Disentangling cognitive processes in externalizing psychopathology using drift diffusion modeling: Antagonism, but not Disinhibition, is associated with poor cognitive control

2021 ◽  
Author(s):  
Nathan T. Hall ◽  
Alison M. Schreiber ◽  
Timothy A. Allen ◽  
Michael N. Hallquist
2020 ◽  
Author(s):  
Nathan T Hall ◽  
Alison Schreiber ◽  
Timothy Allen ◽  
Michael Hallquist

Although externalizing psychopathology has been linked to deficits in cognitive control, the cognitive processes underlying this association are unclear. In this study, we linked the two major subcomponents of externalizing, Antagonism and Disinhibition, with specific control processes using a battery of inhibitory control tasks and corresponding computational modeling. Participants (final N = 104) completed the flanker, go/no-go, and recent probes tasks, as well as normal and maladaptive personality inventories and measures of psychological distress. We fit participants’ task behavior using a hierarchical drift diffusion model (DDM) to decompose their decisions into specific cognitive processes. Using multilevel structural equation models, we found that Antagonism was associated with faster RTs on the flanker task and lower accuracy on flanker and go/no-go tasks. These results were complemented by DDM parameter associations: Antagonism was linked to decreased threshold and drift rate parameter estimates in the flanker task and a decreased drift rate on no-go trials. Altogether, our findings indicate that Antagonism is associated with specific impairments in fast (sub-second) inhibitory control processes involved in withholding prepared/prepotent responses and filtering distracting information. Disinhibition, however, was not associated with task performance.


2016 ◽  
Vol 6 (1-2) ◽  
pp. 119-146 ◽  
Author(s):  
Henrike K. Blumenfeld ◽  
Scott R. Schroeder ◽  
Susan C. Bobb ◽  
Max R. Freeman ◽  
Viorica Marian

Abstract Recent research suggests that bilingual experience reconfigures linguistic and nonlinguistic cognitive processes. We examined the relationship between linguistic competition resolution and nonlinguistic cognitive control in younger and older adults who were either bilingual or monolingual. Participants heard words in English and identified the referent among four pictures while eye-movements were recorded. Target pictures (e.g., cab) appeared with a phonological competitor picture (e.g., cat) and two filler pictures. After each eye-tracking trial, priming probes assessed residual activation and inhibition of target and competitor words. When accounting for processing speed, results revealed that age-related changes in activation and inhibition are smaller in bilinguals than in monolinguals. Moreover, younger and older bilinguals, but not monolinguals, recruited similar inhibition mechanisms during word identification and during a nonlinguistic Stroop task. Results suggest that, during lexical access, bilinguals show more consistent competition resolution and recruitment of cognitive control across the lifespan than monolinguals.


2019 ◽  
Author(s):  
Anne Saulin ◽  
Ulrike Horn ◽  
Martin Lotze ◽  
Jochen Kaiser ◽  
Grit Hein

AbstractBecause the motives behind goal-directed behaviors are often complex, most behaviors result from the interplay between different motives. However, it is unclear how this interplay between multiple motives affects the neural computation of goal-directed behaviors. Using a combination of drift-diffusion modeling and fMRI, we show that the interplay between different social motives changes initial preferences for prosocial behavior before a person makes a behavioral choice. This increase in preferences for the prosocial choice option was tracked by neural responses in the bilateral dorsal striatum, which in turn lowered the amount of information necessary for choosing prosocial behavior. We obtained these results using a paradigm in which each participant performed the same behavior based on different, simultaneously activated motives, or based on each of the motives separately. Thus, our findings provide a model of behavioral choice computation in complex motivational states, i.e., the motivational setting that drives most goal-directed human behaviors.


Author(s):  
Matthew P. Lumb ◽  
Christopher G. Bailey ◽  
Jessica G. J. Adams ◽  
Glen Hillier ◽  
Francis Tuminello ◽  
...  

AIP Advances ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 035026 ◽  
Author(s):  
Timofey Golubev ◽  
Dianyi Liu ◽  
Richard Lunt ◽  
Phillip Duxbury

2020 ◽  
Vol 31 (9) ◽  
pp. 1191-1199
Author(s):  
Susanne Becker ◽  
Martin Löffler ◽  
Ben Seymour

The notion that reward inhibits pain is a well-supported observation in both humans and animals, allowing suppression of pain reflexes to acquired rewarding stimuli. However, a blanket inhibition of pain by reward would also impair pain discrimination. In contrast, early counterconditioning experiments implied that reward might actually spare pain discrimination. To test this hypothesis, we investigated whether discriminative performance was enhanced or inhibited by reward. We found in adult human volunteers ( N = 25) that pain-based discriminative ability is actually enhanced by reward, especially when reward is directly contingent on discriminative performance. Drift-diffusion modeling shows that this relates to an augmentation of the underlying sensory signal strength and is not merely an effect of decision bias. This enhancement of sensory-discriminative pain-information processing suggests that whereas reward can promote reward-acquiring behavior by inhibition of pain in some circumstances, it can also facilitate important discriminative information of the sensory input when necessary.


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