scholarly journals Oral Microbiota Composition and Antimicrobial Antibody Response in Patients with Recurrent Aphthous Stomatitis

2019 ◽  
Vol 7 (12) ◽  
pp. 636 ◽  
Author(s):  
Zuzana Stehlikova ◽  
Vojtech Tlaskal ◽  
Natalie Galanova ◽  
Radka Roubalova ◽  
Jakub Kreisinger ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Serum Levels ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Common Disease ◽  
Oral Microbiota ◽  
Healthy Controls ◽  
Alpha And Beta Diversity ◽  
Oral Site ◽  
Bacteria And Fungi

Recurrent aphthous stomatitis (RAS) is the most common disease of the oral mucosa, and it has been recently associated with bacterial and fungal dysbiosis. To study this link further, we investigated microbial shifts during RAS manifestation at an ulcer site, in its surroundings, and at an unaffected site, compared with healed mucosa in RAS patients and healthy controls. We sampled microbes from five distinct sites in the oral cavity. The one site with the most pronounced differences in microbial alpha and beta diversity between RAS patients and healthy controls was the lower labial mucosa. Detailed analysis of this particular oral site revealed strict association of the genus Selenomonas with healed mucosa of RAS patients, whereas the class Clostridia and genera Lachnoanaerobaculum, Cardiobacterium, Leptotrichia, and Fusobacterium were associated with the presence of an active ulcer. Furthermore, active ulcers were dominated by Malassezia, which were negatively correlated with Streptococcus and Haemophilus and positively correlated with Porphyromonas species. In addition, RAS patients showed increased serum levels of IgG against Mogibacterium timidum compared with healthy controls. Our study demonstrates that the composition of bacteria and fungi colonizing healthy oral mucosa is changed in active RAS ulcers, and that this alteration persists to some extent even after the ulcer is healed.

Recent advances in the aetiology of recurrent aphthous stomatitis (RAS)

2021 ◽  
pp. postgradmedj-2020-139421
Author(s):  
Zihan Wang ◽  
Haibo Cao ◽  
Jianqi Xiong ◽  
Yilong Lu ◽  
Yixiao Deng ◽  
...  
Keyword(s):  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Common Disease ◽  
Research Model ◽  
Sample Collection ◽  
Comprehensive View ◽  
Recent Advances ◽  
Potential Factors ◽  
New Treatments

Recurrent aphthous stomatitis (RAS) is the most common disease of oral mucosa, which almost attacks each individual once in their lifespan. Although plenty of factors have been suggested to play a role in the pathogenesis of RAS, the aetiology of RAS is still controversial, which might lead to limited clinical therapies in accordance with each RAS patient. This review mainly illustrates recent advances in potential causes associated with RAS in detail. Deeper comprehension of the aetiology of RAS will support doctors and researchers to make a better management of RAS patients and to discover new treatments. The aetiology of RAS is complicated, hence we should take a comprehensive view into its aetiology, with multiple potential factors being considered. Sample collection of RAS patients have greatly limited the progress in the aetiology of RAS. A research model of multiagency cooperation can help achieve perfect sample collection of year-round and multiposition.

scholarly journals RECURRENT APHTHOUS STOMATITIS RELATED TO PSYCHOLOGICAL STRESS, FOOD ALLERGY AND GERD

2019 ◽  
Vol 6 ◽  
pp. 45
Author(s):  
Rina Kartika Sari ◽  
Diah Savitri Ernawati ◽  
Bagus Soebadi
Keyword(s):  
Food Allergy ◽  
Psychological Stress ◽  
Oral Mucosa ◽  
Recurrent Aphthous Stomatitis ◽  
Predisposing Factors ◽  
Aphthous Stomatitis ◽  
Cow Milk ◽  
Esophageal Mucosa ◽  
History Of ◽  
Multiple Ulcers

Background: Recurrent Aphthous Stomatitis (RAS) is inflammation in oral mucosa characterized by recurrent single or multiple ulcers that usually affected in non keratinized mucosa. Etiology RAS is unknown but psychological stress, allergy, and gastrointestinal disease can be predisposing factors Case Management: A 23rd years old complained recurrent oral ulcer with free ulcer period for 3-5 days. The patient had a history of food allergy, GERD and psychological stress. Intraoral examination showed recurrent multiple ulcers in variation site of the mouth. DASS 42 screening showed high stress and high anxiety. Skin Prick Test showed positive allergy to kapok, beef, chicken, cow milk, white egg, duck egg, shrimp, cob fish, milkfish, chocolate, and peanut. Ulcers treated with nonsteroid antiinflammation Aloe Vera gel and stress management by reading assignment method.Discussion: Psychological stress altered the immune system so oral mucosa prone to inflammation, and make the history of GERD getting worse. Stress causes cortisol secretion that changes the imbalance of proinflammatory and antiinflammatory cytokines. Oral mucosa becomes more susceptible to hypersensitivity. In addition, stress decreased oral and esophageal mucosa resistance to GERDConclusion: RAS triggered by psychological stress, allergy, and GERD. Treatment of RAS is by elimination predisposing factors to prevent recurrence.

scholarly journals Serum Levels of Neuropeptides in Cows with Left Abomasal Displacement

2018 ◽  
Vol 5 (4) ◽  
pp. 103
Author(s):  
Marlene Sickinger ◽  
Joachim Roth ◽  
Klaus Failing ◽  
Axel Wehrend
Keyword(s):  
Substance P ◽  
Dairy Cows ◽  
Vasoactive Intestinal Polypeptide ◽  
Serum Levels ◽  
Common Disease ◽  
Healthy Controls ◽  
Serum Concentrations ◽  
Blood Samples ◽  
Breed Difference ◽  
Abomasal Displacement

Abomasal displacement (AD) to the left is a common disease in high-yielding dairy cows after parturition. In view of the previously reported changes in tissue neuropeptide concentrations in cows with AD, the primary aim of this study was to evaluate the effect of AD and breed on serum neuropeptide concentrations. For this purpose, blood samples of 33 German Holstein (GH) cows with AD, 36 healthy controls (GH), and 32 healthy German Fleckvieh (GF) cows were collected, and concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin1β (IL-1β) were measured via commercially available ELISA kits. To examine the effect of AD, we compared GH cows with and without AD and observed no significant effects of AD on SP, VIP, or Il-1 β concentrations. To evaluate the effect of breed, we compared healthy GH with healthy GF cows and detected markedly higher VIP serum levels in the healthy GF cows (p < 0.01). No significant differences in SP or IL-1β were detected. According to our results, there seems to be no effect of AD on the serum concentrations of SP, VIP, or IL-1 β. In contrast, there seems to be a breed difference concerning serum VIP concentrations.

scholarly journals Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study

2021 ◽  
Vol 35 ◽  
pp. 205873842110644
Author(s):  
Shereen A Baioumy ◽  
Shaimaa H Fouad ◽  
Shaimaa A Abdalgeleel ◽  
Ahmed A Baiomy ◽  
Dina E Sallam ◽  
...  
Keyword(s):  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Recurrent Aphthous Stomatitis ◽  
Mannose Binding Lectin ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Control Study

Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS) development. The main objective of this case–control study is to investigate the blood levels of mannose-binding lectin (MBL) and the frequency of the MBL2 gene (gly54asp) polymorphism in RAS patients, including 40 RAS patients and 40 healthy controls. Methods: Serum MBL levels were determined by ELISA, while the PCR-restriction fragment length polymorphism was used in MBL2 genotyping. Results: The median serum MBL level was significantly lower in the RAS group than in the control group (975 ng/mL (545–1320) vs. 1760 ng/mL (1254–2134); p≤ 0.001). The MBL levels were significantly lower in the BB genotype, whereas they were significantly higher in the wild type AA with a median of 525 and 1340 ng/mL, respectively ( p =0.005). The B allele was expressed in significantly higher percentages of RAS patients than in controls. There was no significant association between MBL serum levels ( p=0.685) or MBL2 codon 54 genotypes ( p=0.382) with the type of ulcers. Conclusion: There was an association between low MBL serum levels and the variant allele B of the MBL2 (gly54asp) gene, and the susceptibility to RAS. As a result, potential novel therapeutic options for RAS patients with MBL deficiency should be investigated.

scholarly journals Penatalaksanaan stomatitis aftosa rekuren mayor dengan infeksi sekunder Management of major recurrent aphtous stomatitis accompanied by secondary infection

2011 ◽  
Vol 10 (1) ◽  
pp. 42
Author(s):  
Nurdiana Nurdiana ◽  
M. Jusri
Keyword(s):  
Immune Response ◽  
Oral Mucosa ◽  
Secondary Infection ◽  
Good Prognosis ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Proper Treatment ◽  
Local Immune Response

Recurrent aphthous stomatitis (RAS)is an ulcerative condition that affects the oral mucosa without evidence ofunderlying disorder. It’s characterized by the appearance of recurring round, shallow ulcerations surrounded byinflammation that mainly involves the nonkeratinized mucosa. The classification of SAR are minor, major, andherpetiform types. Although rare, secondary infection may occur. Treatment is directed to avoid local traumaticprecipitants, lessen the pain and duration of ulceration by suppressing the local immune response, and preventsecondary infection. The objective of this paper is to discuss the treatment of RAS with secondary infection, a caseof 24-year-old man with multiple large ulcers that did not heal for almost 4 weeks. The ulcers were diagnosed asmajor RAS with secondary infection, and treated with metronidazole and ciprofloxacin, healed in 2 weeks withscars. Although secondary infection will delay healing, but with proper treatment, major RAS has good prognosis.

W1630 Oral Microbiota in Inflammatory Bowel Disease and Recurrent Aphthous Stomatitis

2009 ◽  
Vol 136 (5) ◽  
pp. A-706
Author(s):  
Garrett C. Zella ◽  
Flavia R. Teles ◽  
Anne D. Haffajee ◽  
Joshua R. Korzenik
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Oral Microbiota ◽  
Inflammatory Bowel

scholarly journals Morphofunctional peculiarities of tissue of oral cavity in chronic recurrent aphthous stomatitis with therapeutical correction

2016 ◽  
Vol 3 (3) ◽  
pp. 146-149
Author(s):  
Kovac I.V., Kravchenko L.I., Gargin V.V.
Keyword(s):  
Oral Cavity ◽  
Oral Mucosa ◽  
Soft Tissues ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Histological Investigation ◽  
Ozone Therapy ◽  
Experimental Animals ◽  
Methods Of Treatment ◽  
Β Carotene

Chronic recurrent aphthous stomatitis (CRAS) belongs to the group of chronic, inflammatory, ulcerative diseases of the oral mucosa. The aim of this study was to identify the morphofunctional peculiarities in chronic recurrent aphthous stomatitis with therapeutical correction in soft tissues of the oral cavity of experimental animals in the modeling of chronic recurrent aphthous stomatitis. We performed experimental investigation for study of the morpho-functional state of tissues of the oral mucosa in CRAS and formed three groups of animals (rabbits) with different methods of treatment. Histological investigation have been performed. Conclusion of our research is that correction of tissual changes in chronic recurrent aphthous stomatitis could be obtained with application of gel with β-carotene, α-tocopherol, a mixture of vegetable oils; with ozone therapy and their combination.Keywords: chronic recurrent aphthous stomatitis, histology, experiment. АннотацияКовач И.В., Кравченко Л.И., Гаргин В.В*.Морфофункциональные особенности тканей ротовой полости при хроническом рецидивирующем афтозном стоматите с терапевтической коррекциейХронический рецидивирующий афтозный стоматит относится к группе хронических, воспалительных, язвенных заболеваний слизистой оболочки полости рта. Целью данного исследования явилось выявление морфофункциональных особенностей мягких тканей ротовой полости экспериментальных животных при моделировании хронического рецидивирующего афтозного стоматита с терапевтической коррекцией. Мы моделировали хронический рецидивирующий афтозный стоматит и изучили морфо-функциональное состояние тканей слизистой оболочки полости рта сформировав три группы животных (кроликов) с различными методами лечения. Было проведено гистологическое исследование. Вывод наших исследований заключается в том, что коррекция тканевых изменений при хроническом рецидивирующем афтозном стоматите может быть получена при применении геля с бета-каротином, альфа-токоферолом, смесью растительных масел, кроме этого при озонотерапии и комбинации указанных методов.Ключевые слова: хронический рецидивирующий афтозный стоматит, гистология, эксперимент. АнотаціяКовач І.В., Кравченко Л.І., Гаргін В.В.*Морфофункціональні особливості тканин ротової порожнини при хронічному рецидивуючому афтозний стоматит з терапевтичної корекцією Хронічний рецидивний афтозний стоматит відноситься до групи хронічних, запальних, виразкових захворювань слизової оболонки порожнини рота. Метою даного дослідження було виявлення морфофункціональних особливостей м'яких тканин ротової порожнини експериментальних тварин при моделюванні хронічного рецидивуючого афтозного стоматиту з терапевтичної корекцією. Ми моделювали хронічний рецидивний афтозний стоматит і вивчали морфо-функціональний стан тканин слизової оболонки порожнини рота сформувавши три групи тварин (кроликів) з різними методами лікування. Було проведено гістологічне дослідження. Висновок наших досліджень полягає в тому, що корекція тканинних змін при хронічному рецидивуючому афтозному стоматит може бути отримана при застосуванні гелю з бета-каротином, альфа-токоферолом, сумішшю рослинних масел, крім цього при озонотерапії та комбінації вказаних методів.Ключові слова: хронічний рецидивуючий афтозний стоматит, гістологія, експеримент.

scholarly journals SUBSTANTIATION OF DIAGNOSIS AND TREATMENT OF CHRONIC RECURRENT APHTHOUS STOMATITIS IN CROHN’S DISEASE

2020 ◽  
Vol 73 (3) ◽  
pp. 512-516
Author(s):  
Oksana Y. Feleshtynska ◽  
Olena O. Dyadyk
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Oral Mucosa ◽  
Morphological Study ◽  
Comparison Group ◽  
Granulomatous Inflammation ◽  
Main Group ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Diagnosis And Treatment

The aim: To substantiate the diagnosis and treatment of chronic recurrent aphthous stomatitis in Crohn’s disease. Materials and methods: The analysis of diagnostic and treatment of 52 patients with chronic recurrent aphthous stomatitis in Crohn’s disease (main group), mean age 31.8 + 2.3 was performed. The comparison group consisted of 50 patients with chronic recurrent aphthous stomatitis not associated with Crohn’s disease (mean age 34.7 + 1.8). Patients in both groups were studied for clinical manifestations, morphological and immunohistochemical studies the aphthae on the oral mucosa were performed. Results: An objective evaluation of the oral mucosa showed that the aphthae on the oral mucosa in patients of both groups did not differ visually. In the morphological study, the patients in the main group had granulomatous inflammation of the oral mucosa, characteristic of Crohn’s disease, while the patients in the comparison group had fibrinous inflammation. Immunohistochemical study of the cell infiltrate phenotype in the area of the lesion revealed that the patients in the main group there prevailed CD68+macrophages, the appearance of both intraepithelial and cell infiltrates of T-lymphocyte suppressors, which is characteristic of Crohn’s disease. Conclusions: Diagnosis of chronic recurrent aphthous stomatitis in Crohn’s disease is based on biopsy of the aphthae on the oral mucosa and their morphological examination, the results of which confirm the presence of granulomatous inflammation, with a large number of macrophages, the presence of T-lymphocytes, characteristic of Crohn’s disease, while recurrent aphthous stomatitis of another genesis morphologically detect fibrinous inflammation. The choice of therapeutic tactics for chronic recurrent aphthous stomatitis depends on the results of the morphological study. When granulomatous inflammation is detected in patients with chronic recurrent aphthous stomatitis, which is characteristic of Crohn’s disease, in addition to topical treatment of the oral mucosa, specific therapy with mesalazine drugs is prescribed.

scholarly journals Distribution of oral ulceration cases in Oral Medicine Integrated Installation of Universitas Padjadjaran Dental Hospital

2020 ◽  
Vol 32 (3) ◽  
pp. 237
Author(s):  
Dewi Zakiawati ◽  
Nanan Nur'aeny ◽  
Riani Setiadhi
Keyword(s):  
Oral Mucosa ◽  
Descriptive Study ◽  
Medical Data ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Herpes Labialis ◽  
Oral Medicine ◽  
Oral Ulceration ◽  
Outpatient Unit ◽  
Dental Hospital

Introduction: Oral ulceration defines as discontinuity of the oral mucosa caused by the damage of both epithelium and lamina propria. Among other types of lesions, ulceration is the most commonly found lesion in the oral mucosa, especially in the outpatient unit. Oral Medicine Integrated Installation (OMII) Department in Universitas Padjadjaran Dental Hospital serves as the centre of oral health and education services, particularly in handling outpatient oral medicine cases. This research was the first study done in the Department which aimed to observe the distribution of oral ulceration in OMII Department university Dental Hospital. The data is essential in studying the epidemiology of the diseases. Methods: The research was a descriptive study using the patient’s medical data between 2010 and 2012. The data were recorded with Microsoft® Excel, then analysed and presented in the table and diagram using GraphPad Prism® Results: During the study, the distribution of oral ulceration cases found in OMII Department was 664 which comprises of traumatic ulcers, recurrent aphthous stomatitis, angular cheilitis, herpes simplex, herpes labialis, and herpes zoster. Additionally, more than 50% of the total case was recurrent aphthous stomatitis, with a precise number of 364. Conclusion: It can be concluded that the OMII Department in university Dental Hospital had been managing various oral ulceration cases, with the most abundant cases being recurrent aphthous stomatitis.

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