Change Gasket: Overview and Recent Developments

2013 ◽  
Author(s):  
Russ Currie
Keyword(s):  
Product Development ◽  
The Novel ◽  
Novel Technology ◽  
Recent Developments

The paper discusses the development of sealing technology within the organisation with particular emphasis on the novel gasket (NG) referred to as Change. The paper will introduce the concept and product; it will discuss the series of tests including comparison with four other gasket styles commonly used in the sealing industry. A brief summary of product development is under taken and sealing industry gasket constants and calculations are used to highlight the benefits of novel technology.

Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

Different polar-map patterns using the novel technology for myocardial perfusion imaging (MPI)

2016 ◽  
Vol 32 ◽  
pp. 113
Author(s):  
C. Scabbio ◽  
O. Zoccarato ◽  
C. Marcassa ◽  
D. Lizio ◽  
L. Leva ◽  
...  
Keyword(s):  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
The Novel ◽  
Novel Technology ◽  
Polar Map

21st Century Citizen Pharma: The FDA & Patient-Focused Product Development

2018 ◽  
Vol 44 (2-3) ◽  
pp. 309-327 ◽  
Author(s):  
Jordan Paradise
Keyword(s):  
Product Development ◽  
Health And Safety ◽  
The United States ◽  
The Public ◽  
United States Food ◽  
Recent Developments ◽  
States Food ◽  
And Control ◽  
Patient Advocacy Groups

Perpetual debate regarding the delicate balance between access and innovation and the protection of the public health and safety dominate discussions of the United States Food and Drug Administration (“FDA”). Established chiefly as a command and control federal administrative agency, iterative changes in legislation have shaped the FDA's activity in drug, biologic, and medical device regulation over the course of the last one hundred plus years. The most recent fundamental reframing of the agency's authority and directive presented itself in the 21st Century Cures Act, reflecting an important role for patient perspectives in the regulatory process. This Article explores recent developments in patient-focused product development efforts at the FDA and offers modest insights on the increasing role of patients, and patient advocacy groups, in agency decision-making. The Article terms this era “21st century citizen pharma.”

Mass Spectrometry-Based Determination of Thyroid Hormones and Their Metabolites in Endocrine Diagnostics and Biomedical Research – Implications for Human Serum Diagnostics

2020 ◽  
Vol 128 (06/07) ◽  
pp. 358-374 ◽  
Author(s):  
Josef Köhrle ◽  
Keith H. Richards
Keyword(s):  
Wide Spectrum ◽  
Quantitative Detection ◽  
Matrix Interferences ◽  
Novel Technology ◽  
Sample Extraction ◽  
Recent Developments ◽  
Serum Diagnostics ◽  
Novel Applications ◽  
Total Concentrations

AbstractThe wide spectrum of novel applications for the LC-MS/MS-based analysis of thyroid hormone metabolites (THM) in blood samples and other biological specimen highlights the perspectives of this novel technology. However, thorough development of pre-analytical sample workup and careful validation of both pre-analytics and LC-MS/MS analytics, is needed, to allow for quantitative detection of the thyronome, which spans a broad concentration range in these biological samples.This minireview summarizes recent developments in advancing LC-MS/MS-based analytics and measurement of total concentrations of THM in blood specimen of humans, methods in part further refined in the context of previous achievements analyzing samples derived from cell-culture or tissues. Challenges and solutions to tackle efficient pre-analytic sample extraction and elimination of matrix interferences are compared. Options for automatization of pre-analytic sample-preparation and comprehensive coverage of the wide thyronome concentration range are presented. Conventional immunoassay versus LC-MS/MS-based determination of total and free THM concentrations are briefly compared.

Multiple Myeloma: From Front-Line to Relapsed Therapies

2015 ◽  
pp. e504-e511 ◽  
Author(s):  
Philippe Moreau ◽  
Cyrille Touzeau
Keyword(s):  
Multiple Myeloma ◽  
Histone Deacetylase Inhibitors ◽  
Major Advance ◽  
The Novel ◽  
Disease Relapse ◽  
Front Line ◽  
Optimal Sequencing ◽  
Recent Developments ◽  
Phase Ii And Iii ◽  
Multiple Relapses

Recent developments in the treatment of multiple myeloma (MM) have led to improvements in response rates and to increased survival. A major advance in the last decade has been the introduction of the novel agents thalidomide, bortezomib, and lenalidomide as part of front-line treatment in both the transplant and nontransplant settings. However, disease relapse is inevitable for the majority of patients and myeloma typically recurs more aggressively with each relapse, eventually leading to the development of treatment-refractory disease. Several phase II and III trials have demonstrated the efficacy of recently approved agents in the setting of relapsed and relapsed and refractory MM, including pomalidomide and carfilzomib. Ixazomib, an oral proteasome inhibitor, and multiple other novel classes of agents are being investigated. These include monoclonal antibodies and histone deacetylase inhibitors, which may further add to the therapeutic armamentarium for this malignancy. Therefore, in a disease characterized by multiple relapses, the optimal sequencing of the different effective options is an important consideration in attempting to prolong survival.

Biomineralization of Electrospun Nano-HA/PHB GTR Membrane

2007 ◽  
Vol 330-332 ◽  
pp. 695-698 ◽  
Author(s):  
Dong Hua Guan ◽  
Chun Peng Huang ◽  
Ji Liu ◽  
Kun Tian ◽  
Lin Niu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Electrospinning Process ◽  
Nanometer Scale ◽  
High Porosity ◽  
The Novel ◽  
Mineral Crystal ◽  
Novel Technology ◽  
Air Jet

Poly 3-hydroxybutyrate (PHB) as a kind of polysaccharides has been proved promising for tissue engineering because of its biocompatibility and biodegradability. But its poor mechanical properties and hydrophilicity limit its application. In order to explore a new useful porch to improve the performance of PHB-based GTR membrane, membrane composed of nano-HA / PHB composite was manufactured through the air/jet electrospinning process which can potentially generate nanometer scale diameter fibers and enlarge surface area of materials while maintaining high porosity. Successively, the biomineralization behavior of the membrane in supersaturated calcification solution (SCS) was studied. The Results of this investigation show that the successfully manufactured porous nano-HA/PHB membrane has high activity in SCS and its ability of inducing the formation of mineral crystal in vitro than that of the unfilled PHB membrane. It can be concluded that the addition of nano-HA and the novel technology could improve the performance of the PHB-based GTR membrane.

scholarly journals Correlative Probe and Electron Microscopy CPEM™ – The Novel Technology for 3D Material Surface Analysis

2019 ◽  
Vol 25 (S2) ◽  
pp. 430-431 ◽  
Author(s):  
Jan Neuman ◽  
Zdenek Novacek ◽  
Michal Pavera ◽  
Veronika Novotna
Keyword(s):  
Electron Microscopy ◽  
Surface Analysis ◽  
Material Surface ◽  
The Novel ◽  
Novel Technology

scholarly journals From Stockholm to Malawi: recent developments in studying human polyomaviruses

2013 ◽  
Vol 94 (3) ◽  
pp. 482-496 ◽  
Author(s):  
Mariet C. W. Feltkamp ◽  
Siamaque Kazem ◽  
Els van der Meijden ◽  
Chris Lauber ◽  
Alexander E. Gorbalenya
Keyword(s):  
Skin Disease ◽  
Merkel Cell Polyomavirus ◽  
Severe Illness ◽  
The Novel ◽  
Merkel Cell ◽  
Transplant Patients ◽  
Recent Developments ◽  
Long Time ◽  
Immunocompromised Hosts ◽  
Human Polyomaviruses

Until a few years ago the polyomavirus family (Polyomaviridae) included a dozen viruses identified in avian and mammalian hosts. Two of these, the JC and BK-polyomaviruses isolated a long time ago, are known to infect humans and cause severe illness in immunocompromised hosts. Since 2007 an unprecedented number of eight novel polyomaviruses were discovered in humans. Among them are the KI- and WU-polyomaviruses identified in respiratory samples, the Merkel cell polyomavirus found in skin carcinomas and the polyomavirus associated with trichodysplasia spinulosa, a skin disease of transplant patients. Another four novel human polyomaviruses were identified, HPyV6, HPyV7, HPyV9 and the Malawi polyomavirus, so far not associated with any disease. In the same period several novel mammalian polyomaviruses were described. This review summarizes the recent developments in studying the novel human polyomaviruses, and touches upon several aspects of polyomavirus virology, pathogenicity, epidemiology and phylogeny.

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