Abstract
Background
Troponin levels may be elevated after long-distance running, probably due to increased membrane permeability of cardiomyocytes. It is believed that elevated troponin post exercise, in contrast to acute coronary syndromes, normalize within 24 (−48) hours. This phenomenon has been mainly studied in young and elite athletes. However, participation in endurance exercise is increasingly popular among elderly and recreational sportsmen.
Purpose
To assess troponin levels in master athletes before and up to 7 days after long-distance running.
Method
We studied 97 participants (56 males and 41 females, matched for age) in the world's largest cross-country race (30 km, Lidingöloppet). They were ≥45 years (53±5 years). Baseline evaluation included a physical exam, blood pressure, BMI, NT-proBNP and an ECG. Blood tests were taken at baseline, immediately after as well as 1d, 4d and 7d after the race, including high sensitive troponin T (TnT), creatinine and high sensitive CRP. Elevated TnT was defined as ≥15 ng/l.
Results
After the race TnT had increased from 5±3 ng/l at baseline to 46±32 ng/l (range 11–180; p<0.0001). TnT was still significantly elevated at day 1 (16±16ng/l, range 4–106; p<0.0001) and day 4 (8±8 ng/l, range 4–63; p<0.01) with a borderline increase at day 7 (6±3; range 4–22; p=0.062). Both men and women showed a significant TnT increases at day 1 and day 4. Elevated TnT above the diagnostic threshold for myocardial infarction was observed in 96% (post race), 34% (day 1), 9% (day 4) and 3% (day 7). Males had generally higher TnT levels. At day 1, elevated TnT levels were present in 39% of males and 17% of females while all subjects with elevated TnT at day 4 and day 7 were male.
Conclusion
TnT is elevated in the vast majority of male and female master athletes after participation in a 30 km cross country race. To our knowledge, this is the first report showing that TnT levels can be still significantly elevated four days after endurance running. Prolonged TnT values above the diagnostic threshold for myocardial infarction were predominantly seen in males. Our findings are relevant to the clinical management of patients with increased troponin values after endurance exercise.
Acknowledgement/Funding
Hjärt och lungfonden (Swedish heart- and lung fund). Governmental grants.