A Numerical and Experimental Study of Blood Disturbances in a Stented Arterial Segment: Flat vs. Cylindrical Mock-Ups

2008 ◽  
Author(s):  
Juan Mejia ◽  
Rosaire Mongrain ◽  
Guy Drapeau ◽  
Josep Cabau-Rodes ◽  
Olivier F. Bertrand
Keyword(s):  
Cardiovascular Disease ◽  
Experimental Study ◽  
Blood Flow ◽  
Cause Of Death ◽  
Balloon Angioplasty ◽  
Cardiac Complications ◽  
Arterial Segment ◽  
Structural Support ◽  
Developed World

Today cardiac complications are the leading cause of death in the developed world [1]. Millions of people suffer from cardiovascular disease, with most of the cases caused by or related to atherosclerosis. Historically, blood flow in stenosed arteries has been restored by means of balloon angioplasty. In 1987 stents were introduced to the procedure in order to provide structural support to the diseased artery.

scholarly journals An Emerging Role for isomiRs and the microRNA Epitranscriptome in Neovascularization

Cells ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 61 ◽  
Author(s):  
Reginald V.C.T. van der Kwast ◽  
Paul H.A. Quax ◽  
A. Yaël Nossent
Keyword(s):  
Cardiovascular Disease ◽  
Blood Flow ◽  
Cause Of Death ◽  
Vascular Remodeling ◽  
Modified Nucleotides ◽  
And Function

Therapeutic neovascularization can facilitate blood flow recovery in patients with ischemic cardiovascular disease, the leading cause of death worldwide. Neovascularization encompasses both angiogenesis, the sprouting of new capillaries from existing vessels, and arteriogenesis, the maturation of preexisting collateral arterioles into fully functional arteries. Both angiogenesis and arteriogenesis are highly multifactorial processes that require a multifactorial regulator to be stimulated simultaneously. MicroRNAs can regulate both angiogenesis and arteriogenesis due to their ability to modulate expression of many genes simultaneously. Recent studies have revealed that many microRNAs have variants with altered terminal sequences, known as isomiRs. Additionally, endogenous microRNAs have been identified that carry biochemically modified nucleotides, revealing a dynamic microRNA epitranscriptome. Both types of microRNA alterations were shown to be dynamically regulated in response to ischemia and are able to influence neovascularization by affecting the microRNA’s biogenesis, or even its silencing activity. Therefore, these novel regulatory layers influence microRNA functioning and could provide new opportunities to stimulate neovascularization. In this review we will highlight the formation and function of isomiRs and various forms of microRNA modifications, and discuss recent findings that demonstrate that both isomiRs and microRNA modifications directly affect neovascularization and vascular remodeling.

Energy-Sensing Pathways in Ischemia: The Counterbalance Between AMPK and mTORC

2020 ◽  
Vol 25 (45) ◽  
pp. 4763-4770
Author(s):  
Angel Cespedes ◽  
Mario Villa ◽  
Irene Benito-Cuesta ◽  
Maria J. Perez-Alvarez ◽  
Lara Ordoñez ◽  
...  
Keyword(s):  
Blood Flow ◽  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Cause Of Death ◽  
Artery Occlusion ◽  
Brain Pathology ◽  
Common Cause ◽  
Specific Analysis ◽  
Energy Sensing ◽  
Cerebral Artery Occlusion

: Stroke is an important cause of death and disability, and it is the second leading cause of death worldwide. In humans, middle cerebral artery occlusion (MCAO) is the most common cause of ischemic stroke. The damage occurs due to the lack of nutrients and oxygen contributed by the blood flow. : The present review aims to analyze to what extent the lack of each of the elements of the system leads to damage and which mechanisms are unaffected by this deficiency. We believe that the specific analysis of the effect of lack of each component could lead to the emergence of new therapeutic targets for this important brain pathology.

scholarly journals Cardioinformatics: the nexus of bioinformatics and precision cardiology

2019 ◽  
Author(s):  
Bohdan B Khomtchouk ◽  
Diem-Trang Tran ◽  
Kasra A Vand ◽  
Matthew Might ◽  
Or Gozani ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cancer Research ◽  
Computational Biology ◽  
Cause Of Death ◽  
Cancer Mortality ◽  
Unmet Need ◽  
Mortality Rates ◽  
Cardiovascular Medicine ◽  
Biology Research

Abstract Cardiovascular disease (CVD) is the leading cause of death worldwide, causing over 17 million deaths per year, which outpaces global cancer mortality rates. Despite these sobering statistics, most bioinformatics and computational biology research and funding to date has been concentrated predominantly on cancer research, with a relatively modest footprint in CVD. In this paper, we review the existing literary landscape and critically assess the unmet need to further develop an emerging field at the multidisciplinary interface of bioinformatics and precision cardiovascular medicine, which we refer to as ‘cardioinformatics’.

Impact of NOTES surgery on intra-abdominal blood flow microcirculation: An experimental study

2011 ◽  
Vol 28 ◽  
pp. 67-68
Author(s):  
M. Vendrell ◽  
Navarro A. Tejedor ◽  
Orellana C. Adelsdorfer ◽  
Olano A. Ibarzábal ◽  
Fortuny A.M. de Lacy ◽  
...  
Keyword(s):  
Experimental Study ◽  
Blood Flow

Measurement of local blood flow of the intestine by hydrogen clearance method; Experimental study

1979 ◽  
Vol 9 (1) ◽  
pp. 63-70 ◽  
Author(s):  
Yoshio Mishima ◽  
Hiroshi Shigematsu ◽  
Yoshiaki Horie ◽  
Masanori Satoh
Keyword(s):  
Experimental Study ◽  
Blood Flow ◽  
Local Blood Flow ◽  
Hydrogen Clearance Method ◽  
Hydrogen Clearance

Subclinical Hypothyroidism as a Risk Factor for Cardiovascular Disease

2021 ◽  
Vol 15 (9) ◽  
pp. 2748-2752
Author(s):  
Roman Evgenyevich Tokmachev ◽  
Andrey Valerievich Budnevsky ◽  
Andrey Yakovlevich Kravchenko ◽  
Tatiana Alexandrovna Chernik ◽  
Sudakov Oleg Valerievich ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cardiovascular Diseases ◽  
Cause Of Death ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Epidemiological Studies ◽  
Cardiovascular Disorders ◽  
The World

Nowadays, more than 485 million people in the world suffer from cardiovascular diseases (CVD). According to large epidemiological studies, the group of CVD is the leading cause of death in the world. One of the neurohumoral mechanisms that appears to be a risk factor for CVD is thyroid dysfunction. In this regard, in recent years, more and more attention is paid to the study the influence of subclinical hypothyroidism on the occurrence and development of cardiovascular disorders. MeSH words: cardiovascular diseases, subclinical hypothyroidism

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