Impact of physical activity on response to stress in people aged 65 and over during COVID ‐19 pandemic lockdown

The purpose of this study is to assess the production of nitric oxide in professional cross-country skiers with normotensive and hypertensive responses to physical activity at maximum load. The observation group included professional cross-country skiers (22.2 ± 7.1 years, = 107) who were current members of the national team of the Komi Republic. All the examined athletes performed the exercise test on a cycle ergometer “until exhaustion.” The following parameters were determined for each participant while they were sitting at rest, while at their anaerobic threshold level, during peak load, and during the recovery period (5th min): systolic blood pressure, diastolic blood pressure, heart rate, and the level of stable nitric oxide metabolites (nitrites, nitrates) in capillary blood samples. According to the blood pressure results, the cross-country skiers were divided into two groups. Group I included athletes with a normotensive response to stress. Group II was composed of individuals with a hypertensive response to stress. During the performance of the test “until exhaustion,” a significant (p < 0.05) increase in the amount of stable metabolites of nitric oxide was observed in the group of athletes with a normotensive response to the load compared with the group with a hypertensive response to the load. In athletes with a normotensive reaction to the load during exercise at maximum load and in the early recovery period, nitrate was prioritized in the regulation of vascular tone. The exercise test on a cycle ergometer “until exhaustion,” combined with the assessment of the levels of stable nitric oxide metabolites in plasma, can be considered a test for the early diagnosis of endothelial dysfunction in professional athletes.

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Polyaneuploid Cancer Cell Dormancy: Lessons From Evolutionary Phyla

Frontiers in Ecology and Evolution ◽

10.3389/fevo.2021.660755 ◽

2021 ◽

Vol 9 ◽

Author(s):

Laurie G. Kostecka ◽

Kenneth J. Pienta ◽

Sarah R. Amend

Keyword(s):

Physical Activity ◽

Cancer Cells ◽

Cancer Metastasis ◽

Survival Strategy ◽

Metabolic Function ◽

Metabolic Rates ◽

Response To Stress ◽

Metabolic Activities ◽

To Come ◽

Cell Dormancy

Dormancy is a key survival strategy in many organisms across the tree of life. Organisms that utilize some type of dormancy (hibernation, aestivation, brumation, diapause, and quiescence) are able to survive in habitats that would otherwise be uninhabitable. Induction into dormant states is typically caused by environmental stress. While organisms are dormant, their physical activity is minimal, and their metabolic rates are severely depressed (hypometabolism). These metabolic reductions allow for the conservation and distribution of energy while conditions in the environment are poor. When conditions are more favorable, the organisms are then able to come out of dormancy and reengage in their environment. Polyaneuploid cancer cells (PACCs), proposed mediators of cancer metastasis and resistance, access evolutionary programs and employ dormancy as a survival mechanism in response to stress. Quiescence, the type of dormancy observed in PACCs, allows these cells the ability to survive stressful conditions (e.g., hypoxia in the microenvironment, transiting the bloodstream during metastasis, and exposure to chemotherapy) by downregulating and altering metabolic function, but then increasing metabolic activities again once stress has passed. We can gain insights regarding the mechanisms underlying PACC dormancy by looking to the evolution of dormancy in different organisms.

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Physical activity and body composition of adolescent boys

JAMA ◽

10.1001/jama.197.11.891 ◽

1966 ◽

Vol 197 (11) ◽

pp. 891-893 ◽

Cited By ~ 2

Author(s):

L. P. Novak

Keyword(s):

Physical Activity ◽

Body Composition ◽

Adolescent Boys

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Aerodynamic and Acoustic Voice Measures Before and After an Acute Public Speaking Stressor

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-19-00252 ◽

2020 ◽

Vol 63 (10) ◽

pp. 3311-3325

Author(s):

Brittany L. Perrine ◽

Ronald C. Scherer

Keyword(s):

Fundamental Frequency ◽

Salivary Cortisol ◽

Public Speaking ◽

Stress System ◽

Before And After ◽

Subglottal Pressure ◽

Response To Stress ◽

System Activation ◽

Speaking Fundamental Frequency ◽

Pituitary Adrenal Axis

Purpose The goal of this study was to determine if differences in stress system activation lead to changes in speaking fundamental frequency, average oral airflow, and estimated subglottal pressure before and after an acute, psychosocial stressor. Method Eighteen vocally healthy adult females experienced the Trier Social Stress Test (TSST) to activate the hypothalamic–pituitary–adrenal axis. The TSST includes public speaking and performing mental arithmetic in front of an audience. At seven time points, three before the stressor and four after the stressor, the participants produced /pa/ repetitions, read the Rainbow Passage, and provided a saliva sample. Measures included (a) salivary cortisol level, (b) oral airflow, (c) estimated subglottal pressure, and (d) speaking fundamental frequency from the second sentence of the Rainbow Passage. Results Ten of the 18 participants experienced a hypothalamic–pituitary–adrenal axis response to stress as indicated by a 2.5-nmol/L increase in salivary cortisol from before the TSST to after the TSST. Those who experienced a response to stress had a significantly higher speaking fundamental frequency before and immediately after the stressor than later after the stressor. No other variable varied significantly due to the stressor. Conclusions This study suggests that the idiosyncratic and inconsistent voice changes reported in the literature may be explained by differences in stress system activation. In addition, laryngeal aerodynamic measures appear resilient to changes due to acute stress. Further work is needed to examine the influence of other stress systems and if these findings hold for dysphonic individuals.

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