Novel approach for non-invasive glucose sensing using vibrational contrast CD absorption measurements (Conference Presentation)

2016 ◽  
Author(s):  
Vladislav V. Yakovlev ◽  
Carlos Tovar ◽  
Brett H. Hokr ◽  
Georgi I. Petrov
Keyword(s):  
Glucose Sensing ◽  
Non Invasive ◽  
Novel Approach ◽  
Absorption Measurements

scholarly journals Tethered Lipid Membranes as a Nanoscale Arrangement Towards Non-Invasive Analysis of Acute Pancreatitis

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 755
Author(s):  
Rima Budvytyte ◽  
Akvile Milasiute ◽  
Dalius Vitkus ◽  
Kestutis Strupas ◽  
Aiste Gulla ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Lipid Membranes ◽  
Electrochemical Impedance ◽  
Membrane Integrity ◽  
Electrochemical Technique ◽  
Label Free ◽  
Non Invasive ◽  
Novel Approach ◽  
Analytical System ◽  
Shock Proteins

Extracellular heat shock proteins (HSPs) mediate immunological functions and are involved in pathologies such as infection, stress, and cancer. Here, we demonstrated the dependence of an amount of HSP70 and HSP90 in serum vs. severity of acute pancreatitis (AP) on a cohort of 49 patients. Tethered bilayer lipid membranes (tBLMs) have been developed to investigate HSPs’ interactions with tBLMs that can be probed by electrochemical impedance spectroscopy (EIS). The results revealed that HSP70 and HSP90 interact via different mechanisms. HSP70 shows the damage of the membrane, while HSP90 increases the insulation properties of tBLM. These findings provide evidence that EIS offers a novel approach for the study of the changes in membrane integrity induced by HSPs proteins. Herein, we present an alternative electrochemical technique, without any immunoprobes, that allows for the monitoring of HSPs on nanoscaled tBLM arrangement in biologics samples such us human urine. This study demonstrates the great potential of tBLM to be used as a membrane based biosensor for novel, simple, and non-invasive label-free analytical system for the prediction of AP severity.

scholarly journals A Review of Non-Invasive Optical Systems for Continuous Blood Glucose Monitoring

Sensors ◽  
2021 ◽  
Vol 21 (20) ◽  
pp. 6820
Author(s):  
Bushra Alsunaidi ◽  
Murad Althobaiti ◽  
Mahbubunnabi Tamal ◽  
Waleed Albaker ◽  
Ibraheem Al-Naib
Keyword(s):  
Blood Glucose ◽  
Glucose Monitoring ◽  
Daily Basis ◽  
Glucose Sensing ◽  
Blood Glucose Monitoring ◽  
Optical Systems ◽  
Glucose Levels ◽  
Non Invasive ◽  
Blood Glucose Levels ◽  
Continuous Blood Glucose Monitoring

The prevalence of diabetes is increasing globally. More than 690 million cases of diabetes are expected worldwide by 2045. Continuous blood glucose monitoring is essential to control the disease and avoid long-term complications. Diabetics suffer on a daily basis with the traditional glucose monitors currently in use, which are invasive, painful, and cost-intensive. Therefore, the demand for non-invasive, painless, economical, and reliable approaches to monitor glucose levels is increasing. Since the last decades, many glucose sensing technologies have been developed. Researchers and scientists have been working on the enhancement of these technologies to achieve better results. This paper provides an updated review of some of the pioneering non-invasive optical techniques for monitoring blood glucose levels that have been proposed in the last six years, including a summary of state-of-the-art error analysis and validation techniques.

Non-Invasive Rhythmic Musical-Electric Trigeminal Nerve Stimulation Improves Consciousness in Patients with Disorders of Consciousness

2021 ◽  
Author(s):  
Min Wu ◽  
Benyan Luo ◽  
Yamei Yu ◽  
Xiaoxia Li ◽  
Jian Gao ◽  
...  
Keyword(s):  
Trigeminal Nerve ◽  
Nerve Stimulation ◽  
Brain Activity ◽  
Minimally Conscious State ◽  
Conscious State ◽  
Disorders Of Consciousness ◽  
Non Invasive ◽  
Trigeminal Nerve Stimulation ◽  
Novel Approach ◽  
Minimally Conscious

Abstract Disorders of consciousness (DOC) are often accompanied by aberrant oscillatory neural activity in the thalamus and cerebral cortex. Patient-friendly non-invasive treatments targeting this functional anomaly are still missing. We propose and validate a novel approach that aims to restore DOC patients’ thalamocortical oscillations by combining rhythmic trigeminal-nerve stimulation (TNS) with comodulated musical stimulation. In a cluster-randomized, placebo-controlled, double-blinded, pretest-posttest clinical study, we show that application of this multisensory approach for 40 min on five consecutive days reliably leads to long-lasting improvements in DOC patients’ consciousness (assessed with Coma Recovery Scale-Revised) and oscillatory brain activity at the musical-electric TNS frequency (assessed with electroencephalography and a novel rhythmic auditory-speech paradigm). We found diagnostic improvement in 47% of patients in minimally conscious state and a positive relationship between patients’ behavioral and neural improvements. Based on this evidence we argue that non-invasive musical-electric TNS may serve as an effective patient-friendly DOC treatment and suggest frequency-specific oscillatory neural enhancement as its mode of action.

Net analyte signal with floating reference theory in non-invasive blood glucose sensing by near-infrared spectroscopy

2012 ◽  
Vol 10 (8) ◽  
pp. 083002-83005 ◽  
Author(s):  
Wanjie Zhang Wanjie Zhang ◽  
Rong Liu Rong Liu ◽  
Wen Zhang Wen Zhang ◽  
Jiaxiang Zheng Jiaxiang Zheng ◽  
Kexin Xu Kexin Xu
Keyword(s):  
Infrared Spectroscopy ◽  
Blood Glucose ◽  
Near Infrared Spectroscopy ◽  
Near Infrared ◽  
Glucose Sensing ◽  
Non Invasive ◽  
Net Analyte Signal ◽  
Analyte Signal ◽  
Reference Theory

scholarly journals A Sensor Platform for Athletes’ Training Supervision: A Proof of Concept Study

Sensors ◽  
2019 ◽  
Vol 19 (18) ◽  
pp. 3948 ◽  
Author(s):  
Zompanti ◽  
Sabatini ◽  
Santonico ◽  
Grasso ◽  
Gianfelici ◽  
...  
Keyword(s):  
Least Squares Method ◽  
Maximal Oxygen Consumption ◽  
Lactate Concentration ◽  
Carbon Dioxide Production ◽  
Exhaled Breath ◽  
Non Invasive ◽  
Sport Practice ◽  
Novel Approach ◽  
Respiratory Parameters ◽  
Partial Least Squares Method

One of the basic needs of professional athletes is the real-time and non-invasive monitoring of their activities. The use of these kind of data is necessary to develop strategies for specific tailored training in order to improve performances. The sensor system presented in this work has the aim to adopt a novel approach for the monitoring of physiological parameters, and athletes’ performances, during their training. The anaerobic threshold is herein identified with the monitoring of the lactate concentration and the respiratory parameters. The data collected by the sensor are used to build a model using a supervised method (based on the partial least squares method, PLS) to predict the values of the parameters of interest. The sensor is able to measure the lactate concentration from a sample of saliva and it can estimate a respiratory parameter, such as maximal oxygen consumption, maximal carbon dioxide production and respiratory rate from a sample of exhaled breath. The main advantages of the device are the low power; the wireless communication; and the non-invasive sampling method, which allow its use in a real context of sport practice.

scholarly journals Finding Suitable Clinical Endpoints for a Potential Treatment of a Rare Genetic Disease: the Case of ARID1B

2020 ◽  
Vol 17 (3) ◽  
pp. 1300-1310 ◽  
Author(s):  
Matthijs D. Kruizinga ◽  
Rob G.J.A. Zuiker ◽  
Elif Sali ◽  
Marieke L. de Kam ◽  
Robert J. Doll ◽  
...  
Keyword(s):  
Neurodevelopmental Disorders ◽  
Event Related Potential ◽  
Body Sway ◽  
Control Group ◽  
Clinical Endpoints ◽  
Non Invasive ◽  
Novel Approach ◽  
Sleep Parameters ◽  
Fit For Purpose ◽  
Potential Waveform

Abstract There is a lack of reliable, repeatable, and non-invasive clinical endpoints when investigating treatments for intellectual disability (ID). The aim of this study is to explore a novel approach towards developing new endpoints for neurodevelopmental disorders, in this case for ARID1B-related ID. In this study, twelve subjects with ARID1B-related ID and twelve age-matched controls were included in this observational case–control study. Subjects performed a battery of non-invasive neurobehavioral and neurophysiological assessments on two study days. Test domains included cognition, executive functioning, and eye tracking. Furthermore, several electrophysiological assessments were performed. Subjects wore a smartwatch (Withings® Steel HR) for 6 days. Tests were systematically assessed regarding tolerability, variability, repeatability, difference with control group, and correlation with traditional endpoints. Animal fluency, adaptive tracking, body sway, and smooth pursuit eye movements were assessed as fit-for-purpose regarding all criteria, while physical activity, heart rate, and sleep parameters show promise as well. The event-related potential waveform of the passive oddball and visual evoked potential tasks showed discriminatory ability, but EEG assessments were perceived as extremely burdensome. This approach successfully identified fit-for-purpose candidate endpoints for ARID1B-related ID and possibly for other neurodevelopmental disorders. Next, results could be replicated in different ID populations or the assessments could be included as exploratory endpoint in interventional trials in ARID1B-related ID.

scholarly journals Study and Suppression of Multipath Signals in a Non-Invasive Millimeter Wave Transmission Glucose-Sensing System

2020 ◽  
Vol 4 (3) ◽  
pp. 187-193
Author(s):  
Maria Koutsoupidou ◽  
Helena Cano-Garcia ◽  
Roberto L. Pricci ◽  
Shimul C. Saha ◽  
George Palikaras ◽  
...  
Keyword(s):  
Millimeter Wave ◽  
Glucose Sensing ◽  
Wave Transmission ◽  
Non Invasive ◽  
Sensing System ◽  
Multipath Signals

Influence of cholesterol on non-invasive blood glucose sensing studied with NIR spectroscopy

2011 ◽  
Author(s):  
Jingying Jiang ◽  
Lingling Zhang ◽  
Qiliang Gong ◽  
Kexin Xu
Keyword(s):  
Blood Glucose ◽  
Nir Spectroscopy ◽  
Glucose Sensing ◽  
Non Invasive
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