Computer-Aided Design, Manufacturing, and Modeling of Polymer Scaffolds for Tissue Engineering

Author(s):  
James J.-S. Stone ◽  
Andrew R. Thoreson ◽  
Kurt L. Langner ◽  
Jay M. Norton ◽  
Daniel J. Stone ◽  
...  

A custom computer-controlled rapid prototyping system was designed and developed in this research. This system for bio-manufacturing of polymer scaffolds included 3D motion control components, a nozzle, a pressure controller, and a temperature-controlled reservoir containing a biomaterial. Heating elements built into the reservoir melted the biomaterial. The pressure line attached to the reservoir provided a controllable force that extruded the polymer biomaterial through the nozzle and deposited the polymer biomaterial onto a platform to fabricate scaffolds. A low pressure (830 KPa) system was designed and fabricated to accommodate different temperatures, motion speeds, and viscosities of polymer biomaterials. The reservoir with the nozzle was mounted to servo motor-controlled linear x-y motion devices along with a third servo motor-controlled device that controlled the z-position of the platform. Poly(ε-caprolactone) [PCL] was used to fabricate scaffolds with designed structure that were used in cell and tissue regeneration studies. 3D computer-aided design (CAD) with Pro-Engineer and computational finite element analysis (FEA) programs with MSC_Patran and MSC_Marc were used to model scaffold designs with appropriate architecture and material selection. The CAD models were used in FEA to develop new methods for determining mechanical properties of tissue scaffolds of desired structure and geometry. FEA models were validated by mechanical testing and other published results. Technology developed in this research has potential for the advancement of bio-manufacturing, and design optimization of scaffolds for tissue engineering.

2021 ◽  
Vol 11 (4) ◽  
pp. 145
Author(s):  
Nenad Bojcetic ◽  
Filip Valjak ◽  
Dragan Zezelj ◽  
Tomislav Martinec

The article describes an attempt to address the automatized evaluation of student three-dimensional (3D) computer-aided design (CAD) models. The driving idea was conceptualized under the restraints of the COVID pandemic, driven by the problem of evaluating a large number of student 3D CAD models. The described computer solution can be implemented using any CAD computer application that supports customization. Test cases showed that the proposed solution was valid and could be used to evaluate many students’ 3D CAD models. The computer solution can also be used to help students to better understand how to create a 3D CAD model, thereby complying with the requirements of particular teachers.


2016 ◽  
Vol 8 (3) ◽  
Author(s):  
Hailin Huang ◽  
Bing Li ◽  
Jianyang Zhu ◽  
Xiaozhi Qi

This paper proposes a new family of single degree of freedom (DOF) deployable mechanisms derived from the threefold-symmetric deployable Bricard mechanism. The mobility and geometry of original threefold-symmetric deployable Bricard mechanism is first described, from the mobility characterstic of this mechanism, we show that three alternate revolute joints can be replaced by a class of single DOF deployable mechanisms without changing the single mobility characteristic of the resultant mechanisms, therefore leading to a new family of Bricard-derived deployable mechanisms. The computer-aided design (CAD) models are used to demonstrate these derived novel mechanisms. All these mechanisms can be used as the basic modules for constructing large volume deployable mechanisms.


Author(s):  
Tahir Abbas Jauhar ◽  
Soonhung Han ◽  
Soonjo Kwon

Abstract Computer-aided design, engineering, and manufacturing (CAx) have improved product design and development. The associativity of revised design in native files for downstream applications, assembly design, finite element analysis, and numerical control (NC) manufacturing has been supported by homogeneous CAx systems. However, heterogeneous CAx environments have issues when neutral models are revised and re-imported because the required identification information is missing. This results in a problem of the associativity of neutral models. In this study, different computer-aided design (CAD) applications have been analyzed with respect to their capabilities for import and export of neutral models with identification information. A tool has been selected to demonstrate the key findings. Moreover, future directions have been discussed to solve associativity issues in design re-import based on neutral models.


Author(s):  
Aditya Balu ◽  
Sambit Ghadai ◽  
Soumik Sarkar ◽  
Adarsh Krishnamurthy

Abstract Computer-aided Design for Manufacturing (DFM) systems play an essential role in reducing the time taken for product development by providing manufacturability feedback to the designer before the manufacturing phase. Traditionally, DFM rules are hand-crafted and used to accelerate the engineering product design process by integrating manufacturability analysis during design. Recently, the feasibility of using a machine learning-based DFM tool in intelligently applying the DFM rules have been studied. These tools use a voxelized representation of the design and then use a 3D-Convolutional Neural Network (3D-CNN), to provide manufacturability feedback. Although these frameworks work effectively, there are some limitations to the voxelized representation of the design. In this paper, we introduce a new representation of the computer-aided design (CAD) model using orthogonal distance fields (ODF). We provide a GPU-accelerated algorithm to convert standard boundary representation (B-rep) CAD models into ODF representation. Using the ODF representation, we build a machine learning framework, similar to earlier approaches, to create a machine learning-based DFM system to provide manufacturability feedback. As proof of concept, we apply this framework to assess the manufacturability of drilled holes. The framework has an accuracy of more than 84% correctly classifying the manufacturable and non-manufacturable models using the new representation.


Author(s):  
Hamza Arshad ◽  
Vrushank Phadnis ◽  
Alison Olechowski

Abstract We present the results of an experiment investigating two different modes of collaboration on a series of computer-aided design (CAD) tasks. Inspired by the pair programming literature, we anticipate that partners working in a fully synchronous collaborative CAD environment will achieve different levels of quality in CAD models depending on their mode of collaboration — one in which the pair is free to work in parallel, and another where the pair must coordinate to share one control. We found that a shared CAD control led to significantly better overall CAD quality than parallel CAD control. In addition, the shared control mode led to more complete and consistent CAD models, as well as the tendency for participants to follow instructions to correctly replicate features for the design task. As is predicted in the literature, a trade-off relationship (albeit weak) between quality and speed via the parallel collaboration was found. In contrast, the shared control mode shows no clear relationship between speed and quality. Collaborative CAD is increasingly seen as an appealing tool for modern product design teams. This study suggests that the benefits of this tool are not solely the effect of the tool itself, but result from the collaboration style of the designers using the tool.


2018 ◽  
Vol 7 (4.27) ◽  
pp. 148
Author(s):  
Wan Muhammad Syahmi Wan Fauzi ◽  
Abdul Rahman Omar ◽  
Helmi Rashid

Recently, studies concerning motorcycle have been an overwhelming area of research interest. As an alternative to the real world assessment, researchers have utilized motorcycle simulator as a workstation to conduct studies in the motorcycle niche area. This paper deal with the development of a new motorcycle simulator named Semi-Interface Motorcycle Simulator (SiMS). Combination of Computer Aided Design (CAD) and Finite Element Analysis (FEA) software made it possible to design and simulates the motorcycle simulator’s conceptual design before being fabricated. The SiMS setup not only provides a near-to-real and immerse motorcycle riding experience on a super sport motorcycle model, but it also allows safer high speed motorcycle simulations to be conducted in a controlled environment that is portable and ergonomically easier to transport to various venues.  


2014 ◽  
Vol 660 ◽  
pp. 753-757
Author(s):  
Mohd Azman Abdullah ◽  
Noreffendy Tamaldin ◽  
Faiz Redza Ramli ◽  
Mohd Nizam Sudin ◽  
Abdul Mu’in Mohamed Muslim

The previously fabricated all terrain vehicle (ATV) chassis and components' designs are further analyzed. The analysis consider the weight distribution ratio during acceleration and braking for the ATV components namely wishbone arm, swing arm and shaft. Preliminary analysis of torsion and static are also performed on the chassis and components. The analysis is performed using commercial computer aided design (CAD) software. The results show good data in term of factor of safety. With further development and research, the ATVs are subjected for improvement. The sustainability of the design and development of the ATVs depends on the material selection, design criteria and components availability.


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