Numerical Simulations of Flow in Cerebral Aneurysms: Comparison of CFD Results and In Vivo MRI Measurements

2008 ◽  
Vol 130 (5) ◽  
Author(s):  
Vitaliy L. Rayz ◽  
Loic Boussel ◽  
Gabriel Acevedo-Bolton ◽  
Alastair J. Martin ◽  
William L. Young ◽  
...  
Keyword(s):  
Flow Fields ◽  
Patient Specific ◽  
Flow Ratio ◽  
Flow Conditions ◽  
Velocity Measurements ◽  
Cfd Simulations ◽  
Specific Flow ◽  
Inlet Flow ◽  
Good Agreement

Computational fluid dynamics (CFD) methods can be used to compute the velocity field in patient-specific vascular geometries for pulsatile physiological flow. Those simulations require geometric and hemodynamic boundary values. The purpose of this study is to demonstrate that CFD models constructed from patient-specific magnetic resonance (MR) angiography and velocimetry data predict flow fields that are in good agreement with in vivo measurements and therefore can provide valuable information for clinicians. The effect of the inlet flow rate conditions on calculated velocity fields was investigated. We assessed the internal consistency of our approach by comparing CFD predictions of the in-plane velocity field to the corresponding in vivo MR velocimetry measurements. Patient-specific surface models of four basilar artery aneurysms were constructed from contrast-enhanced MR angiography data. CFD simulations were carried out in those models using patient-specific flow conditions extracted from MR velocity measurements of flow in the inlet vessels. The simulation results computed for slices through the vasculature of interest were compared with in-plane velocity measurements acquired with phase-contrast MR imaging in vivo. The sensitivity of the flow fields to inlet flow ratio variations was assessed by simulating five different inlet flow scenarios for each of the basilar aneurysm models. In the majority of cases, altering the inlet flow ratio caused major changes in the flow fields predicted in the aneurysm. A good agreement was found between the flow fields measured in vivo using the in-plane MR velocimetry technique and those predicted with CFD simulations. The study serves to demonstrate the consistency and reliability of both MR imaging and numerical modeling methods. The results demonstrate the clinical relevance of computational models and suggest that realistic patient-specific flow conditions are required for numerical simulations of the flow in aneurysmal blood vessels.

scholarly journals Optimization of the flow conditions in the spawning ground of the Chinese sturgeon (Acipenser sinensis) through Gezhouba Dam generating units

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Anyang Huang ◽  
Jinzhong Yao ◽  
Jiazhi Zhu ◽  
Xingchen Gao ◽  
Wei Jiang
Keyword(s):  
Spawning Ground ◽  
Chinese Sturgeon ◽  
Flow Conditions ◽  
Velocity Measurements ◽  
Acipenser Sinensis ◽  
Critically Endangered Species ◽  
Gezhouba Dam ◽  
Opening Mode ◽  
Suitable Area ◽  
Good Agreement

AbstractChinese sturgeon (Acipenser sinensis) is a critically endangered species, and waters downstream from Gezhouba Dam are the only known spawning ground. To optimize the velocity conditions in the spawning ground by controlling the opening mode of Gezhouba Dam generator units, a mathematical model of Chinese sturgeon spawning ground was established in FLOW-3D. The model was evaluated with velocity measurements, and the results were determined to be in good agreement. By inverting the 2016–2019 field monitoring results, the model shows that the preferred velocity range for Chinese sturgeon spawning is 0.6–1.5 m/s. Velocity fields of different opening modes of the generator units were simulated with identical discharge. The suitable-velocity area was maximal when all units of Dajiang Plant of Gezhouba Dam were open. For discharges below 12,000 m3/s, most of the area was suitable; for discharges above 12,000 m3/s, the suitable area rapidly decreased with increasing discharge. A comparison of suitable areas under high-flow showed that at discharges of 12,000–15,000 m3/s, opening 11–13 units on the left side was optimal. For discharges above 15,000 m3/s, all units should be open. We used these results to recommend a new operation scheme to support the conservation of Chinese sturgeon.

Comparison of Experimental and Numerical Simulations of Flow Within an Arterio-Venous Graft

2000 ◽  
Author(s):  
Paul F. Fischer ◽  
Seung Lee ◽  
Francis Loth ◽  
Hisham S. Bassiouny ◽  
Nurullah Arslan
Keyword(s):  
Flow Field ◽  
Steady Flow ◽  
Laser Doppler Anemometry ◽  
Transition To Turbulence ◽  
Flow Conditions ◽  
Venous Graft ◽  
Venous Anastomosis ◽  
Av Graft ◽  
Good Agreement

Abstract This was a study to compare computational and experimental results of flow field inside the venous anastomosis of an arteriovenous (AV) graft. Laser Doppler anemometry (LDA) measurements were conducted inside an upscaled end-to-side graft model under steady flow conditions at Reynolds number 1820 which is representative of the in vivo flow conditions inside a human AV graft. The distribution of the velocity and turbulence intensity was measured at several locations in the plane of the bifurcation. This flow field was simulated using computation fluid dynamics (CFD) and shown to be in good agreement. Under steady flow conditions, the flow field demonstrated an unsteady character (transition to turbulence).

scholarly journals Flow-induced, inflammation-mediated arterial wall remodeling in the formation and progression of intracranial aneurysms

2019 ◽  
Vol 47 (1) ◽  
pp. E21 ◽  
Author(s):  
Juhana Frösen ◽  
Juan Cebral ◽  
Anne M. Robertson ◽  
Tomohiro Aoki
Keyword(s):  
Drug Therapy ◽  
Intracranial Aneurysms ◽  
Arterial Wall ◽  
Macrophage Infiltration ◽  
Patient Specific ◽  
Diagnostic Tools ◽  
Flow Conditions ◽  
Internal Elastic Lamina ◽  
Specific Flow ◽  
Unruptured Intracranial Aneurysms

OBJECTIVEUnruptured intracranial aneurysms (UIAs) are relatively common lesions that may cause devastating intracranial hemorrhage, thus producing considerable suffering and anxiety in those affected by the disease or an increased likelihood of developing it. Advances in the knowledge of the pathobiology behind intracranial aneurysm (IA) formation, progression, and rupture have led to preclinical testing of drug therapies that would prevent IA formation or progression. In parallel, novel biologically based diagnostic tools to estimate rupture risk are approaching clinical use. Arterial wall remodeling, triggered by flow and intramural stresses and mediated by inflammation, is relevant to both.METHODSThis review discusses the basis of flow-driven vessel remodeling and translates that knowledge to the observations made on the mechanisms of IA initiation and progression on studies using animal models of induced IA formation, study of human IA tissue samples, and study of patient-derived computational fluid dynamics models.RESULTSBlood flow conditions leading to high wall shear stress (WSS) activate proinflammatory signaling in endothelial cells that recruits macrophages to the site exposed to high WSS, especially through macrophage chemoattractant protein 1 (MCP1). This macrophage infiltration leads to protease expression, which disrupts the internal elastic lamina and collagen matrix, leading to focal outward bulging of the wall and IA initiation. For the IA to grow, collagen remodeling and smooth muscle cell (SMC) proliferation are essential, because the fact that collagen does not distend much prevents the passive dilation of a focal weakness to a sizable IA. Chronic macrophage infiltration of the IA wall promotes this SMC-mediated growth and is a potential target for drug therapy. Once the IA wall grows, it is subjected to changes in wall tension and flow conditions as a result of the change in geometry and has to remodel accordingly to avoid rupture. Flow affects this remodeling process.CONCLUSIONSFlow triggers an inflammatory reaction that predisposes the arterial wall to IA initiation and growth and affects the associated remodeling of the UIA wall. This chronic inflammation is a putative target for drug therapy that would stabilize UIAs or prevent UIA formation. Moreover, once this coupling between IA wall remodeling and flow is understood, data from patient-specific flow models can be gathered as part of the diagnostic workup and utilized to improve risk assessment for UIA initiation, progression, and eventual rupture.

scholarly journals Modeling of Natural Convection in Electronic Enclosures

2005 ◽  
Vol 128 (2) ◽  
pp. 157-165 ◽  
Author(s):  
Peter M. Teertstra ◽  
M. Michael Yovanovich ◽  
J. Richard Culham
Keyword(s):  
Natural Convection ◽  
Numerical Data ◽  
Composite Model ◽  
Circuit Board ◽  
Flow Conditions ◽  
Transition Flow ◽  
Cfd Simulations ◽  
Wide Range ◽  
Using Data ◽  
Good Agreement

An analytical model is developed for natural convection from a single circuit board in a sealed electronic equipment enclosure. The circuit card is modeled as a vertical isothermal plate located at the center of an isothermal, cuboid shaped enclosure. A composite model is developed based on asymptotic solutions for three limiting cases: pure conduction, laminar boundary layer convection, and transition flow convection. The conduction shape factor and natural convection models are validated using data from CFD simulations for a wide range of enclosure geometries and flow conditions. The model is shown to be in good agreement, to within 10% RMS, with the numerical data for all test configurations.

Electrical conductivity of low-pressure shock-ionized argon

1963 ◽  
Vol 17 (2) ◽  
pp. 182-192 ◽  
Author(s):  
P. R. Smy ◽  
H. S. Driver
Keyword(s):  
Electrical Conductivity ◽  
Shock Tube ◽  
Plasma Radiation ◽  
Conductivity Measurements ◽  
Flow Conditions ◽  
Velocity Measurements ◽  
Pressure Shock ◽  
Ionized Gas ◽  
Order Of Magnitude ◽  
Good Agreement

The electrical conductivity of shock-ionized argon produced in an electromagnetic shock tube of low attenuation has been measured at shock speeds of March 10–33, with initial pressures of 0·01–2·0 mm Hg. These measurements extend considerably the range of previous measurements performed with pressure-driven shock tubes. With the higher initial pressures or at the highest Mach numbers the measured conductivity is in good agreement with the previous measurements and with the Spitzer–Harm (1953) formula for the conductivity of a fully ionized gas. With the lower initial pressures (which have not previously been investigated) and at the lower March numbers the conductivity falls to less than half of the Spitzer-Harm value. Order-of-magnitude calculations show that diffusion of atoms, and heat conduction by the plasma atoms from the plasma to the shock-tube walls, can cause appreciable plasma cooling (and hence a reduction of the electrical conductivity) with the lowest initial pressures. This mechanism in conjunction with non-attainment of equilibrium ionization appears to explain the observed diminution in conductivity at the lowest pressures, but not the reduced conductivity at the medium pressures.Induced e.m.f. flow-velocity measurements indicate steady-flow conditions in the shock tube while photomultiplier measurements of the plasma radiation indicate that the column of shock-heated gas is 10–20 cm long; this latter figure is supported by the conductivity measurements. The fact that the length of the shock-heated gas column is not drastically shortened at low initial pressures in constrast to the work of Duff (1959), Roshko (1960) and Hooker (1961) is attributed to the fact that in this experiment both driver and driven gases are at high temperature.

scholarly journals Experimental and numerical investigation of thermal and flow conditions inside a large pharmaceutical storage after the ventilation system failure

2021 ◽  
pp. 346-346
Author(s):  
Ilija Tabasevic ◽  
Rastko Jovanovic ◽  
Dragan Milanovic
Keyword(s):  
Temperature Distribution ◽  
Flow Field ◽  
Flow Rate ◽  
Ventilation System ◽  
Pharmaceutical Products ◽  
System Failure ◽  
Flow Conditions ◽  
Cfd Simulations ◽  
Depth Analysis ◽  
Good Agreement

Safe storage of pharmaceutical products is of great importance due to potential hazards for human health. The aim of this study was to assess the ability of pharmaceutical storage to recover design temperature during ventilation system recovery. The performed CFD simulations showed good agreement with experimental temperature measurements. Numerical results allowed in-depth analysis of flow field and temperature distribution inside the storage. It was discovered that the flow field is highly non-uniform, which consequently leads to an uneven temperature distribution of pallets with products. However, a high inlet mass flow rate ensured that all pallets reach the designed temperature.

PIV-Measured Versus CFD-Predicted Flow Dynamics in Anatomically Realistic Cerebral Aneurysm Models

2008 ◽  
Vol 130 (2) ◽  
Author(s):  
Matthew D. Ford ◽  
Hristo N. Nikolov ◽  
Jaques S. Milner ◽  
Stephen P. Lownie ◽  
Edwin M. DeMont ◽  
...  
Keyword(s):  
Boundary Conditions ◽  
Cardiac Cycle ◽  
Flow Dynamics ◽  
Cfd Modeling ◽  
Patient Specific ◽  
Flow Loop ◽  
Cfd Simulations ◽  
Flow Through

Computational fluid dynamics (CFD) modeling of nominally patient-specific cerebral aneurysms is increasingly being used as a research tool to further understand the development, prognosis, and treatment of brain aneurysms. We have previously developed virtual angiography to indirectly validate CFD-predicted gross flow dynamics against the routinely acquired digital subtraction angiograms. Toward a more direct validation, here we compare detailed, CFD-predicted velocity fields against those measured using particle imaging velocimetry (PIV). Two anatomically realistic flow-through phantoms, one a giant internal carotid artery (ICA) aneurysm and the other a basilar artery (BA) tip aneurysm, were constructed of a clear silicone elastomer. The phantoms were placed within a computer-controlled flow loop, programed with representative flow rate waveforms. PIV images were collected on several anterior-posterior (AP) and lateral (LAT) planes. CFD simulations were then carried out using a well-validated, in-house solver, based on micro-CT reconstructions of the geometries of the flow-through phantoms and inlet/outlet boundary conditions derived from flow rates measured during the PIV experiments. PIV and CFD results from the central AP plane of the ICA aneurysm showed a large stable vortex throughout the cardiac cycle. Complex vortex dynamics, captured by PIV and CFD, persisted throughout the cardiac cycle on the central LAT plane. Velocity vector fields showed good overall agreement. For the BA, aneurysm agreement was more compelling, with both PIV and CFD similarly resolving the dynamics of counter-rotating vortices on both AP and LAT planes. Despite the imposition of periodic flow boundary conditions for the CFD simulations, cycle-to-cycle fluctuations were evident in the BA aneurysm simulations, which agreed well, in terms of both amplitudes and spatial distributions, with cycle-to-cycle fluctuations measured by PIV in the same geometry. The overall good agreement between PIV and CFD suggests that CFD can reliably predict the details of the intra-aneurysmal flow dynamics observed in anatomically realistic in vitro models. Nevertheless, given the various modeling assumptions, this does not prove that they are mimicking the actual in vivo hemodynamics, and so validations against in vivo data are encouraged whenever possible.

Fluid-Solid Interaction Simulation of Flow and Stress Pattern in Thoracoabdominal Aneurysms: A Patient Specific Study

2006 ◽  
Author(s):  
Alessandro Borghi ◽  
Nigel B. Wood ◽  
Raad H. Mohiaddin ◽  
X. Yun Xu
Keyword(s):  
Wall Stress ◽  
Aortic Aneurysms ◽  
Maximum Diameter ◽  
Patient Specific ◽  
Specific Flow ◽  
Hyperelastic Materials ◽  
Abdominal Aortic ◽  
Magnetic Resonance Imaging Mri ◽  
Fluid Solid Interaction

Thoracoabdominal aneurysm (TA) is a pathology that involves the enlargement of the aortic diameter in the inferior descending thoracic aorta and has risk factors including aortic dissection, aortitis or connective tissue disorders (Webb, T. H. and Williams, G. M. 1999). Abnormal flow patterns and stress on the diseased aortic wall are thought to play an important role in the development of this pathology and the internal wall stress has proved to be more reliable as a predictor of rupture than the maximum diameter for abdominal aortic aneurysms (Fillinger, M. F., et al. 2003). In the present study, two patients with TAs of different maximum diameters were scanned using magnetic resonance imaging (MRI) techniques. Realistic models of the aneurysms were reconstructed from the in vivo MRI data acquired from the patients, and subject-specific flow conditions were applied as boundary conditions. The wall and thrombus were modeled as hyperelastic materials and their properties were derived from the literature. Fully coupled fluid-solid interaction simulations were performed for both cases using ADINA 8.2. Results were obtained for both the flow and wall stress patterns within the aneurysms. The results show that the wall stress distribution and its magnitude are strongly dependent on the 3-D shape of the aneurysm and the distribution of thrombus.

scholarly journals Preclinical testing platforms for mechanical thrombectomy in stroke: a review on phantoms, in-vivo animal, and cadaveric models

2021 ◽  
pp. neurintsurg-2020-017133
Author(s):  
Yang Liu ◽  
Mehdi Abbasi ◽  
Jorge L Arturo Larco ◽  
Ramanathan Kadirvel ◽  
David F Kallmes ◽  
...  
Keyword(s):  
Comprehensive Evaluation ◽  
Cerebral Arteries ◽  
Patient Specific ◽  
Flow Conditions ◽  
Vessel Occlusion ◽  
Preclinical Testing ◽  
Multiple Test ◽  
3D Printed ◽  
Device Interaction

Preclinical testing platforms have been instrumental in the research and development of thrombectomy devices. However, there is no single model which fully captures the complexity of cerebrovascular anatomy, physiology, and the dynamic artery-clot-device interaction. This article provides a critical review of phantoms, in-vivo animal, and human cadaveric models used for thrombectomy testing and provides insights into the strengths and limitations of each platform. Articles published in the past 10 years that reported thrombectomy testing platforms were identified. Characteristics of each test platform, such as intracranial anatomy, artery tortuosity, vessel friction, flow conditions, device-vessel interaction, and visualization, were captured and benchmarked against human cerebral vessels involved in large-vessel occlusion stroke. Thrombectomy phantoms have been constructed from silicone, direct 3D-printed polymers, and glass. These phantoms represent oversimplified patient-specific cerebrovascular geometry but enable adequate visualization of devices and clots under appropriate flow conditions. They do not realistically mimic the artery-clot interaction. For the animal models, arteries from swine, canines, and rabbits have been reported. These models can reasonably replicate the artery-clot-device interaction and have the unique value of evaluating the safety of thrombectomy devices. However, the vasculature geometries are substantially less complex and flow conditions are different from human cerebral arteries. Cadaveric models are the most accurate vascular representations but with limited access and challenges in reproducibility of testing conditions. Multiple test platforms should be likely used for comprehensive evaluation of thrombectomy devices. Interpretation of the testing results should take into consideration platform-specific limitations.

Sign in / Sign up

Export Citation Format

Share Document