Which serum uric acid levels are associated with increased cardiovascular risk in the general adult population?

BACKGROUND AND OBJECTIVE: we have examined the concentration of serum uric acid and the serum uric acid/creatinine ratio as well as their correlations with the main determinants of the hemorheological profile in a group of subjects with subclinical carotid atherosclerosis. METHODS: we evaluated the concentration of serum uric acid and the serum uric acid/creatine ratio in 43 men and 57 women [median age 66.00 (25)] with subclinical carotid atherosclerosis, subsequently divided according to the number of traditional cardiovascular risk factors and to the insulin resistance degree. RESULTS: serum uric acid, but not the serum uric acid/creatinine ratio, results strongly influenced by the number of cardiovascular risk factors and by the insulin resistance degree. In the whole group and in the subgroups of subclinical carotid atherosclerosis subjects, serum uric acid and serum uric acid/creatinine ratio show significant correlation, besides with whole blood viscosity, with plasma viscosity and erythrocyte aggregation. The influence of the serum uric acid on the erythrocyte aggregability that is a part of the erythrocyte aggregation is to ascribe to the action carried out by serum uric acid on the erythrocyte zeta potential. CONCLUSIONS: it is reasonable to think that the treatment of the asymptomatic or symptomatic hyperuricemia with the urate-lowering therapy that reduces the serum uric acid concentration may reflect on the hemorheological profile which role on the atherosclerotic cardiovascular disease is well known.

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Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease

Clinical Rheumatology ◽

10.1007/s10067-015-2878-1 ◽

2015 ◽

Vol 34 (9) ◽

pp. 1605-1611 ◽

Cited By ~ 11

Author(s):

Xiao-Min Dai ◽

Lei Wei ◽

Li-Li Ma ◽

Hui-Yong Chen ◽

Zhuo-Jun Zhang ◽

...

Keyword(s):

Coronary Artery Disease ◽

Uric Acid ◽

Cardiovascular Risk ◽

Coronary Artery ◽

Serum Uric Acid ◽

Early Onset ◽

Risk Profile ◽

Chinese Patients ◽

Cardiovascular Risk Profile ◽

Artery Disease

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Serum uric acid is associated with common cardiovascular risk factors in Uygur population

International Journal of Cardiology ◽

10.1016/j.ijcard.2009.09.173 ◽

2009 ◽

Vol 137 ◽

pp. S52

Author(s):

HONGMEI WANG ◽

NANFANG LI ◽

JING HONG ◽

LING ZHOU

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Uygur Population

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Reply to: Serum uric acid levels positively correlates with 10-year cardiovascular risk score in the general population from China

International Journal of Cardiology ◽

10.1016/j.ijcard.2018.02.020 ◽

2018 ◽

Vol 258 ◽

pp. 298

Author(s):

Claudio Borghi

Keyword(s):

Uric Acid ◽

Cardiovascular Risk ◽

General Population ◽

Serum Uric Acid ◽

Risk Score ◽

Cardiovascular Risk Score

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Association of uric acid with metabolic parameters and obesity

Nutrition & Food Science ◽

10.1108/nfs-01-2020-0003 ◽

2020 ◽

Vol 50 (6) ◽

pp. 1241-1254

Author(s):

Marjan Mahdavi-Roshan ◽

Mina Movahedian ◽

Hamed Kord Varkaneh ◽

Arsalan Salari ◽

Melahat Sedanur Macit ◽

...

Keyword(s):

Uric Acid ◽

Serum Uric Acid ◽

Communicable Disease ◽

Adult Population ◽

Elevated Serum ◽

Cross Sectional Study ◽

Metabolic Parameters ◽

Cross Sectional ◽

Content Type ◽

Non Communicable Disease

Purpose Recent studies have shown that hyperuricemia is a predictor of non-communicable disease and an increment of mortality rate. Also, elevated serum uric acid may be associated with obesity in the adult population. This study aims to evaluate the association between serum uric acid levels with metabolic parameters and risk of obesity in the Iranian population. Design/methodology/approach The cross-sectional study was done on 550 participants, who were referred to a hospital for elective angiography in Rasht, Iran; anthropometric indices (waist circumference (WC) and body mass index (BMI)) and hematological factors were measured using the standard approaches. Based to the angiography results, the severity of atherosclerosis was defined. Findings The mean (SD) concentration of serum uric acid for all participants was 5.15 (1.37) mg/dl. Individuals who were at the highest tertile had higher mean (SD) of weight (p = 0.004), creatinine and blood urea nitrogen (p < 0.001) lower fasting blood sugar (FBS) (p = 0.000) and HbA1c (p = 0.016), and they were mostly men compared with those in the lowest tertile. After adjusting for confounders, FBS (ß = –0.145, p = 0.001) and HbA1c (%) (ß = –0.130, p = 0.019) had inverse and weight (ß = 0.156, p = 0.001) had direct association with serum uric acid. After adjustment for additionally potential confounders subjects in the highest tertile of serum uric acid had 92 per cent higher chance of obesity compared with subjects in the lowest tertile (OR 1.92; 95 per cent CI 1.13, 3.23). Originality/value The present study has concluded that increase serum uric acid related to high risk of obesity and low mean of FBS and HbA1c.

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Association of High Serum Uric Acid and Increased Arterial Stiffness is Dependent on Cardiovascular Risk Factors in Female Population

Hormone and Metabolic Research ◽

10.1055/a-0882-7382 ◽

2019 ◽

Vol 51 (06) ◽

pp. 367-374 ◽

Cited By ~ 3

Author(s):

Yin Yuan ◽

Feng Huang ◽

Fan Lin ◽

Min Lin ◽

Pengli Zhu

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Cardiovascular Risk ◽

Arterial Stiffness ◽

Cardiovascular Risk Factors ◽

Serum Uric Acid ◽

Pulse Wave ◽

Elevated Serum ◽

High Serum ◽

Female Population

AbstractAn elevated serum uric acid (SUA) level is closely associated with increased arterial stiffness. However, whether this association is independent of conventional cardiovascular risk factors is controversial. This study aimed to investigate whether SUA is independently associated with arterial stiffness as assessed by Brachial-ankle pulse wave velocity (baPWV), and to what extent this association is dependent on cardiovascular risk factors. Increased arterial stiffness was defined as baPWV>1 400 cm/s. Cardiovascular risk factors were defined as hypertension, diabetes, dyslipidaemia, and a BMI≥24.0 kg/m2. A total of 3 342 subjects (1 334 men and 2008 women, mean age 53.79±13.18 years) were included. SUA levels exhibited a graded elevation with an increasing number of cardiovascular risk factors. In female subjects with more than two cardiovascular risk factors, compared with the first quartile of SUA, higher SUA quartiles were associated with a higher probability of increased baPWV (OR=1.500, 1.478, 1.774 for SUA Q2–Q4). In further stratified association analysis, compared with Q1, SUA quartiles showed a graded association with increased baPWV in subjects with TC≥5.2 mmol/l (OR=1.758, 1.942, 2.354 for Q2, Q3, and Q4 respectively), LDL-C≥3.3 mmol/l (OR=1.510, 2.255 for Q3 and Q4) and FBG≥7.0 mmol/l (OR=1.516, 1.748 for Q3 and Q4). In the Chinese coastal female population, the association of high SUA and increased arterial stiffness is dependent on the coexistence of at least one cardiovascular risk factor, especially hypercholesterolemia.

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