Molecular and serological infection marker screening in blood donors indicates high endemicity of hepatitis E virus in Poland

AbstractThe prevalence of anti-hepatitis E virus (HEV) antibodies has a high heterogeneity worldwide. South American data are still scarce. The aim of this study was to evaluate the prevalence of HEV in populations at risk in comparison to blood donors (BD). A cross-sectional study was carried out in adults of different risk populations including crack users (CK), residents in a low income area (LIA), cirrhotic (CIR) and liver transplant patients (LT) compared with BD. The WANTAI HEV ELISA test was used and real-time PCR (in-house for screening and ALTONA as confirmatory test) for HEV RNA screening. A total of 400 participants were included. Anti-HEV IgG was positive in 19.5% of the total sample, reaching the highest rate in the CIR group, 22.5%, followed by CK, LT, and LIA (20%, 18.7%, and 17.5%, respectively). The prevalence found in BD individuals was of 18.7% (p = NS). Anti-HEV IgM was positive in only 1.5% of the sample (6/400). No blood or stools samples were positive for HEV RNA. The seroprevalence reported is among the highest rates ever found in Brazil. Considering the intense diagnostic investigation, data show that HEV circulation is more common that might be expected in our country.

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Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0b013e3282f5195a ◽

2008 ◽

Vol 20 (8) ◽

pp. 784-790 ◽

Cited By ~ 186

Author(s):

Harry R. Dalton ◽

William Stableforth ◽

Prem Thurairajah ◽

Simon Hazeldine ◽

Rene Remnarace ◽

...

Keyword(s):

Seasonal Variation ◽

Liver Disease ◽

Natural History ◽

Chronic Liver Disease ◽

Hepatitis E Virus ◽

Blood Donors ◽

The Elderly ◽

Hepatitis E ◽

Chronic Liver

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Hepatitis E Virus: Relevance in Blood Donors and Risk Groups

Vox Sanguinis ◽

10.1046/j.1423-0410.1999.7620078.x ◽

1999 ◽

Vol 76 (2) ◽

pp. 78-80 ◽

Cited By ~ 34

Author(s):

Maria Luisa Mateos ◽

Cristina Camarero ◽

Elena Lasa ◽

Jose Luis Teruel ◽

Nuria Mir ◽

...

Keyword(s):

Hepatitis E Virus ◽

Blood Donors ◽

Risk Groups ◽

Hepatitis E

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Seroprevalence of Hepatitis E Virus Infection among Blood Donors in Bulgaria

Viruses ◽

10.3390/v13030492 ◽

2021 ◽

Vol 13 (3) ◽

pp. 492

Author(s):

Magdalena Baymakova ◽

Krasimira Terzieva ◽

Rumen Popov ◽

Elisaveta Grancharova ◽

Todor Kundurzhiev ◽

...

Keyword(s):

Virus Infection ◽

Hepatitis E Virus ◽

Blood Donors ◽

Hepatitis E ◽

Elisa Test ◽

Blood Samples ◽

Wild Boars ◽

Domestic Pigs ◽

Specific Questionnaire ◽

Positive Results

Hepatitis E virus (HEV) infection is widespread among domestic pigs, industrial swine, and wild boars in Bulgaria. The aim of the current research was to present the HEV seroprevalence among blood donors in Bulgaria. In the present study, 555 blood donors (479 males and 76 females) were enrolled from five districts in the country (Shumen, Pleven, Stara Zagora, Plovdiv, and Sofia districts). All blood samples were tested for anti-HEV IgG using the recomWell HEV IgG ELISA test (Mikrogen GmbH, Neuried, Germany). Each participating donor completed a short, structured, and specific questionnaire to document data on the current study. Anti-HEV IgG positive results were detected in 144 (25.9%) blood donors, including 129 (26.9%) males and 15 (19.7%) females. The established HEV seropositivity was 28.8% (23/80) in Shumen district, 23.2% (22/95) in Pleven district, 27.1% (38/140) in Stara Zagora district, 27.5% (44/160) in Plovdiv district, and 21.3% (17/80) in Sofia district. A high HEV seroprevalence was found for persons who declared that they were general hunters (48.7%; 19/39; p = 0.001) and hunters of wild boars (51.6%; 16/31; p = 0.001). We present the first seroprevalence rates of HEV infection in blood donors from Bulgaria. The results of our research showed high HEV seropositivity among blood donors.

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Seroprevalence of the hepatitis E virus antibodies among blood donors in the Qassim region, Saudi Arabia

Future Virology ◽

10.2217/fvl-2021-0013 ◽

2021 ◽

Author(s):

Bader Y Alhatlani ◽

Waleed A Aljabr ◽

Mohammed S Almarzouqi ◽

Sami M Alhatlani ◽

Rayan N Alzunaydi ◽

...

Keyword(s):

Public Health ◽

Saudi Arabia ◽

Blood Transfusion ◽

Hepatitis E Virus ◽

Blood Donors ◽

Indirect Elisa ◽

Hepatitis E ◽

Public Health Issue ◽

Serum Samples ◽

Major Public Health Issue

Aim: Hepatitis E virus (HEV) transmission through blood transfusion is a major public health issue worldwide. We aimed to determine the seroprevalence of HEV in blood donors in the Qassim region of Saudi Arabia. Materials & methods: Serum samples (n = 1078) were collected from volunteer blood donors and tested for the presence of anti-HEV IgG and IgM by indirect ELISA. Results: The seroprevalence of anti-HEV IgG among the blood donors was 5.7% overall. Anti-HEV IgG and IgM seropositivity were significantly higher in non-Saudi donors than in Saudi donors (22.1 vs 3 and 7.8 vs 0.2% for anti-HEV IgG and IgM, respectively). Conclusion: The seroprevalence of HEV among blood donors in the Qassim region was lower than previous estimates for other regions of the country and neighboring countries.

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