Reactive oxygen species: Key players in the anticancer effects of apigenin?

2022 ◽  
Author(s):  
Omolola R. Oyenihi ◽  
Ayodeji B. Oyenihi ◽  
Toyin D. Alabi ◽  
Oluwatosin G. Tade ◽  
Anne A. Adeyanju ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Key Players

Endogenous reactive oxygen species burst induced and spatiotemporally controlled multiple drug release by traceable nanoparticles for enhancing antitumor efficacy

2021 ◽  
Author(s):  
Ning Wang ◽  
Chenyu Liu ◽  
Weihe Yao ◽  
Hengjun Zhou ◽  
Simiao Yu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Drug Release ◽  
Reactive Oxygen ◽  
Combined Effect ◽  
Antitumor Efficacy ◽  
Multiple Drug ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Endogenous Reactive Oxygen Species ◽  
Reactive Oxygen Species Burst

Reactive oxygen species (ROS) are not only used as a therapeutic reagent in chemodynamic therapy (CDT), to stimulate the release of drugs, they can also be used to achieve a combined effect of CDT and chemotherapy to enhance anticancer effects.

Anticancer effects of anandamide on head and neck squamous cell carcinoma cells via the production of receptor-independent reactive oxygen species

Head & Neck ◽  
2014 ◽  
Vol 37 (8) ◽  
pp. 1187-1192 ◽  
Author(s):  
Seok-Woo Park ◽  
Ji-Eun Kim ◽  
Sang-Mi Oh ◽  
Won-Jae Cha ◽  
Jeong-Hun Hah ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Reactive Oxygen ◽  
Carcinoma Cells ◽  
Neck Squamous Cell Carcinoma ◽  
Oxygen Species ◽  
Anticancer Effects

scholarly journals Reactive Oxygen Species and NOX Enzymes Are Emerging as Key Players in Cutaneous Wound Repair

2017 ◽  
Vol 18 (10) ◽  
pp. 2149 ◽  
Author(s):  
Dominik André-Lévigne ◽  
Ali Modarressi ◽  
Michael Pepper ◽  
Brigitte Pittet-Cuénod
Keyword(s):  
Reactive Oxygen Species ◽  
Wound Repair ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cutaneous Wound ◽  
Key Players

Decoration of Cisplatin on 2D Metal–Organic Frameworks for Enhanced Anticancer Effects through Highly Increased Reactive Oxygen Species Generation

2018 ◽  
Vol 10 (37) ◽  
pp. 30930-30935 ◽  
Author(s):  
Yaojia Li ◽  
Zhiguo Gao ◽  
Fanghui Chen ◽  
Chaoqun You ◽  
Hongshuai Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Metal Organic Frameworks ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Anticancer Effects ◽  
Metal Organic

scholarly journals Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Hamid R. Molavian ◽  
Aaron Goldman ◽  
Colin J. Phipps ◽  
Mohammad Kohandel ◽  
Bradly G. Wouters ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Cell Membrane ◽  
Reactive Oxygen ◽  
Membrane Properties ◽  
Oxygen Species ◽  
Drug Induced ◽  
Anticancer Effects

scholarly journals IgG-aggregates rapidly up-regulate FcgRI expression at the surface of human neutrophils in a FcgRII-dependent fashion: A crucial role for FcgRI in the generation of reactive oxygen species

2020 ◽  
Author(s):  
Sandrine Huot ◽  
Cynthia Laflamme ◽  
Paul R. Fortin ◽  
Eric Boilard ◽  
Marc Pouliot
Keyword(s):  
Reactive Oxygen Species ◽  
Immune Cells ◽  
Immune Complexes ◽  
Tissue Damage ◽  
Reactive Oxygen ◽  
Surface Expression ◽  
Human Neutrophils ◽  
Ros Production ◽  
Oxygen Species ◽  
Key Players

AbstractAutoimmune complexes are an important feature of several autoimmune diseases such as lupus, as they contribute to tissue damage through the activation of immune cells. Neutrophils, key players in lupus, interact with immune complexes through Fc gamma receptors (FcgR). Incubation of neutrophils with aggregated-IgGs caused degranulation and increased the surface expression of FcgRI within minutes in a concentration-dependent fashion. After 30 min, IgG aggregates (1 mg/ml) up-regulated FcgRI by 4.95 ± 0.45-fold. FcgRI-positive neutrophils reached 67.24% ± 6.88% on HA-IgGs stimulated neutrophils, from 3.12% ± 1.62% in non-stimulated cells, ranking IgG-aggregates among the most potent known agonists. FcgRIIa, and possibly FcgRIIIa, appeared to mediate this up-regulation. Also, FcgRI-dependent signaling proved necessary for reactive oxygen species (ROS) production in response to IgG-aggregates. Finally, combinations of bacterial materials with aggregates dramatically boosted ROS production. This work suggests FcgRI as an essential component in the response of human neutrophils to immune complexes leading to the production of ROS, which may help explain how neutrophils contribute to tissue damage associated with immune complex-associated diseases, such as lupus.

Interplay Between Reactive Oxygen Species and Key Players in the DNA Damage Response Signaling Network

2021 ◽  
pp. 1-18
Author(s):  
Siddavaram Nagini ◽  
Paranthaman Thiyagarajan ◽  
Kunchala Sridhar Rao
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Reactive Oxygen ◽  
Signaling Network ◽  
Oxygen Species ◽  
Damage Response ◽  
Key Players
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