scholarly journals Development of an anaesthetized-rat model of exercise hyperpnoea: an integrative model of respiratory control using an equilibrium diagram

2018 ◽  
Vol 103 (5) ◽  
pp. 748-760 ◽  
Author(s):  
Tadayoshi Miyamoto ◽  
Kou Manabe ◽  
Shinya Ueda ◽  
Hidehiro Nakahara
Keyword(s):  
Rat Model ◽  
Equilibrium Diagram ◽  
Respiratory Control ◽  
Integrative Model ◽  
Exercise Hyperpnoea ◽  
Anaesthetized Rat

The contribution of muscarinic-receptor-mediated responses to epineurial vascular diameter at the sciatic nerve

2018 ◽  
Vol 96 (8) ◽  
pp. 855-858
Author(s):  
Chelsa Killey ◽  
Shane Cleary ◽  
Julie Orr ◽  
Jefferson C. Frisbee ◽  
Dwayne Jackson ◽  
...  
Keyword(s):  
Mean Arterial Pressure ◽  
Sciatic Nerve ◽  
Arterial Pressure ◽  
Muscarinic Receptor ◽  
Topical Application ◽  
Rat Model ◽  
Receptor Agonist ◽  
Vessel Diameter ◽  
Anaesthetized Rat ◽  
Baseline Diameter

This study used an anaesthetized rat model to directly observe changes in diameter of the vessels supplying the sciatic nerve in response to acetylcholine (10−4 M), a muscarinic receptor agonist, and atropine (10−5 M), a muscarinic receptor antagonist. Topical application of acetylcholine resulted in increases in vessel diameter (baseline: 22.0 ± 2.5 μm, acetylcholine: 28.8 ± 3.3 μm), while topical application of atropine resulted in a decrease in diameter (baseline: 26.6 ± 3.2 μm, atropine: 15.5 ± 3.6 μm) of the epineurial vessels. Mean arterial pressure was not affected by either acetylcholine (baseline: 103.8 ± 1.8 mm Hg, acetylcholine: 102.8 ± 3.2 mm Hg) or atropine (baseline: 104.0 ± 1.9 mm Hg, atropine: 105.2 ± 2.2 mm Hg). These data suggest that muscarinic-receptor-mediated responses can affect the diameter of the epineurial vessels at the sciatic nerve. In addition, muscarinic-receptor-mediated responses appear to contribute to baseline diameter of epineurial vessels at the sciatic nerve.

No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer’s disease

2019 ◽  
Vol 265 ◽  
pp. 55-67 ◽  
Author(s):  
Eric F. Lucking ◽  
Kevin H. Murphy ◽  
David P. Burns ◽  
Anirudh V. Jaisimha ◽  
Kevin J. Barry-Murphy ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Respiratory Control ◽  
Model Of Alzheimer’S Disease

scholarly journals BRAIN ENERGETICS EVALUATION IN EARLY STAGES OF AMYLOID PATHOLOGY IN A RAT MODEL OF ALZHEIMER’S DISEASE

2021 ◽  
Author(s):  
Carolina Soares ◽  
Débora G. Souza ◽  
Andreia Silva da Rocha ◽  
Luiza Machado ◽  
Bruna Bellaver ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Respiratory Control ◽  
Transgenic Rat ◽  
Amyloid Pathology ◽  
Model Of Alzheimer’S Disease ◽  
Preclinical Ad ◽  
Similar Disease ◽  
The Brain

Background: Transgenic models of Alzheimer’s disease (AD) overexpress human APP, PS1 or PS2 mutations. These models present amyloid-beta pathology but do not recapitulate the complexity of AD. Interestingly, the transgenic rat model TgF344-AD, which overpresses human APP and PS1 mutations, seems to follow a more similar disease progression, manifesting progressive tau tangle-like pathology and late cognitive impairment. Yet, whether they develop energy metabolism changes as we see in AD remains unclear. Objective: Here, we investigated brain bioenergetics in 6-7 months F344-AD/WT rats, an age where animals present early amyloid pathology but no memory impairment - mimicking the human preclinical AD. Methods: We used high-resolution respirometry to assess mitochondrial oxidative phosphorylation capacity (OXPHOS), electron transfer capacity (ET), respiratory control ratio (RCR) and reserve capacity (R) in brain homogenates of male and female F344-AD and WT rats (n = 6-8, per group). Results: The results were analyzed by Welch’s t test: 1. Frontal cortex a)OXPHOS (p=0.307); b)ET (p=0.99); c)RCR (p=0.138); d)R (p=0.482). 2. Hippocampus a)OXPHOS (p=0.446); b)ET (p=0.409); c)RCR (p=0.952); d)R (p=0.503). Conclusion: In conclusion, at 6-7 months, changes in the respirometry in the brain of F344-AD rats were not observed. We hypothesize that these measures will be altered at older ages.

Cromakalim does not protect against skeletal muscle fatigue in an anaesthetized rat model of acute hindlimb ischaemia

1993 ◽  
Vol 250 (1) ◽  
pp. 109-116 ◽  
Author(s):  
Derek J. Trezise ◽  
Geoffrey M. Drew ◽  
Alan G. Roach ◽  
Ian S. Watts ◽  
Arthur H. Weston
Keyword(s):  
Skeletal Muscle ◽  
Muscle Fatigue ◽  
Rat Model ◽  
Skeletal Muscle Fatigue ◽  
Anaesthetized Rat

Integrin-receptor inhibition reduces colorectal tumorigenesis in a chemically induced rat model

2001 ◽  
Vol 120 (5) ◽  
pp. A614-A614
Author(s):  
J HAIER ◽  
U GOLDMANN ◽  
U KEILHOLZ ◽  
H BUHR
Keyword(s):  
Rat Model ◽  
Integrin Receptor ◽  
Colorectal Tumorigenesis ◽  
Receptor Inhibition ◽  
Chemically Induced

1045: Pioglitazone Ameliorates Penile Corpora Veno-Occlusive Dysfunction (CVOD) in a Rat Model of Type 2 Diabetes

2005 ◽  
Vol 173 (4S) ◽  
pp. 283-284
Author(s):  
Istvan Kovanecz ◽  
Monica G. Ferrini ◽  
Hugo H. Davila ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Type 2 Diabetes ◽  
Rat Model
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