NUMERICAL ANALYSIS ON MATHEMATICAL MODEL FOR DRUG DELIVERY SYSTEM ON BLOOD FLOW IN EXTERNAL MAGNETIC FIELDS BY MAGNETIC NANOPARTICLES

2016 ◽  
Vol 78 (4-4) ◽  
Author(s):  
Norma Alias ◽  
Sakinah Abdul Hanan ◽  
Akhtar Ali ◽  
Zakaria Dollah
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Blood Flow ◽  
Magnetic Nanoparticles ◽  
Numerical Analysis ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sequential Algorithm ◽  
Convergence Criterion ◽  
Time Accuracy

A new design of mathematical model of therapeutic compound in blood flow patterns in a capillary attached the magnetic nanoparticles by the external magnetic field which is applied uniformly is considered. The blood flowing through the capillary is dominated to be Newtonian and the flow is assumed unsteady, incompressible and laminar. Based on the present knowledge of the drug delivery, the mathematical models have highly potential to develop by researchers. The implementation of the sequential algorithm is used to model the magnetic nanoparticles drug delivery system. Discretization of the governing equation together with the boundary condition is carried out before they are solved numerically using a finite difference scheme. The sequential algorithms on the mathematical model based on some numerical methods such as Jacobi and Gauss Seidel. The numerical analysis investigates in terms of execution time, accuracy, computational complexity, convergence criterion, root means square error and maximum error. The Gauss Seidel is the superior method compared to Jacobi.

Implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system

2021 ◽  
Vol 11 ◽  
Author(s):  
Lalit Singh ◽  
Vijay Sharma
Keyword(s):  
Mathematical Model ◽  
Drug Delivery ◽  
Sustained Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Dosage Form ◽  
Quality By Design ◽  
Design Principles ◽  
Release Drug

Aim: Aim of the present work is implementation of Quality by Design principles for the evolution of optimized sustained release drug delivery system Background: Quality by Design (QbD) approach refers to an advance approach to develop a optimized dosage form.QbD has become a vital modern scientific approach to develop a quality dosage form.In modern era of science researcher can develop a optimized dosage form with least effort, money and manpower. Objectives: Objective of research work wasthe successful development of optimized floating bioadhesive tablets of glipizide using floating-bioadhesive potential of cellulosic polymer and carbomersusing quality by design (QbD) approach. Method: Quality Target Product Profile (QTPP) of drug delivery system was defined as well as critical quality attributes (CQAs) were identified. A face centered central composite design (CCD) was utilized in assessing the impact of individual critical material attribute (CMA) like Hydro Propyl Methyl Cellulose K4M(HPMC K4M)and Carbopol 934P (CP 934P) and their interactions, using least experimentation. Formulations were developed and quantitative impact on CQAs was determined using mathematical model. The optimized formulation was obtained and characterized for in-vitro as well as in-vivo parameters. Results: A Fishikawa diagram and Failure Mode and Effect Analysis (FMEA) were performed to identify potential failure modes associated with the dosage form. The optimum formulation was embarked upon using mathematical model developed yielding desired CQAs followed for confirmation of data. Sustained release drug delivery system was successfully developed by using QbD approach. In-vivo X-ray imaging in rabbit and γ-scintigraphic study in manconfirmed the buoyant nature of the mucoadhesive floating tablet for 8 h in the upper gastrointestinal tract. Conclusion: Optimized formulation shows phenomenal floating, bioadhesive properties and drug release retardation characteristics, utilizing a mixture of cost-effective polymers Hence, QbD approach may be regarded as an important tool in development of floating bioadhesive CR dosage forms.

scholarly journals Liposome Drug Delivery System across Endothelial Plasma Membrane: Role of Distance between Endothelial Cells and Blood Flow Rate

Molecules ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 1875
Author(s):  
Olga E. Glukhova
Keyword(s):  
Drug Delivery ◽  
Endothelial Cells ◽  
Blood Flow ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Small Diameter ◽  
Movement Pattern ◽  
Wall Layer ◽  
Near Wall

This paper discusses specific features of the interactions of small-diameter liposomes with the cytoplasmic membrane of endothelial cells using in silico methods. The movement pattern of the liposomal drug delivery system was modeled in accordance with the conditions of the near-wall layer of blood flow. Our simulation results show that the liposomes can become stuck in the intercellular gaps and even break down when the gap is reduced. Liposomes stuck in the gaps are capable of withstanding a shell deformation of ~15% with an increase in liposome energy by 26%. Critical deformation of the membrane gives an impetus to drug release from the liposome outward. We found that the liposomes moving in the near-wall layer of blood flow inevitably stick to the membrane. Liposome sticking on the membrane is accompanied by its gradual splicing with the membrane bilayer. This leads to a gradual drug release inside the cell.

Magnetic stimulus responsive vancomycin drug delivery system based on chitosan microbeads embedded with magnetic nanoparticles

2017 ◽  
Vol 106 (6) ◽  
pp. 2169-2176 ◽  
Author(s):  
Ankita Mohapatra ◽  
Michael A. Harris ◽  
David LeVine ◽  
Madhav Ghimire ◽  
Jessica A. Jennings ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Magnetic Stimulus ◽  
Stimulus Responsive

Ultrasonic Measurement and Control of Microrobotic Drug Delivery System

1992 ◽  
Vol 4 (3) ◽  
pp. 218-222
Author(s):  
Ken Ishihara ◽  
◽  
Toshiyuki Furukawa
Keyword(s):  
Drug Delivery ◽  
Blood Flow ◽  
Drug Delivery System ◽  
Delivery System ◽  
Imaging System ◽  
Drug Carriers ◽  
Ultrasonic Measurement ◽  
Resonant Ultrasound ◽  
And Control ◽  
Measurement And Control

We attempt a microrobotic drug delivery system (DDS) in which drug carriers of air-filled microcapsules are recognized with echography and are controlled using resonant ultrasound. We have confirmed the physical possibility of resonance design for drug carriers depending on the shell structure of the microcapsule. In addition, we have developed a novel echographic imaging system to locate microrobots precisely. Path lines of microrobots in blood flow could be clearly visualized.

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