Characterizing mechanical properties of soft tissues using non-contact displacement measurements: how should we assess the uncertainty?

2021 ◽  
Author(s):  
Ami Kling ◽  
Sean J. Kirkpatrick ◽  
Jingfeng Jiang
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues ◽  
Contact Displacement ◽  
Displacement Measurements

scholarly journals Development of a Compound Speckle Interferometer for Precision Three-Degree-of-Freedom Displacement Measurement

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1828
Author(s):  
Hung-Lin Hsieh ◽  
Bo-Yen Sun
Keyword(s):  
Speckle Interferometry ◽  
Degree Of Freedom ◽  
Heterodyne Interferometry ◽  
Beam Splitting ◽  
Speckle Interferometer ◽  
Real World Applications ◽  
Three Degree Of Freedom ◽  
Contact Displacement ◽  
Displacement Measurements ◽  
Measurement Capabilities

In this study, a compound speckle interferometer for measuring three-degree-of-freedom (3-DOF) displacement is proposed. The system, which combines heterodyne interferometry, speckle interferometry and beam splitting techniques, can perform precision 3-DOF displacement measurements, while still having the advantages of high resolution and a relatively simple configuration. The incorporation of speckle interferometry allows for non-contact displacement measurements by detecting the phase of the speckle interference pattern formed from the convergence of laser beams on the measured rough surface. Experiments were conducted to verify the measurement capabilities of the system, and the results show that the proposed system has excellent measurement capabilities suitable for future real-world applications.

A Nanoindentation Method for Hydrated Compliant Materials

2011 ◽  
Author(s):  
Donna M. Ebenstein
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues ◽  
Adhesion Forces ◽  
Surface Detection ◽  
Heterogeneous Samples ◽  
Mineralized Tissues ◽  
Fluid Interactions

Nanoindentation is becoming an increasingly popular tool in the biomaterials field due to its ability to measure local mechanical properties in small, irregularly-shaped or heterogeneous samples.1 Although this technique was readily adapted to the study of mineralized tissues, the application of nanoindentation to compliant, hydrated biomaterials such as soft tissues and hydrogels has led to many challenges.1 Three key concerns associated with nanoindentation of compliant, hydrated materials are inaccurate surface detection, errors due to adhesion forces, and fluid interactions with the tip.1–4

Inexpensive, semi-automated system for measuring mechanical properties of soft tissues

1999 ◽  
Vol 284 (4) ◽  
pp. 374-378 ◽  
Author(s):  
David E. Alexander ◽  
Kenneth L. Ratzlaff ◽  
Ricardo J. Roggero ◽  
Jennifer S.-Y. Hsieh
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues ◽  
Automated System

The Convexity Properties of the Fung Model for Soft Tissues

2001 ◽  
Author(s):  
J. Patrick Wilber ◽  
Jay R. Walton
Keyword(s):  
Mechanical Properties ◽  
Nonlinear Elasticity ◽  
Continuum Mechanics ◽  
Soft Tissues ◽  
Basic Tool ◽  
Nonlinear Continuum Mechanics ◽  
Pathological Conditions ◽  
Convexity Properties ◽  
Nonlinear Continuum ◽  
Fung Model

Abstract During the last three decades, the theory of nonlinear elasticity has been used extensively to model biological soft tissues. The now widely accepted belief that an understanding of the mechanical properties of these tissues is critical in order to understand the advent, progression, and treatment of disease has driven this research. More recently, those interested in how soft tissues grow and remodel themselves in response to both normal and pathological conditions have used nonlinear continuum mechanics as a basic tool.

scholarly journals Fabrication and Testing of Breast Tissue-Mimicking Phantom for Needle Biopsy Cutting: A Pilot Study

2017 ◽  
Author(s):  
Yu-Chen Jheng ◽  
Chi-Lun Lin
Keyword(s):  
Mechanical Properties ◽  
Pilot Study ◽  
Needle Biopsy ◽  
Large Scale ◽  
Soft Tissues ◽  
Indentation Test ◽  
Cutting Conditions ◽  
Insertion Force ◽  
Tissue Cutting ◽  
Tissue Phantoms

Breast lesion tissue can be extremely stiff, e.g. calcification or soft, e.g. adipose. When performing needle biopsy, too small or scanty samples can be retrieved due to the tissue is mainly compressed instead of being cut. In order to studying the tissue cutting performance in various cutting conditions, tissue-mimicking phantoms are frequently used as a surrogate of human tissue. The advantage of using tissue phantoms is that their mechanical properties can be controlled. The stiffness of a tissue phantom can be measured by an indentation test. Previous studies have demonstrated mathematic models to estimate Young’s moduli of tissue phantoms from force-displacement data with an adjustable coefficient according to the geometry of the indenter. Tissue force reactions occurred needle insertion has been largely researched [1], but few studies investigated the tissue cutting with a rotational needle, which is a cutting method largely used in the breast needle biopsy. Research has demonstrated that the influence of rotation can significantly reduce the insertion force [2], but the experiment was conducted on a specific formula of silicone-based tissue phantoms. This paper served as a pilot study of a large-scale experiment to study the effect of rotational cutting on various cutting conditions and target materials, including artificial and biological soft tissues. Two most common types of soft tissue phantoms, biopolymers (gelatin gels and agar) and chemically synthesized polymers (polydimethylsiloxane, PDMS) were investigated. Indentation tests were performed to estimate the mechanical properties of tissue phantoms which were then verified by finite element simulations. Tissue cutting tests with and without rotation were conducted to evaluate the effect of needle rotation on the tissue force reactions.

A Novel Non-Destructive Method for Measuring Elastic Moduli of Cultivated Cartilage Tissues

2007 ◽  
Vol 342-343 ◽  
pp. 853-856 ◽  
Author(s):  
Duk Young Jung ◽  
Yu Bong Kang ◽  
Toshie Tsuchiya ◽  
Sadami Tsutsumi
Keyword(s):  
Mechanical Properties ◽  
Bulk Modulus ◽  
Soft Tissues ◽  
Articular Chondrocytes ◽  
Collagen Gel ◽  
Accuracy And Precision ◽  
Novel Method ◽  
Silicone Rubbers ◽  
High Degree ◽  
Non Destructive

Accurate measurement of the mechanical properties of artificial or cultivated cartilage is a major factor for determining successive regeneration of defective soft tissues. In this study, we developed a novel method that enabled the bulk modulus (k-modulus) to be measured nondestructively using the relationship between volume and pressure of living soft tissues. In order to validate this method we estimated the bulk modulus of soft silicone rubbers using our new method and a conventional method. The results showed a 5 ~ 10% difference between the results obtained with the two methods. Our method was used subsequently to measure the mechanical properties of cultivated cartilage samples (collagen gel type), that had been incubated for four weeks in the presence or absence of human articular chondrocytes (HACs). Our experiments showed that cultivated cartilage tissues grown in the presence of HACs had a higher bulk modulus (120 ± 20 kPa) than samples grown without HACs (90 ± 15 kPa). The results indicated that our novel method offered an effective method for measurement of volume changes in minute living soft tissues, with the measurements having a high degree of accuracy and precision. Furthermore, this method has significant advantages over conventional approaches as it can be used to rapidly and accurately evaluate the strength of soft tissues during cultivation without causing damage to the specimen.

Reliability Investigation of Tissue Resonator Indenter Device

2010 ◽  
Author(s):  
Ming Jia ◽  
Jean W. Zu ◽  
Alireza Hariri
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Tissue Properties ◽  
University Of Toronto ◽  
In Vivo Measurements ◽  
Disease Diagnostics ◽  
Working Principle ◽  
The University

Knowledge of tissue mechanical properties is widely required by medical applications, such as disease diagnostics, surgery operation, simulation, planning, and training. A new portable device, called Tissue Resonator Indenter Device (TRID), has been developed for measurement of regional viscoelastic properties of soft tissues at the Bio-instrument and Biomechanics Lab of the University of Toronto. As a device for soft tissue properties in-vivo measurements, the reliability of TRID is crucial. This paper presents TRID’s working principle and the experimental study of TRID’s reliability with respect to inter-reliability, intra-reliability, and the indenter misalignment effect as well. The experimental results show that TRID is a reliable device for in-vivo measurements of soft tissue mechanical properties.

Development of Anisotropy in Fibroblast Populated Collagen Gels

2002 ◽  
Author(s):  
Stavros Thomopoulos ◽  
Vedran Knezevic ◽  
Kevin D. Costa ◽  
Jeffrey W. Holmes
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues ◽  
Mechanical Load ◽  
The Other ◽  
Collagen Structure ◽  
Collagen Gels ◽  
Specific Loading ◽  
Anisotropic Mechanical Properties ◽  
Muscle Loading ◽  
Heart Wall

The development of anisotropic mechanical properties is critical for the successful tissue engineering of many soft tissues. Load bearing tissues naturally develop varying degrees of anisotropy, presumably in response to their specific loading environment. For example, the heart wall develops a collagen structure that varies in a predictable manner through its depth [1]. Tendon, on the other hand, develops a matrix that does not vary much in orientation and is highly aligned in the direction of muscle loading [2]. These varied levels of anisotropy may be due to inherent differences between the cells in each tissue, to differences in the mechanical load and boundary conditions seen by the cells, or to a combination of these factors.

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