Spontaneous resorption of a diabetic cataract in a geriatric dog

2005 ◽  
Vol 46 (8) ◽  
pp. 406-408 ◽  
Author(s):  
E. Gonzalez-Alonso-Alegre ◽  
A. Rodriguez-Alvaro
Keyword(s):  
Diabetic Cataract

scholarly journals Diabetic Cataract—Pathogenesis, Epidemiology and Treatment

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Andreas Pollreisz ◽  
Ursula Schmidt-Erfurth
Keyword(s):  
Experimental Studies ◽  
Disease Process ◽  
Basic Research ◽  
Polyol Pathway ◽  
Population Based ◽  
Diabetic Patients ◽  
Diabetic Cataract ◽  
Cataract Development

Cataract in diabetic patients is a major cause of blindness in developed and developing countries. The pathogenesis of diabetic cataract development is still not fully understood. Recent basic research studies have emphasized the role of the polyol pathway in the initiation of the disease process. Population-based studies have greatly increased our knowledge concerning the association between diabetes and cataract formation and have defined risk factors for the development of cataract. Diabetic patients also have a higher risk of complications after phacoemulsification cataract surgery compared to nondiabetics. Aldose-reductase inhibitors and antioxidants have been proven beneficial in the prevention or treatment of this sightthreatening condition in in vitro and in vivo experimental studies. This paper provides an overview of the pathogenesis of diabetic cataract, clinical studies investigating the association between diabetes and cataract development, and current treatment of cataract in diabetics.

scholarly journals Lens Lipid Peroxides and Glutathione Concentrations in Diabetic Cataract

1997 ◽  
Vol 34 (2) ◽  
pp. 190-192 ◽  
Author(s):  
D Özmen ◽  
I Mutaf ◽  
B Özmen ◽  
J Mentes ◽  
O Bayindir
Keyword(s):  
G Protein ◽  
Lipid Peroxide ◽  
Lipid Peroxides ◽  
Thiobarbituric Acid ◽  
Thiobarbituric Acid Reactive Substances ◽  
Diabetic Cataract ◽  
Free Radical Damage ◽  
Significant Difference ◽  
Radical Damage

This study aims to explore the role of reactive oxygen radicals in the genesis of diabetic cataract. Lipid peroxide (LPO) concentrations in senile ( n = 30) and diabetic ( n = 14) cataractous lenses, were determined as thiobarbituric acid-reactive substances (TBARS) by a method modified from Satoh and Yagi, and reduced glutathione (GSH) concentrations were measured according to Beutler. Lens LPO levels (mean, SD; nmol TBARS/g protein) were significantly higher in diabetics (107·54, 18·12) than senile cataractous subjects (53·54, 15·48) ( P < 0·0001). Lens GSH levels (mean, SD; nmol/g protein) showed no significant difference between diabetics (4·29, 2·05) and senile cataractous subjects (4·68, 3·12). These results suggest that free radical damage is more effective in the genesis of diabetic cataract than in senile cataract.

scholarly journals 2347 Diabetic cataract and oxidative degradation of lens proteins

1995 ◽  
Vol 35 ◽  
pp. S110
Author(s):  
S. Requejo ◽  
J.S. Ramalho ◽  
P. Pereira ◽  
M.C. Mota
Keyword(s):  
Oxidative Degradation ◽  
Diabetic Cataract ◽  
Lens Proteins

Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice

2014 ◽  
Vol 35 (1) ◽  
pp. 115-120 ◽  
Author(s):  
Emrah Kan ◽  
Elif Kiliçkan ◽  
Ahmet Ayar ◽  
Ramis Çolak
Keyword(s):  
Lipoic Acid ◽  
Diabetic Cataract

A clinical study of diabetic cataract and retinopathy

2016 ◽  
Vol 4 (1) ◽  
pp. 19
Author(s):  
K Vishwanath ◽  
Malladi Padma ◽  
DPadma Prabha
Keyword(s):  
Clinical Study ◽  
Diabetic Cataract

Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract

2020 ◽  
Author(s):  
Ramachandran Kaliaperumal ◽  
Ramesh Venkatachalam ◽  
Prithiviraj Nagarajan ◽  
Satheesh Kumar Sabapathy
Keyword(s):  
Oxidative Stress ◽  
Serum Magnesium ◽  
Diabetic Cataract

scholarly journals Diabetic Cataract in Spontaneously Diabetic Torii Fatty Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Kasumi Kikuchi ◽  
Miyuki Murata ◽  
Kousuke Noda ◽  
Satoru Kase ◽  
Yoshiaki Tagawa ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Animal Model ◽  
Cataract Formation ◽  
Sprague Dawley ◽  
Diabetic Cataract ◽  
Glucose Levels ◽  
Sd Rats ◽  
Ocular Disorders ◽  
And Control

Spontaneously Diabetic Torii (SDT) fatty rat is a novel animal model of type 2 diabetes with obesity. SDT fatty rats develop hyperglycemia, dyslipidemia, and other diabetic complications including ocular disorders; however, diabetic cataract formation in SDT fatty rats has not been fully investigated. The aim of the current study was to investigate the characteristics of cataract in the SDT fatty rats. The mean body weight of SDT fatty rats is larger than that of age-matched Sprague-Dawley (SD) rats and control animals until 8 weeks of age, and thereafter the growing speed decreased until the end of observation at 16 weeks of age. Blood glucose levels in SDT fatty rats were significantly higher than those in SD rats throughout the observational period. Slit-lamp examination revealed that no rats showed cataract formation at 5 weeks of age; however, SDT fatty rats gradually developed cortical cataract and posterior subcapsular cataract, both of which are the common types of cataract in patients with type 2 diabetes. The levels of glucose, sorbitol, and fructose were higher in the lens tissues of SDT fatty rats in comparison with that of SD rats. Furthermore, the level of 4-hydroxynonenal (4-HNE) was higher in the lens of SDT fatty rats than in that of SD rats. By contrast, total glutathione (GSH) concentration was lower in the lens of SDT fatty rats than in that of SD rats. The present study demonstrated that the cataractogenesis in SDT fatty rats resembled human diabetic cataract formation, indicating that SDT fatty rats serve as a potential animal model in researches on human cataract associated with type 2 diabetes and obesity.

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