Microglial changes in healthy mice retina in an early aging stage

The aging hardening behaviors of Al-8Si-3%Cu (wt%) and Al-3Cu (wt%) alloys have been investigated. Samples were solution treated at 500 for 24 h followed by water quenching before aging. Hardness has been measured for quenched samples aging at 150°C. Strong age hardening occurs for Al-3Cu alloy and hardness increases by about 60% after peak aging. There is a hardness decrease in the early aging stage of Al-8Si-3Cu alloy and hardness increases by about 15% after peak aging. The age precipitation behaviors have been analyzed using DSC and TEM. Effects of microstructure characteristics on age precipitation and age hardening response of Al-8Si-3Cu alloy have been discussed.

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Microglial changes in the early aging stage in a healthy retina and an experimental glaucoma model

Progress in Brain Research - Glaucoma: A Neurodegenerative Disease of the Retina and Beyond - Part A ◽

10.1016/bs.pbr.2020.05.024 ◽

2020 ◽

pp. 125-149 ◽

Cited By ~ 1

Author(s):

Ana I. Ramírez ◽

José A. Fernández-Albarral ◽

Rosa de Hoz ◽

Inés López-Cuenca ◽

Elena Salobrar-García ◽

...

Keyword(s):

Experimental Glaucoma ◽

Early Aging ◽

Aging Stage

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Atomic Bonding of Precipitate and Properties of Al-Cu-Mg Alloy

Materials Science Forum ◽

10.4028/www.scientific.net/msf.539-543.417 ◽

2007 ◽

Vol 539-543 ◽

pp. 417-422

Author(s):

Ying Jun Gao ◽

Xian Hua Hou ◽

Chuang Gao Huang

Keyword(s):

Phase Transformation ◽

Bond Energy ◽

Binding Capacity ◽

S Phase ◽

Electron Theory ◽

Empirical Electron Theory ◽

Early Aging ◽

The Matrix ◽

Aging Stage ◽

Net Framework

Atomic bonding of the GPB zone and S′′ phase of Al-Cu-Mg alloys in early aging stage are calculated using the empirical electron theory (EET) in Solid. The results show that not only the covalence bond-net is very strong in GPB zone, but the whole covalence bond energy of S′′ phase is also very large, all the primary bond-net framework of these precipitates can consolidate the matrix of alloy. Phase transformation from GPB zone to S′′ phase is explained reasonably based on atomic bonding and total binding capacity of Al and Cu atoms in these precipitates.

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Features of carotid artery remodeling in patients with obstructive sleep apnea syndrome in the context of the concept of early aging

Practical medicine ◽

10.32000/2072-1757-2019-2-84-88 ◽

2019 ◽

Vol 17 (2) ◽

pp. 84-88 ◽

Cited By ~ 1

Author(s):

O. O. Grishchenko ◽

◽

T. O. Brodovskaya ◽

I. F. Grishina ◽

T. F. Peretolchina ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Carotid Artery ◽

Obstructive Sleep Apnea Syndrome ◽

Sleep Apnea Syndrome ◽

Obstructive Sleep ◽

Early Aging ◽

Apnea Syndrome ◽

Artery Remodeling

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Dietary Habits of Mongolian People, and Their Influence on Lifestyle-Related Diseases and Early Aging

Current Aging Science ◽

10.2174/1874609810801020084 ◽

2008 ◽

Vol 1 (2) ◽

pp. 84-100 ◽

Cited By ~ 10

Author(s):

Fumio Komatsu ◽

Yasuo Kagawa ◽

Terue Kawabata ◽

Yoshinori Kaneko ◽

Baatar Purvee ◽

...

Keyword(s):

Dietary Habits ◽

Early Aging ◽

Lifestyle Related Diseases

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Tensile Behavior after Oxidative Aging of Gum and Black-Filled Vulcanizates of SBR and NR

Rubber Chemistry and Technology ◽

10.5254/1.3538829 ◽

1999 ◽

Vol 72 (4) ◽

pp. 721-730 ◽

Cited By ~ 39

Author(s):

G. R. Hamed ◽

J. Zhao

Keyword(s):

Tensile Strength ◽

Natural Rubber ◽

Tensile Behavior ◽

Styrene Butadiene Rubber ◽

Butadiene Rubber ◽

Oxidative Aging ◽

Prolonged Aging ◽

Aging Period ◽

Early Aging ◽

Styrene Butadiene

Abstract Typical sulfur-cured vulcanizates of styrene-butadiene rubber (SBR) and natural rubber (NR) were prepared, and subjected to air-oven aging at 100 °C. Gum specimens exhibited an initial aging period in which stiffness was unchanged, while tensile strength and strain-to-break were significantly reduced. In contrast, black-filled vulcanizates stiffened during early aging. After intermediate aging times, NR specimens softened, while SBR stiffened. With prolonged aging, all compositions became hard and inextensible.

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Influence of Different Commercial Yeasts on Volatile Fraction of Sparkling Wines

Foods ◽

10.3390/foods10020247 ◽

2021 ◽

Vol 10 (2) ◽

pp. 247

Author(s):

Valeriu V. Cotea ◽

Mihai Cristian Focea ◽

Camelia Elena Luchian ◽

Lucia Cintia Colibaba ◽

Elena Cristina Scutarașu ◽

...

Keyword(s):

International Organization ◽

Volatile Fraction ◽

Chemical Parameters ◽

Physical Chemical ◽

Organoleptic Characteristics ◽

Mass Spectrometry Technique ◽

Minor Influence ◽

Spectrometry Technique ◽

A Minor ◽

Aging Stage

The occurrence of aroma constituents in sparkling wines, with direct impact on their organoleptic characteristics, is affected by several factors, for example the base-wine particularities, grapes cultivar conditions, inoculated yeasts, the aging stage, and wine-making practices. This study evaluated the influence of different four commercial yeasts (IOC FIZZ™, IOC DIVINE™, LEVULIA CRISTAL™, and IOC 18-2007™) on the volatile composition of experimental sparkling wines. For this, five sparkling wines variants from the Muscat Ottonel grape variety were obtained. The base-wine was obtained through reverse osmosis and had a predetermined alcoholic concentration (10.5% vol.). In order to fulfill the proposed purpose, the experimental sparkling wines were characterized by the physical–chemical parameters (according to International Organization of Vine and Wine methods of analysis), volatile fraction (using gas-chromatography coupled with mass spectrometry technique), and sensory descriptors. Data showed a key impact on the concentration of the volatile constituents (p < 0.05), depending on the type of inoculated yeast for the second fermentation. Regarding the sensory analysis, important differences can be observed due to the type of inoculated yeast. Only a minor influence on the physical–chemical parameters was registered.

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Rats with Low Brain Angiotensinogen Do Not Exhibit Insulin Resistance During Early Aging

Endocrine ◽

10.1385/endo:30:2:167 ◽

2006 ◽

Vol 30 (2) ◽

pp. 167-174 ◽

Cited By ~ 19

Author(s):

Sherry O. Kasper ◽

Carlos M. Ferrario ◽

Detlev Ganten ◽

Debra I. Diz

Keyword(s):

Insulin Resistance ◽

Early Aging

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Identification of Biochemical and Molecular Markers of Early Aging in Childhood Cancer Survivors

10.1101/2021.04.01.438017 ◽

2021 ◽

Author(s):

Silvia Ravera ◽

Tiziana Vigliarolo ◽

Silvia Bruno ◽

Fabio Morandi ◽

Danilo Marimpietri ◽

...

Keyword(s):

Cancer Survivors ◽

Childhood Cancer ◽

Childhood Cancer Survivors ◽

Antioxidant Defenses ◽

Elderly Subjects ◽

Cancer Type ◽

Metabolism Regulation ◽

Increased Risk ◽

Early Aging ◽

The Impact

ABSTRACTPurposeSurvival rates of Childhood Cancer Patients have improved tremendously over the past four decades. However, cancer treatments are associated with an increased risk of developing an anticipated onset of chronic diseases typical of aging. Thus, we aimed to identify molecular/metabolic cellular alterations responsible for early aging in Childhood Cancer Survivors (CCS).Patients and MethodsBiochemical, proteomic and molecular biology analyses were conducted on mononuclear cells (MNCs) isolated from peripheral blood of 196 CCS, comparing the results with those obtained on MNCs of 154 healthy subjects.ResultsData demonstrate that CCS-MNCs show: i) inefficient oxidative phosphorylation associated with low energy status and a metabolic switch to lactate fermentation compared with age-matched normal controls; ii) increment of lipid peroxidation due to an unbalance among the oxidative stress production and the activation of the antioxidant defenses; (iii) significantly lower expression of genes and proteins involved in mitochondrial biogenesis and metabolism regulation, such as CLUH, PGC1-α, and SIRT6 in CCS, not observed in the age-matched healthy or elderly subjects. The application of a mathematical model based on biochemical parameters predicts that CCS have a biological age significantly increased by decades compared to the chronological age. Overall, the results show that the impact of chemo/chemoradiotherapy on mitochondria efficiency in 196 CCS was rather homogeneous, irrespective of cancer type, treatment protocols, and time elapsed from the end of the curative period.ConclusionsOur study identifies some biochemical and molecular alterations possibly contributing to the pathophysiology of anticipated aging and metabolic deficiency described in CCS. These results may be useful in identifying approaches to restore the mitochondrial function, slowing down the aging and the associated pathological conditions in CCS.

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