Reliability Investigation of Tissue Resonator Indenter Device

2010 ◽  
Author(s):  
Ming Jia ◽  
Jean W. Zu ◽  
Alireza Hariri
Keyword(s):  
Mechanical Properties ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Tissue Properties ◽  
University Of Toronto ◽  
In Vivo Measurements ◽  
Disease Diagnostics ◽  
Working Principle ◽  
The University

Knowledge of tissue mechanical properties is widely required by medical applications, such as disease diagnostics, surgery operation, simulation, planning, and training. A new portable device, called Tissue Resonator Indenter Device (TRID), has been developed for measurement of regional viscoelastic properties of soft tissues at the Bio-instrument and Biomechanics Lab of the University of Toronto. As a device for soft tissue properties in-vivo measurements, the reliability of TRID is crucial. This paper presents TRID’s working principle and the experimental study of TRID’s reliability with respect to inter-reliability, intra-reliability, and the indenter misalignment effect as well. The experimental results show that TRID is a reliable device for in-vivo measurements of soft tissue mechanical properties.

scholarly journals Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Mary Beth Wandel ◽  
Craig A. Bell ◽  
Jiayi Yu ◽  
Maria C. Arno ◽  
Nathan Z. Dreger ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Biological Tissues ◽  
Soft Tissue Regeneration ◽  
Soft Tissue Engineering ◽  
Degradation Properties ◽  
Enhance Cell Adhesion

AbstractComplex biological tissues are highly viscoelastic and dynamic. Efforts to repair or replace cartilage, tendon, muscle, and vasculature using materials that facilitate repair and regeneration have been ongoing for decades. However, materials that possess the mechanical, chemical, and resorption characteristics necessary to recapitulate these tissues have been difficult to mimic using synthetic resorbable biomaterials. Herein, we report a series of resorbable elastomer-like materials that are compositionally identical and possess varying ratios of cis:trans double bonds in the backbone. These features afford concomitant control over the mechanical and surface eroding degradation properties of these materials. We show the materials can be functionalized post-polymerization with bioactive species and enhance cell adhesion. Furthermore, an in vivo rat model demonstrates that degradation and resorption are dependent on succinate stoichiometry in the elastomers and the results show limited inflammation highlighting their potential for use in soft tissue regeneration and drug delivery.

scholarly journals In vivo soft tissue reinforcement with bacterial nanocellulose

2021 ◽  
Author(s):  
Irene Anton-Sales ◽  
Soledad Roig-Sanchez ◽  
Kamelia Anna Traeger ◽  
Christine Weis ◽  
Anna Laromaine ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissues ◽  
Hernia Surgery ◽  
Bacterial Nanocellulose ◽  
Surgical Meshes

The use of surgical meshes to reinforce damaged internal soft tissues has been instrumental for successful hernia surgery; a highly prevalent condition affecting yearly more than 20 million patients worldwide....

Determination of In-Vivo Elastic Properties of Soft Tissue Using Magnetic Resonance Elastography

2003 ◽  
Author(s):  
Francis E. Kennedy ◽  
Marvin M. Doyley ◽  
Elijah E. W. Van Houten ◽  
John B. Weaver ◽  
Keith D. Paulsen
Keyword(s):  
Magnetic Resonance ◽  
Soft Tissue ◽  
Elastic Properties ◽  
Magnetic Resonance Elastography ◽  
Tissue Properties ◽  
In Vivo Measurement ◽  
Ultrasonic Methods ◽  
Accurate Quantification

In-vivo measurement of the elastic properties of soft tissue have been made using a variety of direct techniques, such as indentation probes and rotary shear actuators, but they are unable to access much of the soft tissue of interest. Indirect ultrasonic methods for imaging elastic properties of soft tissue were first introduced about 15 years ago, see Ophir (1991). Although the results of ultrasonic elastography studies have been quite promising, they may not be suited for applications requiring accurate quantification of soft tissue properties. An alternative to ultrasound, magnetic resonance imaging, has the advantage of enabling precise measurement of all three components of tissue displacement. The reconstruction of elastic properties from the imaged displacement field is called magnetic resonance elastography (MRE), and is the subject of this paper.

Using MR Imaging and X-Ray Fluoroscopy to Quantify the Effects of Soft-Tissue Artifact on Measurement of Knee-Joint Kinematics

2009 ◽  
Author(s):  
Massoud Akbarshahi ◽  
Justin W. Fernandez ◽  
Anthony Schache ◽  
Richard Baker ◽  
Marcus G. Pandy
Keyword(s):  
Soft Tissue ◽  
Knee Joint ◽  
Soft Tissues ◽  
Surgical Techniques ◽  
Joint Kinematics ◽  
Segmental Motion ◽  
Coordinate Systems ◽  
Knee Joint Kinematics ◽  
Soft Tissue Artifact

The ability to accurately measure joint kinematics in vivo is of critical importance to researchers in the field of biomechanics [1]. Applications range from the quantitative evaluation of different surgical techniques, treatment methods and/or implant designs, to the development of computer-based models capable of simulating normal and pathological musculoskeletal conditions [1,2]. Currently, non-invasive marker-based three dimensional (3D) motion analysis is the most commonly used method for quantitative assessment of normal and pathological locomotion. The accuracy of this technique is influenced by movement of the soft tissues relative to the underlying bones, which causes inaccuracies in the determination of segmental anatomical coordinate systems and tracking of segmental motion. The purpose of this study was to quantify the errors in the measurement of knee-joint kinematics due solely to soft-tissue artifact (STA) in healthy subjects. To facilitate valid inter-subject comparisons of the kinematic data, relevant anatomical coordinate systems were defined using 3D bone models generated from magnetic resonance imaging (MRI).

Non-Invasive Measurement of In-Vivo Elasticity of Skeletal Muscles with MR-Elastography

2007 ◽  
Vol 342-343 ◽  
pp. 901-904
Author(s):  
Yu Bong Kang ◽  
T. Oida ◽  
Duk Young Jung ◽  
A. Fukuma ◽  
T. Azuma ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Shear Modulus ◽  
Skeletal Muscles ◽  
Soft Tissues ◽  
Viscosity Coefficient ◽  
Non Invasive ◽  
Novel Method ◽  
Human Calf ◽  
Invasive Measurement

In order to evaluate the mechanical properties of the human skeletal muscles, the elasticity and viscosity of the human calf muscles were measured with Magnetic Resonance Elastography (MRE). MRE is a novel method to measure the mechanical properties of living soft tissues in vivo quantitatively by observing the strain waves propagated in the object. In this study, the shear modulus and viscosity coefficient were measured with MRE. The shear modulus was 3.7 kPa in relaxed state, and increased with increasing the muscle forces. Interestingly, the viscosity was changed with the vibration frequency applied to the muscles, that was 4.5 Pa·s at 100Hz vibration and 2.4 Pa·s at 200Hz vibration. This shows clearly the visco-elastic property.

Study on the Mechanical Properties of Tissue-Mimicking Phantom Composites Using Ultrasound Indentation

2007 ◽  
Vol 334-335 ◽  
pp. 133-136
Author(s):  
Hang Yin Ling ◽  
P. Carrie Choi ◽  
Y.P. Zheng ◽  
Alan Kin Tak Lau
Keyword(s):  
Mechanical Properties ◽  
Genetic Algorithm ◽  
Soft Tissue ◽  
Soft Tissues ◽  
Load Cell ◽  
Indentation Technique ◽  
Deformation Curves ◽  
Ultrasound Indentation ◽  
Indentation Process

This paper demonstrates the use of ultrasound (US) indentation technique for estimating the mechanical properties of tissue- mimicking phantom composites. A tissue-mimicking phantom composite is used to simulate two-layer soft tissue in human. Investigation on the mechanical properties of the phantom composites is extremely important for the understanding of the viscoelastic behaviours of soft tissues and the validation of our proposed US indentation system. The hand-held indentation probe embedded with a US transducer and a load cell together with a US pulser/ receiver. The output of the whole indentation process can be illustrated as force-deformation curves. The mechanical properties of the phantom composites can be estimated by analyzing the force-deformation curves using genetic algorithm (GA).

scholarly journals Fabrication and Modeling of Dynamic Multipolymer Nanofibrous Scaffolds

2009 ◽  
Vol 131 (10) ◽  
Author(s):  
Brendon M. Baker ◽  
Nandan L. Nerurkar ◽  
Jason A. Burdick ◽  
Dawn M. Elliott ◽  
Robert L. Mauck
Keyword(s):  
Mechanical Properties ◽  
Rational Design ◽  
Cell Infiltration ◽  
Tissue Properties ◽  
Matrix Deposition ◽  
Native Tissue ◽  
Nanofibrous Scaffolds ◽  
Wide Range ◽  
Anisotropic Mechanical Properties

Aligned nanofibrous scaffolds hold tremendous potential for the engineering of dense connective tissues. These biomimetic micropatterns direct organized cell-mediated matrix deposition and can be tuned to possess nonlinear and anisotropic mechanical properties. For these scaffolds to function in vivo, however, they must either recapitulate the full dynamic mechanical range of the native tissue upon implantation or must foster cell infiltration and matrix deposition so as to enable construct maturation to meet these criteria. In our recent studies, we noted that cell infiltration into dense aligned structures is limited but could be expedited via the inclusion of a distinct rapidly eroding sacrificial component. In the present study, we sought to further the fabrication of dynamic nanofibrous constructs by combining multiple-fiber populations, each with distinct mechanical characteristics, into a single composite nanofibrous scaffold. Toward this goal, we developed a novel method for the generation of aligned electrospun composites containing rapidly eroding (PEO), moderately degradable (PLGA and PCL/PLGA), and slowly degrading (PCL) fiber populations. We evaluated the mechanical properties of these composites upon formation and with degradation in a physiologic environment. Furthermore, we employed a hyperelastic constrained-mixture model to capture the nonlinear and time-dependent properties of these scaffolds when formed as single-fiber populations or in multipolymer composites. After validating this model, we demonstrated that by carefully selecting fiber populations with differing mechanical properties and altering the relative fraction of each, a wide range of mechanical properties (and degradation characteristics) can be achieved. This advance allows for the rational design of nanofibrous scaffolds to match native tissue properties and will significantly enhance our ability to fabricate replacements for load-bearing tissues of the musculoskeletal system.

Dynamic instrumented palpation – a new method for soft tissue quality assessment: application to prostate disease diagnosis

2017 ◽  
Vol 231 (12) ◽  
pp. 1101-1115 ◽  
Author(s):  
TH Jimmy Yang ◽  
Simon Phipps ◽  
Steve KW Leung ◽  
Robert L Reuben ◽  
Fouad K Habib ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mechanical Properties ◽  
Soft Tissue ◽  
Transurethral Resection ◽  
Benign Prostate Hyperplasia ◽  
Dynamic Mechanical Properties ◽  
Prostate Hyperplasia ◽  
Dynamic Mechanical ◽  
Benign Prostate

The objective is to establish the feasibility of using dynamic instrumented palpation, a novel technique of low-frequency mechanical testing, applied here to diagnose soft tissue condition. The technique is applied, in vitro, to samples of excised prostate gland affected by benign prostate hyperplasia and/or prostate cancer. Particular attention is paid to the relationship between the histological structure of the tissue and the dynamic mechanical properties in an attempt to separate patient-specific aspects from histopathological condition (i.e. prostate cancer or benign prostate hyperplasia). The technique is of clinical interest because it is potentially deployable in vivo. Prostate samples were obtained from a total of 36 patients who had undergone transurethral resection of the prostate to relieve prostatic obstruction and 4 patients who had undergone radical cystoprostatectomy for bladder cancer. Specimens (chips) recovered from transurethral resection of the prostate were of nominal size 5 mm × 8 mm and thicknesses between 2 and 4 mm, whereas those from the cystoprostatectomy were in the form of transverse slices of thickness approximately 6 mm. Specimens were mechanically tested by a controlled strain cyclic compression technique, and the resulting dynamic mechanical properties expressed as the amplitude ratio and phase difference between the cyclic stress and cyclic strain. After mechanical testing, the percentage areas of glandular and smooth muscle were measured at each probe point. Good contrast between the dynamic modulus of chips from benign prostate hyperplasia and prostate cancer patients was demonstrated, and absolute values similar to those published by other authors are reported. For the slices, modulus values were considerably higher than for chips, and good in-patient mechanical contrast was revealed for predominantly nodular and predominantly stromal areas. Extending this classification between patients required pattern recognition techniques. Overall, the study has demonstrated that dynamic mechanical properties can potentially be used for diagnosis of prostate condition using in vivo measurements.

A Hand-Held Indentation System for the Assessment of Mechanical Properties of Soft Tissues In Vivo

2009 ◽  
Vol 58 (9) ◽  
pp. 3079-3085 ◽  
Author(s):  
Min-Hua Lu ◽  
W. Yu ◽  
Qing-Hua Huang ◽  
Yan-Ping Huang ◽  
Yong-Ping Zheng
Keyword(s):  
Mechanical Properties ◽  
Soft Tissues
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