scholarly journals Defining successful non‐invasive ventilation initiation: Data from a real‐life cohort

Respirology ◽  
2021 ◽  
Author(s):  
Grégoire Jolly ◽  
Léa Razakamanantsoa ◽  
Emeline Fresnel ◽  
Zouhaier Gharsallaoui ◽  
Antoine Cuvelier ◽  
...  
Keyword(s):  
Real Life ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation

scholarly journals Use and performance of non-invasive ventilation in Internal Medicine ward: a real-life study

2015 ◽  
Author(s):  
Francesco Ventrella ◽  
Armando Giancola ◽  
Sergio Cappello ◽  
Maria Pipino ◽  
Graziano Minafra ◽  
...  
Keyword(s):  
Internal Medicine ◽  
Real Life ◽  
Invasive Ventilation ◽  
Internal Medicine Ward ◽  
Life Study ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Real Life Study ◽  
And Performance

scholarly journals Remdesivir in Severe COVID-19 and Non-Invasive Ventilation: A Real-Life Experience

Healthcare ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1108
Author(s):  
Francesca Simioli ◽  
Carmine Nicoletta ◽  
Maria Rosaria Valentino ◽  
Maria Martino ◽  
Anna Annunziata ◽  
...  
Keyword(s):  
Clinical Improvement ◽  
Antiviral Treatment ◽  
Clinical Signs ◽  
Real Life ◽  
Lung Damage ◽  
Lung Involvement ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Markers Of Inflammation ◽  
Non Invasive Ventilation

Background: Antiviral treatment is a hot topic regarding therapy for COVID-19. Several antiviral drugs have been tested in the months since the pandemic began. Yet only Remdesivir obtained approval after first trials. The best time to administer Remdesivir is still a matter for discussion and this could also depend upon the severity of lung damage and the staging of the infection. Methods: We performed a real-life study of patients hospitalized forCOVID-19 and receiving non-invasive ventilation (NIV). In this single-center study, a 5 day course of Remdesivir was administered as compassionate use. Further therapeutic supports included antibiotics, low molecular weight heparin and steroids. Data collection included clinical signs and symptoms, gas exchange, laboratory markers of inflammation, and radiological findings. Major outcomes were de-escalation of oxygen-support requirements, clinical improvement defined by weaning from ventilation to oxygen therapy or discharge, and mortality. Adverse drug reactions were also recorded. All data were collected during hospitalization and during a 20-day follow up after treatment. Results: 51 patients were enrolled. A global clinical improvement was recorded in 22 patients (43%) at 12 days, and 36 (71%) at 20 days; in particular, at 12 days, 27 patients (53%) also had a de-escalation of oxygen-support class from a therapeutic point of view. Remdesivir use was associated with a lower hazard ratio for clinical improvement in the elderly (older than 70 years) and in subjects with more extensive lung involvement (total severity score at HRCT of more than 14). The 20-day mortality was 13%. Conclusions: Results demonstrated that Remdesivir is associated with an improvement in clinical, laboratory and radiological parameters in patients with severe COVID-19 and showed an overall mortality of 13%. We conclude that, in this cohort, Remdesivir was a beneficial add-on therapy for severe COVID-19, especially in adults with moderate lung involvement at HRCT.

scholarly journals Clinical characterization of respiratory droplet production during common airway procedures using high-speed imaging

2020 ◽  
Author(s):  
SK Mueller ◽  
R Veltrup ◽  
B Jakubaß ◽  
JS Kempfle ◽  
S Kniesburges ◽  
...  
Keyword(s):  
Airway Management ◽  
High Speed ◽  
Clinical Care ◽  
Real Life ◽  
Invasive Ventilation ◽  
High Speed Imaging ◽  
Non Invasive ◽  
Non Invasive Ventilation ◽  
Management Procedures

AbstractBackgroundDuring the COVID-19 pandemic, a significant number of healthcare workers have been infected with SARS-CoV-2. However, there remains little knowledge regarding droplet dissemination during airway management procedures in real life settings.Methods12 different airway management procedures were investigated during routine clinical care. A high-speed video camera (1000 frames/second) was for imaging. Quantitative droplet characteristics as size, distance traveled, and velocity were computed.ResultsDroplets were detected in 8/12 procedures. The droplet trajectories could be divided into two distinctive patterns (type 1/2). Type 1 represented a ballistic trajectory with higher speed droplets whereas type 2 represented a random trajectory of slower particles that persisted longer in air. Speaking and coughing lead to a larger amount of droplets than non-invasive ventilation therapy. The use of tracheal cannula filters reduced the amount of droplets.ConclusionsRespiratory droplet patterns generated during airway management procedures follow two distinctive trajectories based on the influence of aerodynamic forces. Speaking and coughing produce more droplets than non-invasive ventilation therapy confirming these behaviors as exposure risks. Even large droplets may exhibit patterns resembling the fluid dynamics smaller airborne aerosols that follow the airflow convectively and may place the healthcare provider at risk.

scholarly journals Ward-based non-invasive ventilation for hypercapnic exacerbations of COPD: a 'real-life' perspective

QJM ◽  
2010 ◽  
Vol 103 (7) ◽  
pp. 505-510 ◽  
Author(s):  
K. M. McLaughlin ◽  
I. M. Murray ◽  
G. Thain ◽  
G. P. Currie
Keyword(s):  
Real Life ◽  
Invasive Ventilation ◽  
Non Invasive ◽  
Non Invasive Ventilation
Sign in / Sign up

Export Citation Format

Share Document