Modeling of Cross Work Hardening and Apparent Normality Loss after Biaxial–Shear Loading Path Change

The specific loading-path change during sheet metal forming may lead to some abnormal deformation phenomena. Two-stage orthogonal loading paths without elastic unloading have revealed a phenomenon of apparent loss of normality, further modeled in the literature by non-normality theories. In this paper, a particular orthogonal strain-path change is investigated using the Teodosiu–Hu hardening rule within an associated plasticity framework. The results indicate that cross work-hardening has a significant contribution to the apparent loss of normality and subsequent asymmetric yield surface evolution. Detailed contributions of the model’s ingredients and features are clarified. The developed material model is intended for sheet metal forming simulation applications.

Methodological approach to optimal geological and technological characteristics determining when planning hydraulic fracturing at multilayer facilities

The paper considers the issue of increasing the hydraulic fracturing efficiency in a multilayer facility at the final stage of development with an uneven degree of reserves development along the section. Based on the results of the analysis, it was found that the upper layers, which have the worst filtration-reservoir properties, are less developed in comparison with the highly productive lower ones. When hydraulic fracturing was carried out in the upper formations, some of the operations had low success due to the breakthrough of hydraulic fractures into the lower depleted formations. On the basis of the revealed dependencies, the work determined the optimal specific loading of proppant per meter of effective power, depending on the geological conditions, and maps of the prospects for hydraulic fracturing are built. Keywords: oil fields development; hydraulic fracturing; hydraulic fracturing optimization; multilayer facilities.

Athletes’ Physical Performance in the System of the Sports Medicine Technologies Effectiveness Evaluation

Aim. To determine the effectiveness of the specific loading testing use in assessing the athletes’ physical performance. Material and methods. We present a post-hoc analysis of data from specific and nonspecific loading testing (bicycle ergometer, treadmill, rowing ergometer, and ski treadmill) of 23 oarsmen athletes (13 male (mean age 25.85±0.88 years) and 10 female (mean age 22.90±1.20 years); 125 track and field athletes (75 male athletes (mean age 24.74±0.91) and 50 female athletes (mean age 23.81±1.35)), 38 ski athletes (22 male athletes (mean age 21.3±2.4) and 16 female athletes (mean age 19.6±1.8)). Results and discussion. When assessing the physical performance of track and field athletes of various positions using a bicycle ergometer and a treadmill, the maximum oxygen consumption (MOC) parameter for throwers and jumpers was in the range of 29-55 ml/min/kg (it is more appropriate to use a statoergometer), for runners – 39-75 ml/min/kg (testing on a treadmill is preferable). The greatest efficiency and physiological validity was obtained by load testing using a rowing ergometer for rowing athletes and a ski roller treadmill for athletes of ski sports (the ratio of heart rate at the anaerobic metabolism threshold level to the heart rate “on failure” is ~ 97%). With bicycle ergometry, low values of MOC were obtained in athletes training for endurance, and, including on the treadmill, in athletes with the main strength load and implies the work of the muscles of the upper shoulder girdle and back. The functional and reserve capabilities of the athlete are not reflected in the data obtained that makes impossible to judge the level of his/her functional readiness. Conclusion. Sports medicine technologies reflecting the dynamic characteristics of athletes’ physical performance should be evaluated from the point of view of informativeness and efficiency of their application depending on the type of sport. Conclusion about the effectiveness of sports medicine technologies should be made considering the results of the functional and physical performance testing under the exertion, specific to a particular sport.

Electrostatic loading and photoredox-based release of molecular cargo from oligoviologen-crosslinked microparticles

Although on-demand cargo release has been demonstrated in a wide range of microparticle platforms, many existing methods lack specific loading interactions and/or undergo permanent damage to the microparticle to release the cargo. Here, we report a novel method for electrostatically loading negatively charged molecular cargo in oligoviologen-crosslinked microparticles, wherein the cargo can be released upon activation by visible light. A water-in-oil (W/O) emulsion polymerization method was used to fabricate narrowly dispersed microparticles crosslinked by a dicationic viologen-based dimer and a poly(ethylene glycol) diacrylate. A zinc-tetraphenyl porphyrin photocatalyst was also polymerized into the microparticle and used to photochemically reduce the viologen subunits to their monoradical cations through a visible-light-mediated photoredox mechanism with triethanolamine (TEOA) as a sacrificial reductant. The microparticles were characterized by microscopy methods revealing uniform, spherical microparticles 481 ± 20.9 nm in diameter. Negatively charged molecular cargo (methyl orange, MO) was electrostatically loaded into the microparticles through counteranion metathesis. Upon irradiation with blue (450 nm) light, the photo-reduced viologen crosslinker subunits lose positive charges, resulting in release of the anionic MO cargo. Controlled release of the dye, as tracked by absorption spectroscopy, was observed over time, yielding release of up to 40% of the cargo in 2d and 60% in 5d in single dynamic dialysis experiment. However, full release of cargo was achieved upon transferring the microparticles to a fresh TEOA solution after the initial 5d period.

Impulse deformation of triangular plates based on the classical theory

This article discusses the impulse effects of various loads on triangular, isosceles, elastic, isotropic plates. Analytical solutions of the direct problem of determining the internal moments and deflections of the plate, as well as the numerical results of calculations of specific loading case are presented. Goal. The goal is to develop a method for solving direct problems of determining internal moments and deflections in rectangular triangular, isosceles, elastic, thin, isotropic plates. Methodology. To solve the direct problem, the Navier method, the classical theory of modeling vibrations of thin plates and the Laplace transform are used. Results. A technique has been obtained that allows one to obtain numerical and analytical dependences for calculating the internal moments and deflections in a triangular plate. Originality. For the first time, a technique was developed for solving direct non-stationary problems to determine the internal moments and deflections in rectangular triangular, isosceles, elastic, thin, isotropic plates based on the classical theory. Practical value. The obtained analytical dependences can be used to simulate impulse vibrations of square and isosceles rectangular triangular thin isotropic elastic plates, which can be critical structural elements.

Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase

This study reports the application of expanding genetic codes in developing protein cage-based delivery systems. The evolved Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)•tRNAPyl pairs derived from directed evolution are examined to probe their recognition for para-substituted phenylalanine analogs. The evolved MmPylRS, AzFRS, harboring a wide range of substrates, is further engineered at the C-terminal region into another variant, AzFRS-MS. AzFRS-MS shows suppression of the elevated sfGFP protein amount up to 10 TAG stop codons when charging p-azido-l-phenylalanine (AzF, 4), which allows the occurrence of click chemistry. Since protein nanocages used as drug delivery systems that encompass multiple drugs through a site-specific loading approach remain largely unexplored, as a proof of concept, the application of AzFRS-MS for the site-specific incorporation of AzF on human heavy chain ferritin (Ftn) is developed. The Ftn-4 conjugate is shown to be able to load multiple fluorescence dyes or a therapeutic agent, doxorubicin (Dox), through the strain-promoted azide-alkyne cycloaddition (SPAAC) click reaction. Aiming to selectively target Her2+ breast cancer cells, Ftn-4-DOX conjugates fused with a HER2 receptor recognition peptide, anti-Her2/neu peptide (AHNP), is developed and demonstrated to be able to deliver Dox into the cell and to prolong the drug release. This work presents another application of evolved MmPylRS systems, whose potential in developing a variety of protein conjugates is noteworthy.

Exploring mechanical assonance for impact energy harvesting using acoustic metamaterials

Acoustic metamaterials are engineered to possess unique dynamic properties that are not commonly found in nature. It has been demonstrated that customizing the characteristics of their local features can help optimize their dynamic performance under specific loading conditions. Drawing inspiration from the literary device called “assonance,” the term “mechanical assonance” may be ascribed to the dynamic phenomenon realized by sequencing oscillators with tuned responses within a waveguide to engineer a prescribed wave transformation across it. In this context, assonance provides a framework to utilize resonant local features within a host structure or material and interactive mechanisms thereof as building blocks to create enriched functionalities for acoustic metamaterials. Using a discrete element representation for an acoustic metamaterial barrier (AMB), a numerical study is conducted to ascertain parametric dependence for assonant mechanisms related to resonator frequencies, their sequencing, and host material stiffness. Normalized metrics are extracted to estimate transmitted pulse mitigation under impact-type loading. It is found that resonator sets with octave spacing having the number of resonators of a specific frequency proportional to that frequency’s amplitude in the input spectrum is desirable for lower transmissibility. Further, sequencing the lowest frequency resonator set closest to the incident-side gives better performance. Engineering a high degree of impedance mismatch between host material sections is also preferable. The energy sequestered by the local resonators can be harvested utilizing the resonator’s mass as the multifunctional kernel for a linear electromagnetic generator. A multiphysical model is developed to predict the harvested electric voltage and power from the AMB and validated using proof-of-concept experiments. Finally, various coil placement and voltage rectification schemes are also studied using simulations to ascertain preferable design configurations.

Stimuli for Adaptations in Muscle Length and the Length Range of Active Force Exertion—A Narrative Review

Treatment strategies and training regimens, which induce longitudinal muscle growth and increase the muscles’ length range of active force exertion, are important to improve muscle function and to reduce muscle strain injuries in clinical populations and in athletes with limited muscle extensibility. Animal studies have shown several specific loading strategies resulting in longitudinal muscle fiber growth by addition of sarcomeres in series. Currently, such strategies are also applied to humans in order to induce similar adaptations. However, there is no clear scientific evidence that specific strategies result in longitudinal growth of human muscles. Therefore, the question remains what triggers longitudinal muscle growth in humans. The aim of this review was to identify strategies that induce longitudinal human muscle growth. For this purpose, literature was reviewed and summarized with regard to the following topics: (1) Key determinants of typical muscle length and the length range of active force exertion; (2) Information on typical muscle growth and the effects of mechanical loading on growth and adaptation of muscle and tendinous tissues in healthy animals and humans; (3) The current knowledge and research gaps on the regulation of longitudinal muscle growth; and (4) Potential strategies to induce longitudinal muscle growth. The following potential strategies and important aspects that may positively affect longitudinal muscle growth were deduced: (1) Muscle length at which the loading is performed seems to be decisive, i.e., greater elongations after active or passive mechanical loading at long muscle length are expected; (2) Concentric, isometric and eccentric exercises may induce longitudinal muscle growth by stimulating different muscular adaptations (i.e., increases in fiber cross-sectional area and/or fiber length). Mechanical loading intensity also plays an important role. All three training strategies may increase tendon stiffness, but whether and how these changes may influence muscle growth remains to be elucidated. (3) The approach to combine stretching with activation seems promising (e.g., static stretching and electrical stimulation, loaded inter-set stretching) and warrants further research. Finally, our work shows the need for detailed investigation of the mechanisms of growth of pennate muscles, as those may longitudinally grow by both trophy and addition of sarcomeres in series.

What do Biphasic Flow Experiments Reveal On the Variability of Exposure on Alluvial Fans and Which Implications for Risk Assessment Result From This?

Autogenic processes, such as sudden avulsions, unexpected channel migrations and backfilling phenomena, can considerably alter the propagation of sediment-laden flows on alluvial fans. Once the initial and boundary conditions of the hazard scenario with a given return period are determined, the delineation of the associated exposed areas is based on one numerical, essentially deterministic, process simulation, which may not adequately reflect the underlying process variability. By following a ‘similarity-of-process concept’ we generated sediment-laden flows on an experimental alluvial fan. Thereby, we considered an alluvial fan model layout with a curved guiding channel and featuring a convex shape. As loading conditions, we defined a reference, an increased and a reduced level for the released water volume and the predisposed solid fraction. Further, we imposed two different stream power regimes and executed, for each factor combination, eight experimental runs. The associated exposure areas were recorded by video and were mapped in a GIS. We then analyzed exposure data and derived exposure probability maps superposing the footprints of the eight repetitions generated by each experimental loading condition. The patterns of exposure associated with specific loading conditions showed a noticeable variability due to the main effect of the total event volume, the solid fraction and the interactions between them and with the imposed stream power in the feeding channel. Our research highlights that a probabilistic notion of exposure in risk assessment and mitigation needs to be considered. Further, a major challenge consists in adapting numerical codes to better mirror the stochastics of process propagation for more reliable flood hazard and risk assessments.

MPC Framework for the Energy Management of Hybrid Ships with an Energy Storage System

This paper proposes an advanced shipboard energy management strategy (EMS) based on model predictive control (MPC). This EMS aims to reduce mission-scale fuel consumption of ship hybrid power plants, taking into account constraints introduced by the shipboard battery system. Such constraints are present due to the boundaries on the battery capacity and state of charge (SoC) values, aiming to ensure safe seagoing operation and long-lasting battery life. The proposed EMS can be used earlier in the propulsion design process and requires no tuning of parameters for a specific operating profile. The novelties of the study reside in (i) studying the impact of mission-scale effects and integral constraints on optimal fuel consumption and controller robustness, (ii) benchmarking the performance of the proposed MPC framework. A case study carried out on a naval vessel demonstrates near-optimal and robust behaviour of the controller for several loading sequences. The application of the proposed MPC framework can lead to up to 3.5% consumption reduction due to utilisation of long term information, considering specific loading sequences and charge depleting (CD) battery operation.