Erythema nodosum, zoster duplex and pityriasis rosea as possible cutaneous adverse effects of Oxford–AstraZeneca COVID‐19 vaccine: report of three cases from India

OBJECTIVE: To report a case of erythromycin base-induced rash and liver function disturbances. CASE SUMMARY: A patient with erythema nodosum and high antistreptolysin-O titers was treated with erythromycin on the assumption that occult streptococcal infection was the cause of the erythema nodosum. Forty-eight hours after the initiation of therapy the patient developed fever, severe generalized rash, pruritus, and cholestatic and hepatocellular liver function disturbances. Extensive evaluation to determine the cause of liver function disturbances was unrevealing. Marked improvement was noticed within days after cessation of erythromycin. DISCUSSION: Case reports in the literature on the adverse effects of erythromycin and its derivatives were reviewed. The possible immunologic mechanism involved is postulated. CONCLUSIONS: Erythromycin base must be added to the list of erythromycin derivatives that can cause rash and liver function disturbances. The concomitant appearance of fever, rash, jaundice, and liver function disturbances raises the possibility of hypersensitivity as the mechanism for the liver disturbances.

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Atypical Case of Pityriasis Rosea in a Child Following Streptococcal Erythema Nodosum

Journal of Interdisciplinary Medicine ◽

10.1515/jim-2017-0083 ◽

2017 ◽

Vol 2 (4) ◽

pp. 354-356

Author(s):

Anca Chiriac ◽

Piotr Brzezinski ◽

Cristian Podoleanu ◽

Simona Stolnicu

Keyword(s):

Young Adults ◽

Erythema Nodosum ◽

Streptococcal Pharyngitis ◽

Unique Case ◽

Case Presentation ◽

Atypical Case ◽

Pityriasis Rosea ◽

Multiple Lesions

Abstract Introduction: Pityriasis rosea (PR) is a widespread skin erythemato-squamous eruption, occurring mostly in young adults. Case presentation: A 9-year-old patient presented with multiple lesions developed after streptococcal pharyngitis and erythema nodosum diagnosed and treated with penicillin prior to the PR. Conclusion: This unique case should be considered a coincidence of two consecutive diseases.

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Evaluation of the influence of genetic variants in Cereblon gene on the response to the treatment of ENL with thalidomide

10.21203/rs.3.rs-415294/v1 ◽

2021 ◽

Author(s):

Perpétua Socorro Silva Costa ◽

Miriãn Ferrão ◽

Thayne Woycinck Kowalski ◽

Lucas Rosa Fraga ◽

Mariléa Furtado Feira ◽

...

Keyword(s):

Multiple Myeloma ◽

Adverse Effects ◽

Inflammatory Reaction ◽

Genetic Variants ◽

Erythema Nodosum ◽

Primary Target ◽

Gene Encoding ◽

Inflammatory Drug ◽

Erythema Nodosum Leprosum ◽

Systemic Inflammatory Reaction

Abstract Erythema Nodosum Leprosum (ENL) is an acute and systemic inflammatory reaction of leprosy characterized by painful nodules and involvement of various organs. Thalidomide is an immunomodulatory and anti-inflammatory drug currently used to treat conditions such as ENL and multiple myeloma (MM). Cereblon protein was described as the primary target of thalidomide teratogenicity. Moreover, it was postulated that CRBN is necessary for the efficacy of thalidomide and its analogs in the treatment of MM. In this study, we evaluate the influence of CRBN genetic variants on the dose of thalidomide used in the treatment of ENL and on the manifestation of adverse effects during treatment for ENL. Polymorphisms rs1620675, rs1672770 and rs4183 located in regions flanking the part of the gene encoding the portion of the protein that binds to thalidomide were evaluated. An association with adverse ocular and gastrointestinal effects was observed. These results show that CRBN polymorphisms could alter the expression or activity of the protein and influence the development of adverse effects in response to thalidomide in ENL.

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Case Report: Pityriasis Rosea-Like Eruption Following COVID-19 Vaccination

Frontiers in Medicine ◽

10.3389/fmed.2021.752443 ◽

2021 ◽

Vol 8 ◽

Author(s):

Kanchana Leerunyakul ◽

Kallapan Pakornphadungsit ◽

Poonkiat Suchonwanit

Keyword(s):

Case Report ◽

Partial Response ◽

Adverse Effects ◽

Triamcinolone Acetonide ◽

Rare Complication ◽

Pityriasis Rosea ◽

Thai Woman

Vaccination is one of the cornerstones in the efforts towards ending the coronavirus disease 2019 (COVID-19) pandemic. However, several adverse effects of COVID-19 vaccination have been identified. Pityriasis rosea (PR)-like eruption is a rare cutaneous complication of immunization. To the best of our knowledge, there have been no reports of PR-like eruptions following inoculation with Oxford/AstraZeneca ChAdOx1 nCoV-19 (AZD1222) vaccine. Here, we described a case of PR-like eruption that developed 14 days after Oxford/AstraZeneca vaccination in a 52-year-old Thai woman with glioblastoma. Treatment with topical 0.1% triamcinolone acetonide twice per day showed partial response after seven days. Despite this rare complication, our report highlights that the presence of PR-like eruption is not a contraindication for subsequent vaccinations.

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The Influence of Specimen Thickness in Quantitative Electron Energy Loss Spectroscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s1431927600000441 ◽

1980 ◽

Vol 38 ◽

pp. 112-113

Author(s):

Nestor J. Zaluzec

Keyword(s):

Quantitative Analysis ◽

Adverse Effects ◽

Energy Loss ◽

Electron Energy ◽

Electron Energy Loss Spectroscopy ◽

Materials Science ◽

Light Element ◽

Specimen Thickness ◽

Element Analysis ◽

Electron Energy Loss

The application of electron energy loss spectroscopy (EELS) to light element analysis is rapidly becoming an important aspect of the microcharacterization of solids in materials science, however relatively stringent requirements exist on the specimen thickness under which one can obtain EELS data due to the adverse effects of multiple inelastic scattering.1,2 This study was initiated to determine the limitations on quantitative analysis of EELS data due to specimen thickness.

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