Novel surgical approach to neoplastic lesions in the distal part of the urethra: A pilot cadaver study comparing open and hybrid techniques

Abstract BACKGROUND Midbrain and surrounding areas are among the most difficult regions to surgically approach in neurosurgery. The subtemporal approach is a well-known neurosurgical approach that is rarely described in children. OBJECTIVE To assess the feasibility, advantages, and disadvantages of subtemporal approach in children. METHODS A total of 20 pediatric patients with intra-axial tumors involving the lateral midbrain or superior cerebellar peduncle or with extra-axial tumors in the middle incisural space/Meckel cave underwent subtemporal transtentorial approaches with the aim to remove (16 cases) or biopsy (4 cases) their lesions. These cases were retrospectively reviewed and the surgical approach described. RESULTS Total resection was achieved in 11 patients. In the 4 patients who underwent biopsies, a diagnosis was obtained. A total of 5 patients presented non-neoplastic lesions (dermoid tumors or cavernomas). A total of 9 patients harbored low-grade tumors and 6 high-grade tumors. Patients with low-grade tumors and non-neoplastic lesions are all alive with no evidence of disease or stable residue. Four patients affected by high grade tumors died. No patient suffered permanent neurological deficits related to the surgical approach. Three patients presented temporary neurological deficits following the procedure: one case of strabismus, one case of aphasia and hemiparesis, secondary to delayed, transient thrombosis of the Labbé vein, and 1 case of trigeminal neuralgia. CONCLUSION The subtemporal approach represents a feasible approach for mesencephalic and perimesencephalic lesions in children. It provides an ample and direct access, with excellent outcomes and acceptable postoperative morbidity.

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Left-Side Surgical Approach to Mitral Valve in Dog Cadaver Study

Journal of Veterinary Clinics ◽

10.17555/jvc.2018.02.35.1.10 ◽

2018 ◽

Vol 35 (1) ◽

pp. 10-12

Author(s):

Jeong-hyeon Moon ◽

Byungmoon Hwang ◽

Daesik Kim ◽

Sunjun Jung ◽

Yongsu Ha ◽

...

Keyword(s):

Mitral Valve ◽

Surgical Approach ◽

Cadaver Study

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A novel surgical approach for treating hiatal hernia with gastroesophageal reflux disease: the laparoscopic total left-side surgical approach

10.21203/rs.3.rs-683019/v1 ◽

2021 ◽

Author(s):

Zhi Zheng ◽

Xiaoye Xiaoye Liu ◽

Chenglin Xin ◽

Weitao Zhang ◽

Yan Gao ◽

...

Keyword(s):

Gastroesophageal Reflux Disease ◽

Gastroesophageal Reflux ◽

Vagus Nerve ◽

Hiatal Hernia ◽

Surgical Approach ◽

Reflux Disease ◽

Cadaver Study ◽

Long Term Results ◽

Perioperative Outcomes

Abstract BackgroundAlthough the traditional bilateral surgical approach can provide local protection of the vagus nerve, the integrity of the entire vagus nerve cannot be evaluated. Therefore, we developed total left-side surgical approach (TLSA), which theoretically eliminates injury to the vagus nerve, and evaluated its safety and effectiveness.MethodsWe initially performed a cadaver study to explore the characteristics of the vagus nerve, and then prospectively evaluated the TLSA in 5 patients with hiatal hernia and gastroesophageal reflux disease between June 2020 and September 2020. Demographic characteristics, surgical parameters, perioperative outcomes, and follow-up findings were analyzed.ResultsThe patients were 40–64 years old and all 5 patients underwent TLSA successfully without any major complications. The median total operative time was 114 min, the median blood loss was 50 mL, and the median postoperative hospital stay was 3.8 days. Gastrointestinal function recovered within 4 days in all patients. The 6-month follow-up gastroscopy examination revealed well-established gastroesophageal flap valves. Relative to the baseline results, the 6-month follow-up revealed lower values for the total GerdQ score (12.4 vs. 6.2) and the total esophageal acid exposure time (3.48% vs. 0.38%). Based on the EORTC QLQ-STO52 questionnaire results, the incidences of dysphagia and flatulence decreased over time after the procedure.ConclusionsTLSA provides a clear and broad surgical field, less trauma, rapid recovery, and is technically simple. Although our results suggest that the TLSA provides good safety and short-term efficacy, long-term results from a larger clinical trial are needed to validate these findings.Trial registrationChiCTR2000034028, registration date is June 21, 2020.

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Prepubic Minilaparotomy as the Surgical Approach in Treatment of Prostate Disorders in Dogs. A Cadaver Study

Bulletin of the Veterinary Institute in Pulawy ◽

10.2478/v10213-012-0119-9 ◽

2012 ◽

Vol 56 (4) ◽

pp. 677-680

Author(s):

Piotr Trębacz ◽

Marek Galanty

Keyword(s):

Body Weight ◽

Surgical Treatment ◽

Surgical Procedures ◽

Surgical Approach ◽

Histopathological Examination ◽

Abdominal Cavity ◽

Cadaver Study ◽

Tissue Specimens ◽

The Right ◽

Minilaparotomy Approach

Abstract The aim of the study was to assess the prepubic minilaparotomy approach in the surgical treatment of prostatic disorders in dogs. The technique of a limited approach to the prostate was developed on the fresh cadavers of 14 intact adult male dogs, diversified in regard to size and body weight. The abdominal cavity was opened in midline, from the right-sided prepubic parapenile incision. The cut was limited to 7 cm. Afterwards, it was expanded by self-retaining retractors: Gelpi, Weislander, Finnochetto Baby, and Adson. Finnochetto Baby and Gelpi retractors used in pairs enabled an adequate exposition of the prostate in small dogs. The Finnochetto Baby retractor enabled an adequate exposition of the prostate in medium dogs and the Adson retractor - in large and giant dogs. The Weislander and Gelpi retractors used individually did not allow for sufficient access to the prostate in any group of the cadavers. Prepubic minilaparotomy can be a useful surgical approach in the treatment of prostate disorders in dogs. It can be used especially for minor surgical procedures, e.g. sampling of large tissue specimens for histopathological examination, partial prostatectomy, or treatment of intraparenchymal cavitary lesions.

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Which surgical approach is optimal for joint preparation in talonavicular fusion – a cadaver study

Foot and Ankle Surgery ◽

10.1016/j.fas.2021.08.003 ◽

2021 ◽

Author(s):

Nicholas A. Andrews ◽

David A. Patch ◽

Timothy W. Torrez ◽

Charles R. Sutherland ◽

Whitt M. Harrelson ◽

...

Keyword(s):

Surgical Approach ◽

Cadaver Study ◽

Joint Preparation

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Endoscopic Transconjunctival Surgical Approach to the Optic Nerve and Medial Intraconal Space: A Cadaver Study

Operative Neurosurgery ◽

10.1227/01.neu.0000327026.01816.e5 ◽

2008 ◽

Vol 63 (suppl_4) ◽

pp. ONS204-ONS209 ◽

Cited By ~ 6

Author(s):

Promod Pillai ◽

Martin Lubow ◽

Alison Ortega ◽

Mario Ammirati

Keyword(s):

Optic Nerve ◽

Minimally Invasive ◽

Surgical Approach ◽

Rectus Muscle ◽

Cadaver Study ◽

Direct Access ◽

Surgical Approaches ◽

Great Precision ◽

Bone Removal ◽

Fresh Cadaver

Abstract Objective: Surgical approaches to the orbit require great precision and care because of the functional and aesthetic importance of this region. Conventional approaches to the posterior orbit often require bone removal, may disrupt extraocular muscles, and may create external surgical scars. We conceived a transconjunctival surgical approach to the medial intraconal space that is aided by a minimally invasive endoscopic technique and avoids muscle transection. Methods: Assisted by a rigid endoscope measuring 2.7 mm in diameter, with 0- and 30-degree lenses, we made a medial conjunctival incision along the limbus to approach the medial intraconal space and optic nerve in 7 fresh cadaver heads (a total of 9 procedures). Results: This approach provided direct and quick access to the medial intraconal space and intraorbital optic nerve with the use of endoscopes via an aesthetically acceptable conjunctival incision, and it provided an excellent view of the operative area. Unlike conventional techniques, this approach left the anatomy relatively undisturbed and did not require detachment of the medial rectus muscle. Conclusion: The endoscopic medial transconjunctival surgical approach provides minimally invasive direct access to the medial intraconal space and the intraorbital optic nerve. The approach is easy; minimally disturbs structures; and lends itself to biopsy, drainage, and even excision of selected lesions in this region without muscle transection and with aesthetically acceptable anatomic closure.

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Endoscopic mucosal resection with anchoring of the snare tip: multicenter retrospective evaluation of effectiveness and safety

Endoscopy International Open ◽

10.1055/a-0990-9068 ◽

2019 ◽

Vol 07 (11) ◽

pp. E1496-E1502 ◽

Cited By ~ 1

Author(s):

Mathieu Pioche ◽

Timothée Wallenhorst ◽

Hugo Lepetit ◽

Vincent Lépilliez ◽

Jérôme Rivory ◽

...

Keyword(s):

Endoscopic Mucosal Resection ◽

Primary Outcome ◽

Lesion Size ◽

Endoscopic Evaluation ◽

Neoplastic Tissue ◽

En Bloc ◽

Hybrid Techniques ◽

Non Invasive ◽

Mucosal Resection ◽

Neoplastic Lesions

Abstract Background Endoscopic mucosal resection (EMR) with snare is the recommended technique to resect non-invasive colorectal neoplastic lesions between 10 and 30 mm in diameter. The objective of EMR is to resect completely the neoplastic tissue en bloc and preferably with free margins (R0), avoiding recurrences. Anchoring the tip of the snare in the submucosa is a technical trick that allows snare sliding to be reduced and larger pieces to be caught. The aim of the present study was to evaluate the effectiveness and safety of anchoring-EMR (A-EMR). Methods This was a retrospective analysis of A-EMR procedures for lesions of diameter between 10 and 30 mm (endoscopic evaluation) performed consecutively in four French centers between May 2017 and January 2018. A-EMR was routinely performed for all EMR using Olympus conventional snares (10 or 25 mm). The primary outcome was evaluation of the proportion of R0 resections. Results A total of 141 A-EMR procedures were performed by 10 operators. Mean lesion size was 19.8 mm. Anchoring was feasible in 96.5 % of cases. There were 81.6 % en bloc resections and 70.2 % R0 resections, with the percentage of procedures decreasing with increasing lesion size (82.8 % < 20 mm, 55.3 % 21 – 30 mm, and 50.0 % > 30 mm, P = 0.002). Complete perforations closed endoscopically occurred in 3/141 cases (2.1 %); none occurred in lesions < 20 mm in size (0 /87). Conclusion The A-EMR technique appears to be promising with a high proportion of R0 for lesions of 10 – 20 mm in size without any perforations. It could also offer an alternative to endoscopic submucosal dissection (ESD), or to hybrid techniques to reach R0 for lesions between 20 and 30 mm in size.

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Automated Image Analysis Of Nuclear And Cytoplasmic Changes In Exfoliated Cells From Tracheas Treated With Carcinogen

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100078638 ◽

1977 ◽

Vol 35 ◽

pp. 220-221

Author(s):

S.F. Stinson ◽

J.C. Lilga ◽

M.B. Sporn

Keyword(s):

Image Analysis ◽

Pattern Analysis ◽

Relative Proportion ◽

Automated Image Analysis ◽

Image Analyzer ◽

Cross Sectional ◽

Exfoliated Cells ◽

Neoplastic Lesions ◽

Analysis System ◽

Morphologic Criterion

Increased nuclear size, resulting in an increase in the relative proportion of nuclear to cytoplasmic sizes, is an important morphologic criterion for the evaluation of neoplastic and pre-neoplastic cells. This paper describes investigations into the suitability of automated image analysis for quantitating changes in nuclear and cytoplasmic cross-sectional areas in exfoliated cells from tracheas treated with carcinogen.Neoplastic and pre-neoplastic lesions were induced in the tracheas of Syrian hamsters with the carcinogen N-methyl-N-nitrosourea. Cytology samples were collected intra-tracheally with a specially designed catheter (1) and stained by a modified Papanicolaou technique. Three cytology specimens were selected from animals with normal tracheas, 3 from animals with dysplastic changes, and 3 from animals with epidermoid carcinoma. One hundred randomly selected cells on each slide were analyzed with a Bausch and Lomb Pattern Analysis System automated image analyzer.

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Differentiation Processes of the Ocellar Retina of the Honeybee (Apis Mellifera L.)

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159692 ◽

1990 ◽

Vol 48 (3) ◽

pp. 430-431

Author(s):

Maria Anna Pabst

Keyword(s):

Apis Mellifera ◽

Distal Part ◽

Cell Layer ◽

Single Layer ◽

Photoreceptor Cells ◽

Distal Segment ◽

Compound Eyes ◽

Thin Sections ◽

Ultrastructural Studies ◽

Adult Worker

In addition to the compound eyes, honeybees have three dorsal ocelli on the vertex of the head. Each ocellus has about 800 elongated photoreceptor cells. They are paired and the distal segment of each pair bears densely packed microvilli forming together a platelike fused rhabdom. Beneath a common cuticular lens a single layer of corneagenous cells is present.Ultrastructural studies were made of the retina of praepupae, different pupal stages and adult worker bees by thin sections and freeze-etch preparations. In praepupae the ocellar anlage consists of a conical group of epidermal cells that differentiate to photoreceptor cells, glial cells and corneagenous cells. Some photoreceptor cells are already paired and show disarrayed microvilli with circularly ordered filaments inside. In ocelli of 2-day-old pupae, when a retinogenous and a lentinogenous cell layer can be clearly distinguished, cell membranes of the distal part of two photoreceptor cells begin to interdigitate with each other and so start to form the definitive microvilli. At the beginning the microvilli often occupy the whole width of the developing rhabdom (Fig. 1).

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