scholarly journals Do Low Levels of Beta-Endorphin in the Cerebrospinal Fluid Indicate Defective Top-Down Inhibition in Patients with Chronic Neuropathic Pain? A Cross-Sectional, Comparative Study

Pain Medicine ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 111-119 ◽  
Author(s):  
Emmanuel Bäckryd ◽  
Bijar Ghafouri ◽  
Britt Larsson ◽  
Björn Gerdle
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuropathic Pain ◽  
Comparative Study ◽  
Top Down ◽  
Chronic Neuropathic Pain ◽  
Cross Sectional ◽  
Beta Endorphin ◽  
Low Levels

Cathepsin S is increased in cerebrospinal fluid from patients with neuropathic pain—A support of the microglia hypothesis in humans

2014 ◽  
Vol 5 (3) ◽  
pp. 208-209
Author(s):  
Torsten Gordh ◽  
Anne-Li Lind ◽  
Constantin Bodolea ◽  
Ellen Hewitt ◽  
Anders Larsson
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuropathic Pain ◽  
Microglial Activation ◽  
Animal Experiments ◽  
Cathepsin S ◽  
Control Group ◽  
Chronic Neuropathic Pain ◽  
Potential Biomarker ◽  
New Treatment ◽  
Pain Patients

AbstractAimsCathepsin S has been reported to be a biomarker of spinal microglial activation, a process suggested to be involved in the pathophysiology of chronic neuropathic pain. So far this has been shown only in animal experiments. The aim of this study was to investigate the concentrations of cathepsin S in human cerebrospinal fluid (CSF) samples from a well-defined patient cohort suffering from neuropathic pain as compared to controls.MethodsCSF samples from patients suffering from chronic neuropathic pain (n = 14) were analyzed for cathepsin S levels using commercial sandwich ELISAs (DY1183, R&D Systems, Minneapolis, MN, USA). Control CSF was sampled from patients undergoing minor urological surgical procedures under spinal anaesthesia (n = 70), having no obvious pain suffering.ResultsThe neuropathic pain group had significantly higher levels of CSF cathepsin S (median 15189 pg/mL, range 3213–40,040), than the control group (median 5911 pg/mL, range 1909–17,188) (p < 0.005, Mann–Whitney U-test).ConclusionThe results support the existence of microglial activation in chronic neuropathic pain patients. CSF Cathepsin S may serve as a potential biomarker for this specific mechanism linked to neuropathic pain. In the future, Cathepsin S inhibiting drugs might become a new treatment alternative for neurophatic pain.

Cerebrospinal fluid levels of substance P (SP) N-terminal fragment SP1–7 in patients with neuropathic pain

2015 ◽  
Vol 8 (1) ◽  
pp. 51-51
Author(s):  
A. Jonsson ◽  
A.-L. Lind ◽  
M. Hallberg ◽  
F. Nyberg ◽  
T. Gordh
Keyword(s):  
Cerebrospinal Fluid ◽  
Neuropathic Pain ◽  
Substance P ◽  
Chronic Neuropathic Pain ◽  
Painful Condition ◽  
Mechanical Hypersensitivity ◽  
Terminal Fragment ◽  
Minor Surgery ◽  
Fluid Levels ◽  
Pain Patients

Abstract Aims Neuropathic pain is a complex and painful condition, which is difficult to treat and causes a lot of suffering. The substance P (SP) system is well known to be involved in nociceptive signaling and it has previously been shown that the cerebrospinal fluid (CSF) level of SP is decreased in neuropathic pain. In this study we analyzed CSF from chronic neuropathic pain patients for the levels of SP1–7, an N-terminal fragment of SP with the ability to alleviate thermal as well as mechanical hypersensitivity in different animal models of chronic neuropathic pain, e.g. [1,2]. Methods CSF was collected from 11 neuropathic pain patients, treated with SCS, who had refrained from using their spinal cord stimulator for 48h. Control CSF was collected from 11 patients without any known neurological disorder, who underwent minor surgery under spinal anesthesia. The CSF samples were analyzed for the levels of SP1–7 using radioimmunoassay. Results The results revealed a decrease in the level of SP1–7 compared to controls. We believe that the lower level ofSP1–7 most likely is a consequence of reduced amount of its precursor SP in the neuropathic pain patients. Conclusions Our results indicate that the SP system is changed in patients with neuropathic pain and that SP-related peptides, including SP1–7, might serve as biological markers for the patho-physiology of chronic neuropathic pain.

scholarly journals Adherence of French GPs to Chronic Neuropathic Pain Clinical Guidelines: Results of a Cross-Sectional, Randomized, “e” Case-Vignette Survey

PLoS ONE ◽  
2014 ◽  
Vol 9 (4) ◽  
pp. e93855 ◽  
Author(s):  
Valéria Martinez ◽  
Nadine Attal ◽  
Bertrand Vanzo ◽  
Eric Vicaut ◽  
Jean Michel Gautier ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Clinical Guidelines ◽  
Case Vignette ◽  
Chronic Neuropathic Pain ◽  
Cross Sectional

ADIPONECTIN SERUM LEVEL DIFFERENCE IN WOMEN WITH ENDOMETRIOTIC AND NON-ENDOMETRIOTIC CYSTS

2015 ◽  
Vol 1 (2) ◽  
Author(s):  
Ruswana Anwar ◽  
Fahdiansyah Fahdiansyah
Keyword(s):  
Serum Level ◽  
Comparative Study ◽  
Inflammatory Process ◽  
Adiponectin Level ◽  
Stage Iv ◽  
Serum Levels ◽  
Serum Adiponectin ◽  
Cross Sectional ◽  
Endometriotic Cyst ◽  
Low Levels

Endometriosis is an estrogen-dependent disease. Low levels of adiponectin resulted in an increased free estrogen levels and the inability to inhibit angiogenesis and the inflammatory process resulting in the development of increasingly severe endometriosis.This study is aimed to determine the differences in serum adiponectin levels in patient with nonendometriotic cyst with endometriosis cyst and its relationship with endometriosis stages. This is an analytical comparative study with cross-sectional method in group of women with endometriotic cyst (n=25) and women with non-endometriotic cysts (n=25), performed either laparoscopic or laparotomy surgery. The serum levels of adiponectin in both groups then compared with statistical analysis.The results showed there were no significant differences (p>0,05) on the characteristics of the study subjects in terms of age (p=0.994) and BMI (p=0.27). Significant differences of adiponectin levels were found between endometriotic patient group (mean=3.91) and nonendometriotic patients group (mean=8.59). There were no significant differences of adiponectin level in stages III endometriosis (mean = 4.24) and stage IV endometriosis (mean = 3.54).It is concluded that serum adiponectin levels in patients with endometriosis is lower than patient with non-endometriotic cyst. There is no relationship between adiponectin levels with endometriosis stage. Keywords: adiponectin, endometriotic cyst, non-endometriotic cyst, endometriosis stage

SIGNIFICANCE OF PLACENTAL HISTOPATHOLOGICAL FINDINGS IN PRETERM/TERM BIRTH

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Monika Kushwaha ◽  
Sanjeev Narang
Keyword(s):  
Preterm Birth ◽  
Comparative Study ◽  
Pregnancy Outcome ◽  
Neonatal Morbidity ◽  
Research Centre ◽  
College Hospital ◽  
Cross Sectional ◽  
Chorionic Villi ◽  
Term Birth ◽  
Medical College

Background: This study is cross-sectional, observational and comparative study, at Index Medical College, Hospital & Research Centre, Indore, Madhya Pradesh from July 2017 to July 2019 with sample size 100 placentae. Method: The placenta received was evaluated blinded of maternal pregnancy outcome. The pattern of morphology was evaluated both qualitatively (type of lesion) and quantitatively (number of lesions). Result: In Present study 79% of the deliveries were term deliveries and 21% were preterm deliveries. On placental macroscopy, placenta weight was significantly low among the neonates of preterm deliveries (370.00±60.49) as compared to term deliveries (440.89±55.22). Preterm placenta had higher number of abnormal placental lesion compared to term pregnancies. Conclusion: The uteroplacental insufficiency defined as placental infarct, fibrosis of chorionic villi, thickening of blood vessels, and poor vascularity of chorionic villi. Placental histopathological lesions are strongly associated with maternal under perfusion and uteroplacental insufficiency. These are the reasons for preterm birth. Thus, knowledge of the etiological factor can be use to reduce maternal and neonatal morbidity and mortility. Keywords: Placenta, Term & Preterm.

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