scholarly journals Serotonin Receptor ( HTR2A ) Gene Polymorphism Modulates Social Sharing of Happiness in Both American and Japanese Adults

2021 ◽  
Author(s):  
Masahiro Matsunaga ◽  
Yohsuke Ohtsubo ◽  
Takahiko Masuda ◽  
Yasuki Noguchi ◽  
Hidenori Yamasue ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Serotonin Receptor ◽  
Japanese Adults ◽  
Social Sharing ◽  
Htr2a Gene

scholarly journals Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder

2011 ◽  
Vol 13 (1) ◽  
pp. 21-26 ◽  
Author(s):  
F W Lohoff ◽  
T D Aquino ◽  
S Narasimhan ◽  
P K Multani ◽  
B Etemad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Gene Polymorphism ◽  
Treatment Response ◽  
Generalized Anxiety Disorder ◽  
Serotonin Receptor ◽  
Generalized Anxiety ◽  
Serotonin Receptor 2A ◽  
Htr2a Gene

Association of a serotonin receptor 2A gene polymorphism with cognitive functions in patients with schizophrenia

2007 ◽  
Vol 144B (5) ◽  
pp. 704-707 ◽  
Author(s):  
Alp Üçok ◽  
Hale Alpsan ◽  
Sibel Çakır ◽  
Güher Saruhan-Direskeneli
Keyword(s):  
Gene Polymorphism ◽  
Cognitive Functions ◽  
Serotonin Receptor ◽  
Serotonin Receptor 2A

SAFETY OF THERAPY WITH ANTIPSYCHOTICS: THE SEROTONIN RECEPTOR 2A (HTR2A) GENE AND METABOLIC DISORDERS

Vrach ◽  
2019 ◽  
Vol 30 (1) ◽  
Author(s):  
L. Akhmetova ◽  
M. Tolmachev ◽  
N. Shnaider ◽  
T. Potupchik ◽  
E. Ershov ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Metabolic Disorders ◽  
Serotonin Receptor 2A ◽  
Htr2a Gene

Serotonin Receptor 2A Gene Polymorphism (–1438A/G) and Short-Term Treatment Response to Citalopram

2005 ◽  
Vol 52 (3) ◽  
pp. 155-162 ◽  
Author(s):  
Myoung-Jin Choi ◽  
Rhee-Hun Kang ◽  
Byung-Joo Ham ◽  
Han-Yong Jeong ◽  
Min-Soo Lee
Keyword(s):  
Gene Polymorphism ◽  
Treatment Response ◽  
Serotonin Receptor ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment ◽  
Serotonin Receptor 2A

scholarly journals Polymorphism in the Serotonin Receptor 2a (HTR2A) Gene as Possible Predisposal Factor for Aggressive Traits

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117792 ◽  
Author(s):  
Zsofia Banlaki ◽  
Zsuzsanna Elek ◽  
Tibor Nanasi ◽  
Anna Szekely ◽  
Zsofia Nemoda ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Serotonin Receptor 2A ◽  
Htr2a Gene

5HTR2A gene polymorphism and personality traits in patients with major psychoses

2002 ◽  
Vol 17 (1) ◽  
pp. 24-28 ◽  
Author(s):  
V.E. Golimbet ◽  
M.V. Alfimova ◽  
K.K. Manandyan ◽  
N.G. Mitushina ◽  
L.I. Abramova ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Personality Traits ◽  
Psychological Assessment ◽  
Affective Disorders ◽  
Serotonin Receptor ◽  
Clinical Symptoms ◽  
Pathological Features ◽  
Significant Difference ◽  
Icd 10 ◽  
Clinical And Pathological Features

SummarySerotonin receptor (5HTR2A) gene polymorphism has been reported to be associated with clinical phenotypes in schizophrenia. The current study attempted to investigate a relationship between 5HTR2A 102T/C polymorphism and personality traits as well as clinical symptoms in patients with ICD-10 diagnoses of schizophrenia and affective disorders. 5HTR2A genotyping, clinical and psychological assessment were administered to 375 patients, 104 first-degree healthy relatives of the patients and 157 controls. In the patients an association was observed between the 2/2 5HTR2A genotype and scores on the Hypochondriasis scale (MMPI) (ANOVA, F = 4.56; P = 0.011) and trait anxiety (F = 4.21; P = 0.002). A significant difference between 1/1 and 2/2 genotypes has been also found for Neuroticism scores (EPI) (t = 2.18; P = 0.0031). No significant differences by 5HTR2A genotype were observed in either the control or first-degree relatives' group for all scales studied. Positive, negative and psychopathological symptoms emerged higher in the 2/2 genotype patients compared to other genotype carriers. Therefore, the 2/2 genotype may contribute to produce the phenotype, with specific clinical and pathological features in common, regardless of nosologic heterogeneity of psychoses.

scholarly journals Serotonin Receptor 2A (HTR2A) Gene Polymorphisms Are Associated with Blood Pressure, Central Adiposity, and the Metabolic Syndrome

2007 ◽  
Vol 5 (4) ◽  
pp. 323-330 ◽  
Author(s):  
Indrani Halder ◽  
Matthew F. Muldoon ◽  
Robert E. Ferrell ◽  
Stephen B. Manuck
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Gene Polymorphisms ◽  
Serotonin Receptor ◽  
Central Adiposity ◽  
The Metabolic Syndrome ◽  
Serotonin Receptor 2A ◽  
Htr2a Gene

scholarly journals Potential Link between T102C Polymorphism in the Serotonin Receptors (5-HT2A) Gene and Treatment Response of Risperidone on Schizophrenia

2021 ◽  
Vol 9 (T3) ◽  
pp. 288-293
Author(s):  
Saidah Syamsuddin ◽  
Andi Fatimah ◽  
Faisal Idrus ◽  
Sonny T. Lisal
Keyword(s):  
Gene Polymorphism ◽  
Healthy Volunteers ◽  
Treatment Response ◽  
Serotonin Receptors ◽  
Serotonin Receptor ◽  
Receptor Gene ◽  
Significant Difference ◽  
Potential Link ◽  
Allele Specific ◽  
T102c Polymorphism

BACKGROUND: Schizophrenia affects 1% of population and its molecular etiology remains enigmatic despite enormous study. Approximately one-third of patients failed to respond with treatment. The 5-HT2A receptor appears to be one of important site of action of atypical antipsychotic drugs. It also has been suggested that the T102C gene polymorphism alters promoter activity and expression of 5-HT2A receptors and might be responsible for the associations with the efficacy of typical antipsychotics. AIM: In this study, we aimed to evaluate the potential link between T102C polymorphism in the Serotonin Receptors (5-HT2A) and their response to risperidone. METHODS: We studied 100 schizophrenia patients and 100 healthy volunteers as a comparison of 5-HT2A receptors gene polymorphism distribution, which were all Indonesian. The peripheral blood samples were obtained from all participants. The patients assessed by Positive and Negative Scale (PANSS) and Clinical Global Impression Scale (CGI) when admitted to the hospital. Clinical improvements then assessed 5 times in 4 weeks (when transferred to sub-acute ward, at the 1st, the 2nd, the 3rd, and the 4th week). To analyze the T102C polymorphism of 5-HT2A receptor gene, we used an allele specific polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: In this study, there were three various polymorphisms of T102C in the serotonin receptor (5-HT2A) gene: T/T, C/C, and T/C. The patients who had homozygous for T/T genotypes were found to give better improvement to risperidone than the patients who were C/C and T/C genotypes (P:0.001). Moreover, the patients with C allele genotype T/C and C/C had minimal response (P:0.001). We found no significant difference distribution of genotypes between schizophrenia patients and healthy volunteers (P:0.498). CONCLUSION: Our result supported that there was a potential link between T102C polymorphism in the serotonin receptor (5-HT2A) gene and treatment response of risperidone. It suggested the importance of genetic screening such as examination of the Serotonin Receptor 5-HT2A (T102C) gene polymorphism to be performed to optimize therapeutic strategies with antipsychotic.

The KCNQ1 gene polymorphism as a shared genetic risk for rheumatoid arthritis and chronic periodontitis in Japanese adults: A pilot case-control study

2018 ◽  
Vol 89 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Tetsuo Kobayashi ◽  
Jun-ichi Kido ◽  
Yuichi Ishihara ◽  
Kazuhiro Omori ◽  
Satoshi Ito ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphism ◽  
Chronic Periodontitis ◽  
Genetic Risk ◽  
Case Control Study ◽  
Case Control ◽  
Kcnq1 Gene ◽  
Japanese Adults ◽  
Control Study ◽  
Shared Genetic
Sign in / Sign up

Export Citation Format

Share Document