Development of the Bristol Proteus Turboprop to 2000 Hr Life Between Overhauls

1959 ◽  
Author(s):  
P. F. Green
Keyword(s):  
Safety Features

Airplane experience with the Bristol Proteus engine in the Britannia from the start of passenger services up to its present overhaul life of 2000 hr and a dsscussion of the basic reliability and safety features of the engine.

scholarly journals Mapping Road Safety Features from Streetview Imagery

2020 ◽  
Vol 1 (3) ◽  
pp. 1-20
Author(s):  
Arpan Man Sainju ◽  
Zhe Jiang
Keyword(s):  
Road Safety ◽  
Safety Features

scholarly journals Pharmacological and clinical evaluation of deferasirox formulations for treatment tailoring

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Andrea Piolatto ◽  
Paola Berchialla ◽  
Sarah Allegra ◽  
Silvia De Francia ◽  
Giovanni Battista Ferrero ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Renal Impairment ◽  
Observational Study ◽  
Iron Overload ◽  
Iron Loading ◽  
Comprehensive Comparison ◽  
Dispersible Tablets ◽  
One Year ◽  
Safety Features

AbstractDeferasirox (DFX) is the newest among three different chelators available to treat iron overload in iron-loading anaemias, firstly released as Dispersible Tablets (DT) and more recently replaced by Film-Coated Tablets (FCT). In this retrospective observational study, pharmacokinetics, pharmacodynamics, and safety features of DFX treatment were analyzed in 74 patients that took both formulations subsequently under clinical practice conditions. Bioavailability of DFX FCT compared to DT resulted higher than expected [Cmax: 99.5 (FCT) and 69.7 (DT) μMol/L; AUC: 1278 (FCT) and 846 (DT), P < 0.0001]. DFX FCT was also superior in scalability among doses. After one year of treatment for each formulation, no differences were observed between the treatments in the overall iron overload levels; however, DFX FCT but not DT showed a significant dose–response correlation [Spearman r (dose-serum ferritin variation): − 0.54, P < 0.0001]. Despite being administered at different dosages, the long-term safety profile was not different between formulations: a significant increase in renal impairment risk was observed for both treatments and it was reversible under strict monitoring (P < 0.002). Altogether, these data constitute a comprehensive comparison of DFX formulations in thalassaemia and other iron-loading anaemias, confirming the effectiveness and safety characteristics of DFX and its applicability for treatment tailoring.

scholarly journals Self-shutdown function induced by sandwich-like gel polymer electrolytes for high safety lithium metal batteries

RSC Advances ◽  
2021 ◽  
Vol 11 (23) ◽  
pp. 14036-14046
Author(s):  
Binxuan Xie ◽  
Shimou Chen ◽  
Yong Chen ◽  
Lili Liu
Keyword(s):  
Polymer Electrolytes ◽  
High Performance ◽  
Gel Polymer Electrolytes ◽  
Lithium Metal ◽  
Lithium Metal Batteries ◽  
Safety Features

The SGPE can achieve high performance and high safety features simultaneously.

scholarly journals Automatic Roadway Features Detection with Oriented Object Detection

2021 ◽  
Vol 11 (8) ◽  
pp. 3531
Author(s):  
Hesham M. Eraqi ◽  
Karim Soliman ◽  
Dalia Said ◽  
Omar R. Elezaby ◽  
Mohamed N. Moustafa ◽  
...  
Keyword(s):  
Object Detection ◽  
Safety Evaluation ◽  
Autonomous Driving ◽  
Detection Accuracy ◽  
The Road ◽  
Detection Model ◽  
Detection Approach ◽  
Roadway Safety ◽  
Safety Features ◽  
Oriented Object

Extensive research efforts have been devoted to identify and improve roadway features that impact safety. Maintaining roadway safety features relies on costly manual operations of regular road surveying and data analysis. This paper introduces an automatic roadway safety features detection approach, which harnesses the potential of artificial intelligence (AI) computer vision to make the process more efficient and less costly. Given a front-facing camera and a global positioning system (GPS) sensor, the proposed system automatically evaluates ten roadway safety features. The system is composed of an oriented (or rotated) object detection model, which solves an orientation encoding discontinuity problem to improve detection accuracy, and a rule-based roadway safety evaluation module. To train and validate the proposed model, a fully-annotated dataset for roadway safety features extraction was collected covering 473 km of roads. The proposed method baseline results are found encouraging when compared to the state-of-the-art models. Different oriented object detection strategies are presented and discussed, and the developed model resulted in improving the mean average precision (mAP) by 16.9% when compared with the literature. The roadway safety feature average prediction accuracy is 84.39% and ranges between 91.11% and 63.12%. The introduced model can pervasively enable/disable autonomous driving (AD) based on safety features of the road; and empower connected vehicles (CV) to send and receive estimated safety features, alerting drivers about black spots or relatively less-safe segments or roads.

Use of Topiramate in the Spectrum of Addictive and Eating Disorders: A Systematic Review Comparing Treatment Schemes, Efficacy, and Safety Features

CNS Drugs ◽  
2021 ◽  
Vol 35 (2) ◽  
pp. 177-213
Author(s):  
Mikail Nourredine ◽  
Lucie Jurek ◽  
Bernard Angerville ◽  
Yannick Longuet ◽  
Julia de Ternay ◽  
...  
Keyword(s):  
Systematic Review ◽  
Eating Disorders ◽  
Efficacy And Safety ◽  
Safety Features

scholarly journals Lantox—The Chinese Botulinum Toxin Drug—Complete English Bibliography and Comprehensive Formalised Literature Review

Toxins ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 370
Author(s):  
Dirk Dressler ◽  
Lizhen Pan ◽  
Junhui Su ◽  
Fei Teng ◽  
Lingjing Jin
Keyword(s):  
Literature Review ◽  
Observational Studies ◽  
Similar Efficacy ◽  
Conversion Ratio ◽  
Brand Names ◽  
Efficacy And Safety ◽  
Paper Citation ◽  
Safety Features ◽  
Randomised Controlled ◽  
Nose And Throat

In 1997, lanbotulinumtoxinA (LAN) was introduced in China. It is now available in Asia, Latin America and Eastern Europe under various brand names including Hengli®, Lantox®, Prosigne®, Lanzox®, Redux®, Liftox®, HBTX-A and CBTX-A. The literature on LAN is mostly published in Chinese language, restricting its international accessibility. We, therefore, wanted to generate a complete English bibliography of all LAN publications and then use it for a comprehensive formalised literature review. Altogether, 379 LAN publications (322 in Chinese and 57 in English) were retrieved from PubMed and Science and Technology Paper Citation Database. Indications covered are motor (257), glandular (16), pain (32) and aesthetics (48). Topics are neurological (250), aesthetic (48), paediatric (38), ophthalmological (18), urological (9), methodological (6), gastroenterological (5), ear, nose and throat (4) and surgical (1). Seventy-one publications are randomised controlled trials, forty-one publications are interventional studies and observational studies, fifteen publications are case studies, eighteen publications are reviews, and two publications are guidelines. LAN publications cover all relevant topics of BT therapy throughout a period of more than 20 years. This constitutes a publication basis resembling those of other BT drugs. None of the LAN publications presents data contradictory to those generated with other BT type-A drugs. LAN seems to have a similar efficacy and safety features when compared to onabotulinumtoxinA using a 1:1 LAN– onabotulinumtoxinA conversion ratio. Large controlled multicentre studies will become necessary for LAN’s registrations in Europe and North America.

scholarly journals The SPES3 Facility for Testing an Integral Layout SMR: BDBE Simulation Analysis

2011 ◽  
Author(s):  
Roberta Ferri ◽  
Andrea Achilli ◽  
Cinzia Congiu ◽  
Gustavo Cattadori ◽  
Fosco Bianchi ◽  
...  
Keyword(s):  
Simulation Analysis ◽  
Nuclear Fission ◽  
Sensitivity Analyses ◽  
Medium Size ◽  
Design Calculation ◽  
Pressurized Water ◽  
Pressure Equalization ◽  
Plant Safety ◽  
Design Basis ◽  
Safety Features

The SPES3 facility is being built at the SIET laboratories, in the frame of an R&D program on Nuclear Fission, led by ENEA and funded by the Italian Ministry of Economic Development. The facility is based on the IRIS reactor design, an advanced medium size, integral layout, pressurized water reactor, based on the proven technology of PWR with an innovative configuration and safety features suitable to cope with Loss of Coolant Accidents through a dynamic coupling of the primary and containment systems. SPES3 is suitable to test the plant response to postulated Design and Beyond Design Basis Events, providing experimental data for code validation and plant safety analysis. It reproduces the primary, secondary and containment systems of the reactor with 1:100 volume scale, full elevation, prototypical fluid and thermal-hydraulic conditions. A design-calculation feedback process, based on the comparison between IRIS and SPES3 simulations, performed respectively by FER, with GOTHIC and RELAP5 coupled codes, and by SIET, with RELAP5 code, led to reduce the differences in the two plants behaviour, versus a 2-inch equivalent DVI line DEG break, considered the most challenging LOCA for the IRIS plant. Once available the final design of SPES3, further calculations were performed to investigate Beyond Design Basis Events, where the intervention of the Passive Containment Condenser is fundamental for the accident recovery. Sensitivity analyses showed the importance of the PCC actuation time, to limit the containment pressure, to reach an early pressure equalization between the primary and containment systems and to allow passive water transfer from the containment to the RPV, enhanced by the ADS Stage-II opening.

Crash Test Software Analysis

2002 ◽  
Author(s):  
Justin F. Harrison ◽  
Ionut Radu ◽  
Alan J. Babcock ◽  
Beth A. Todd
Keyword(s):  
Automotive Industry ◽  
Simulation Software ◽  
Crash Test ◽  
Software Analysis ◽  
Design Engineers ◽  
Software Packages ◽  
The Disabled ◽  
Safety Features ◽  
Physical Construction ◽  
Advanced Computer

The development of highly advanced computer simulation software packages has enabled design engineers to more effectively integrate safety features into their designs. Designs can be tested long before any physical construction ever begins. This saves money, allowing more extensive testing to be performed, and it also saves time, expediting the process of moving concept to reality. In the automotive industry, such software can be especially useful, since computer simulations can be run over and over again, making it possible to observe the effects of adjusting single variables in dynamic situations. This has opened the door for testing of non-typical occupants. Restraints and safety devices are no longer designed to suit the needs of the average person; they can be tailored to account for all body types, or even for the disabled.

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