Photodynamic Therapy (PDT) is a promising alternative treatment for malignancies based
on photochemical reaction induced by Photosensitizers (PS) under light irradiation. Recent studies
show that PDT caused the abundant release of exosomes from tumor tissues. It is well-known that
exosomes as carriers play an important role in cell-cell communication through transporting many
kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore
the role of exosomes in photodynamic anticancer therapy has been attracting significant attention.
In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and
focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and
boost the development of PDT.