0001). A similar pattern is found for comparisons between baseline and consolidation (ps < .05). There were no significant differences between recovery and consolidation. Conclusions: Although pts experienced declines in QOL across most domains after concurrent cetuximab and radiotherapy, there was improvement in lung cancer specific symptoms. Pts were also able to maintain their ability to perform ADLs. High attrition after recovery is a notable limitation.

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Quality of Life for People With Dementia Living in Residential and Nursing Home Care: The Impact of Performance on Activities of Daily Living, Behavioral and Psychological Symptoms, Language Skills, and Psychotropic Drugs

International Psychogeriatrics ◽

10.1017/s1041610201007499 ◽

2001 ◽

Vol 13 (1) ◽

pp. 93-106 ◽

Cited By ~ 107

Author(s):

Clive Ballard ◽

John O'Brien ◽

Ian James ◽

Pat Mynt ◽

Marisa Lana ◽

...

Keyword(s):

Quality Of Life ◽

Activities Of Daily Living ◽

Psychotropic Drugs ◽

Daily Living ◽

Psychological Symptoms ◽

Well Being ◽

Nursing Home Care ◽

People With Dementia ◽

The Impact

Many people with dementia reside in care facilities. Little is known about how key parameters impact upon their quality of life (QOL). All 209 people with dementia in six facilities received a standardized assessment (Neuropsychiatric Inventory [NPI], Barthel Scale, psychotropic drugs). One hundred twelve residents were assessed using Dementia Care Mapping, an observational method for QOL indices. Lower performance on activities of daily living (reduced well-being [WB] r = +0.39, p < .0001; social withdrawal [SW] r = +0.42, p < .0001; engagement in activities [EA] r = +0.31, p = .001) and taking psychotropics (WB 2.5 vs. 3.2, t = .2.3, p = .02; SW 11.4% vs. 2.7%, t = 3.0, p = .004; EA 56.5% vs. 71.9%; t = 3.5, p = .001) were associated with reduced QOL, but symptoms from the NPI were not. More focused prescribing of psychotropics and better staff training are essential.

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Assessment of patient-reported outcomes after polytrauma: protocol for a systematic review

BMJ Open ◽

10.1136/bmjopen-2017-017571 ◽

2018 ◽

Vol 8 (3) ◽

pp. e017571 ◽

Cited By ~ 2

Author(s):

Irmela Gnass ◽

Michaela Ritschel ◽

Silke Andrich ◽

Silke Kuske ◽

Kai Moschinski ◽

...

Keyword(s):

Quality Of Life ◽

Systematic Review ◽

Activities Of Daily Living ◽

Daily Living ◽

Patient Reported Outcomes ◽

Short Term ◽

Patient Reported

IntroductionSurvivors of polytrauma experience long-term and short-term burden that influences their lives. The patients’ view of relevant short-term and long-term outcomes should be captured in instruments that measure quality of life and other patient-reported outcomes (PROs) after a polytrauma. The aim of this systematic review is to (1) collect instruments that assess PROs (quality of life, social participation and activities of daily living) during follow-up after polytrauma, (2) describe the instruments’ application (eg, duration of period of follow-up) and (3) investigate other relevant PROs that are also assessed in the included studies (pain, depression, anxiety and cognitive function).Methods and analysisThe systematic review protocol is developed in line with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement. MEDLINE, EMBASE, Cumulative Index to Nursing and Allied Health Literature, PsycINFO, Cochrane Central Register of Controlled Trials and the trials registers ClinicalTrials.gov and WHO International Clinical Trials Registry Platform will be searched. Keywords, for example, ‘polytrauma’, ‘multiple trauma’, ‘quality of life’, ‘activities of daily living’ or ‘pain’ will be used. Publications published between January 2005 and the most recent date (currently: August 2016) will be included. In order to present the latest possible results, an update of the search is conducted before publication. The data extraction and a content analysis will be carried out systematically. A critical appraisal will be performed.Ethics and disseminationFormal ethical approval is not required as primary data will not be collected. The results will be published in a peer-reviewed publication.PROSPERO registration numberCRD42017060825.

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Associations between occupational performance and quality of life, well-being, and instrumental activities of daily living in older adults

Cadernos Brasileiros de Terapia Ocupacional ◽

10.4322/2526-8910.ctoao2096 ◽

2020 ◽

Author(s):

Emi Miki ◽

Risa Kawabata

Keyword(s):

Quality Of Life ◽

Older Adults ◽

Activities Of Daily Living ◽

Daily Living ◽

Well Being ◽

Occupational Performance ◽

Instrumental Activities

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Montessori-Based Activities Among Persons with Late-Stage Dementia: Evaluation of Mental and Behavioral Health Outcomes

Dementia ◽

10.1177/1471301217703242 ◽

2017 ◽

Vol 18 (4) ◽

pp. 1373-1392 ◽

Cited By ~ 4

Author(s):

Scott E Wilks ◽

P August Boyd ◽

Samantha M Bates ◽

Daphne S Cain ◽

Jennifer R Geiger

Keyword(s):

Quality Of Life ◽

Activities Of Daily Living ◽

Behavioral Health ◽

Problem Behaviors ◽

Late Stage ◽

Social Engagement ◽

Daily Living ◽

Well Being ◽

Psychological Well Being

Objectives Literature regarding Montessori-based activities with older adults with dementia is fairly common with early stages of dementia. Conversely, research on said activities with individuals experiencing late-stage dementia is limited because of logistical difficulties in sampling and data collection. Given the need to understand risks and benefits of treatments for individuals with late-stage dementia, specifically regarding their mental and behavioral health, this study sought to evaluate the effects of a Montessori-based activity program implemented in a long-term care facility. Method Utilizing an interrupted time series design, trained staff completed observation-based measures for 43 residents with late-stage dementia at three intervals over six months. Empirical measures assessed mental health (anxiety, psychological well-being, quality of life) and behavioral health (problem behaviors, social engagement, capacity for activities of daily living). Results Group differences were observed via repeated measures ANOVA and paired-samples t-tests. The aggregate, longitudinal results—from baseline to final data interval—for the psychological and behavioral health measures were as follows: problem behaviors diminished though not significantly; social engagement decreased significantly; capacities for activities of daily living decreased significantly; quality of life increased slightly but not significantly; anxiety decreased slightly but not significantly; and psychological well-being significantly decreased. Conclusion Improvements observed for quality of life and problem behaviors may yield promise for Montessori-based activities and related health care practices. The rapid physiological and cognitive deterioration from late-stage dementia should be considered when interpreting these results.

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Boxing Training for Patients With Parkinson Disease: A Case Series

Physical Therapy ◽

10.2522/ptj.20100142 ◽

2011 ◽

Vol 91 (1) ◽

pp. 132-142 ◽

Cited By ~ 45

Author(s):

Stephanie A. Combs ◽

M. Dyer Diehl ◽

William H. Staples ◽

Lindsay Conn ◽

Kendra Davis ◽

...

Keyword(s):

Quality Of Life ◽

Activities Of Daily Living ◽

Parkinson Disease ◽

Training Program ◽

Outcome Measures ◽

Daily Living ◽

Case Series ◽

Short Term

Background and PurposeA nontraditional form of exercise recently applied for patients with Parkinson disease (PD) is boxing training. The primary purpose of this case series is to describe the effects of disease severity and duration of boxing training (short term and long term) on changes in balance, mobility, and quality of life for patients with mild or moderate to severe PD. The feasibility and safety of the boxing training program also were assessed.Case DescriptionsSix patients with idiopathic PD attended 24 to 36 boxing training sessions for 12 weeks, with the option of continuing the training for an additional 24 weeks (a seventh patient attended sessions for only 4 weeks). The 90-minute sessions included boxing drills and traditional stretching, strengthening, and endurance exercises. Outcomes were tested at the baseline and after 12, 24, and 36 weeks of boxing sessions (12-, 24-, and 36-week tests). The outcome measures were the Functional Reach Test, Berg Balance Scale, Activities-specific Balance Confidence Scale, Timed “Up & Go” Test, Six-Minute Walk Test, gait speed, cadence, stride length, step width, activities of daily living and motor examination subscales of the Unified Parkinson Disease Rating Scale, and Parkinson Disease Quality of Life Scale.OutcomesSix patients completed all phases of the case series, showed improvements on at least 5 of the 12 outcome measures over the baseline at the 12-week test, and showed continued improvements at the 24- and 36-week tests. Patients with mild PD typically showed improvements earlier than those with moderate to severe PD.DiscussionDespite the progressive nature of PD, the patients in this case series showed short-term and long-term improvements in balance, gait, activities of daily living, and quality of life after the boxing training program. A longer duration of training was necessary for patients with moderate to severe PD to show maximal training outcomes. The boxing training program was feasible and safe for these patients with PD.

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Areas of Discharge Agreement and Disagreement Between Older Adult Patients and Nurses

Care Management Journals ◽

10.1891/cmaj.4.4.185.63690 ◽

2003 ◽

Vol 4 (4) ◽

pp. 185-190 ◽

Cited By ~ 2

Author(s):

Dawn Joosten ◽

Marilyn Potts

Keyword(s):

Quality Of Life ◽

Activities Of Daily Living ◽

Older Adult ◽

Daily Living ◽

Management Practice ◽

Well Being ◽

Adult Patients ◽

Positive Effects ◽

Quality Of Life Index

The objectives of this study were to identify areas of agreement and disagreement between nursing staff and older adult patients about discharge needs, and to explore relationships between hospitalized older adults’ perceived postdischarge Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL) dependency, social networks, and quality of life. Differences between patients and nurses for the ADL scale showed that patients perceived themselves as being more independent with respect to ADLs upon discharge than did their nurses. Agreement between patients and nurses for the Quality of Life Index indicated high agreement about patients’ general well-being upon discharge. Positive relationships between overall IADL and both overall Social Network and Friend subscale scores were indicative of the positive effects of social support on patients’ perceptions of IADL independence. Implications for case management practice were suggested.

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Hand Surgery and Quality of Life

Journal of Hand Surgery (European Volume) ◽

10.1054/jhsb.1998.0211 ◽

1999 ◽

Vol 24 (3) ◽

pp. 263-266 ◽

Cited By ~ 21

Author(s):

R. J. I. COLVILLE ◽

K. S. NICHOLSON ◽

H. J. C. R. BELCHER

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Activities Of Daily Living ◽

Daily Living ◽

Hand Function ◽

Hand Surgery ◽

Well Being ◽

Metacarpophalangeal Joints ◽

Hand Pain

The outcome in patients having surgery to the hand was assessed subjectively using a questionnaire that covered activities of daily living (ADL), hand pain and psychological well-being. The questionnaires were completed on average 6.9 months preoperatively and 20.6 months postoperatively by 15 patients with osteoarthritis undergoing trapeziectomy and 25 patients with rheumatoid arthritis undergoing Swanson arthroplasties of the metacarpophalangeal joints. Surgery resulted in significant improvements in reported ADL and hand pain, in both groups. Improvement in perception of hand function and health was only seen in the osteoarthritic group. There was no improvement in arthritis activity, mood or quality of life in either group. These results confirm that surgery for arthritis of the hand relieves pain and improves ADL. However, it has a greater effect in patients with localized osteoarthritis than in those with rheumatoid arthritis.

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Enabling meaningful activities and quality of life in long-term care facilities: The stepwise development of a participatory client-centred approach in Flanders

British Journal of Occupational Therapy ◽

10.1177/0308022618775880 ◽

2018 ◽

Vol 82 (1) ◽

pp. 15-26 ◽

Cited By ~ 4

Author(s):

Patricia De Vriendt ◽

Elise Cornelis ◽

Ruben Vanbosseghem ◽

Valerie Desmet ◽

Dominique Van de Velde

Keyword(s):

Quality Of Life ◽

Activities Of Daily Living ◽

Social Life ◽

Daily Living ◽

Long Term Care ◽

Term Care ◽

Positive Effects ◽

Care Facilities

Introduction Meaningful activities of daily living promote the quality of life of residents of long-term care facilities. This project aimed to develop an approach to enable meaningful activities of daily living and to guide long-term care facilities in a creative and innovative attitude towards residents' meaningful activities of daily living. Method The approach was developed in six steps: (1) in-depth-interviews with 14 residents; (2) a survey with 171 residents; (3) a systematic map and synthesis review on interventions enriching meaningful activities of daily living; (4) qualitative analysis of 24 ‘good examples’ and, to support future implementation, (5) focus groups with staff ( n = 69). Results determined the components of the new approach which was (6) pilot-tested in one long-term care facility. Quantitative and qualitative data were gathered concerning benefits for the residents and feasibility for the staff. Results A client- and activity-oriented approach was developed, characterised by an active participatory attitude of residents and staff and a systematic iterative process. Significant positive effects were found for the number of activities, the satisfaction with the leisure offered, the social network, medication use, but not for quality of life. The approach appeared to be feasible. Conclusion This approach stimulates residents' meaningful activities of daily living and social life. Further investigation is needed to evaluate its outcome and implementation potentials.

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