Modeling folate, one-carbon metabolism, and DNA methylation

2008 ◽  
Vol 66 ◽  
pp. S27-S30 ◽  
Author(s):  
Cornelia M Ulrich ◽  
Michael C Reed ◽  
H Frederik Nijhout
Keyword(s):  
Dna Methylation ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

Metformin regulates global DNA methylation via mitochondrial one-carbon metabolism

Oncogene ◽  
2017 ◽  
Vol 37 (7) ◽  
pp. 963-970 ◽  
Author(s):  
E Cuyàs ◽  
S Fernández-Arroyo ◽  
S Verdura ◽  
R Á-F García ◽  
J Stursa ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Carbon Metabolism ◽  
Global Dna Methylation ◽  
One Carbon Metabolism

scholarly journals Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism

2018 ◽  
Vol 19 (10) ◽  
pp. 3106 ◽  
Author(s):  
Kuniyasu Soda
Keyword(s):  
Dna Methylation ◽  
Carbon Metabolism ◽  
Methylation Status ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Dna Methyltransferases ◽  
Polyamine Metabolism ◽  
Methyl Group ◽  
Wide Range ◽  
One Carbon Metabolism

Recent investigations have revealed that changes in DNA methylation status play an important role in aging-associated pathologies and lifespan. The methylation of DNA is regulated by DNA methyltransferases (DNMT1, DNMT3a, and DNMT3b) in the presence of S-adenosylmethionine (SAM), which serves as a methyl group donor. Increased availability of SAM enhances DNMT activity, while its metabolites, S-adenosyl-l-homocysteine (SAH) and decarboxylated S-adenosylmethionine (dcSAM), act to inhibit DNMT activity. SAH, which is converted from SAM by adding a methyl group to cytosine residues in DNA, is an intermediate precursor of homocysteine. dcSAM, converted from SAM by the enzymatic activity of adenosylmethionine decarboxylase, provides an aminopropyl group to synthesize the polyamines spermine and spermidine. Increased homocysteine levels are a significant risk factor for the development of a wide range of conditions, including cardiovascular diseases. However, successful homocysteine-lowering treatment by vitamins (B6, B12, and folate) failed to improve these conditions. Long-term increased polyamine intake elevated blood spermine levels and inhibited aging-associated pathologies in mice and humans. Spermine reversed changes (increased dcSAM, decreased DNMT activity, aberrant DNA methylation, and proinflammatory status) induced by the inhibition of ornithine decarboxylase. The relation between polyamine metabolism, one-carbon metabolism, DNA methylation, and the biological mechanism of spermine-induced lifespan extension is discussed.

scholarly journals Association between one-carbon metabolism indices and DNA methylation status in maternal and cord blood

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Anna K. Knight ◽  
Hea Jin Park ◽  
Dorothy B. Hausman ◽  
Jennifer M. Fleming ◽  
Victoria L. Bland ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Cord Blood ◽  
Carbon Metabolism ◽  
Methylation Status ◽  
One Carbon Metabolism

scholarly journals Genetic polymorphisms relevant for one-carbon metabolism show no effect on homocysteine plasma levels and DNA methylation in alcoholism

2009 ◽  
Vol 19 (4) ◽  
pp. 215-216 ◽  
Author(s):  
Bernd Lenz ◽  
Carmen Soehngen ◽  
Michael Linnebank ◽  
Annemarie Heberlein ◽  
Helge Frieling ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Genetic Polymorphisms ◽  
Carbon Metabolism ◽  
Plasma Levels ◽  
One Carbon Metabolism

scholarly journals Study on the Relationship Between Folate, Dna Methylation and Esophagus Cancer

2017 ◽  
Vol 1 (3) ◽  
Author(s):  
Huang Guiling
Keyword(s):  
Dna Methylation ◽  
Carbon Metabolism ◽  
Early Screening ◽  
Methyl Group ◽  
Esophagus Cancer ◽  
Multiple Factors ◽  
Chinese Characteristic ◽  
The World ◽  
One Carbon Metabolism ◽  
The Relationship

Esophagus cancer is a common malignant tumor in China, and itsprevalence rate and fatality rate are the highest in the world whoseoccurrence is related to multiple factors, including family heredity,race, gender, region, diet and so on. Esophagus cancer is the diseasewith the most Chinese characteristic. The pathogenesis of esophagus cancer is very complicated, and the epigenetics in the pathogenetic process has become the current research hotspot, and the reversible feature provides a new direction for the early screening, prevention and treatment of esophagus cancer. DNA methylation is the most deep epigenetics in the current study, and the pattern of genome methylation is often abnormal in the cancerization of esophagus cancer. The folate, as the methyl group donor, and B-vitamins related to one-carbon metabolism, shall directly influence the condition of DNA methylation, give rise to the change of epigenetics, affect the occurrence of esophagus cancer. This paper summarizes the relationship among the occurrence of esophagus cancer and folate, several kinds of B-vitamins related to one-carbon metabolism, DNA methylation.

scholarly journals Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues

Epigenetics ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. 727-735 ◽  
Author(s):  
Adana A M Llanos ◽  
Catalin Marian ◽  
Theodore M Brasky ◽  
Ramona G Dumitrescu ◽  
Zhenhua Liu ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Genetic Variation ◽  
Carbon Metabolism ◽  
Normal Breast ◽  
One Carbon Metabolism ◽  
Breast Tissues

Abstract 2777: One-carbon metabolism genetic variant and genome-wide DNA methylation in breast tissues from healthy women

2016 ◽  
Author(s):  
Min-Ae Song ◽  
Theodore M. Brasky ◽  
Catalin Marian ◽  
Daniel Y. Weng ◽  
Cenny Taslim ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Carbon Metabolism ◽  
Genetic Variant ◽  
Healthy Women ◽  
Genome Wide ◽  
One Carbon Metabolism ◽  
Breast Tissues

scholarly journals Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape

2019 ◽  
Vol 149 (3) ◽  
pp. 372-380 ◽  
Author(s):  
Denise Mafra ◽  
Marta Esgalhado ◽  
Natalia A Borges ◽  
Ludmila F M F Cardozo ◽  
Milena B Stockler-Pinto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Chronic Kidney Disease ◽  
Dna Methylation ◽  
Kidney Disease ◽  
Carbon Metabolism ◽  
Epigenetic Landscape ◽  
Methyl Donor ◽  
Disease Impact ◽  
One Carbon Metabolism ◽  
Altered Gene

ABSTRACT Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Although few studies have actually reported alterations of DNA methylation via methyl donor nutrient intake, emerging evidence indicates that nutritional modification of the microbiome can affect one-carbon metabolism and the capacity to methylate the genome in CKD. In this review, we discuss the nutritional modifications that may affect one-carbon metabolism and the possible impact of methyl donor nutrients on the microbiome, CKD, and its phenotype.

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