Systematic Sensitivity Analysis of Spatial One-DOF Models of Diarthrodial Joints

Author(s):  
R. Di Gregorio ◽  
V. Parenti-Castelli

The identification of an equivalent mechanism which may reproduce at best the relative passive motion of the main anatomical structures of a human articulation is a target of great importance in the study of diarthrodial joints. Passive motion, that is the motion of the joint under virtually unloaded condition, is of basic importance for understanding the role of elements like bones, ligaments, etc. The identification is based on measurements performed during in vitro experiments. Passive motion of a number of human diarthrodial joints may be reproduced by equivalent mechanisms. However, the most critical points when devising the equivalent mechanism are represented by the changes of the subject articulation geometry due to age, sex, body constitution, etc. Thus, the equivalent mechanism sensitivity to the variations of the geometric parameters needs a careful investigation. The passive motion of many diarthrodial joints can be modeled by an equivalent mechanism with one degree of freedom (dof). This paper shows how the sensitivity of a one-dof equivalent mechanism with a finite number of geometric parameters can be studied in a systematic way. A sensitivity index together with some coefficients, called influence coefficients, are proposed which enable measuring the sensitivity of a mechanism, thus allowing the comparison of different equivalent mechanisms from the sensitivity viewpoint. Finally, a case study shows the application of the proposed methodology.

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109645 ◽  
Author(s):  
Soledad Gonzalo ◽  
Veronica Llaneza ◽  
Gerardo Pulido-Reyes ◽  
Francisca Fernández-Piñas ◽  
Jean Claude Bonzongo ◽  
...  

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Hongjie Li ◽  
Chang-Yu Sun ◽  
Yihang Fang ◽  
Caitlin M. Carlson ◽  
Huifang Xu ◽  
...  

AbstractAlthough calcareous anatomical structures have evolved in diverse animal groups, such structures have been unknown in insects. Here, we report the discovery of high-magnesium calcite [CaMg(CO3)2] armor overlaying the exoskeletons of major workers of the leaf-cutter ant Acromyrmex echinatior. Live-rearing and in vitro synthesis experiments indicate that the biomineral layer accumulates rapidly as ant workers mature, that the layer is continuously distributed, covering nearly the entire integument, and that the ant epicuticle catalyzes biomineral nucleation and growth. In situ nanoindentation demonstrates that the biomineral layer significantly hardens the exoskeleton. Increased survival of ant workers with biomineralized exoskeletons during aggressive encounters with other ants and reduced infection by entomopathogenic fungi demonstrate the protective role of the biomineral layer. The discovery of biogenic high-magnesium calcite in the relatively well-studied leaf-cutting ants suggests that calcareous biominerals enriched in magnesium may be more common in metazoans than previously recognized.


2020 ◽  
Author(s):  
Hongjie Li ◽  
Chang-Yu Sun ◽  
Yihang Fang ◽  
Caitlin M. Carlson ◽  
Huifang Xu ◽  
...  

AbstractAlthough calcareous anatomical structures have evolved in diverse animal groups, such structures have been unknown in insects. Here, we report the discovery of high-magnesium calcite [CaMg(CO3)2] armor overlaying the exoskeletons of major workers of the leaf-cutter ant Acromyrmex echinatior. Live-rearing and in vitro synthesis experiments indicate that the biomineral layer accumulates rapidly as ant workers mature, that the layer is continuously distributed, covering nearly the entire integument, and that the ant epicuticle catalyzes biomineral nucleation and growth. In situ nanoindentation demonstrates that the biomineral layer significantly hardens the exoskeleton. Increased survival of ant workers with biomineralized exoskeletons during aggressive encounters with other ants and reduced infection by entomopathogenic fungi demonstrate the protective role of the biomineral layer. The discovery of biosynthesized high-magnesium calcite in the relatively well-studied leaf-cutting ants suggests that calcareous biominerals enriched in magnesium may be more common in metazoans than previously recognized.


Author(s):  
Janet H. Woodward ◽  
D. E. Akin

Silicon (Si) is distributed throughout plant tissues, but its role in forages has not been clarified. Although Si has been suggested as an antiquality factor which limits the digestibility of structural carbohydrates, other research indicates that its presence in plants does not affect digestibility. We employed x-ray microanalysis to evaluate Si as an antiquality factor at specific sites of two cultivars of bermuda grass (Cynodon dactvlon (L.) Pers.). “Coastal” and “Tifton-78” were chosen for this study because previous work in our lab has shown that, although these two grasses are similar ultrastructurally, they differ in in vitro dry matter digestibility and in percent composition of Si.Two millimeter leaf sections of Tifton-7 8 (Tift-7 8) and Coastal (CBG) were incubated for 72 hr in 2.5% (w/v) cellulase in 0.05 M sodium acetate buffer, pH 5.0. For controls, sections were incubated in the sodium acetate buffer or were not treated.


Author(s):  
David B. Warheit ◽  
Lena Achinko ◽  
Mark A. Hartsky

There is a great need for the development of a rapid and reliable bioassay to evaluate the pulmonary toxicity of inhaled particles. A number of methods have been proposed, including lung clearance studies, bronchoalveolar lavage analysis, and in vitro cytotoxicity tests. These methods are often limited in scope inasmuch as they measure only one dimension of the pulmonary response to inhaled, instilled or incubated dusts. Accordingly, a comprehensive approach to lung toxicity studies has been developed.To validate the method, rats were exposed for 6 hours or 3 days to various concentrations of either aerosolized alpha quartz silica (Si) or carbonyl iron (CI) particles. Cells and fluids from groups of sham and dust-exposed animals were recovered by bronchoalveolar lavage (BAL). Alkaline phosphatase, LDH and protein values were measured in BAL fluids at several time points postexposure. Cells were counted and evaluated for viability, as well as differential and cytochemical analysis. In addition, pulmonary macrophages (PM) were cultured and studied for morphology, chemotaxis, and phagocytosis by scanning electron microscopy.


2012 ◽  
Vol 82 (3) ◽  
pp. 228-232 ◽  
Author(s):  
Mauro Serafini ◽  
Giuseppa Morabito

Dietary polyphenols have been shown to scavenge free radicals, modulating cellular redox transcription factors in different in vitro and ex vivo models. Dietary intervention studies have shown that consumption of plant foods modulates plasma Non-Enzymatic Antioxidant Capacity (NEAC), a biomarker of the endogenous antioxidant network, in human subjects. However, the identification of the molecules responsible for this effect are yet to be obtained and evidences of an antioxidant in vivo action of polyphenols are conflicting. There is a clear discrepancy between polyphenols (PP) concentration in body fluids and the extent of increase of plasma NEAC. The low degree of absorption and the extensive metabolism of PP within the body have raised questions about their contribution to the endogenous antioxidant network. This work will discuss the role of polyphenols from galenic preparation, food extracts, and selected dietary sources as modulators of plasma NEAC in humans.


1987 ◽  
Author(s):  
William A. Worrall ◽  
Ann W. Stockman

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
HM Lee ◽  
TG Ahn ◽  
CW Kim ◽  
HJ An
Keyword(s):  

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