Ultrasound-Induced Treatment of Neurodegenerative Diseases across the Blood-Brain Barrier

Blood Brain Barrier ◽

Huntington Disease ◽

Treatment Strategies ◽

Present Review ◽

Brain Barrier ◽

Treatment Level ◽

: Neurodegenerative diseases including Alzheimer’s, Parkinson’s and Huntington disease are have serious concern due to its effect on the quality of life of affected persons. Neurodegenerative diseases have some limitations for both diagnostic as well as at treatment level. Introducing nanotechnology, for the treatment of these diseases may contribute significantly in solving the problem. There are several treatment strategies for the neurodegenerative diseases, but their limitations are the entry into the due to the presence of the blood-brain barrier (BBB). The present review highlights the application of nanotechnology during last 20 years for the treatment of neurodegenerative diseases.

Nanocarriers as a powerful vehicle to overcome blood-brain barrier in treating neurodegenerative diseases: Focus on recent advances

Asian Journal of Pharmaceutical Sciences ◽

10.1016/j.ajps.2018.09.005 ◽

2019 ◽

Vol 14 (5) ◽

pp. 480-496 ◽

Cited By ~ 31

Author(s):

Xiaoqian Niu ◽

Jiejian Chen ◽

Jianqing Gao

Keyword(s):

Blood Brain Barrier ◽

Brain Barrier ◽

Blood Brain ◽

Recent Advances

Brain targeting with docosahexaenoic acid as a prospective therapy for neurodegenerative diseases and its passage across blood brain barrier

Biochimie ◽

10.1016/j.biochi.2020.01.013 ◽

2020 ◽

Vol 170 ◽

pp. 203-211 ◽

Cited By ~ 2

Author(s):

Mayssa Hachem ◽

Mounir Belkouch ◽

Amanda Lo Van ◽

Madeleine Picq ◽

Nathalie Bernoud-Hubac ◽

...

Keyword(s):

Docosahexaenoic Acid ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Brain Targeting ◽

Building a better blood-brain barrier

eLife ◽

10.7554/elife.31808 ◽

2017 ◽

Vol 6 ◽

Cited By ~ 2

Author(s):

Courtney Lane-Donovan ◽

Joachim Herz

Keyword(s):

Blood Brain Barrier ◽

Three Dimensional ◽

Brain Barrier ◽

Dimensional Model ◽

Three Dimensional Model ◽

A new three-dimensional model of the blood-brain barrier can be used to study processes that are involved in neurodegenerative diseases.

Review: Role of developmental inflammation and blood-brain barrier dysfunction in neurodevelopmental and neurodegenerative diseases

Neuropathology and Applied Neurobiology ◽

10.1111/j.1365-2990.2008.01005.x ◽

2009 ◽

Vol 35 (2) ◽

pp. 132-146 ◽

Cited By ~ 130

Author(s):

H. B. Stolp ◽

K. M. Dziegielewska

Keyword(s):

Blood Brain Barrier ◽

Brain Barrier ◽

Barrier Dysfunction ◽

Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

Journal of Controlled Release ◽

10.1016/j.jconrel.2016.05.044 ◽

2016 ◽

Vol 235 ◽

pp. 34-47 ◽

Cited By ~ 523

Author(s):

Cláudia Saraiva ◽

Catarina Praça ◽

Raquel Ferreira ◽

Tiago Santos ◽

Lino Ferreira ◽

...

Keyword(s):

Drug Delivery ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Brain Drug Delivery ◽

Blood-brain barrier opening for facilitating drug delivery in neurological and neurodegenerative diseases in non-human primates

10.31225/osf.io/s5wvg ◽

2018 ◽

Author(s):

Elisa E. Konofagou

Keyword(s):

Blood Brain Barrier ◽

Focused Ultrasound ◽

Neurological Diseases ◽

Brain Barrier ◽

Blood Brain ◽

Therapeutic Molecules ◽

After Cancer ◽

Large Animals

After cancer and heart disease, neurodegenerative diseases, such as Alzheimer's, Parkinson's, multiple sclerosis (MS), amythrophic lateral sclerosis (ALS), and neurological diseases take more lives each year than any other illness. Although great progress has been made in recent years toward understanding of central nervous system (CNS) diseases, few effective treatments and no cures are currently available. This is mainly because the blood-brain barrier (BBB) limits the delivery of the vast majority of systemically-administered drugs available to treat those diseases. The underlying hypothesis of this study is that delivery of therapeutic molecules is safe and effective through the blood-brain barrier (BBB) using Focused Ultrasound (FUS) in large animals in vivo. Our preliminary results have shown that the FUS technique can induce BBB opening entirely noninvasively, selectively and be monitored with MRI at sub-millimeter resolution in vivo. The specific aims are therefore to: 1) build a MRcompatible system for FUS targeting and monitoring in the MRI system; 2) test and demonstrate delivery of neurotrophic factors to the hippocampus and putamen of monkeys; 3) test and demonstrate delivery of inhibitors to the visual cortex of monkeys; and 4) assess the safety of the FUS method in monkeys.

Altered Blood-Brain Barrier and Blood-Spinal Cord Barrier Dynamics in Amyotrophic Lateral Sclerosis: Impact on Medication Efficacy and Safety

10.22541/au.163287853.31203482/v1 ◽

2021 ◽

Author(s):

Yijun Pan ◽

Joseph Nicolazzo

Keyword(s):

Spinal Cord ◽

Amyotrophic Lateral Sclerosis ◽

Blood Brain Barrier ◽

Large Body ◽

Brain Barrier ◽

Blood Brain ◽

Blood Spinal Cord Barrier ◽

The Brain ◽

Lateral Sclerosis

The access of drugs into the central nervous system (CNS) is regulated by the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB). A large body of evidence supports perturbation of these barriers in neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. Modifications to the BBB and BSCB are also reported in amyotrophic lateral sclerosis (ALS), albeit these modifications have received less attention relative to those in other neurodegenerative diseases. Such alterations to the BBB and BSCB have the potential to impact on CNS exposure of drugs in ALS, modulating the effectiveness of drugs intended to reach the brain and the toxicity of drugs that are not intended to reach the brain. Given the clinical importance of these phenomena, this review will summarise reported modifications to the BBB and BSCB in ALS, discuss their impact on CNS drug exposure and suggest further research directions so as to optimise medicine use in people with ALS.

Pathomechanisms of Blood-Brain Barrier Disruption in ALS

Neuroscience Journal ◽

10.1155/2019/2537698 ◽

2019 ◽

Vol 2019 ◽

pp. 1-16 ◽

Cited By ~ 6

Author(s):

Nicholas Kakaroubas ◽

Samuel Brennan ◽

Matthew Keon ◽

Nitin K. Saksena

Keyword(s):

Blood Brain Barrier ◽

Brain Barrier ◽

Blood Brain Barrier Disruption ◽

Blood Brain ◽

Neurological Processes ◽

Brain Barrier Disruption ◽

Pass Through ◽

Blood Spinal Cord Barrier ◽

Novel Therapeutic Strategies

The blood-brain barrier (BBB) and the blood-spinal cord barrier (BSCB) are responsible for controlling the microenvironment within neural tissues in humans. These barriers are fundamental to all neurological processes as they provide the extreme nutritional demands of neural tissue, remove wastes, and maintain immune privileged status. Being a semipermeable membrane, both the BBB and BSCB allow the diffusion of certain molecules, whilst restricting others. In amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases, these barriers become hyperpermeable, allowing a wider variety of molecules to pass through leading to more severe and more rapidly progressing disease. The intention of this review is to discuss evidence that BBB hyperpermeability is potentially a disease driving feature in ALS and other neurodegenerative diseases. The various biochemical, physiological, and genomic factors that can influence BBB permeability in ALS and other neurodegenerative diseases are also discussed, in addition to novel therapeutic strategies centred upon the BBB.

Stem Cell Therapy for Neurodegenerative Diseases: How Do Stem Cells Bypass the Blood-Brain Barrier and Home to the Brain?

Stem Cells International ◽

10.1155/2020/8889061 ◽

2020 ◽

Vol 2020 ◽

pp. 1-8

Author(s):

Yvonne Cashinn Chia ◽

Clarice Evey Anjum ◽

Hui Rong Yee ◽

Yenny Kenisi ◽

Mike K. S. Chan ◽

...

Keyword(s):

Stem Cells ◽

Blood Brain Barrier ◽

Cellular Therapy ◽

Immune Cell ◽

Brain Barrier ◽

Normal Brain ◽

Brain Functions ◽

Blood Brain ◽

The Brain

Blood-brain barrier (BBB) is a term describing the highly selective barrier formed by the endothelial cells (ECs) of the central nervous system (CNS) homeostasis by restricting movement across the BBB. An intact BBB is critical for normal brain functions as it maintains brain homeostasis, modulates immune cell transport, and provides protection against pathogens and other foreign substances. However, it also prevents drugs from entering the CNS to treat neurodegenerative diseases. Stem cells, on the other hand, have been reported to bypass the BBB and successfully home to their target in the brain and initiate repair, making them a promising approach in cellular therapy, especially those related to neurodegenerative disease. This review article discusses the mechanism behind the successful homing of stem cells to the brain, their potential role as a drug delivery vehicle, and their applications in neurodegenerative diseases.