FACEBOOK AS A RECRUITMENT TOOL FOR YOUNG ADULTS ENROLLED IN THE VICTORIAN INFANT COLLABORATIVE STUDY (VICS) 1991‐92 COHORT

Background: A growing population of young adults is presenting to cardiologists with late manifestations of Kawasaki disease (KD) that include cardiomyopathy, ischemia, and infarction. The management of these conditions differs in important ways from atherosclerotic heart disease, and yet there is little awareness in the adult cardiology community regarding the special challenges posed by the cardiovascular sequelae of KD. Methods: Observations were made on a population of 140 adult KD patients enrolled in the San Diego Adult KD Collaborative Study. Results: Coronary artery aneurysms resulting from KD in childhood are associated with a high risk of thrombosis and stenosis at the inlet or outlet of the aneurysm. These aneurysms are often highly calcified and may contain a large thrombus burden that may obscure the true size of the aneurysm. Pitfalls in the management of these patients stem largely from failure to recognize the nature of the lesions, which leads to attempts to dilate highly calcified stenotic segments and undersizing of stents. Intravascular ultrasound is helpful in appreciating the true dimensions of the aneurysm, which may be filled with thrombus. Thrombolysis and use of anti-platelet agents followed by systemic anti-coagulation are appropriate management strategies for patients presenting with acute infarction. Bypass grafting with the internal thoracic arteries can be a successful strategy, but care must be taken to avoid competitive flow through the native vessel leading to graft failure. In contrast to the individuals who developed coronary artery aneurysms, young adults who had documented normal echocardiograms associated with their acute KD in childhood and who have no evidence of calcium deposition in the arterial wall as assessed by computed tomography (CT) calcium score appear to have no increased cardiovascular risk in the medium term. Long-term outcomes for adults post-KD in childhood are still being defined. Conclusions: KD poses special management challenges for the adult cardiologist who must recognize the unique features of the cardiovascular lesions in this growing population of patients.

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Hodgkin’s Lymphoma in Adolescents and Young Adults

Oncology & Hematology Review (US) ◽

10.17925/ohr.2012.08.2.116 ◽

2012 ◽

Vol 08 (02) ◽

pp. 116 ◽

Cited By ~ 1

Author(s):

Laura Rodriguez ◽

Angela Punnett ◽

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Keyword(s):

Young Adults ◽

Hodgkin’S Lymphoma ◽

Collaborative Study ◽

Study Groups ◽

Primary Treatment ◽

Adolescents And Young Adults ◽

Adolescent And Young Adult ◽

Hodgkin's Lymphoma

Adolescents and young adults (AYAs) are defined as those individuals between the ages of 15 and 39 years. Hodgkin’s lymphoma (HL) is the most common cancer observed in AYAs. Over the last two decades, significant improvements in both survival from HL and the reduction of therapy-related late effects have resulted from the work of collaborative study groups in pediatric and adult domains. The adolescent and young adult (AYA) population falls between these domains. AYA patients are in a critical developmental transition, with significant psychosocial challenges that may impact on the outcome of the primary treatment as well as on the medical care and surveillance of long-term sequelae in survivors. This article will examine available literature regarding outcomes for HL in the AYA population, identifying issues unique to this group, therapeutic options, and specific concerns in follow-up.

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Management and Outcomes of Atrial Fibrillation in 241 Healthy Children and Young Adults: Revisiting “Lone” Atrial Fibrillation. A Multi-Institutional PACES Collaborative Study

Heart Rhythm ◽

10.1016/j.hrthm.2021.07.066 ◽

2021 ◽

Author(s):

Iqbal El Assaad ◽

Benjamin H. Hammond ◽

Lukas D. Kost ◽

Sarah Worley ◽

Christopher M. Janson ◽

...

Keyword(s):

Atrial Fibrillation ◽

Young Adults ◽

Collaborative Study ◽

Healthy Children ◽

Lone Atrial Fibrillation ◽

Children And Young Adults

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The association of polygenic risk for schizophrenia, bipolar disorder, and depression with neural connectivity in adolescents and young adults: examining developmental and sex differences

Translational Psychiatry ◽

10.1038/s41398-020-01185-7 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

J. L. Meyers ◽

D. B. Chorlian ◽

T. B. Bigdeli ◽

E. C. Johnson ◽

F. Aliev ◽

...

Keyword(s):

Young Adults ◽

Sex Differences ◽

Family History ◽

Collaborative Study ◽

Adolescents And Young Adults ◽

Risk Scores ◽

Eeg Coherence ◽

Neural Connectivity ◽

Polygenic Risk ◽

History Of

AbstractNeurodevelopmental abnormalities in neural connectivity have been long implicated in the etiology of schizophrenia (SCZ); however, it remains unclear whether these neural connectivity patterns are associated with genetic risk for SCZ in unaffected individuals (i.e., an absence of clinical features of SCZ or a family history of SCZ). We examine whether polygenic risk scores (PRS) for SCZ are associated with functional neural connectivity in adolescents and young adults without SCZ, whether this association is moderated by sex and age, and if similar associations are observed for genetically related neuropsychiatric PRS. One-thousand four-hundred twenty-six offspring from 913 families, unaffected with SCZ, were drawn from the Collaborative Study of the Genetics of Alcoholism (COGA) prospective cohort (median age at first interview = 15.6 (12–26), 51.6% female, 98.1% European American, 41% with a family history of alcohol dependence). Participants were followed longitudinally with resting-state EEG connectivity (i.e., coherence) assessed every two years. Higher SCZ PRS were associated with elevated theta (3–7 Hz) and alpha (7–12 Hz) EEG coherence. Associations differed by sex and age; the most robust associations were observed between PRS and parietal-occipital, central-parietal, and frontal-parietal alpha coherence among males between ages 15–19 (B: 0.15–0.21, p < 10–4). Significant associations among EEG coherence and Bipolar and Depression PRS were observed, but differed from SCZ PRS in terms of sex, age, and topography. Findings reveal that polygenic risk for SCZ is robustly associated with increased functional neural connectivity among young adults without a SCZ diagnosis. Striking differences were observed between men and women throughout development, mapping onto key periods of risk for the onset of psychotic illness and underlining the critical importance of examining sex differences in associations with neuropsychiatric PRS across development.

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Continuum of Care Following Sports-Related Concussion

American Journal of Speech-Language Pathology ◽

10.1044/2020_ajslp-19-00131 ◽

2020 ◽

Vol 29 (3) ◽

pp. 1389-1403

Author(s):

Jessica Brown ◽

Kelly Knollman-Porter

Keyword(s):

Young Adults ◽

Life Span ◽

Sports Injuries ◽

Continuum Of Care ◽

Medical Professional ◽

Structured Interviews ◽

Youth Athletes ◽

Speech Language Pathologist ◽

History Of ◽

Injury Reporting

Purpose Although guidelines have changed regarding federally mandated concussion practices since their inception, little is known regarding the implementation of such guidelines and the resultant continuum of care for youth athletes participating in recreational or organized sports who incur concussions. Furthermore, data regarding the role of speech-language pathologists in the historic postconcussion care are lacking. Therefore, the purpose of this retrospective study was to investigate the experiences of young adults with history of sports-related concussion as it related to injury reporting and received follow-up care. Method Participants included 13 young adults with history of at least one sports-related concussion across their life span. We implemented a mixed-methods design to collect both quantitative and qualitative information through structured interviews. Participants reported experiencing 42 concussions across the life span—26 subsequent to sports injuries. Results Twenty-three concussions were reported to a parent or medical professional, 14 resulted in a formal diagnosis, and participants received initial medical care for only 10 of the incidents and treatment or services on only two occasions. Participants reported concussions to an athletic trainer least frequently and to parents most frequently. Participants commented that previous experience with concussion reduced the need for seeking treatment or that they were unaware treatments or supports existed postconcussion. Only one concussion incident resulted in the care from a speech-language pathologist. Conclusion The results of the study reported herein shed light on the fidelity of sports-related concussion care management across time. Subsequently, we suggest guidelines related to continuum of care from injury to individualized therapy.

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