scholarly journals Nitric Oxide Production in Professional Skiers During Physical Activity at Maximum Load

2020 ◽  
Vol 7 ◽  
Author(s):  
Olga I. Parshukova ◽  
Nina G. Varlamova ◽  
Evgeny R. Bojko
Keyword(s):  
Physical Activity ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
Exercise Test ◽  
Recovery Period ◽  
Maximum Load ◽  
Cycle Ergometer ◽  
Response To Stress ◽  
Cross Country ◽  
Nitric Oxide Metabolites

The purpose of this study is to assess the production of nitric oxide in professional cross-country skiers with normotensive and hypertensive responses to physical activity at maximum load. The observation group included professional cross-country skiers (22.2 ± 7.1 years, = 107) who were current members of the national team of the Komi Republic. All the examined athletes performed the exercise test on a cycle ergometer “until exhaustion.” The following parameters were determined for each participant while they were sitting at rest, while at their anaerobic threshold level, during peak load, and during the recovery period (5th min): systolic blood pressure, diastolic blood pressure, heart rate, and the level of stable nitric oxide metabolites (nitrites, nitrates) in capillary blood samples. According to the blood pressure results, the cross-country skiers were divided into two groups. Group I included athletes with a normotensive response to stress. Group II was composed of individuals with a hypertensive response to stress. During the performance of the test “until exhaustion,” a significant (p < 0.05) increase in the amount of stable metabolites of nitric oxide was observed in the group of athletes with a normotensive response to the load compared with the group with a hypertensive response to the load. In athletes with a normotensive reaction to the load during exercise at maximum load and in the early recovery period, nitrate was prioritized in the regulation of vascular tone. The exercise test on a cycle ergometer “until exhaustion,” combined with the assessment of the levels of stable nitric oxide metabolites in plasma, can be considered a test for the early diagnosis of endothelial dysfunction in professional athletes.

scholarly journals Evaluation of intense physical effort in subjects with temporal lobe epilepsy

2009 ◽  
Vol 67 (4) ◽  
pp. 1007-1012 ◽  
Author(s):  
Fabio Camilo ◽  
Fúlvio Alexandre Scorza ◽  
Marly de Albuquerque ◽  
Rodrigo Luiz Vancini ◽  
Esper Abrão Cavalheiro ◽  
...  
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Healthy Subjects ◽  
Recovery Period ◽  
Physical Effort ◽  
Objective Evidence ◽  
Blood Pressure Responses ◽  
Intensity Of Exercise

People with epilepsy have been discouraged from participating in physical activity due to the fear that it will exacerbate seizures. Although the beneficial effect of aerobic exercise in people with epilepsy, little objective evidence regarding the intensity of exercise has been reported. We investigated the effect of incremental physical exercise to exhaustion in people with epilepsy. Seventeen persons with temporal lobe epilepsy and twenty one control healthy subjects participated in this study. Both groups were submitted to echocolordoppler and electrocardiogram at rest and during physical effort. None of patients reported seizures during physical effort or in the recovery period of ergometric test. Both groups presented physiological heart rate and blood pressure responses during the different stages of the ergometric test. Only few patients presented electrocardiography or echocardiography alterations at rest or during effort. In conclusion, this work suggests that physical effort to exhaustion is not a seizure-induced component.

scholarly journals Cycling above rather than below lactate threshold is more effective for nitric oxide release and post-exercise blood pressure reduction in individuals with type-2 diabetes

2013 ◽  
Vol 19 (3) ◽  
pp. 633-640 ◽  
Author(s):  
Ricardo Yukio Asano ◽  
Rodrigo Alberto Vieira Browne ◽  
Rafael da Costa Sotero ◽  
Marcelo Magalhães Sales ◽  
José Fernando Vila Nova de Moraes ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Lactate Threshold ◽  
Blood Pressure Reduction ◽  
Cycle Ergometer ◽  
Exercise Session ◽  
Post Exercise ◽  
Exercise Blood Pressure

The purposes of this study were to analyze and compare the effects of exercise performed in different intensities, above and below lactate threshold (LT) on post-exercise blood pressure (BP) and nitric oxide (NO) responses in individuals with type 2 diabetes (T2D). For this, 11 T2D underwent the following sessions: 1) control session; 2) 20-min of moderate cycling (80% LT); and 3) 20-min of high intensity cycling (120%LT) on a cycle ergometer. Plasma NO and BP measurements were carried out at rest and at 15 and 45 min of post-sessions. When compared to rest, only the exercise session performed at 120%LT elicited an increase of NO (from 7.2 to 9.5 µM, p<0.05), as well as a decrease in systolic BP (from 126.6±7.9 to 118.7±3.9 mmHg, p<0.05) during the post-exercise period. In conclusion, the results suggest that NO release and post-exercise BP decrease are intensity-dependent for individuals with T2D.

Sprint Interval Training: Recovery Format, Enjoyment and Blood Pressure in Inactive Men

2021 ◽  
Vol 10 (3) ◽  
pp. 75-84
Author(s):  
Yuri Kriel ◽  
Hugo A. Kerhervé ◽  
Christopher David Askew ◽  
Colin Solomon
Keyword(s):  
Physical Activity ◽  
Blood Pressure ◽  
Interval Training ◽  
Cycle Ergometer ◽  
Sprint Interval Training ◽  
Active Recovery ◽  
Positive Health ◽  
Passive Recovery ◽  
Postexercise Recovery ◽  
Activity Enjoyment

ABSTRACT Background: While the efficacy of sprint interval training (SIT) to provide positive health effects in inactive populations is established, feasibility is associated with enjoyment and safety, which are dependent on the acute physiological and perceptual responses. The recovery format likely influences physiological and perceptual responses that occur during and immediately after SIT. It was hypothesized that during SIT interspersed with active recovery periods, enjoyment and blood pressure (BP) values would be higher compared with passive recovery periods, in inactive participants. Methods: Twelve males (mean ± SD; age 23 ± 3 y) completed 3 exercise sessions on a cycle ergometer in a randomized order on separate days: (a) SIT with passive recovery periods between 4 bouts (SITPASS), (b) SIT with active recovery periods between 4 bouts (SITACT), and (c) SITACT with the 4 SIT bouts replaced with passive periods. BP was measured immediately after each bout and every 2 min during a 6 min recovery. Physical activity enjoyment was measured during postexercise recovery. Results: There were no significant differences in physical activity enjoyment or systolic BP between SITPASS and SITACT. Diastolic BP was lower during recovery in SITACT (P = 0.025) and SITPASS (P = 0.027), compared with resting BP. Furthermore, diastolic BP was lower after 6 min of recovery following SITPASS, compared with SITACT (P = 0.01). Conclusion: Exercise enjoyment and acute systolic BP responses were independent of SIT recovery format in inactive men. Reductions in diastolic BP were greater and more prolonged after SIT protocols that included passive recovery periods.

Body Temperature and Plasma Nitric Oxide Metabolites in Response to Standardized Exercise Test in the Athletic Horse

2015 ◽  
Vol 35 (9) ◽  
pp. 709-713 ◽  
Author(s):  
Daniela Alberghina ◽  
Giuseppe Piccione ◽  
Angela Maria Amorini ◽  
Giacomo Lazzarino ◽  
Fulvio Congiu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Body Temperature ◽  
Exercise Test ◽  
Nitric Oxide Metabolites ◽  
Athletic Horse

Cardiovascular and metabolic responses to passive hypoxic conditioning in overweight and mildly obese individuals

2020 ◽  
Vol 319 (2) ◽  
pp. R211-R222
Author(s):  
Samarmar Chacaroun ◽  
Anna Borowik ◽  
Stephane Doutreleau ◽  
Elise Belaidi ◽  
Bernard Wuyam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Blood Glucose ◽  
Lipid Profile ◽  
Vascular Function ◽  
Arterial Oxygen ◽  
Nitric Oxide Metabolites

Although severe intermittent hypoxia (IH) is well known to induce deleterious cardiometabolic consequences, moderate IH may induce positive effects in obese individuals. The present study aimed to evaluate the effect of two hypoxic conditioning programs on cardiovascular and metabolic health status of overweight or obese individuals. In this randomized single-blind controlled study, 35 subjects (54 ± 9.3 yr, 31.7 ± 3.5 kg/m2) were randomized into three 8-wk interventions (three 1-h sessions per week): sustained hypoxia (SH), arterial oxygen saturation ([Formula: see text]) = 75%; IH, 5 min [Formula: see text] = 75% – 3 min normoxia; normoxia. Ventilation, heart rate, blood pressure, and tissue oxygenation were measured during the first and last hypoxic conditioning sessions. Vascular function, blood glucose and insulin, lipid profile, nitric oxide metabolites, and oxidative stress were evaluated before and after the interventions. Both SH and IH increased ventilation in hypoxia (+1.8 ± 2.1 and +2.3 ± 3.6 L/min, respectively; P < 0.05) and reduced normoxic diastolic blood pressure (−12 ± 15 and −13 ± 10 mmHg, respectively; P < 0.05), whereas changes in normoxic systolic blood pressure were not significant (+3 ± 9 and −6 ± 13 mmHg, respectively; P > 0.05). IH only reduced heart rate variability (e.g., root-mean-square difference of successive normal R-R intervals in normoxia −21 ± 35%; P < 0.05). Both SH and IH induced no significant change in body mass index, vascular function, blood glucose, insulin and lipid profile, nitric oxide metabolites, or oxidative stress, except for an increase in superoxide dismutase activity following SH. This study indicates that passive hypoxic conditioning in obese individuals induces some positive cardiovascular and respiratory improvements despite no change in anthropometric data and even a reduction in heart rate variability during IH exposure.

scholarly journals Urinary nitric oxide metabolites and individual blood pressure progression to overt hypertension

2011 ◽  
Vol 18 (4) ◽  
pp. 656-663 ◽  
Author(s):  
Marcus Baumann ◽  
Christoph Schmaderer ◽  
Tatiana Kuznetsova ◽  
Roger Bartholome ◽  
Jos FM Smits ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Nitric Oxide Metabolites

scholarly journals Consumption of Aged White Wine under a Veil of Flor Reduces Blood Pressure-Increasing Plasma Nitric Oxide in Men at High Cardiovascular Risk

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1266 ◽  
Author(s):  
Irene Roth ◽  
Rosa Casas ◽  
Margarita Ribó-Coll ◽  
Ramón Estruch
Keyword(s):  
Physical Activity ◽  
Nitric Oxide ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Food Intake ◽  
Controlled Trial ◽  
Alcoholic Beverage ◽  
White Wine ◽  
Polyphenol Content ◽  
High Cardiovascular Risk

Background: Hypertension remains the largest attributable risk factor of cardiovascular disease (CVD), and a reduction of cardiovascular events is linked to diminished elevated blood pressure (BP) values. High alcohol intake is a common cause of hypertension, but some studies have suggested that moderate wine consumption may reduce BP and increase plasma nitric oxide (NO) due to its polyphenol content. Objective: The aim of the present study was to compare the effects of Andalusian aged white wine (AWW) under a veil of flor, an alcoholic beverage with a moderate polyphenol content, with those of gin, an alcoholic beverage without polyphenols, on BP and plasma NO in men at high cardiovascular risk. Methods: This study was designed as an open, randomized crossover-controlled trial in which 38 high-risk male volunteers, aged 55 to 80, received 30 g of ethanol daily in the form of AWW or gin. This was carried out over the course of three weeks, after a two-week washout period. At baseline and after each intervention period, BP, anthropometric parameters, and plasma NO were measured; food intake was also recorded, and physical activity was monitored. Results: Compared to gin, AWW significantly reduced systolic and diastolic BP (p ≤ 0.033; both) and increased plasma NO levels (p = 0.013). Additionally, changes in BP values observed after AWW significantly correlated with increases in plasma NO. No changes in food intake, physical activity, body weight, or waist were observed between the two intervention periods. Conclusions: Moderate daily consumption of AWW may be useful to reduce elevated BP due to an increase of NO synthesis. This effect could be attributed to grape-derived compounds in AWW, such as polyphenols, which are not present in gin.

scholarly journals Studies to Elucidate the Effects of Furostanol Glycosides from Dioscorea deltoidea Cell Culture in a Rat Model of Endothelial Dysfunction

Molecules ◽  
2019 ◽  
Vol 25 (1) ◽  
pp. 169 ◽  
Author(s):  
Mikhail Korokin ◽  
Oleg Gudyrev ◽  
Vladimir Gureev ◽  
Liliya Korokina ◽  
Anna Peresypkina ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Pressure ◽  
Cell Culture ◽  
Endothelial Dysfunction ◽  
Histological Structure ◽  
Dioscorea Deltoidea ◽  
Furostanol Glycosides ◽  
Nitric Oxide Metabolites ◽  
Oxide Synthase ◽  
Endothelial Nitric Oxide

Currently, there is no doubt surrounding a theory that the cardiotropic effects of sex hormones can be due to their direct effect on the cardiovascular system. In recent years, interest in the study of steroid glycosides has increased. We studied the effects of furostanol glycosides (protodioscin and deltozid) from the cell culture of the Dioscorea deltoidea (laboratory code DM-05) on the physiological and biochemical parameters of vascular endothelial function in hypoestrogen-induced endothelial dysfunction after bilateral ovariectomy. It was shown that the use of DM-05 at a dose of 1 mg/kg makes it possible to prevent the development of arterial hypertension (the level of systolic blood pressure (SBP) decreases by 9.7% (p < 0.05) and diastolic blood pressure (DBP) by 8.2%), to achieve a decrease in the coefficient of endothelial dysfunction by 1.75 times against the background of a hypoestrogenic state. With DM-05, an increase in the concentration of stable nitric oxide metabolites (NOx) by 45.6% (p < 0.05) and an increase in mRNA endothelial nitric oxide synthase (eNOS) expression by 34.8% (p < 0.05) was established, which indicates a positive effect of furostanol glycosides on the metabolism of nitric oxide after ovariectomy. Positive dynamics in the histological structure of the heart and the abdominal aorta indicate the pronounced endothelio- and atheroprotective effects of DM-05.

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