A Model for Heat Transfer From Embedded Blood Vessels in Two-Dimensional Tissue Preparations

1995 ◽  
Vol 117 (1) ◽  
pp. 64-73 ◽  
Author(s):  
Liang Zhu ◽  
Sheldon Weinbaum
Keyword(s):  
Heat Transfer ◽  
Blood Vessels ◽  
Three Dimensional ◽  
Tissue Preparation ◽  
Basic Solution ◽  
Two Dimensional ◽  
Dimensional Solution ◽  
Tissue Conductivity ◽  
Thermal Equilibration ◽  
Insight Into

Two-dimensional microvascular tissue preparations have been extensively used to study blood flow in the microcirculation, and, most recently, the mechanism of thermal equilibration between thermally significant countercurrent artery-vein pairs. In this paper, an approximate three-dimensional solution for the heat transfer from a periodic array of blood vessels in a tissue preparation of uniform thickness with surface convection is constructed using a newly derived fundamental solution for a Green’s function for this flow geometry. This approximate solution is exact when the ratio K′ of the blood to tissue conductivity is unity and a highly accurate approximation when K′ ≠ 1. This basic solution is applied to develop a model for the heat transfer from a countercurrent artery-vein pair in an exteriorized rat cremaster muscle preparation. The numerical results provide important new insight into the design of microvascular experiments in which the axial variation of the thermal equilibration in microvessels can be measured for the first time. The solutions also provide new insight into the design of fluted fins and microchips that are convectively cooled by internal pores.

scholarly journals Maximal heat transfer between two parallel plates

2018 ◽  
Vol 851 ◽  
Author(s):  
Shingo Motoki ◽  
Genta Kawahara ◽  
Masaki Shimizu
Keyword(s):  
Heat Transfer ◽  
Velocity Field ◽  
Large Scale ◽  
Three Dimensional ◽  
Temperature Fields ◽  
Two Dimensional ◽  
Parallel Plates ◽  
Solution Branch ◽  
Search Range ◽  
Dimensional Solution

The divergence-free time-independent velocity field has been determined so as to maximise heat transfer between two parallel plates with a constant temperature difference under the constraint of fixed total enstrophy. The present variational problem is the same as that first formulated by Hassanzadeh et al. (J. Fluid Mech., vol. 751, 2014, pp. 627–662); however, the search range for optimal states has been extended to a three-dimensional velocity field. A scaling of the Nusselt number $Nu$ with the Péclet number $Pe$ (i.e., the square root of the non-dimensionalised enstrophy with thermal diffusion time scale), $Nu\sim Pe^{2/3}$, has been found in the three-dimensional optimal states, corresponding to the asymptotic scaling with the Rayleigh number $Ra$, $Nu\sim Ra^{1/2}$, expected to appear in an ultimate state, and thus to the Taylor energy dissipation law in high-Reynolds-number turbulence. At $Pe\sim 10^{0}$, a two-dimensional array of large-scale convection rolls provides maximal heat transfer. A three-dimensional optimal solution emerges from bifurcation on the two-dimensional solution branch at $Pe\sim 10^{1}$, and the three-dimensional solution branch has been tracked up to $Pe\sim 10^{4}$ (corresponding to $Ra\approx 2.7\times 10^{6}$). At $Pe\gtrsim 10^{3}$, the optimised velocity fields consist of convection cells with hierarchical self-similar vortical structures, and the temperature fields exhibit a logarithmic-like mean profile near the walls.

New insight into the generation of ship bow waves

2000 ◽  
Vol 421 ◽  
pp. 15-38 ◽  
Author(s):  
E. FONTAINE ◽  
O. M. FALTINSEN ◽  
R. COINTE
Keyword(s):  
Asymptotic Expansions ◽  
Near Field ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Asymptotic Approach ◽  
Dimensional Solution ◽  
First Order ◽  
Bow Waves ◽  
Insight Into

The generation of ship bow waves is studied within the framework of potential flow theory. Assuming the ship bow to be slender, or thin, a pattern of the flow is derived using the method of matched asymptotic expansions. This method leads to the determination of three different zones in which three asymptotic expansions are performed and matched. To first order with respect to the slenderness parameter, the near-field flow appears to be two-dimensional in each transverse plane along the bow. However, it is demonstrated that three-dimensional effects are important in front of the ship and must be taken into account in the composite solution. This leads to a three-dimensional correction to be added to the two-dimensional solution along the ship. The asymptotic approach is then applied to explain the structure of the bow flow in connection with experimental observations and numerical simulations.

scholarly journals Effect of buried depth on thermal performance of a vertical U-tube underground heat exchanger

Open Physics ◽  
2021 ◽  
Vol 19 (1) ◽  
pp. 327-330
Author(s):  
Li Yang ◽  
Bo Zhang ◽  
Jiří Jaromír Klemeš ◽  
Jie Liu ◽  
Meiyu Song ◽  
...  
Keyword(s):  
Heat Transfer ◽  
Heat Exchanger ◽  
Fluid Velocity ◽  
Three Dimensional ◽  
Simplified Model ◽  
Two Dimensional ◽  
Construction Sites ◽  
Full Size ◽  
Unit Depth ◽  
Research Show

Abstract Many researchers numerically investigated U-tube underground heat exchanger using a two-dimensional simplified pipe. However, a simplified model results in large errors compared to the data from construction sites. This research is carried out using a three-dimensional full-size model. A model validation is conducted by comparing with experimental data in summer. This article investigates the effects of fluid velocity and buried depth on the heat exchange rate in a vertical U-tube underground heat exchanger based on fluid–structure coupled simulations. Compared with the results at a flow rate of 0.4 m/s, the results of this research show that the heat transfer per buried depth at 1.0 m/s increases by 123.34%. With the increase of the buried depth from 80 to 140 m, the heat transfer per unit depth decreases by 9.72%.

Local Heat Transfer Characteristics in Simulated Electronic Modules

2003 ◽  
Vol 125 (3) ◽  
pp. 362-368 ◽  
Author(s):  
Seong-Yeon Yoo ◽  
Jong-Hark Park ◽  
Min-Ho Chung
Keyword(s):  
Heat Transfer ◽  
Mass Transfer ◽  
Three Dimensional ◽  
Vortex Generator ◽  
Local Heat Transfer ◽  
Local Heat ◽  
Two Dimensional ◽  
Heat Transfer Characteristics ◽  
Dimensional Array ◽  
Transfer Characteristics

When heat is released by forced convection from electronic modules in a narrow printed circuit board channel, complex flow phenomena—such as stagnation and acceleration on the front surface, separation and reattachment on the top surface, wake or cavity flow near the rear surface—affect the heat transfer characteristics. The purpose of this study is to investigate how these flow conditions influence the local heat transfer from electronic modules. Experiments are performed on a three-dimensional array of hexahedral elements as well as on a two-dimensional array of rectangular elements. Naphthalene sublimation technique is employed to measure three-dimensional local mass transfer, and the mass transfer data are converted to their counterparts of the heat transfer process using the analogy equation between heat and mass transfer. Module location and streamwise module spacing are varied, and the effect of vortex generators on heat transfer enhancement is also examined. Dramatic change of local heat transfer coefficients is found on each surface of the module, and three-dimensional modules have a little higher heat transfer value than two-dimensional modules because of bypass flow. Longitudinal vortices formed by vortex generator enhance the mixing of fluids and thereby heat transfer, and the rectangular wing type vortex generator is found to be more effective than the delta wing type vortex generator.

Effect of Edge Conditions on Natural Convective Heat Transfer From a Narrow Vertical Flat Plate With a Uniform Surface Heat Flux

2007 ◽  
Author(s):  
Patrick H. Oosthuizen ◽  
Jane T. Paul
Keyword(s):  
Heat Transfer ◽  
Heat Flux ◽  
Convective Heat Transfer ◽  
Convective Heat ◽  
Surface Heat Flux ◽  
Three Dimensional ◽  
Surface Heat ◽  
Heated Plate ◽  
Two Dimensional ◽  
Adiabatic Surface

Two-dimensional natural convective heat transfer from vertical plates has been extensively studied. However, when the width of the plate is relatively small compared to its height, the heat transfer rate can be greater than that predicted by these two-dimensional flow results. Because situations that can be approximately modelled as narrow vertical plates occur in a number of practical situations, there exists a need to be able to predict heat transfer rates from such narrow plates. Attention has here been given to a plate with a uniform surface heat flux. The magnitude of the edge effects will, in general, depend on the boundary conditions existing near the edge of the plate. To examine this effect, two situations have been considered. In one, the heated plate is imbedded in a large plane adiabatic surface, the surfaces of the heated plane and the adiabatic surface being in the same plane while in the second there are plane adiabatic surfaces above and below the heated plate but the edge of the plate is directly exposed to the surrounding fluid. The flow has been assumed to be steady and laminar and it has been assumed that the fluid properties are constant except for the density change with temperature which gives rise to the buoyancy forces, this having been treated by using the Boussinesq approach. It has also been assumed that the flow is symmetrical about the vertical centre-plane of the plate. The solution has been obtained by numerically solving the full three-dimensional form of the governing equations, these equations being written in terms of dimensionless variables. Results have only been obtained for a Prandtl number of 0.7. A wide range of the other governing parameters have been considered for both edge situations and the conditions under which three dimensional flow effects can be neglected have been deduced.

Three-Dimensional Modelling of Heat Transfer in Micro-Channels With Synthetic Jet

2010 ◽  
Author(s):  
Ann Lee ◽  
Victoria Timchenko ◽  
Guan H. Yeoh ◽  
John A. Reizes
Keyword(s):  
Heat Transfer ◽  
Silicon Substrate ◽  
Three Dimensional ◽  
Synthetic Jet ◽  
Numerical Results ◽  
Maximum Temperature ◽  
Complex Conjugate ◽  
Two Dimensional ◽  
Flow And Heat Transfer ◽  
Micro Channels

An in-house computer code is developed and applied to investigate the effect of a synthetic jet on heat transfer rates in forced convection of water in silicon micro-channels etched in the rear side of the silicon substrate. To account for the deflection of the membrane located at the bottom of the actuator cavity, a moving mesh technique to solve the flow and heat transfer is purposefully adopted. The governing equations are transformed into the curvilinear coordinate system in which the grid velocities evaluated are then fed into the computation of the flow in the cavity domain thus allowing the conservation equations of mass, momentum and energy to be solved within the stationary computational domain. The fully three-dimensional model considers the SIMPLE method to link the pressure and velocity. A heat flux of 1 MW/m2 is applied at the surface of the top of the silicon wafer and the resulting complex, conjugate heat transfer through the silicon substrate is included. The hydrodynamics feature of the flow is validated against existing experimental results and verified against numerical results from commercial package ANSYS CFX 11.0. Good agreement has been achieved. To track the development of the flow and heat transfer when the actuator is switched on, numerical results of 20 full cycles of the actuator are simulated. When the actuator is switched on, noticeable temperature drop is observed at all points in the substrate from those which existed when there has been a steady water flow in the channel. At the end of 20th cycle of actuation, the maximum temperature in the wafer has reduced by 5.4 K in comparison with the steady flow values. In comparison with the two-dimensional study which account for 17K reduction, it indicates that synthetic jet has only smaller beneficial cooling and has been over-estimated in the previous two-dimensional study.

scholarly journals Put Some Guts into It: Intestinal Organoid Models to Study Viral Infection

Viruses ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1288 ◽  
Author(s):  
Inés García-Rodríguez ◽  
Adithya Sridhar ◽  
Dasja Pajkrt ◽  
Katja C. Wolthers
Keyword(s):  
Viral Infection ◽  
Cell Lines ◽  
Barrier Function ◽  
Three Dimensional ◽  
3D Models ◽  
Cellular Heterogeneity ◽  
Two Dimensional ◽  
Intestinal Organoids ◽  
Insight Into

The knowledge about enteric viral infection has vastly increased over the last eight years due to the development of intestinal organoids and enteroids that suppose a step forward from conventional studies using cell lines. Intestinal organoids and enteroids are three-dimensional (3D) models that closely mimic intestinal cellular heterogeneity and organization. The barrier function within these models has been adapted to facilitate viral studies. In this review, several adaptations (such as organoid-derived two-dimensional (2D) monolayers) and original intestinal 3D models are discussed. The specific advantages and applications, as well as improvements of each model are analyzed and an insight into the possible path for the field is given.

scholarly journals Visualization of CD2 interaction with LFA-3 and determination of the two-dimensional dissociation constant for adhesion receptors in a contact area.

1996 ◽  
Vol 132 (3) ◽  
pp. 465-474 ◽  
Author(s):  
M L Dustin ◽  
L M Ferguson ◽  
P Y Chan ◽  
T A Springer ◽  
D E Golan
Keyword(s):  
Contact Area ◽  
Dissociation Constants ◽  
Three Dimensional ◽  
Lateral Diffusion ◽  
Solution Phase ◽  
Phospholipid Bilayer ◽  
Cell Contact ◽  
Two Dimensional ◽  
Adhesion Receptors ◽  
Dimensional Solution

Many adhesion receptors have high three-dimensional dissociation constants (Kd) for counter-receptors compared to the KdS of receptors for soluble extracellular ligands such as cytokines and hormones. Interaction of the T lymphocyte adhesion receptor CD2 with its counter-receptor, LFA-3, has a high solution-phase Kd (16 microM at 37 degrees C), yet the CD2/LFA-3 interaction serves as an effective adhesion mechanism. We have studied the interaction of CD2 with LFA-3 in the contact area between Jurkat T lymphoblasts and planar phospholipid bilayers containing purified, fluorescently labeled LFA-3. Redistribution and lateral mobility of LFA-3 were measured in contact areas as functions of the initial LFA-3 surface density and of time after contact of the cells with the bilayers. LFA-3 accumulated at sites of contact with a half-time of approximately 15 min, consistent with the previously determined kinetics of adhesion strengthening. The two-dimensional Kd for the CD2/LFA-3 interaction was 21 molecules/microns 2, which is lower than the surface densities of CD2 on T cells and LFA-3 on most target or stimulator cells. Thus, formation of CD2/LFA-3 complexes should be highly favored in physiological interactions. Comparison of the two-dimensional (membrane-bound) and three-dimensional (solution-phase) KdS suggest that cell-cell contact favors CD2/LFA-3 interaction to a greater extent than that predicted by the three-dimensional Kd and the intermembrane distance at the site of contact. LFA-3 molecules in the contact site were capable of lateral diffusion in the plane of the phospholipid bilayer and did not appear to be irreversibly trapped in the contact area, consistent with a rapid off-rate. These data provide insights into the function of low affinity interactions in adhesion.

A two-dimensional boundary layer encountering a three-dimensional hump

1977 ◽  
Vol 83 (1) ◽  
pp. 163-176 ◽  
Author(s):  
F. T. Smith ◽  
R. I. Sykes ◽  
P. W. M. Brighton
Keyword(s):  
Boundary Layer ◽  
Constant Width ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Flow Properties ◽  
Nonlinear Motion ◽  
Dimensional Boundary ◽  
Incompressible Boundary ◽  
Insight Into ◽  
Steady Laminar

A shallow three-dimensional hump disturbs the two-dimensional incompressible boundary layer developed on an otherwise flat surface. The steady laminar flow is studied by means of a three-dimensional extension of triple-deck theory, so that there is the prospect of separation in the nonlinear motion. As a first step, however, a linearized analysis valid for certain shallow obstacles gives some insight into the flow properties. The most striking features then are the reversal of the secondary vortex motions and the emergence of a ‘corridor’ in the wake of the hump. The corridor stays of constant width downstream and within it the boundary-layer displacement and skin-friction perturbation are much greater than outside. Extending outside the corridor, there is a zone where the surface fluid is accelerated, in contrast with the deceleration near the centre of the corridor. The downstream decay (e.g. of displacement) here is much slower than in two-dimensional flows.

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