Abstract
Background
Cardiovascular diseases (CVD) are among the most prevalent illnesses worldwide, causing substantial mortality, morbidity and hospitalization. Understanding the correlation of thyroid function and glycemic metabolism and inflammation to body composition and cardiorespiratory and muscular function is imperative. This manuscript's main goal is to evaluate the association of thyroid function and glycemic metabolism to body mass composition and cardiovascular fitness (CRF) and muscular function in a group of coronary artery disease (CAD) patients.
Methods
To examine cross-sectional associations of thyroid function, glycemia, hemoglobin A1c (HgA1c) and C-reactive protein (CRP) with CRF, muscular function and body mass composition. Forty-five stable CAD patients were enrolled (aged 54.9 ± 10.0 years). Participants were assessed for body composition (DXA®), muscle strength (Biodex®), cardiorespiratory fitness (6-minute walking test) and blood biomarkers, including [CRP, Tyrode Hormones higher free thyroxine (FT4), lower total triiodothyronine (FT3) and metabolic parameters]. The Pearson correlation and t-test statistical measures were used for associations between thyroid function, glycemia, insulin, HgA1c and CRF/muscle strength, body composition.
Results
We found significant inter-correlations between body fat and FT4 (P < 0.01), HgA1c (P = 0.01), insulin (P = 0.01) and blood glucose (P = 0.05); lean mass and FT3 (P = 0.001); and a negative inter-correlation between C-reactive protein and knee extensor and flexor isokinetic peak torques (P < 0.01), and cardiorespiratory fitness (P < 0.05).
Conclusions
Our findings showed that THs function and body mass fat, HgA1c, blood glucose, insulin and CRP were associated with the CRF, muscle strength or body composition. These results highlight the importance of endocrine and metabolic mechanisms concerning CRF and muscle strength in a group of patients with CAD.