scholarly journals Role of Junction‐Mediating and Regulatory Protein in the Pathogenesis of Glucocorticoid‐Induced Endothelial Cell Lesions

2020 ◽  
Vol 12 (3) ◽  
pp. 964-973
Author(s):  
Wei Zuo ◽  
Wan‐shou Guo ◽  
Hua‐chen Yu ◽  
Pei Liu ◽  
Qi‐dong Zhang
Keyword(s):  
Endothelial Cell ◽  
Regulatory Protein

C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis

2000 ◽  
Vol 278 (5) ◽  
pp. F747-F757 ◽  
Author(s):  
Jeremy Hughes ◽  
Masaomi Nangaku ◽  
Charles E. Alpers ◽  
Stuart J. Shankland ◽  
William G. Couser ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Regulatory Protein ◽  
Membrane Attack Complex ◽  
Fold Increase ◽  
Renal Perfusion ◽  
Con A ◽  
Immune Mediated ◽  
The Right ◽  
Endothelial Integrity

We studied the role of the C5b-9 membrane attack complex in two models of inflammatory glomerulonephritis (GN) initiated by acute glomerular endothelial injury in Piebold-viral-Glaxo (PVG) complement-sufficient rats (C+), C6-deficient rats (C6−), and rats systematically depleted of complement with cobra venom factor (CVF). GN was induced by performing a left nephrectomy and selectively perfusing the right kidney with either 1) the lectin concanavalin A (Con A) followed by complement-fixing anti-Con A (Con A GN) or 2) purified complement-fixing goat anti-rat glomerular endothelial cell (GEN) antibody [immune-mediated thrombotic microangiopathy (ITM)]. Comparable levels of GEN apoptosis were detected in C+ animals in both models. CVF administration reduced GEN apoptosis by 10- to 12-fold. GEN apoptosis was C5b-9 dependent because PVG C6− rats were protected from GEN loss. Furthermore, functional inhibition of the cell surface complement regulatory protein CD59 by renal perfusion with anti-CD59 antibody in ITM resulted in a 3.5-fold increase in GEN apoptosis. Last, in Con A GN, abrogation of GEN apoptosis preserved endothelial integrity and renal function. This study demonstrates the specific role of C5b-9 in the induction of GEN apoptosis in experimental inflammatory GN, a finding with implications for diseases associated with the presence of antiendothelial cell antibodies.

scholarly journals The role of anti-endothelial cell antibodies in Kawasaki disease -in vitro and in vivo studies

2002 ◽  
Vol 130 (2) ◽  
pp. 233-240 ◽  
Author(s):  
E. GRUNEBAUM ◽  
M. BLANK ◽  
S. COHEN ◽  
A. AFEK ◽  
J. KOPOLOVIC ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Kawasaki Disease ◽  
In Vivo Studies

scholarly journals The Role of Putative Fibrinogen Aα-, Bβ-, and γA-chain Integrin Binding Sites in Endothelial Cell-mediated Clot Retraction

1997 ◽  
Vol 272 (35) ◽  
pp. 22080-22085 ◽  
Author(s):  
Richard A. Smith ◽  
M. W. Mosesson ◽  
Michael M. Rooney ◽  
Susan T. Lord ◽  
A.U. Daniels ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Binding Sites ◽  
Clot Retraction

scholarly journals Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

2020 ◽  
Vol 10 (01) ◽  
pp. e104-e109
Author(s):  
Antonio Molina-Carballo ◽  
Antonio Emilio Jerez-Calero ◽  
Antonio Muñoz-Hoyos
Keyword(s):  
Endothelial Cell ◽  
Free Radical ◽  
Chronic Administration ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Energetic Metabolism ◽  
Beneficial Effects ◽  
Molecular Crosstalk

AbstractMelatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.

scholarly journals Role of endothelial cell receptors in the context of SARS-CoV-2 infection (COVID-19)

2021 ◽  
Vol 34 (2) ◽  
pp. 262-268
Author(s):  
Jun Zhang ◽  
Kristen M. Tecson ◽  
Peter A. McCullough
Keyword(s):  
Endothelial Cell ◽  
Cell Receptors
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