Short-term effects of severe hypoglycaemia in children and adolescents with type 1 diabetes. A cost-of-illness study

2007 ◽  
Vol 90 (2) ◽  
pp. 137-142 ◽  
Author(s):  
S Nordfeldt ◽  
D Jonsson
2010 ◽  
Vol 105 (1) ◽  
pp. 49-56 ◽  
Author(s):  
Richard Olivier Fourcade ◽  
ÁGnes Benedict ◽  
Libby K. Black ◽  
Michael E. Stokes ◽  
Antonio Alcaraz ◽  
...  

2008 ◽  
Vol 9 (3pt2) ◽  
pp. 74-82 ◽  
Author(s):  
Jodie M Ambrosino ◽  
Kristopher Fennie ◽  
Robin Whittemore ◽  
Sarah Jaser ◽  
Michael F Dowd ◽  
...  

Author(s):  
Josine C. van der Heyden ◽  
Erwin Birnie ◽  
Sarah A. Bovenberg ◽  
Pim Dekker ◽  
Henk J. Veeze ◽  
...  

Abstract Aim To assess 1) the prevalence of children and adolescents with type 1 diabetes (T1D) changing from low-risk into borderline-high-risk lipid levels or from borderline-high-risk into high-risk lipid levels (‘lose track of lipids’) and 2) the power of a risk score including the determinants HbA1c, body mass index (BMI), gender, age, diabetes duration and ethnicity in predicting which patients lose track of lipids. Methods 651 children and adolescents with T1D were included in this longitudinal retrospective cohort study. Lipid dynamics and the impact of the risk score on losing track of lipids were evaluated. Kaplan-Meier analysis was used to estimate screening intervals. Results 31–43% percent of the patients had lost track of one or more lipids at the next lipid measurement. This happened more frequently in patients with a low-risk lipid level at start. Depending on the lipid parameter, 5% of patients with low-risk lipid levels lost track of lipids after 13–23 months. The risk score based on concomitant information on the determinants was moderately able to predict which patients would lose track of lipids on the short term. Conclusions A considerable number of children and adolescents with T1D loses track of lipids and does so within a 2-year screening interval. The predictive power of a risk score including age, BMI, gender, HbA1c, diabetes duration and ethnicity is only moderate. Future research should focus on another approach to the determinants used in this study or other determinants predictive of losing track of lipids on the short term.


2018 ◽  
Vol 32 (6) ◽  
pp. 580-585 ◽  
Author(s):  
Martina Kostkova ◽  
Peter Durdik ◽  
Miriam Ciljakova ◽  
Jarmila Vojtkova ◽  
Anna Sujanska ◽  
...  

Diabetologia ◽  
2007 ◽  
Vol 50 (5) ◽  
pp. 965-971 ◽  
Author(s):  
M. K. Bulsara ◽  
C. D. J. Holman ◽  
F. M. van Bockxmeer ◽  
E. A. Davis ◽  
P. H. Gallego ◽  
...  

2014 ◽  
Vol 71 (9) ◽  
pp. 817-820 ◽  
Author(s):  
Ljiljana Plavsic ◽  
Katarina Mitrovic ◽  
Sladjana Todorovic ◽  
Rade Vukovic ◽  
Tatjana Milenkovic ◽  
...  

Background/Aim. An ideal insulin regimen for children and adolescents with type 1 diabetes mellitus (T1DM) should be physiological, flexibile and predictable, protecting against hypoglycaemia. The aim of this study was to evaluate the influence of insulin analogues on glycaemic control and the occurrence of hypoglycaemic episodes in children and adolescents with T1DM. Methods. The study group consisted of 151 children and adolescents (90 boys, 61 girls) treated with human insulins for at least 12 months before introducing insulin analogues. All the patients were divided into two groups: the group I consisted of 72 (47.7%) patients treated with three injections of regular human insulin before meals and long-acting analogue (RHI/LA), and the group II of 79 (52.3%) patients treated with a combination of rapid-acting and long-acting analogue (RA/LA). The levels of glycated hemoglobin (HbA1c) and the number of hypoglycaemic episodes were assessed at the beginning of therapy with insulin analogues, and after 6 and 12 months. Results. The mean HbA1c was significantly lower in the group I (RHI/LA) after 6 months (9.15% vs 8.20%, p < 0.001) and after 12 months (9.15% vs 8.13%, p < 0.001) as well as in the group II (RA/LA) after 6 months (9.40% vs 8.24%, p < 0.001) and after 12 months of insulin analogues treatment (9.40% vs 8.38%, p < 0.001). The frequency of severe hypoglycaemia was significantly lower in both groups after 6 months (in the group I from 61.1% to 4.2% and in the group II from 54.4% to 1.3%, p < 0.001), and after 12 months (in the group I from 61.1% to 1.4% and in the group II from 54.4% to 1.3%, p < 0.001). Conclusion. Significantly better HbA1c values and lower risk of severe hypoglycaemia were established in children and adolescents with T1DM treated with insulin analogues.


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