Novel Nanolipoidal Systems for the Management of Skin Cancer

2020 ◽  
Vol 14 (2) ◽  
pp. 108-125
Author(s):  
Apoorva Singh ◽  
Nimisha
Keyword(s):  
Skin Cancer ◽  
Survival Rates ◽  
Cancer Therapeutics ◽  
The Body ◽  
Surgical Removal ◽  
The Novel ◽  
Skin Cancers ◽  
Recent Developments ◽  
Abnormal Cells ◽  
The Stability

: Skin cancer, among the various kinds of cancers, is a type that emerges from skin due to the growth of abnormal cells. These cells are capable of spreading and invading the other parts of the body. The occurrence of non-melanoma and melanoma, which are the major types of skin cancers, has increased over the past decades. Exposure to ultraviolet radiations (UV) is the main associative cause of skin cancer. UV exposure can inactivate tumor suppressor genes while activating various oncogenes. The conventional techniques like surgical removal, chemotherapy and radiation therapy lack the potential for targeting cancer cells and harm the normal cells. However, the novel therapeutics show promising improvements in the effectiveness of treatment, survival rates and better quality of life for patients. Different methodologies are involved in the skin cancer therapeutics for delivering the active ingredients to the target sites. Nano carriers are very efficient as they have the ability to improve the stability of drugs and further enhance their penetration into the tumor cells. The recent developments and research in nanotechnology have entitled several targeting and therapeutic agents to be incorporated into nanoparticles for an enhancive treatment of skin cancer. To protect the research works in the field of nanolipoidal systems various patents have been introduced. Some of the patents acknowledge responsive liposomes for specific targeting, nanocarriers for the delivery or co-delivery of chemotherapeutics, nucleic acids as well as photosensitizers. Further recent patents on the novel delivery systems have also been included here.

scholarly journals Skin cancer awareness and sunscreen use among outpatients of a South African hospital: need for vigorous public education

2018 ◽  
Vol 60 (4) ◽  
pp. 53
Author(s):  
N. C. Dlova ◽  
R. Gathers ◽  
J. Tsoka-Gwegweni ◽  
R. J. Hift
Keyword(s):  
Skin Cancer ◽  
South African ◽  
Survival Rates ◽  
Cancer Awareness ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
South Africans ◽  
Melanoma Incidence ◽  
Skin Cancers ◽  
Black Patients

Background: Melanoma incidence among white South Africans is increasing. Among black individuals, melanoma is associated with advanced stage at presentation and significant mortality.Objectives: A study was undertaken to assess the perception of skin cancer risk, knowledge of skin cancer, and understanding of the importance and use of sunscreens among South Africans.Methods: A cross-sectional survey was conducted in general outpatients over four months at a large central hospital in Durban, South Africa.Results: Only half the white respondents reported regular use of a sunscreen. Among black and Indian respondents, the number was substantially lower. Less than 20% of white respondents had ever checked their skin for suspicious moles. Most black patients were not aware that they are at risk of skin cancer, and only 10% were aware of the risk of developing skin cancers on acral sites and nails.Conclusions: There is a worrying lack of knowledge about skin cancer and sun protection behaviours among all South Africans. Given the increase in melanoma incidence and racial disparities in survival rates, it is imperative to target each population with effective, culturally sensitive educational programmes.

scholarly journals Detection of Skin Cancer using Deep CNN

2020 ◽  
Vol 8 (5S) ◽  
pp. 22-24
Keyword(s):  
Neural Network ◽  
Skin Cancer ◽  
Convolutional Neural Network ◽  
The Body ◽  
The Sun ◽  
Layer System ◽  
Data Set ◽  
Abnormal Cells ◽  
Deep Cnn ◽  
Uv Rays

Development of abnormal cells are the cause of skin cancer that have the ability to attack or spread to various parts of the body. The skin cancer signs may include mole that has varied in size, shape, color, and may also haveno –uniform edges, might be having multiple colours, and would itch orevn bleed in some cases. The exposure to the UV-rays from the sun is considered to be accountable for more than 90% of the Skin Cancer cases which are recorded.In this paper, the development of a classificiation system for skin cancer, is discussed, using Convolutional Neural Network which would help in classifying the cancer usingTensorFlow and Keras as Malignantor Benign. The collected images from the data set are fed into the system and it is processed to classify the skin cancer. After the implementation the accuracy of the Convolutional 2-D layer system developed is found to be 78%.

scholarly journals Applying an Author-Weighted Scheme to Identify the Most Influential Countries in Research Achievements on Skin Cancer: Observational Study

10.2196/11015 ◽  
2019 ◽  
Vol 2 (1) ◽  
pp. e11015 ◽  
Author(s):  
Tsair-Wei Chien ◽  
Hsien-Yi Wang ◽  
Feng-Jie Lai
Keyword(s):  
Skin Cancer ◽  
Keyword Search ◽  
The United States ◽  
The Body ◽  
Kano Model ◽  
Country Level ◽  
Visual Basic For Applications ◽  
Choropleth Maps ◽  
Scatter Plots ◽  
Abnormal Cells

Background Skin cancers are caused by the development of abnormal cells that can invade or spread to other parts of the body. The countries whose authors contribute the most amount of articles on skin cancer to academia is still unknown. Objective The objectives of this study are to apply an author-weighted scheme (AWS) to quantify the credits for coauthors on an article byline and allocate the author weights to the country-level credits in articles. Methods On July 20, 2019, we obtained 16,804 abstracts published since 1938, based on a keyword search of “skin cancer” in PubMed. The author names, countries/areas, and journals were recorded. International author collaborations on skin cancer were analyzed based on country-level credits in articles. We aimed to do the following: (1) present country distribution for the first authors and the most popular journals, (2) show choropleth maps to highlight the most influential countries, and (3) draw scatter plots based on the Kano model to characterize the features of country-level research achievements. We programmed Excel Visual Basic for Applications (Microsoft Corp) routines to extract data from PubMed. Google Maps was used to display graphical representations. Results Our results suggest that researchers in the United States have published most frequently, accounting for 30.37% (5103), while Germany accounts for 7.34% (1234), followed by Australia (997, 5.93%). The top three continents for the proportion of published articles are North America, Europe, and Asia, accounting for 32.29%, 31.71%, and 10.41%, respectively. Conclusions This study offers an objective picture of the representativeness and evolution of international research on the topic of skin cancer. The research approaches used here have the potential to be applied to other areas besides skin cancer.

scholarly journals Preoperative AI-Driven Fluorescence Diagnosis of Non-Melanoma Skin Cancer

Diagnostics ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 72
Author(s):  
Victoriya Andreeva ◽  
Evgeniia Aksamentova ◽  
Andrey Muhachev ◽  
Alexey Solovey ◽  
Igor Litvinov ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Normal Skin ◽  
Invasive Procedure ◽  
Biopsy Material ◽  
Fluorescence Diagnosis ◽  
Non Melanoma Skin Cancer ◽  
Skin Cancers ◽  
Abnormal Cells ◽  
Diagnosis Method ◽  
Melanoma Skin

The diagnosis and treatment of non-melanoma skin cancer remain urgent problems. Histological examination of biopsy material—the gold standard of diagnosis—is an invasive procedure that requires a certain amount of time to perform. The ability to detect abnormal cells using fluorescence spectroscopy (FS) has been shown in many studies. This technique is rapidly expanding due to its safety, relative cost-effectiveness, and efficiency. However, skin lesion FS-based diagnosis is challenging due to a number of single overlapping spectra emitted by fluorescent molecules, making it difficult to distinguish changes in the overall spectrum and the molecular basis for it. We applied deep learning (DL) algorithms to quantitatively assess the ability of FS to differentiate between pathologies and normal skin. A total of 137 patients with various forms of primary and recurrent basal cell carcinoma (BCC) were observed by a multispectral laser-based device with a built-in neural network (NN) “DSL-1”. We measured the fluorescence spectra of suspected non-melanoma skin cancers and compared them with “normal” skin spectra. These spectra were input into DL algorithms to determine whether the skin is normal, pigmented normal, benign, or BCC. The preoperative differential AI-driven fluorescence diagnosis method correctly predicted the BCC lesions. We obtained an average sensitivity of 62% and average specificity of 83% in our experiments. Thus, the presented “DSL-1” diagnostic device can be a viable tool for the real-time diagnosis and guidance of non-melanoma skin cancer resection.

Opposing Roles of Antimicrobial Peptides in Skin Cancers

2021 ◽  
Vol 27 ◽  
Author(s):  
Chanisa Kiatsurayanon ◽  
Ge Peng ◽  
François Niyonsaba
Keyword(s):  
Skin Cancer ◽  
Antimicrobial Peptides ◽  
Cancer Biology ◽  
Skin Diseases ◽  
Immune Defense ◽  
The Body ◽  
Skin Tumor ◽  
Host Defense Peptides ◽  
Skin Cancers ◽  
The Impact

: Antimicrobial peptides (AMPs), also known as host defense peptides, are ubiquitous naturally occurring molecules secreted by various cell types of the body. In the skin, AMPs serve as a first-line innate immune defense against exogenous microorganisms, and they orchestrate adaptive immune responses to exert several immunomodulatory functions. Emerging evidence indicates that AMPs not only contribute to certain inflammatory skin diseases but also play a role in skin tumor carcinogenesis. Available data support the hypothesis that AMPs possess both pro-tumor and anti-neoplastic properties. Although inconsistent observations reported by multiple studies make it challenging to summarize the precise roles of AMPs in cancer, the differential expression of AMPs in skin cancers, such as the increased expression of human beta-defensins in squamous cell carcinoma and the ability of cathelicidin LL-37 to induce malignant melanoma cell invasion, implies they have procancer activities. On the other hand, the observation that certain AMPs show cytotoxic activity against cancer cells of the colon and kidney suggests their inherent antitumor properties. In this review, we describe the roles and mechanisms of AMPs in skin cancer development. We believe that further research is needed to elucidate the impact of these AMPs in skin cancer biology and to explore their potential roles as diagnostic/prognostic biomarkers and as novel therapeutic targets.

scholarly journals Advances in the Understanding of Skin Cancer: Ultraviolet Radiation, Mutations, and Antisense Oligonucleotides as Anticancer Drugs

Molecules ◽  
2019 ◽  
Vol 24 (8) ◽  
pp. 1516 ◽  
Author(s):  
Laikova ◽  
Oberemok ◽  
Krasnodubets ◽  
Gal’chinsky ◽  
Useinov ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Cancer Cells ◽  
Antisense Oligonucleotides ◽  
The Body ◽  
Rapid Progression ◽  
Tumor Focus ◽  
Skin Cancers ◽  
Initial Tumor ◽  
Before And After ◽  
Artificial Uv

Skin cancer has always been and remains the leader among all tumors in terms of occurrence. One of the main factors responsible for skin cancer, natural and artificial UV radiation, causes the mutations that transform healthy cells into cancer cells. These mutations inactivate apoptosis, an event required to avoid the malignant transformation of healthy cells. Among these deadliest of cancers, melanoma and its ‘younger sister’, Merkel cell carcinoma, are the most lethal. The heavy toll of skin cancers stems from their rapid progression and the fact that they metastasize easily. Added to this is the difficulty in determining reliable margins when excising tumors and the lack of effective chemotherapy. Possibly the biggest problem posed by skin cancer is reliably detecting the extent to which cancer cells have spread throughout the body. The initial tumor is visible and can be removed, whereas metastases are invisible to the naked eye and much harder to eliminate. In our opinion, antisense oligonucleotides, which can be used in the form of targeted ointments, provide real hope as a treatment that will eliminate cancer cells near the tumor focus both before and after surgery.

scholarly journals Applying an Author-Weighted Scheme to Identify the Most Influential Countries in Research Achievements on Skin Cancer: Observational Study (Preprint)

2018 ◽  
Author(s):  
Tsair-Wei Chien ◽  
Hsien-Yi Wang ◽  
Feng-Jie Lai
Keyword(s):  
Skin Cancer ◽  
Keyword Search ◽  
The United States ◽  
The Body ◽  
Kano Model ◽  
Country Level ◽  
Visual Basic For Applications ◽  
Choropleth Maps ◽  
Scatter Plots ◽  
Abnormal Cells

BACKGROUND Skin cancers are caused by the development of abnormal cells that can invade or spread to other parts of the body. The countries whose authors contribute the most amount of articles on skin cancer to academia is still unknown. OBJECTIVE The objectives of this study are to apply an author-weighted scheme (AWS) to quantify the credits for coauthors on an article byline and allocate the author weights to the country-level credits in articles. METHODS On July 20, 2019, we obtained 16,804 abstracts published since 1938, based on a keyword search of “skin cancer” in PubMed. The author names, countries/areas, and journals were recorded. International author collaborations on skin cancer were analyzed based on country-level credits in articles. We aimed to do the following: (1) present country distribution for the first authors and the most popular journals, (2) show choropleth maps to highlight the most influential countries, and (3) draw scatter plots based on the Kano model to characterize the features of country-level research achievements. We programmed Excel Visual Basic for Applications (Microsoft Corp) routines to extract data from PubMed. Google Maps was used to display graphical representations. RESULTS Our results suggest that researchers in the United States have published most frequently, accounting for 30.37% (5103), while Germany accounts for 7.34% (1234), followed by Australia (997, 5.93%). The top three continents for the proportion of published articles are North America, Europe, and Asia, accounting for 32.29%, 31.71%, and 10.41%, respectively. CONCLUSIONS This study offers an objective picture of the representativeness and evolution of international research on the topic of skin cancer. The research approaches used here have the potential to be applied to other areas besides skin cancer.

scholarly journals Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Manisha Lalan ◽  
Pranav Shah ◽  
Kalyani Barve ◽  
Khushali Parekh ◽  
Tejal Mehta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Skin Cancer ◽  
Environmental Changes ◽  
Cancer Therapeutics ◽  
Drug Carriers ◽  
Magic Bullet ◽  
Main Body ◽  
Topical Drug Delivery ◽  
Cancer Statistics ◽  
Skin Cancers

Abstract Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. Main body of the abstract The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Short conclusion Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies. Graphic abstract

scholarly journals Botanical Agents for the Treatment of Nonmelanoma Skin Cancer

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jillian W. Millsop ◽  
Raja K. Sivamani ◽  
Nasim Fazel
Keyword(s):  
Skin Cancer ◽  
Cell Carcinoma ◽  
The United States ◽  
Nonmelanoma Skin Cancer ◽  
Surgical Removal ◽  
Chemopreventive Agents ◽  
Treatment And Prevention ◽  
Skin Cancers ◽  
United States Standard ◽  
Nonmelanoma Skin Cancers

Nonmelanoma skin cancers, including basal cell carcinoma and squamous cell carcinoma, are common neoplasms worldwide and are the most common cancers in the United States. Standard therapy for cutaneous neoplasms typically involves surgical removal. However, there is increasing interest in the use of topical alternatives for the prevention and treatment of nonmelanoma skin cancer, particularly superficial variants. Botanicals are compounds derived from herbs, spices, stems, roots, and other substances of plant origin and may be used in the form of dried or fresh plants, extracted plant material, or specific plant-derived chemicals. They possess multiple properties including antioxidant, anti-inflammatory, and immunomodulatory properties and are, therefore, believed to be possible chemopreventive agents or substances that may suppress or reverse the process of carcinogenesis. Here, we provide a review of botanical agents studied for the treatment and prevention of nonmelanoma skin cancers.

scholarly journals "Desperate Fictions": Space, Identity and Indeterminacy in William Gaddis and Don DeLillo

2021 ◽  
Author(s):  
◽  
Timothy Garlick
Keyword(s):  
Don Delillo ◽  
The Body ◽  
Cultural Critique ◽  
The Novel ◽  
Self Identity ◽  
William Gaddis ◽  
Intimate Knowledge ◽  
Ambivalent Relationship ◽  
Radical Revision ◽  
The Stability

<p>Don DeLillo has frequently acknowledged William Gaddis as a significant influence, particularly in his concern with the vagaries of self-identity. DeLillo's The Body Artist (2001) and Gaddis's Carpenter's Gothic (1985) both thematically explore the relationship between self and space, employing gothic motifs and metafictional devices which intersect with the dramatic content of the novel, in which characters experience disruption to the stability of the known and located. In both, even the most intimate knowledge of relationships and environments is portrayed as a contingent construction, open to radical revision. As has been acknowledged by a number of critics, the transitory nature of postmodern spatiality is a central thematic preoccupation of both writers. The novels of both writers confront postmodern space by the way they complicate processes of identification and communication through a formalist evocation of indeterminacy. However differences become apparent in a careful comparison of their larger works. In Gaddis's J R (1975) Gaddis attempts to govern this indeterminacy in the service of cultural critique; rhetorically manipulating readerly identification in the service of an overall vision of decline. DeLillo's Underworld (1997), on the other hand, destabilizes meaning, and as a result the reader is directed towards a more ambivalent relationship to postmodern existence.</p>

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