Methodology for Predicting Oxygen Transport on an Intravenous Membrane Oxygenator Combining Computational and Analytical Models

2005 ◽  
Vol 127 (7) ◽  
pp. 1127-1140 ◽  
Author(s):  
Amador M. Guzmán ◽  
Rodrigo A. Escobar ◽  
Cristina H. Amon
Keyword(s):  
Experimental Data ◽  
Numerical Simulations ◽  
Oxygen Transport ◽  
Oxygen Transfer ◽  
Analytical Models ◽  
Pulsation Frequency ◽  
Membrane Oxygenator ◽  
Transfer Rates ◽  
Numerical Predictions ◽  
Flow Mixing

A computational methodology for accurately predicting flow and oxygen-transport characteristics and performance of an intravenous membrane oxygenator (IMO) device is developed, tested, and validated. This methodology uses extensive numerical simulations of three-dimensional computational models to determine flow-mixing characteristics and oxygen-transfer performance, and analytical models to indirectly validate numerical predictions with experimental data, using both blood and water as working fluids. Direct numerical simulations for IMO stationary and pulsating balloons predict flow field and oxygen transport performance in response to changes in the device length, number of fibers, and balloon pulsation frequency. Multifiber models are used to investigate interfiber interference and length effects for a stationary balloon whereas a single fiber model is used to analyze the effect of balloon pulsations on velocity and oxygen concentration fields and to evaluate oxygen transfer rates. An analytical lumped model is developed and validated by comparing its numerical predictions with experimental data. Numerical results demonstrate that oxygen transfer rates for a stationary balloon regime decrease with increasing number of fibers, independent of the fluid type. The oxygen transfer rate ratio obtained with blood and water is approximately two. Balloon pulsations show an effective and enhanced flow mixing, with time-dependent recirculating flows around the fibers regions which induce higher oxygen transfer rates. The mass transfer rates increase approximately 100% and 80%, with water and blood, respectively, compared with stationary balloon operation. Calculations with combinations of frequency, number of fibers, fiber length and diameter, and inlet volumetric flow rates, agree well with the reported experimental results, and provide a solid comparative base for analysis, predictions, and comparisons with numerical and experimental data.

Convective Oxygen Transport Enhancement in Intravenous Membrane Oxygenators

2003 ◽  
Author(s):  
Rodrigo A. Escobar ◽  
Cristina H. Amon
Keyword(s):  
Experimental Data ◽  
Computational Model ◽  
Numerical Simulations ◽  
Oxygen Transport ◽  
Transport Model ◽  
Moving Boundaries ◽  
Membrane Oxygenator ◽  
Transport Enhancement ◽  
Membrane Oxygenators ◽  
Good Agreement

Numerical simulations of blood and water flow and oxygen transport in a computational model of an intravenous membrane oxygenator including moving boundaries are presented. The simulations are compared to an analytical transport model which is validated by comparing its result to experimental data reported in the literature. Good agreement is found between numerical, analytical and experimental results.

Flow Mixing Enhancement from Balloon Pulsations in an Intravenous Oxygenator

2004 ◽  
Vol 127 (3) ◽  
pp. 400-415 ◽  
Author(s):  
Amador M. Guzmán ◽  
Rodrigo A. Escobar ◽  
Cristina H. Amon
Keyword(s):  
Numerical Simulations ◽  
Oxygen Transfer ◽  
Fiber Bundle ◽  
Transfer Rate ◽  
Oxygen Transfer Rate ◽  
Three Dimensional ◽  
Time Dependent ◽  
Fiber Placement ◽  
Flow Mixing ◽  
Dependent Flow

Computational investigations of flow mixing and oxygen transfer characteristics in an intravenous membrane oxygenator (IMO) are performed by direct numerical simulations of the conservation of mass, momentum, and species equations. Three-dimensional computational models are developed to investigate flow-mixing and oxygen-transfer characteristics for stationary and pulsating balloons, using the spectral element method. For a stationary balloon, the effect of the fiber placement within the fiber bundle and the number of fiber rings is investigated. In a pulsating balloon, the flow mixing characteristics are determined and the oxygen transfer rate is evaluated. For a stationary balloon, numerical simulations show two well-defined flow patterns that depend on the region of the IMO device. Successive increases of the Reynolds number raise the longitudinal velocity without creating secondary flow. This characteristic is not affected by staggered or non-staggered fiber placement within the fiber bundle. For a pulsating balloon, the flow mixing is enhanced by generating a three-dimensional time-dependent flow characterized by oscillatory radial, pulsatile longitudinal, and both oscillatory and random tangential velocities. This three-dimensional flow increases the flow mixing due to an active time-dependent secondary flow, particularly around the fibers. Analytical models show the fiber bundle placement effect on the pressure gradient and flow pattern. The oxygen transport from the fiber surface to the mean flow is due to a dominant radial diffusion mechanism, for the stationary balloon. The oxygen transfer rate reaches an asymptotic behavior at relatively low Reynolds numbers. For a pulsating balloon, the time-dependent oxygen-concentration field resembles the oscillatory and wavy nature of the time-dependent flow. Sherwood number evaluations demonstrate that balloon pulsations enhance the oxygen transfer rate, even for smaller flow rates.

Numerical simulations of the flow through the inlet and isolator of a Mach 4 dual mode scramjet

2012 ◽  
Vol 116 (1182) ◽  
pp. 833-846 ◽  
Author(s):  
S. Janarthanam ◽  
V. Babu
Keyword(s):  
Experimental Data ◽  
Numerical Simulations ◽  
Three Dimensional ◽  
Pressure Rise ◽  
Dual Mode ◽  
Flow Distortion ◽  
Capture Ratio ◽  
Boundary Interaction ◽  
Numerical Predictions ◽  
Mass Capture

Abstract Results from numerical simulations of the three dimensional flow in the intake-isolator of a dual mode scramjet are presented. The FANS calculations have utilised the SST k -ω turbulence model. The effect of cowl length and cowl convergence angle on the inlet mass capture ratio, flow distortion, shock strength and pressure rise are studied in detail. Three cowl lengths and four or five cowl convergence angles for each cowl length are considered. The predicted values of the dimensionless wall static pressure and inlet mass capture ratio are compared with experimental data reported in the literature. The numerical predictions are shown to agree well with the experimental data. In addition, details of the flow field such as shocks, expansion fans and shock boundary interaction are also captured accurately. Inlet unstart is also demonstrated for one case.

Computational Fluid Dynamics Analysis of a Hydrokinetic Turbine Based on Oscillating Hydrofoils

2012 ◽  
Vol 134 (2) ◽  
Author(s):  
Thomas Kinsey ◽  
Guy Dumas
Keyword(s):  
Fluid Dynamics ◽  
Experimental Data ◽  
Computational Fluid Dynamics ◽  
Numerical Simulations ◽  
Spatial Configuration ◽  
Operating Conditions ◽  
Power Extraction ◽  
Numerical Predictions ◽  
Hydrokinetic Turbine ◽  
Computational Fluid Dynamics Analysis

The performance of a new concept of hydrokinetic turbine using oscillating hydrofoils to extract energy from water currents (tidal or gravitational) is investigated using URANS numerical simulations. The numerical predictions are compared with experimental data from a 2 kW prototype, composed of two rectangular oscillating hydrofoils of aspect ratio 7 in a tandem spatial configuration. 3D computational fluid dynamics (CFD) predictions are found to compare favorably with experimental data especially for the case of a single-hydrofoil turbine. The validity of approximating the actual arc-circle trajectory of each hydrofoil by an idealized vertical plunging motion is also addressed by numerical simulations. Furthermore, a sensitivity study of the turbine’s performance in relation to fluctuating operating conditions is performed by feeding the simulations with the actual time-varying experimentally recorded conditions. It is found that cycle-averaged values, as the power-extraction efficiency, are little sensitive to perturbations in the foil kinematics and upstream velocity.

Reusable tubular membrane oxygenator for isolated organ hemoperfusion

1976 ◽  
Vol 40 (3) ◽  
pp. 476-482
Author(s):  
W. H. Waugh ◽  
T. E. Bales ◽  
H. Nihei
Keyword(s):  
Surface Area ◽  
Oxygen Transfer ◽  
Ex Vivo ◽  
Membrane Oxygenator ◽  
Effective Surface Area ◽  
Effective Surface ◽  
Transfer Rates ◽  
Tubular Membrane ◽  
Blood Flows ◽  
Wall Compliance

A reusable tubular membrane oxygenator is described for hypotraumatic hemoperfusion of isolated organs in physiological studies. The constructed oxygenator was of approximately 0.24-m2 effective surface area and contained 450 silicone rubber capillaries of 0.51-mm nominal ID, 34.9 cm long, fixed by conical-shaped, plastic blood headers at manifolds made from Dow-Corning MDX-4–4210 silicone elastomer. During ex vivo hemoperfusions in dogs at inlet hemoglobin saturations near 67%, oxygen transfer rates of the oxygenator increased serially, from 16.6 +/- 1.7 ml/min per m2 (mean +/- SD) at blood flows of 100 ml/min to 34.1 +/- 3.8 ml/min per m2 at flows of 500 ml/min. The oxygenator was thromboresistant and of much loss priming blood volume and wall compliance than the nonresuable Travenol membrane oxygenator of 0.26-m2 effective surface area. The tubular oxygenator was easily cleaned and reassembled, with reproducible oxygen transfer rates. It should prove useful for hemoperfusion studies in organs of moderate size, such as the isolated canine kidney, stomach, and pancreas.

COMPARISON OF NUMERICAL SIMULATIONS WITH EXPERIMENTAL DATA FOR VERTICAL ANNULAR AND CHURN GAS-LIQUID FLOWS

2020 ◽  
Author(s):  
Larissa Steiger de Freitas ◽  
Marcus Vinícius Canhoto Alves ◽  
Rafael Rodrigues Francisco
Keyword(s):  
Experimental Data ◽  
Numerical Simulations ◽  
Liquid Flows

Forced Convection Past a Rotating Sphere: Modeling Oxygen Transport to a Pond Snail Embryo

2013 ◽  
Vol 135 (12) ◽  
Author(s):  
D. A. Nield ◽  
A. V. Kuznetsov
Keyword(s):  
Forced Convection ◽  
Quantitative Study ◽  
Oxygen Transport ◽  
Oxygen Transfer ◽  
Pond Snail ◽  
Gaseous Exchange ◽  
Helisoma Trivolvis ◽  
Rotating Sphere

Helisoma trivolvis pond snail embryos are known for their rotation, which is induced by beating of cilia at the embryo's surface. A common hypothesis links this behavior to enhancing oxygen transfer to the embryo's surface. In this paper, this hypothesis is quantified, and the effect of the rotation on the supply of oxygen to an embryo, which is approximately spherical in shape, is studied. To the best of our knowledge, this is the first research presenting a quantitative study on the effect of an embryo's rotation on facilitating gaseous exchange between the embryo and the environment.

Experimental and Numerical Investigation on the Influence of Process Speed on the Blanking Process

2002 ◽  
Vol 124 (2) ◽  
pp. 416-419 ◽  
Author(s):  
A. M. Goijaerts ◽  
L. E. Govaert ◽  
F. P. T. Baaijens
Keyword(s):  
Stainless Steel ◽  
Constitutive Model ◽  
Numerical Simulations ◽  
Ferritic Stainless Steel ◽  
Fracture Criterion ◽  
Fracture Initiation ◽  
Rate Dependence ◽  
Numerical Predictions ◽  
Punch Velocity ◽  
Blanking Process

In a previous work a numerical tool was presented which accurately predicted both process force and fracture initiation for blanking of a ferritic stainless steel in various blanking geometries. This approach was based on the finite element method, employing a rate-independent elasto-plastic constitutive model combined with a fracture criterion which accounts for the complete loading history. In the present investigation this work is extended with respect to rate-dependence by employing an elasto-viscoplastic constitutive model in combination with the previously postulated fracture criterion for ferritic stainless steel. Numerical predictions are compared to experimental data over a large range of process speeds. The rate-dependence of the process force is significant and accurately captured by the numerical simulations at speeds ranging from 0.001 to 10 mm/s. Both experiments and numerical simulations show no influence of punch velocity on fracture initiation.

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