Marked Testosterone Deficiency‐Related Symptoms May be Associated to Higher Metabolic Risk in Men with Low Testosterone Levels

2014 ◽  
Vol 11 (9) ◽  
pp. 2292-2301 ◽  
Author(s):  
Eduard García‐Cruz ◽  
Asier Leibar‐Tamayo ◽  
Javier Romero‐Otero ◽  
Ignacio Asiaín ◽  
Albert Carrión ◽  
...  
Keyword(s):  
Metabolic Risk ◽  
Testosterone Deficiency ◽  
Testosterone Levels ◽  
Low Testosterone

scholarly journals Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes

2013 ◽  
Vol 169 (6) ◽  
pp. 725-733 ◽  
Author(s):  
Vakkat Muraleedharan ◽  
Hazel Marsh ◽  
Dheeraj Kapoor ◽  
Kevin S Channer ◽  
T Hugh Jones
Keyword(s):  
Type 2 Diabetes ◽  
Untreated Group ◽  
Testosterone Replacement ◽  
Testosterone Deficiency ◽  
Testosterone Levels ◽  
All Cause Mortality ◽  
Low Testosterone

ObjectiveMen with type 2 diabetes are known to have a high prevalence of testosterone deficiency. No long-term data are available regarding testosterone and mortality in men with type 2 diabetes or any effect of testosterone replacement therapy (TRT). We report a 6-year follow-up study to examine the effect of baseline testosterone and TRT on all-cause mortality in men with type 2 diabetes and low testosterone.Research design and methodsA total of 581 men with type 2 diabetes who had testosterone levels performed between 2002 and 2005 were followed up for a mean period of 5.8±1.3 s.d. years. Mortality rates were compared between total testosterone >10.4 nmol/l (300 ng/dl; n=343) and testosterone ≤10.4 nmol/l (n=238). The effect of TRT (as per normal clinical practise: 85.9% testosterone gel and 14.1% intramuscular testosterone undecanoate) was assessed retrospectively within the low testosterone group.ResultsMortality was increased in the low testosterone group (17.2%) compared with the normal testosterone group (9%; P=0.003) when controlled for covariates. In the Cox regression model, multivariate-adjusted hazard ratio (HR) for decreased survival was 2.02 (P=0.009, 95% CI 1.2–3.4). TRT (mean duration 41.6±20.7 months; n=64) was associated with a reduced mortality of 8.4% compared with 19.2% (P=0.002) in the untreated group (n=174). The multivariate-adjusted HR for decreased survival in the untreated group was 2.3 (95% CI 1.3–3.9, P=0.004).ConclusionsLow testosterone levels predict an increase in all-cause mortality during long-term follow-up. Testosterone replacement may improve survival in hypogonadal men with type 2 diabetes.

scholarly journals Low Testosterone Levels Are Common and Associated with Insulin Resistance in Men with Diabetes

2008 ◽  
Vol 93 (5) ◽  
pp. 1834-1840 ◽  
Author(s):  
Mathis Grossmann ◽  
Merlin C. Thomas ◽  
Sianna Panagiotopoulos ◽  
Ken Sharpe ◽  
Richard J. MacIsaac ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Free Testosterone ◽  
Total Testosterone ◽  
Testosterone Deficiency ◽  
Testosterone Levels ◽  
Low Testosterone

Abstract Context: Low testosterone levels are common in men with type 2 diabetes and may be associated with insulin resistance. Objective: We investigated prevalence of testosterone deficiency and the relationship between testosterone and insulin resistance in a large cohort of men with type 2 and type 1 diabetes. Design: The study was a cross-sectional survey of 580 men with type 2 diabetes and 69 men with type 1 diabetes. A subgroup of 262 men with type 2 diabetes was then reassessed after a median of 6 months. Results: Forty-three percent of men with type 2 diabetes had a reduced total testosterone, and 57% had a reduced calculated free testosterone. Only 7% of men with type 1 diabetes had low total testosterone. By contrast, 20.3% of men with type 1 diabetes had low calculated free testosterone, similar to that observed in type 2 diabetes (age-body mass index adjusted odds ratio = 1.4; 95% confidence interval = 0.7–2.9). Low testosterone levels were independently associated with insulin resistance in men with type 1 diabetes as well as type 2 diabetes. Serial measurements also revealed an inverse relationship between changes in testosterone levels and insulin resistance. Conclusions: Testosterone deficiency is common in men with diabetes, regardless of the type. Testosterone levels are partly influenced by insulin resistance, which may represent an important avenue for intervention, whereas the utility of testosterone replacement remains to be established in prospective trials.

scholarly journals Six Months of Treatment with Cabergoline Restores Sexual Potency in Hyperprolactinemic Males: An Open Longitudinal Study Monitoring Nocturnal Penile Tumescence

2004 ◽  
Vol 89 (2) ◽  
pp. 621-625 ◽  
Author(s):  
Michele De Rosa ◽  
Stefano Zarrilli ◽  
Giovanni Vitale ◽  
Carolina Di Somma ◽  
Francesco Orio ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Longitudinal Study ◽  
Testosterone Deficiency ◽  
Nocturnal Penile Tumescence ◽  
Healthy Men ◽  
Testosterone Levels ◽  
Penile Tumescence ◽  
Sexual Disturbances ◽  
Low Testosterone ◽  
Study Monitoring

This open longitudinal study investigated the prevalence of depressed sexual potency by monitoring erectile dysfunction using nocturnal penile tumescence (NPT) in 51 consecutive men with hyperprolactinemia (41 macroprolactinomas and 10 microprolactinomas) and evaluated potential reversibility of sexual failure after 6 months of treatment with cabergoline. Fifty-one healthy men served as controls. Compared with controls, the patients with either micro- or macroprolactinoma had low testosterone levels with severe alterations of erectile function. Testosterone deficiency was present in 73.2% of macro- and 50% of microprolactinomas; reduced libido and sexual potency were referred by 53.6% of macroprolactinomas, 50% of microprolactinomas, and none of controls. Fewer than three erectile events per night by NPT were found in 96.7% of patients and 13.7% of controls (P < 0.0001). After 6 months of cabergoline treatment, prolactin levels normalized in 74.5% of patients: 73.2% of macroprolactinomas and 80% of microprolactinomas. Testosterone levels normalized in 68.6% of patients, whereas NPT normalized in 60.6% of patients who had normalized prolactin levels and in 7.7% of patients who did not. In conclusion, at study entry, 50% of the patients complained of sexual disturbances, 96.7% of whom had an impairment of erectile events per night compared with 13.7% of controls. Six months of treatment with cabergoline normalized testosterone levels in most cases, thus restoring and maintaining during treatment the capability of normal sexual activity in hyperprolactinemic males.

212-OR: Testosterone Deficiency Increases Hypothalamic Gliosis and Metabolic Risk

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 212-OR
Author(s):  
MAURICIO D. DORFMAN ◽  
JEREMY FREY ◽  
KELLY M. NESS ◽  
ANZELA NIRAULA ◽  
JENNY E. KANTER ◽  
...  
Keyword(s):  
Metabolic Risk ◽  
Testosterone Deficiency

Metabolic Syndrome in Men with Low Testosterone Levels: Relationship with Cardiovascular Risk Factors and Comorbidities and with Erectile Dysfunction

2013 ◽  
Vol 10 (10) ◽  
pp. 2529-2538 ◽  
Author(s):  
Eduardo García‐Cruz ◽  
Asier Leibar‐Tamayo ◽  
Javier Romero ◽  
Marta Piqueras ◽  
Pilar Luque ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Erectile Dysfunction ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Testosterone Levels ◽  
Low Testosterone

Obese Men with Both Elevated Estradiol and Low Testosterone Levels Have an Adverse Cardiovascular Risk Profile

2011 ◽  
pp. P1-334-P1-334
Author(s):  
Tomas Ahern ◽  
Michelle Corrigan ◽  
Emer O'Malley ◽  
Colin Dunlevy ◽  
Donal O'Shea ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Testosterone Levels ◽  
Low Testosterone

Impact of long-term testosterone treatment on plasma levels of free TFPI and TF-induced thrombin generation ex vivo in elderly men with low testosterone levels

2009 ◽  
Vol 102 (11) ◽  
pp. 945-950 ◽  
Author(s):  
Ingvild Agledahl ◽  
Johan Svartberg ◽  
John-Bjarne Hansen ◽  
Ellen Brodin
Keyword(s):  
Tissue Factor ◽  
Plasma Levels ◽  
Thrombin Generation ◽  
Ex Vivo ◽  
Favorable Effect ◽  
Elderly Men ◽  
Testosterone Treatment ◽  
Testosterone Levels ◽  
Low Testosterone ◽  
One Year

SummaryMen have a higher incidence of cardiovascular disease (CVD) than women of similar age, and it has been suggested that testosterone may influence the development of CVD. Recently, we demonstrated that elderly men with low testosterone levels had lower plasma levels of free tissue factor pathway inhibitor (TFPI) Ag associated with shortened tissue factor (TF)-induced coagulation initiation in a population based case-control study. Our hypothesis was that one year of testosterone treatment to physiological levels in elderly men would increase the levels of free TFPI Ag in plasma and have a favorable effect on TF-induced coagulation. Twenty-six men with low testosterone levels (≤11.0 nM) were randomly assigned to treatment with intramuscular testosterone depot injections (testosterone undecanoate 1,000 mg) or placebo in a double-blinded study. Each participant received a total of five injections, at baseline, 6, 16, 28 and 40 weeks, and TF-induced thrombin generation ex vivo and plasma free TFPI Ag were measured after one year. At the end of the study total and free testosterone levels were significantly higher in the testosterone treated group (14.9 ± 4.5 nM vs. 8.1 ± 2.4 nM; p<0.001, and 363.3 ± 106.6 pM vs. 187.3 ± 63.2 pM; p<0.001, respectively). Testosterone treatment for one year did neither cause significant changes in TF-induced thrombin generation ex vivo nor changes in plasma levels of free TFPI Ag. In conclusion, normalising testosterone levels by testosterone treatment for 12 months in elderly men did not affect TF-induced coagulation or plasma TFPI levels. The potential antithrombotic role of testosterone therapy remains to be elucidated.

scholarly journals How Do We Love? Romantic Love Style in Men Is Related to Lower Testosterone Levels

2017 ◽  
pp. 695-703 ◽  
Author(s):  
J. BABKOVÁ DURDIAKOVÁ ◽  
P. CELEC ◽  
I. KOBOROVÁ ◽  
T. SEDLÁČKOVÁ ◽  
G. MINÁRIK ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Romantic Love ◽  
Social Background ◽  
Plasma Testosterone ◽  
Love Styles ◽  
Testosterone Levels ◽  
The Family ◽  
Low Testosterone ◽  
And Behavior ◽  
Attitudes And Behavior

Testosterone has been widely investigated in associations with many aspects of social interactions, emotions and behavior. No research has been conducted on its contribution to the variability of love styles in human. The aim of this paper was to uncover the possible relationship between not only the actual plasma testosterone levels, but also the prenatal testosterone level (expressed as 2D:4D ratio) and the sensitivity of androgen receptor and love typology in young healthy men. There are six love styles which are primary including Eros (passionate romantic love), Ludus (playful) and Storge (friendly) and secondary love consisting of Mania (obsessive), Pragma (practical realistic) and Agape (altruistic). Our results pointed out that low testosterone concentrations are associated with higher score for Eros, Ludus, Pragma, Mania love style. No significant association was proved for other tested parameters of androgenicity (2D:4D, sensitivity of androgen receptor) and love style after correction was applied. Different attitudes and behavior in relationships do have a biological foundation related to endogenous testosterone levels in plasma. Future studies should address questions about the family and social background of participants to differentiate here between moral rules or/and social-conventional rules.

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