A LEUCOCYTE MIGRATION STUDY ON THE CELL-MEDIATED IMMUNITY AGAINST ADULT HUMAN ORAL MUCOSA AND STREPTOCOCCAL ANTIGENS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS

2009 ◽  
Vol 84C (3) ◽  
pp. 227-234 ◽  
Author(s):  
O. Donatsky
Keyword(s):  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Cell Mediated Immunity ◽  
Adult Human ◽  
Migration Study ◽  
Leucocyte Migration ◽  
Streptococcal Antigens

scholarly journals RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD

2019 ◽  
Vol 6 ◽  
pp. 45
Author(s):  
Rina Kartika Sari ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi
Keyword(s):  
Food Allergy ◽  
Psychological Stress ◽  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Predisposing Factors ◽  
Aphthous Stomatitis ◽  
Cow Milk ◽  
Esophageal Mucosa ◽  
History Of ◽  
Multiple Ulcers

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

scholarly journals Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (12) ◽  
pp. 636 ◽  
Author(s):  
Zuzana Stehlikova ◽  
Vojtech Tlaskal ◽  
Natalie Galanova ◽  
Radka Roubalova ◽  
Jakub Kreisinger ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Serum Levels ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Common Disease ◽  
Oral Microbiota ◽  
Healthy Controls ◽  
Alpha And Beta Diversity ◽  
Oral Site ◽  
Bacteria And Fungi

Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.

scholarly journals Penatalaksanaan stomatitis aftosa rekuren mayor dengan infeksi sekunder Management of major recurrent aphtous stomatitis accompanied by secondary infection

2011 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Nurdiana Nurdiana ◽  
M. Jusri
Keyword(s):  
Immune Response ◽  
Oral Mucosa ◽  
Secondary Infection ◽  
Good Prognosis ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Proper Treatment ◽  
Local Immune Response

Recurrent aphthous stomatitis (RAS)is an ulcerative condition that affects the oral mucosa without evidence ofunderlying disorder. It’s characterized by the appearance of recurring round, shallow ulcerations surrounded byinflammation that mainly involves the nonkeratinized mucosa. The classification of SAR are minor, major, andherpetiform types. Although rare, secondary infection may occur. Treatment is directed to avoid local traumaticprecipitants, lessen the pain and duration of ulceration by suppressing the local immune response, and preventsecondary infection. The objective of this paper is to discuss the treatment of RAS with secondary infection, a caseof 24-year-old man with multiple large ulcers that did not heal for almost 4 weeks. The ulcers were diagnosed asmajor RAS with secondary infection, and treated with metronidazole and ciprofloxacin, healed in 2 weeks withscars. Although secondary infection will delay healing, but with proper treatment, major RAS has good prognosis.

scholarly journals Morphofunctional peculiarities of tissue of oral cavity in chronic recurrent aphthous stomatitis with therapeutical correction

2016 ◽  
Vol 3 (3) ◽  
pp. 146-149
Author(s):  
Kovac I.V., Kravchenko L.I., Gargin V.V.
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Soft Tissues ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Histological Investigation ◽  
Ozone Therapy ◽  
Experimental Animals ◽  
Methods Of Treatment ◽  
Β Carotene

Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to identify the morphofunctional peculiarities in chronic recurrent aphthous stomatitis with therapeutical correction in soft tissues of the oral cavity of experimental animals in the modeling of chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS and formed three groups of animals (rabbits) with different methods of treatment. Histological investigation have been performed. Conclusion of our research is that correction of tissual changes in chronic recurrent aphthous stomatitis could be obtained with application of gel with β-carotene, α-tocopherol, a mixture of vegetable oils; with ozone therapy and their combination.Keywords: chronic recurrent aphthous stomatitis, histology, experiment. АннотацияКовач И.В., Кравченко Л.И., Гаргин В.В*.Морфофункциональные особенности тканей ротовой полости при хроническом рецидивирующем афтозном стоматите с терапевтической коррекциейХронический рецидивирующий афтозный стоматит относится к группе хронических, воспалительных, язвенных заболеваний слизистой оболочки полости рта. Целью данного исследования явилось выявление морфофункциональных особенностей мягких тканей ротовой полости экспериментальных животных при моделировании хронического рецидивирующего афтозного стоматита с терапевтической коррекцией. Мы моделировали хронический рецидивирующий афтозный стоматит и изучили морфо-функциональное состояние тканей слизистой оболочки полости рта сформировав три группы животных (кроликов) с различными методами лечения. Было проведено гистологическое исследование. Вывод наших исследований заключается в том, что коррекция тканевых изменений при хроническом рецидивирующем афтозном стоматите может быть получена при применении геля с бета-каротином, альфа-токоферолом, смесью растительных масел, кроме этого при озонотерапии и комбинации указанных методов.Ключевые слова: хронический рецидивирующий афтозный стоматит, гистология, эксперимент. АнотаціяКовач І.В., Кравченко Л.І., Гаргін В.В.*Морфофункціональні особливості тканин ротової порожнини при хронічному рецидивуючому афтозний стоматит з терапевтичної корекцією Хронічний рецидивний афтозний стоматит відноситься до групи хронічних, запальних, виразкових захворювань слизової оболонки порожнини рота. Метою даного дослідження було виявлення морфофункціональних особливостей м'яких тканин ротової порожнини експериментальних тварин при моделюванні хронічного рецидивуючого афтозного стоматиту з терапевтичної корекцією. Ми моделювали хронічний рецидивний афтозний стоматит і вивчали морфо-функціональний стан тканин слизової оболонки порожнини рота сформувавши три групи тварин (кроликів) з різними методами лікування. Було проведено гістологічне дослідження. Висновок наших досліджень полягає в тому, що корекція тканинних змін при хронічному рецидивуючому афтозному стоматит може бути отримана при застосуванні гелю з бета-каротином, альфа-токоферолом, сумішшю рослинних масел, крім цього при озонотерапії та комбінації вказаних методів.Ключові слова: хронічний рецидивуючий афтозний стоматит, гістологія, експеримент.

scholarly journals SUBSTANTIATION OF DIAGNOSIS AND TREATMENT OF CHRONIC RECURRENT APHTHOUS STOMATITIS IN CROHN’S DISEASE

2020 ◽  
Vol 73 (3) ◽  
pp. 512-516
Author(s):  
Oksana Y. Feleshtynska ◽  
Olena O. Dyadyk
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Oral Mucosa ◽  
Morphological Study ◽  
Comparison Group ◽  
Granulomatous Inflammation ◽  
Main Group ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Diagnosis And Treatment

The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn’s disease. Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn’s disease (main group), mean age 31.8 + 2.3 was performed. The comparison group consisted of 50 patients with chronic recurrent aphthous stomatitis not associated with Crohn’s disease (mean age 34.7 + 1.8). Patients in both groups were studied for clinical manifestations, morphological and immunohistochemical studies the aphthae on the oral mucosa were performed. Results: An objective evaluation of the oral mucosa showed that the aphthae on the oral mucosa in patients of both groups did not differ visually. In the morphological study, the patients in the main group had granulomatous inflammation of the oral mucosa, characteristic of Crohn’s disease, while the patients in the comparison group had fibrinous inflammation. Immunohistochemical study of the cell infiltrate phenotype in the area of the lesion revealed that the patients in the main group there prevailed CD68+macrophages, the appearance of both intraepithelial and cell infiltrates of T-lymphocyte suppressors, which is characteristic of Crohn’s disease. Conclusions: Diagnosis of chronic recurrent aphthous stomatitis in Crohn’s disease is based on biopsy of the aphthae on the oral mucosa and their morphological examination, the results of which confirm the presence of granulomatous inflammation, with a large number of macrophages, the presence of T-lymphocytes, characteristic of Crohn’s disease, while recurrent aphthous stomatitis of another genesis morphologically detect fibrinous inflammation. The choice of therapeutic tactics for chronic recurrent aphthous stomatitis depends on the results of the morphological study. When granulomatous inflammation is detected in patients with chronic recurrent aphthous stomatitis, which is characteristic of Crohn’s disease, in addition to topical treatment of the oral mucosa, specific therapy with mesalazine drugs is prescribed.

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