Weight loss, cortisol levels, and dexamethasone suppression in major depressive disorder

1987 ◽  
Vol 75 (3) ◽  
pp. 243-250 ◽  
Author(s):  
R.C. Casper ◽  
A.C. Swann ◽  
P.E. Stokes ◽  
S. Chang ◽  
M.M. Katz ◽  
...  
Keyword(s):  
Weight Loss ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Major Depressive ◽  
Cortisol Levels ◽  
Dexamethasone Suppression

Dexamethasone Suppression Test in Depression and other Psychiatric Illness

1983 ◽  
Vol 142 (5) ◽  
pp. 498-504 ◽  
Author(s):  
A. Coppen ◽  
M. Abou-Saleh ◽  
P. Milln ◽  
M. Metcalfe ◽  
J. Harwood ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Affective Disorders ◽  
Psychiatric Illness ◽  
Dexamethasone Suppression Test ◽  
Major Depressive ◽  
Abnormal Response ◽  
Suppression Test ◽  
Dexamethasone Suppression ◽  
Normal Controls

SummaryThe prevalence of an abnormal response to the dexamethasone suppression test (DST) was examined in 119 in-patients suffering from a major depressive disorder and in 79 normal controls. Only 11 per cent of controls showed an abnormal DST as against 70 per cent of depressed patients. The specificity of the DST was examined by testing patients with other psychiatric disorders. Abnormal responses were found in one-fifth of a sample of schizophrenics, over one-quarter of abstinent alcoholics, two-fifths of neurotics (including neurotic depressives) and almost half of senile dements. Abnormal DST was also found in 33 per cent of patients receiving prophylactic lithium for recurrent affective disorders.

Relationship between the hippocampal shape abnormality and serum cortisol levels in first-episode and drug-naïve major depressive disorder patients

2017 ◽  
Vol 34 (5) ◽  
pp. 401-409 ◽  
Author(s):  
Rieko Watanabe ◽  
Shingo Kakeda ◽  
Keita Watanabe ◽  
Xiaodan Liu ◽  
Asuka Katsuki ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Serum Cortisol ◽  
First Episode ◽  
Major Depressive ◽  
Drug Naïve ◽  
Cortisol Levels

Endocrine and behavioural responses to methylphenidate in depression

1986 ◽  
Vol 16 (3) ◽  
pp. 531-540 ◽  
Author(s):  
Peter R. Joyce ◽  
Richard A. Donald ◽  
M. Gary Nicholls ◽  
John H. Livesey ◽  
Robyn M. Abbott
Keyword(s):  
Growth Hormone ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Dexamethasone Suppression Test ◽  
Cortisol Response ◽  
Major Depressive ◽  
Behavioural Responses ◽  
Baseline Cortisol ◽  
Suppression Test ◽  
Dexamethasone Suppression

SynopsisTwenty patients with a major depressive disorder and 20 control subjects were subjected to a 1 mg dexamethasone suppression test (DST) and a challenge with intravenous (IV) methylphenidate (MP)(0·3 mg/kg). None of the controls, but 9 depressives, were DST non-suppressors. Among the depressives there were correlations between DST-cortisol and baseline (4 p.m.) levels of cortisol, growth hormone, prolactin and adrenaline. Compared with the controls the depressives had a decreased cortisol response and an enhanced adrenaline response to the MP challenge. The decreased cortisol response was not related to either DST-cortisol or baseline cortisol, but was correlated with the mood response to MP.

scholarly journals Disrupted Regional Homogeneity in Major Depressive Disorder With Gastrointestinal Symptoms at Rest

2021 ◽  
Vol 12 ◽  
Author(s):  
Meiqi Yan ◽  
Jindong Chen ◽  
Feng Liu ◽  
Huabing Li ◽  
Renzhi Huang ◽  
...  
Keyword(s):  
Weight Loss ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Inferior Frontal Gyrus ◽  
Gastrointestinal Symptoms ◽  
Regional Homogeneity ◽  
Major Depressive ◽  
Functional Changes ◽  
Gi Symptoms ◽  
The Right

Background: Gastrointestinal (GI) symptoms are prominent in patients with major depressive disorder (MDD). Previous studies have reported brain structural and functional changes in both MDD and digestive system diseases but it remains unclear whether MDD patients with GI symptoms have brain imaging changes.Methods: We recruited 35 MDD patients with GI symptoms, 17 MDD patients without GI symptoms and 28 age-, gender-, and education-matched healthy controls. All participants were scanned by resting-state functional magnetic resonance imaging (fMRI). Imaging data were analyzed with regional homogeneity (ReHo).Results: The GI group showed higher total HRSD-17 scores, anxiety/somatization, weight loss, and sleep disturbance scores compared to the non-GI group. We found increased ReHo in the right inferior parietal gyrus (IPL), bilateral supplementary motor area (SMA), bilateral cerebellum Crus II, left inferior frontal gyrus (IFG), and bilateral superior medial frontal cortex (SMFC) and decreased ReHo in the right posterior cingulate cortex (PCC), bilateral cuneus, and left middle occipital gyrus (MOG) in patients with GI symptoms relative to the HCs. The GI group showed higher ReHo values in the bilateral precuneus than the non-GI group.Conclusion: MDD patients with GI symptoms showed a greater severity of symptoms than MDD patients without GI symptoms, particularly in terms of anxiety/somatization, weight loss, and sleep disturbances. Increased activity in the default-mode network might be associated with GI symptoms in MDD patients.

scholarly journals Lack of Evidence for a Relationship Between the Hypothalamus-Pituitary-Adrenal and the Hypothalamus-Pituitary-Thyroid Axis in Adolescent Depression

2021 ◽  
Vol 12 ◽  
Author(s):  
Raphael Hirtz ◽  
Lars Libuda ◽  
Anke Hinney ◽  
Manuel Föcker ◽  
Judith Bühlmeier ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Hpa Axis ◽  
Effect Size ◽  
Major Depressive ◽  
Cross Sectional ◽  
Age Related ◽  
Small Effect Size ◽  
Cortisol Levels ◽  
Hpt Axis

In adults with major depressive disorder (MDD), a dysfunction between the hypothalamus-pituitary-adrenal (HPA) and the hypothalamus-pituitary-thyroid (HPT) axis has been shown, but the interaction of both axes has not yet been studied in adolescent major depressive disorder (MDD). Data from 273 adolescents diagnosed with MDD from two single center cross-sectional studies were used for analysis. Serum levels of thyrotropin (TSH), free levothyroxine (fT4), and cortisol were determined as indicators of basal HPT and HPA axis functioning and compared to that of adolescent controls by t-tests. Quantile regression was employed in the sample of adolescents with MDD to investigate the relationship between both axes in the normal as well as the pathological range of cortisol levels, considering confounders of both axes. In adolescent MDD, cortisol levels and TSH levels were significantly elevated in comparison to controls (p = <.001, d = 1.35, large effect size, and p = <.001, d = 0.79, moderate effect size, respectively). There was a positive linear relationship between TSH and cortisol (p = .003, d = 0.25, small effect size) at the median of cortisol levels (50th percentile). However, no relationship between TSH and cortisol was found in hypercortisolemia (cortisol levels at the 97.5th percentile). These findings imply that HPT and HPA axis dysfunction is common in adolescents with MDD and that function of both axes is only loosely related. Moreover, the regulation of the HPA and HPT axis are likely subjected to age-related maturational adjustments since findings of this study differ from those reported in adults.

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