TRANS-FATTY ACIDS AND SERUM CHOLESTEROL LEVELS

2009 ◽  
Vol 49 (2) ◽  
pp. 57-60
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Trans Fatty Acids ◽  
Cholesterol Levels

scholarly journals Impact of Danish ban of industrial produced trans fatty acids on serum cholesterol levels 1993-2006

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
K Bjornsboe ◽  
M U Jakobsen ◽  
A Bysted ◽  
S Fagt ◽  
T Christensen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Trans Fatty Acids ◽  
Western Europe ◽  
Food Composition ◽  
Decision Makers ◽  
Cholesterol Levels ◽  
Regulatory Interventions ◽  
The Impact ◽  
The Eu

Abstract Industrially produced trans fatty acids (ITFA) increase the LDL:HDL ratio and hereby the risk of cardiovascular disease (CVD). Therefore, ITFA has been reduced in Western Europe over the last decades but is still high in Eastern Europe and in subgroups of the EU population. Regulatory interventions are the only way to minimize ITFA intake for all. The Danish ITFA ban (2004) can elucidate the impact of elimination of ITFA on CVD. In Denmark cardiac mortality declined by 70% through 1980-2009. Data on ITFA intake and blood lipids from the 1990s, where the average Danish ITFA intake was about 3 g/d, and up to today are needed to study the correlation between intake of ITFA and serum cholesterol (CHOL). The Danish food composition databank has been updated with TFA intake values. Hereby the correlation between ITFA intake and CHOL level in Denmark from 1993 -2006 can be investigated. Methods Ecological analyses of ITFA and CHOL in participants from 3 cohorts: Diet, Cancer and Health (1993-1997); n = 57,054; 50-64 yrInter99 (1999-2001); n = 6,784, 30-60 yrHealth 2006 (2006); n = 3,471, 18-69 yr Results ITFA-intake was 0.02 g/d in Inter99. Data will be extended to include ITFA intake data of all cohorts as well as age adjusted correlations with CHOL. Mean CHOL all men (n = 31,675) declined from 6.3 ± 1.0 in 1993 to 5.4± 1.0 in 2006 Mean CHOL all women (n = 34,675) declined from 6.6 ± 1.5 in 1993 to 5.4± 1.1 in 2006 Similar declines were found in participants without self-reported hypercholesterolemia: Mean CHOL men (n = 28,999) declined from 6.1 ± 0.9 in 1993 to 5.1± 1.0 in 2006 Mean CHOL women (n = 32,593) declined from 6.5 ± 1.5 in 1993 to 5.2± 1.1 in 2006 There was a significant decrease in CHOL (p < 0.0001) from 1993, where average Danish intake of ITFA was about 3 g/d to 2006 where ITFA was banned Conclusions Data show a non-treatment related significant decline in CHOL. Data from 2000 and 2006 are collected in younger populations, which may explain lower CHOL levels. Key messages Cholesterol decline significantly in Danish participants simultaneously with ITFA elimination. Results are important for decision makers in countries which consider ITFA regulation.

Effects of chronic treatment with carbutamide on distribution and biosynthesis of fatty acids and cholesterol in obese-hyperglycemic mice

1959 ◽  
Vol 196 (3) ◽  
pp. 603-606 ◽  
Author(s):  
Jean Christophe ◽  
Jean Mayer
Keyword(s):  
Fatty Acids ◽  
Weight Gain ◽  
Food Intake ◽  
Blood Sugar ◽  
Serum Cholesterol ◽  
Chronic Treatment ◽  
Oral Treatment ◽  
Cholesterol Levels ◽  
Sugar Levels

Oral treatment with carbutamide (BZ-55) for 7 weeks (2.5 gm/kg of ground chow) left the food intake and rate of weight gain of obese-hyperglycemic mice and lean littermates unmodified as compared with untreated controls. Obese-hyperglycemic animals, after 49 days of treatment showed the usual distribution and rate of biosynthesis of fatty acids and cholesterol in the liver and carcass. Liver hypertrophy, marked increase in serum cholesterol levels and lack of improvement of the ‘diabetes’ were also observed in these animals. Lean littermates similarly treated showed no modification in the distribution of fatty acids and cholesterol and in the biosynthesis of fatty acids in the liver and carcass. An increase in hepatic cholesterologenesis, liver hypertrophy, some increase in serum cholesterol levels and a small but significant increase in the blood sugar levels were noticed.

Effect of Trans Fatty Acids on Protein Utilization and Serum Cholesterol

1983 ◽  
Vol 48 (1) ◽  
pp. 100-103 ◽  
Author(s):  
MIR N. ISLAM ◽  
JENNIFER L. SCHLITZER ◽  
NAFISA B. ISLAM
Keyword(s):  
Fatty Acids ◽  
Serum Cholesterol ◽  
Trans Fatty Acids ◽  
Protein Utilization

scholarly journals The fall of the traditional lipid hypothesis

1993 ◽  
Vol 2 (5) ◽  
pp. 447-452
Author(s):  
Kari Salminen
Keyword(s):  
Fatty Acids ◽  
Trans Fatty Acids ◽  
Blood Cholesterol ◽  
Blood Cholesterol Level ◽  
Finnish Population ◽  
Men And Women ◽  
Cholesterol Levels ◽  
Unfavourable Effect ◽  
Low Cholesterol ◽  
Catalytic Hydrogenation Process

The Finnish recommendation "Diagnosis and treatment of hypercholesterolaemia and other hyperlipidaemias in adults"(6) is mainly based on the traditional lipid hypothesis. The expediency of the recommendation should be reviewed in the light of the latest studies on diet, blood serum cholesterol and mortality. According to this information: 1. The mortality of the population increases both at high and at low cholesterol levels. The U-shape (Fig. 1) illustrating mortality vs. blood cholesterol level is different for men and women. Hence, the optimum blood cholesterol range should be set for men and for women separately. The present target value, below 5 mmol/1 for the entire Finnish population, is not reasonable. 2. The trans fatty acids formed in the catalytic hydrogenation process of polyunsaturated fatty acids have an unfavourable effect on blood cholesterol and may contribute to the occurrence of CHD. Thus the Finnish recommendation to increase the use of margarines is not well-founded. There are considerably better alternatives on the Finnish yellow fat market (Table 1).

scholarly journals IndustrialTransFatty Acid and Serum Cholesterol: The Allowable Dietary Level

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Hiroyuki Takeuchi ◽  
Michihiro Sugano
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Serum Cholesterol ◽  
Unsaturated Fatty Acids ◽  
Plasma Cholesterol ◽  
Dietary Fats ◽  
Blood Cholesterol ◽  
Complex Situation ◽  
Dietary Level ◽  
Cholesterol Levels

Transfatty acid (TFA) from partially hydrogenated oil is regarded as the worst dietary fatty acid per gram due to its role in coronary heart disease. TFA consumption is decreasing worldwide, but some but not all observational studies indicate that TFA intake has little relevance to serum cholesterol levels in populations with low TFA intake (<1%E[percentage of total energy intake], <approximately 2 g/day). Few intervention trials examined the effect of TFAs on blood cholesterol at relatively low levels (<2%E); no definite evidence is available on the tolerable upper level of the intake. A series of our intervention studies in Japanese suggested that an industrial TFA intake at <1%Edoes not influence the serum cholesterol level. To establish allowable level, we must consider not only the dietary level of TFAs, but also the composition of dietary fats simultaneously consumed, that is, saturated and unsaturated fatty acids. These fatty acids strengthen or counteract the adverse effect of TFAs on serum cholesterol levels. In this review we describe the complex situation of the cardiovascular effects of industrial TFAs. The relationship between dietary industrial TFAs and concentration of plasma cholesterol should be evaluated from the viewpoint of dietary patterns rather than TFAs alone.　

scholarly journals Trans fatty acids and cholesterol levels: An evidence map of the available science

2016 ◽  
Vol 98 ◽  
pp. 269-281 ◽  
Author(s):  
DeAnn J. Liska ◽  
Chad M. Cook ◽  
Ding Ding Wang ◽  
P. Courtney Gaine ◽  
David J. Baer
Keyword(s):  
Fatty Acids ◽  
Trans Fatty Acids ◽  
Evidence Map ◽  
Cholesterol Levels
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