Rapid and longer‐term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice

2020 ◽  
Author(s):  
Alberto A. Castro ◽  
Hannah Rabitoy ◽  
Gerald C. Claghorn ◽  
Theodore Garland
Keyword(s):  
Selective Breeding ◽  
Exercise Behavior ◽  
Voluntary Exercise ◽  
House Mice ◽  
Skeletal Morphology

Effects of selective breeding for voluntary exercise, chronic exercise, and their interaction on muscle attachment site morphology in house mice

2021 ◽  
Author(s):  
Alberto A. Castro ◽  
Fotios Alexandros Karakostis ◽  
Lynn E. Copes ◽  
Holland E. McClendon ◽  
Aayushi P. Trivedi ◽  
...  
Keyword(s):  
Selective Breeding ◽  
Attachment Site ◽  
Voluntary Exercise ◽  
House Mice ◽  
Chronic Exercise ◽  
Muscle Attachment

scholarly journals Effects of Selective Breeding for Voluntary Exercise, Chronic Exercise, and Their Interaction on Muscle Attachment Site Morphology in House Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Alberto A. Castro ◽  
Holland E. McClednon ◽  
Aayushi P. Trivedi ◽  
Nicolas L. Schwartz ◽  
Theodore Garland
Keyword(s):  
Selective Breeding ◽  
Attachment Site ◽  
Voluntary Exercise ◽  
House Mice ◽  
Chronic Exercise ◽  
Muscle Attachment

Effects of Selective Breeding, Voluntary Exercise, and Sex on Endocannabinoid Levels in the Mouse Small-Intestinal Epithelium

2021 ◽  
pp. 113675
Author(s):  
Margaret P. Schmill ◽  
Zoe Thompson ◽  
Donovan A. Argueta ◽  
Nicholas V. DiPatrizio ◽  
Theodore Garland
Keyword(s):  
Intestinal Epithelium ◽  
Selective Breeding ◽  
Voluntary Exercise ◽  
Small Intestinal Epithelium ◽  
Small Intestinal

scholarly journals A twin study on the correlates of voluntary exercise behavior in adolescence

2019 ◽  
Vol 40 ◽  
pp. 99-109
Author(s):  
Nienke M. Schutte ◽  
Ineke Nederend ◽  
Meike Bartels ◽  
Eco J.C. de Geus
Keyword(s):  
Twin Study ◽  
Exercise Behavior ◽  
Voluntary Exercise

scholarly journals Coadaptation of the chemosensory system with voluntary exercise behavior in mice

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241758
Author(s):  
Quynh Anh Thi Nguyen ◽  
David Hillis ◽  
Sayako Katada ◽  
Timothy Harris ◽  
Crystal Pontrello ◽  
...  
Keyword(s):  
Selective Breeding ◽  
Wheel Running ◽  
Vomeronasal Organ ◽  
Voluntary Exercise ◽  
Wild Mice ◽  
Chemosensory System ◽  
Chemosensory Receptors ◽  
Receptor Clusters ◽  
Rewarding Behavior ◽  
And Control

Ethologically relevant chemical senses and behavioral habits are likely to coadapt in response to selection. As olfaction is involved in intrinsically motivated behaviors in mice, we hypothesized that selective breeding for a voluntary behavior would enable us to identify novel roles of the chemosensory system. Voluntary wheel running (VWR) is an intrinsically motivated and naturally rewarding behavior, and even wild mice run on a wheel placed in nature. We have established 4 independent, artificially evolved mouse lines by selectively breeding individuals showing high VWR activity (High Runners; HRs), together with 4 non-selected Control lines, over 88 generations. We found that several sensory receptors in specific receptor clusters were differentially expressed between the vomeronasal organ (VNO) of HRs and Controls. Moreover, one of those clusters contains multiple single-nucleotide polymorphism loci for which the allele frequencies were significantly divergent between the HR and Control lines, i.e., loci that were affected by the selective breeding protocol. These results indicate that the VNO has become genetically differentiated between HR and Control lines during the selective breeding process. Although the role of the vomeronasal chemosensory receptors in VWR activity remains to be determined, the current results suggest that these vomeronasal chemosensory receptors are important quantitative trait loci for voluntary exercise in mice. We propose that olfaction may play an important role in motivation for voluntary exercise in mammals.

scholarly journals Effects of selective breeding for high voluntary wheel-running behavior on femoral nutrient canal size and abundance in house mice

2018 ◽  
Vol 233 (2) ◽  
pp. 193-203 ◽  
Author(s):  
Nicolas L. Schwartz ◽  
Biren A. Patel ◽  
Theodore Garland ◽  
Angela M. Horner
Keyword(s):  
Selective Breeding ◽  
Wheel Running ◽  
House Mice ◽  
Voluntary Wheel Running ◽  
Voluntary Wheel

Selective Breeding and Short-Term Access to a Running Wheel Alter Stride Characteristics in House Mice

2017 ◽  
Vol 90 (5) ◽  
pp. 533-545 ◽  
Author(s):  
Gerald C. Claghorn ◽  
Zoe Thompson ◽  
Jarren C. Kay ◽  
Genesis Ordonez ◽  
Thomas G. Hampton ◽  
...  
Keyword(s):  
Selective Breeding ◽  
House Mice ◽  
Short Term ◽  
Running Wheel

Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart

2003 ◽  
Vol 12 (2) ◽  
pp. 129-138 ◽  
Author(s):  
A. M. Bronikowski ◽  
P. A. Carter ◽  
T. J. Morgan ◽  
T. Garland ◽  
N. Ung ◽  
...  
Keyword(s):  
Gene Expression ◽  
Selective Breeding ◽  
Voluntary Exercise ◽  
Transcriptional Level ◽  
Expression Change ◽  
Oligonucleotide Arrays ◽  
Treatment Groups ◽  
Active Population ◽  
Sedentary Population ◽  
Age Related

We present the first quantitative gene expression analysis of cardiac aging under conditions of sedentary and active lifestyles using high-density oligonucleotide arrays representing 11,904 cDNAs and expressed sequence tags (ESTs). With these data, we test the hypothesis that exercise attenuates the gene expression changes that normally occur in the aging heart. Male mice ( Mus domesticus) were sampled from the 16th generation of selective breeding for high voluntary exercise. For the selective breeding protocol, breeders were chosen based on the maximum number of wheel revolutions run on days 5 and 6 of a test at 8 wk of age. For the colony sampled herein, mice were housed individually over their entire lifetimes (from weaning) either with or without access to running wheels. The hearts of these two treatment groups (active and sedentary) were assayed at middle age (20 mo) and old age (33 mo). Genes significantly affected by age in the hearts of the sedentary population by at least a 50% expression change ( n = 137) were distributed across several major categories, including inflammatory response, stress response, signal transduction, and energy metabolism. Genes significantly affected by age in the active population were fewer ( n = 62). Of the 42 changes in gene expression that were common to both treatment groups, 32 (72%) displayed smaller fold changes as a result of exercise. Thus exercise offset many age-related gene expression changes observed in the hearts of the sedentary animals. These results suggest that adaptive physiological mechanisms that are induced by exercise can retard many effects of aging on heart muscle at the transcriptional level.

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