Biomechanical Responses of Swine Esophagus Tissue to Irreversible Electroporation

2018 ◽  
Author(s):  
Lars M. Mattison ◽  
Chloe Johnson ◽  
Paul A. Iaizzo
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Irreversible Electroporation ◽  
The United States ◽  
Common Disease ◽  
Fatal Disease ◽  
Increased Risk ◽  
Biomechanical Responses ◽  
Ventricular Filling

Atrial Fibrillation (AF) is a common disease that may occur in the heart, especially as we age. AF is due to non-normal myocardial ectopic foci that then causes an uncoordinated atrium contraction. This effectively reduces the atrial kick to the ventricles, which can account for up to 20% of ventricular filling. While not an immediately fatal disease, it can cause reduced quality of life for patients and also puts them at increased risk for stroke. AF as a disease, is expected to affect over 50 million people in the United States alone by 2050 [1].

Biopsychosocial Patterning of Multimorbidity and Its Consequences

2018 ◽  
pp. 220-236
Author(s):  
Elliot Friedman ◽  
Beth LeBreton ◽  
Lindsay Fuzzell ◽  
Elizabeth Wehrpsann
Keyword(s):  
Quality Of Life ◽  
Older Adults ◽  
Functional Outcomes ◽  
The United States ◽  
Chronic Medical Conditions ◽  
Quality Of Life Research ◽  
Increased Risk ◽  
Over Time

By many estimates the majority of adults over age 65 have two or more chronic medical conditions (multimorbidity) and are consequently at increased risk of adverse functional outcomes. Nonetheless, many older adults with multimorbidity are able to maintain high levels of function and retain good quality of life. Research presented here is designed to understand the influences that help ensure better functional outcomes in these older adults. This chapter presents findings that draw on data from the Midlife in the United States study. The independent and interactive contributions of diverse factors to multimorbidity and changes in multimorbidity over time are reviewed. The degree that multimorbidity increases risk of cognitive impairment and disability is examined. The role of inflammation as a mediator is considered. Multimorbidity is increasingly the norm for older adults, so better understanding of factors contributing to variability in multimorbidity-related outcomes can lead to improved quality of life.

scholarly journals Atrial fibrillation and clinical outcomes 1 to 3 years after myocardial infarction

Open Heart ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. e001726
Author(s):  
Anthony P Carnicelli ◽  
Ruth Owen ◽  
Stuart J Pocock ◽  
David B Brieger ◽  
Satoshi Yasuda ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Myocardial Infarction ◽  
Atrial Fibrillation ◽  
Clinical Outcomes ◽  
Oral Anticoagulants ◽  
Adverse Outcomes ◽  
Increased Risk ◽  
History Of ◽  
The Impact

ObjectiveAtrial fibrillation (AF) and myocardial infarction (MI) are commonly comorbid and associated with adverse outcomes. Little is known about the impact of AF on quality of life and outcomes post-MI. We compared characteristics, quality of life and clinical outcomes in stable patients post-MI with/without AF.Methods/resultsThe prospective, international, observational TIGRIS (long Term rIsk, clinical manaGement and healthcare Resource utilization of stable coronary artery dISease) registry included 8406 patients aged ≥50 years with ≥1 atherothrombotic risk factor who were 1–3 years post-MI. Patient characteristics were summarised by history of AF. Quality of life was assessed at baseline using EQ-5D. Clinical outcomes over 2 years of follow-up were compared. History of AF was present in 702/8277 (8.5%) registry patients and incident AF was diagnosed in 244/7575 (3.2%) over 2 years. Those with AF were older and had more comorbidities than those without AF. After multivariable adjustment, patients with AF had lower self-reported quality-of-life scores (EQ-5D UK-weighted index, visual analogue scale, usual activities and pain/discomfort) than those without AF. CHA2DS2-VASc score ≥2 was present in 686/702 (97.7%) patients with AF, although only 348/702 (49.6%) were on oral anticoagulants at enrolment. Patients with AF had higher rates of all-cause hospitalisation (adjusted rate ratio 1.25 [1.06–1.46], p=0.008) over 2 years than those without AF, but similar rates of mortality.ConclusionsIn stable patients post-MI, those with AF were commonly undertreated with oral anticoagulants, had poorer quality of life and had increased risk of clinical outcomes than those without AF.Trial registration numberClinicalTrials: NCT01866904.

Abstract 15680: Sinus Node Dysfunction in Associated With Higher Symptom Burden and Increased Risk of Progression to Permanent Atrial Fibrillation: Results From ORBIT-AF Registry

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Larry R Jackson ◽  
Sung Hee Kim ◽  
Jonathan P Piccini ◽  
Bernard J Gersh ◽  
Gerald V Naccarelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Sinus Bradycardia ◽  
Sinus Node ◽  
Sinus Node Dysfunction ◽  
Left Ventricular Ejection ◽  
Increased Risk ◽  
Risk Of Progression

Background: Patients with sinus node dysfunction (SND) are at increased risk of atrial tachyarrhythmias, including atrial fibrillation (AF). Whether the presence of SND is also associated with worse outcomes among those with AF has not been well described. Methods: The ORBIT-AF registry enrolled patients with AF from a range of clinical practices across the US. SND was defined clinically, based on the presence of sinus bradycardia, severe sinus bradycardia, sinus arrest, sinoatrial exit block, or features of tachycardia-bradycardia syndrome. Descriptive statistics and multivariable logistic regression analysis were used to describe treatment patterns and outcomes for patients with and without SND and AF. Results: Overall, 1,710 (17.7%) patients had SND at enrollment. Patients with SND had lower left-ventricular ejection fractions, higher CHA 2 DS 2 -VASc risk scores, and more prior cerebrovascular events. Patients with SND had more severe symptoms (EHRA class IV: 17.5% vs. 13.9%; p=0.007) and poorer quality of life (median AFEQT 77.5 vs. 81.1; p=0.008) as compared to those without. SND patients were more frequently treated with oral anticoagulants (79.2% vs. 75.9%, p=0.004) and had more often received interventional therapy for AF (16.1% vs. 10.5%, p<0.0001). There were no differences in the current AF management strategy between patients with SND and those without [rate control (69.7% vs. 67.7%), rhythm control (30.0% vs. 32.0%); P=0.11]. After adjustment, significantly more patients with SND had progressed from paroxysmal AF at baseline to persistent or permanent AF at any follow-up or persistent AF at baseline to permanent AF at any follow-up than those without (OR 1.23, 95% CI 1.01-1.49, p=0.035). Conclusion: Sinus node dysfunction is associated worse symptoms, lower quality of life, and higher risk of progression to permanent AF. However, SND is not associated with increased risk of all-cause hospitalization, incident stroke, or all-cause death.

How to Improve Atrial Fibrillation Ablation Outcome?

2017 ◽  
Vol 2 (43) ◽  
pp. 14-17
Author(s):  
Artur Fuglewicz
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Patient Group ◽  
Atrial Fibrillation Ablation ◽  
Thromboembolic Complications ◽  
Invasive Treatment ◽  
Increased Risk

Atrial fibrillation is associated with a quality of life deterioration, increased risk of hospitalization, stroke and other thromboembolic complications, as well as a significant increase in mortality in this patient group. Invasive treatment is more effective than other’s. The continued growth of population with the atrial fibrillation, and the growing awareness of all these facts among both, physicians and patients, are drivers for searching more effective and safe ways of treatment. This article summarizes issues that have to be taken into consideration when discussing how can we better and safer perform ablation of atrial fibrillation substrats.

scholarly journals Burnout, Compassion Satisfaction, and Personality Among Nursing Assistants: Who is at Risk?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. 853-853
Author(s):  
Mallory Richert
Keyword(s):  
Quality Of Life ◽  
Compassion Satisfaction ◽  
The United States ◽  
Nursing Assistants ◽  
Term Care ◽  
Resident Care ◽  
Increased Risk ◽  
Quality Of Life Scale ◽  
Care Outcomes

Abstract Nursing assistants often experience high rates of turnover and burnout, which may lead to poor resident care outcomes and quality of life, as well as continued staff shortages and increased workload for nursing assistants. This study examined personality correlates of burnout and compassion satisfaction among 100 nursing assistants employed as nursing assistants in long-term care (LTC) and hospitals throughout the United States. Participants completed the Professional Quality of Life Scale 5 (ProQOL 5) and the Big Five Inventory – 2 Short (BFI-2-S). There was a significant positive correlation between compassion satisfaction and agreeableness, and extraversion, and between burnout and neuroticism. Additionally, there were significant negative correlations between compassion satisfaction and neuroticism, and between burnout and agreeableness, and extraversion. These results indicate which nursing assistants may be more likely to experience burnout and may be at an increased risk of turnover. Specific interventions may be developed for such individuals to increase compassion satisfaction, reduce burnout, and reduce staff turnover. Furthermore, information regarding personality types of individuals at greater or lesser risk for burnout may be helpful for LTC administrators in the recruitment and hiring of nursing assistants, and thus may reduce rates of turnover. Resident care outcomes may also improve as nursing assistant hiring efforts are focused more on individuals who are less likely to experience burnout. Future researchers might investigate potential risk and protective factors for burnout and compassion satisfaction in nursing assistants.

scholarly journals Recent Trials of Atrial Fibrillation Therapy

2015 ◽  
Vol 01 (01) ◽  
pp. 17
Author(s):  
Baktash Morrad ◽  
Bulent Gorenek ◽  
◽  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Clinical Practice ◽  
Functional Status ◽  
Therapeutic Intervention ◽  
Healthcare Systems ◽  
Mortality And Morbidity ◽  
Risk Of Mortality ◽  
Increased Risk

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinical practice. It may cause significant symptoms and impair both functional status and quality of life. Without therapeutic intervention, affected patients are at increased risk of mortality and morbidity, so AF places a major burden on healthcare systems. Many trials have been published on AF therapy in recent years. In this editorial, we will briefly discuss recent trials of AF therapies.

scholarly journals Contemporary Surgical Management of Atrial Fibrillation

2020 ◽  
Vol 29 (02) ◽  
pp. 123-130
Author(s):  
Tyler M. Gunn ◽  
Tessa E. London ◽  
Sibu P. Saha
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Atrial Fibrillation ◽  
Sudden Death ◽  
Surgical Management ◽  
Surgical Techniques ◽  
The Past ◽  
Increased Risk ◽  
Technical Advances

AbstractAtrial fibrillation is a common arrhythmia which may cause symptoms that significantly impact quality of life and is associated with increased risk of stroke, heart failure, and sudden death. Over the past three decades many surgical techniques as well as catheter-bases procedures have been developed to treat atrial fibrillation. In this review we describe the indications, treatments, outcomes, surgical techniques, and technical advances reported in the literature.

Management of atrial fibrillation and anticoagulant therapies

2017 ◽  
pp. 793-804
Author(s):  
Mark O’Neill ◽  
John Whitaker ◽  
Jonathan Birns ◽  
Matthew Wright
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Treatment Options ◽  
Bleeding Risk ◽  
Ventricular Rate ◽  
Supraventricular Arrhythmia ◽  
Increased Risk ◽  
The Impact ◽  
Careful Documentation

Atrial fibrillation (AF) is a common supraventricular arrhythmia which is commonly found in older adults. It is associated with an increased risk of stroke and has a detrimental effect on quality of life. Management of AF involves an attempt to reduce the increased risk of stroke and to treat the symptoms that result from a high (or low) ventricular rate as well as, in some cases, the atrial rhythm itself. The management of AF involves a comprehensive assessment of a patient’s individual stroke and bleeding risk and a careful documentation of the impact of their symptoms on quality of life. Treatment options range from conservative to highly invasive. Selecting the appropriate combination from the range of options necessitates an understanding of the risks and benefits of each, so that the patient and physician can jointly identify the most appropriate management strategy.

Psoriasis: skin and nails

2018 ◽  
Author(s):  
Cheryl F. Rosen ◽  
Brian Kirby
Keyword(s):  
Quality Of Life ◽  
Psoriatic Arthritis ◽  
The United States ◽  
Chronic Plaque Psoriasis ◽  
Increased Risk ◽  
Generalized Pustular Psoriasis ◽  
Erythrodermic Psoriasis ◽  
Guttate Psoriasis ◽  
Nail Involvement

Psoriasis is seen in many patients with psoriatic arthritis. It forms part of the CASPAR criteria for establishing the diagnosis of psoriatic arthritis (PsA). The psoriasis accompanying PsA may be mild or quite severe, with a very large impact on quality of life. The presence of cutaneous disease may alter the treatment of a patient’s PsA. Psoriasis affects up to 2–3% of the population of Europe, the United States and Canada. The majority of patients have chronic plaque psoriasis (80%). Other clinical phenotypes include guttate psoriasis, erythrodermic psoriasis, inverse psoriasis, sebopsoriasis and pustular subtypes including generalized pustular psoriasis. Nail involvement is a frequent occurrence and indicate an increased risk of developing psoriatic arthritis. In this chapter, the different psoriatic phenotypes are described as well as the histology and, briefly, the pathophysiology of psoriasis. Environmental factors that can impact psoriasis are reviewed.

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