Negligible Effects of β-Hydroxy-β-Methylbutyrate Free Acid and Calcium Salt on Strength and Hypertrophic Responses to Resistance Training: A Randomized, Placebo-Controlled Study

2019 ◽  
Vol 29 (5) ◽  
pp. 505-511 ◽  
Author(s):  
Aline C. Tritto ◽  
Salomão Bueno ◽  
Rosa M.P. Rodrigues ◽  
Bruno Gualano ◽  
Hamilton Roschel ◽  
...  
Keyword(s):  
Resistance Training ◽  
Body Mass ◽  
Muscle Soreness ◽  
Calcium Salt ◽  
Free Acid ◽  
Time Effect ◽  
Controlled Study ◽  
Cross Sectional ◽  
Repetition Maximum ◽  
Leg Press

This study evaluated the effects of β-hydroxy-β-methylbutyrate free acid (HMB-FA) and calcium salt (HMB-Ca) on strength, hypertrophy, and markers of muscle damage. In this randomized, double-blind, placebo-controlled study, 44 resistance-trained men (age: 26 ± 4 years; body mass: 84.9 ± 12.0 kg) consuming ≥1.7 g·kg−1·day−1 of protein received HMB-FA (3 g/day; n = 14), HMB-Ca (3 g/day; n = 15), or placebo (PL; cornstarch, 3 g/day; n = 15) for 12 weeks, while performing a periodized resistance training program. Before and after intervention, lean body mass (measured with dual X-ray absorptiometry), maximal dynamic strength (one-repetition maximum), knee extension maximal isometric strength (maximal voluntary isometric contraction [MVIC]), cross-sectional area (measured with ultrasound), and muscle soreness were assessed. MVIC was also measured 48 hr after the first and the last training sessions. All groups increased lean body mass (main time effect: p < .0001; HMB-FA: 1.8 ± 1.8 kg; HMB-Ca: 0.8 ± 1.4 kg; PL: 0.9 ± 1.4 kg), cross-sectional area (main time effect: p < .0001; HMB-FA: 6.6 ± 3.8%; HMB-Ca: 4.7 ± 4.4%; PL: 6.9 ± 3.8%), one-repetition maximum bench press (main time effect: p < .0001; HMB-FA: 14.8 ± 8.4 kg; HMB-Ca: 11.8 ± 7.4 kg; PL: 11.2 ± 6.6 kg), MVIC (main time effect: p < .0001; HMB-FA: 34.4 ± 39.3%; HMB-Ca: 32.3 ± 27.4%; PL: 17.7 ± 20.9%) after the intervention, but no differences between groups were shown. HMB-FA group showed greater leg press strength after the intervention than HMB-Ca and PL groups (Group × Time interaction: p < .05; HMB-FA: 47.7 ± 31.2 kg; HMB-Ca: 43.8 ± 31.7 kg; PL: 30.2 ± 20.9 kg). MVIC measured 48 hr after the first and the last sessions showed no attenuation of force decline with supplementation. Muscle soreness following the first and last sessions was not different between groups. The authors concluded that neither HMB-Ca nor HMB-FA improved hypertrophy or reduced muscle damage in resistance-trained men undergoing resistance training ingesting optimal amounts of protein. HMB-FA but not HMB-Ca resulted in a statistically significant yet minor improvement on leg press one-repetition maximum.

scholarly journals Muscles adaptation to aging and training: architectural changes – a randomised trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Adrien J. Létocart ◽  
Franck Mabesoone ◽  
Fabrice Charleux ◽  
Christian Couppé ◽  
René B. Svensson ◽  
...  
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Cross Sectional Area ◽  
Muscle Volume ◽  
Triceps Surae ◽  
Moderate Intensity ◽  
Training Volume ◽  
Sectional Area ◽  
Cross Sectional ◽  
Repetition Maximum

Abstract Background To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo. Methods The old participants were randomly assigned to moderate (O55, n = 13) or high-load (O80, n = 14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n = 11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans. Results Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+ 96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+ 4.3%; + 6.7%; 4.2% respectively) and triceps surae (+ 2.8%; + 7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed. Conclusions Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass. Trial registration NCT03079180 in ClinicalTrials.gov. Registration date: March 14, 2017.

Rate of Force Development, Muscle Architecture, and Performance in Elite Weightlifters

2020 ◽  
pp. 1-8 ◽  
Author(s):  
Nikolaos Zaras ◽  
Angeliki-Nikoletta Stasinaki ◽  
Polyxeni Spiliopoulou ◽  
Giannis Arnaoutis ◽  
Marios Hadjicharalambous ◽  
...  
Keyword(s):  
Body Composition ◽  
Lean Body Mass ◽  
Body Mass ◽  
Time Windows ◽  
Muscle Architecture ◽  
Peak Force ◽  
Countermovement Jump ◽  
Repetition Maximum ◽  
Force Development ◽  
Leg Press

Purpose: The purpose of the present study was to investigate the relationship between weightlifting performance and the rate of force development (RFD), muscle architecture, and body composition in elite Olympic weightlifters. Methods: Six male Olympic weightlifters (age 23.3 [3.4] y, body mass 88.7 [10.2] kg, body height 1.76 [0.07] m, snatch 146.7 [15.4] kg, clean and jerk 179.4 [22.1] kg), all members of the national team, participated in the study. Athletes completed a 16-week periodized training program aiming to maximize their performance at the national competition event. Measurements, including maximal strength (1-repetition maximum) in snatch, clean and jerk, back and front squat, isometric leg press RFD and peak force, countermovement jump, vastus lateralis muscle architecture, and body composition, were performed before and after the training period. Results: Weightlifting performance increased significantly after training (P < .05). Leg press RFD increased only in time windows of 0 to 200 and 0 to 250 milliseconds after training (8.9% [8.5%] and 9.4% [7.7%], respectively, P < .05) while peak force remained unaltered (P < .05). Front squat strength increased significantly (P < .05), while countermovement jump power increased 2.3% (2.1%) (P < .05). No changes were observed for muscle architecture and lean body mass (P > .05). Significant correlations were observed between performance in snatch and clean and jerk with isometric leg press RFD, at all time windows, as well as with lean body mass and squat 1-repetition maximum. Conclusions: These results suggest that regular examination of RFD, lean body mass, and lower extremities’ 1-repetition maximum may be useful performance predictors in elite Olympic weightlifters.

scholarly journals Mitochondrial Content, but Not Function, Is Altered With a Multimodal Resistance Training Protocol and Adequate Protein Intake in Leucine-Supplemented Pre/Frail Women

2021 ◽  
Vol 7 ◽  
Author(s):  
Kathryn J. Jacob ◽  
Vita Sonjak ◽  
Sally Spendiff ◽  
Russell T. Hepple ◽  
Stéphanie Chevalier ◽  
...  
Keyword(s):  
Resistance Training ◽  
Frail Elderly ◽  
Elderly Women ◽  
Controlled Study ◽  
Voltage Dependent Anion Channel ◽  
Post Intervention ◽  
Mitochondrial Content ◽  
Frailty Phenotype ◽  
Leg Press ◽  
Mptp Opening

Background: Frailty is a clinical condition associated with loss of muscle mass and strength (sarcopenia). Mitochondria are centrally implicated in frailty and sarcopenia. Leucine (Leu) can alter mitochondrial content in myocytes, while resistance training (RT) is the strongest stimulus to counteract sarcopenia and may enhance mitochondrial biogenesis.Objective: We determined the effects of Leu supplementation and RT on mitochondrial content and function in pre/frail elderly women in a randomized double-blinded placebo-controlled study.Methods: Nineteen pre/frail elderly women (77.5 ± 1.3 y, BMI: 25.1 ± 0.9 kg/m2), based on the Frailty Phenotype, underwent 3-months of RT 3×/week with protein-optimized diet and were randomized to 7.5 g/d of Leu supplementation or placebo alanine (Ala). Pre/post-intervention mitochondrial respiration, reactive oxygen species (ROS) production, calcium retention capacity (CRC), time to permeability transition pore (mPTP) opening, mitochondrial voltage-dependent anion channel (VDAC) protein content, leg press 1-repetition maximum (1RM), and 6-min walk test (6MWT) were measured.Results: No time, supplementation, or interaction effects were observed for respiration, ROS, time to mPTP opening, and CRC. VDAC levels significantly increased in the Leu group post-intervention (p = 0.012). Both groups significantly increased leg press 1RM and 6MWT, with no effect of supplementation.Discussion: Leu supplementation with 3 months of RT increased mitochondrial content. Future studies should investigate if there is an increase in mitochondrial turnover or a shift in quality control (mitophagy) in leucine supplemented pre/frail elderly women who undergo 12 weeks of RT.Clinical Trial Registration:ClinicalTrials.gov, identifier: NCT01922167.

The Effects of an Intensive 2-wk Resistance Training Period on Strength Performance and Nocturnal Heart Rate Variability

2020 ◽  
Vol 15 (10) ◽  
pp. 1448-1454
Author(s):  
Piia Kaikkonen ◽  
Esa Hynynen ◽  
Arto Hautala ◽  
Juha P. Ahtiainen
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Resistance Training ◽  
Effect Size ◽  
Training Load ◽  
Training Period ◽  
Short Term ◽  
Strength Performance ◽  
Repetition Maximum ◽  
Leg Press

Purpose: It is known that modifying the endurance-type training load of athletes may result in altered cardiac autonomic modulation that may be estimated with heart rate variability (HRV). However, the specific effects of intensive resistance-type training remain unclear. The main aim of this study was to find out whether an intensive 2-wk resistance training period affects the nocturnal HRV and strength performance of healthy participants. Methods: Young healthy men (N = 13, age 24 [2] y) performed 2-wk baseline training, 2-wk intensive training, and a 9-d tapering periods, with 2, 5, and 2 hypertrophic whole-body resistance exercise sessions per week, respectively. Maximal isometric and dynamic strength were tested at the end of these training periods. Nocturnal HRV was also analyzed at the end of these training periods. Results: As a main finding, the nocturnal root mean square of differences of successive R-R intervals decreased (P = .004; from 49 [18] to 43 [15] ms; 95% CI, 2.4–10.4; effect size = 0.97) during the 2-wk intensive resistance training period. In addition, maximal isometric strength improved slightly (P = .045; from 3933 [1362] to 4138 [1540] N; 95% CI, 5.4–404; effect size = 0.60). No changes were found in 1-repetition-maximum leg press or leg press repetitions at 80% 1-repetition maximum. Conclusions: The present data suggest that increased training load due to a short-term intensive resistance training period can be detected by nocturnal HRV. However, despite short-term accumulated physiological stress, a tendency of improvement in strength performance was detected.

scholarly journals The Effect of Orally Dosed Levagen+™ (palmitoylethanolamide) on Exercise Recovery in Healthy Males—A Double-Blind, Randomized, Placebo-Controlled Study

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 596 ◽  
Author(s):  
Alistair Mallard ◽  
David Briskey ◽  
Andrew Richards ◽  
Dean Mills ◽  
Amanda Rao
Keyword(s):  
Muscle Damage ◽  
Blood Lactate ◽  
Muscle Soreness ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Controlled Study ◽  
Thigh Circumference ◽  
Double Blind ◽  
Post Exercise ◽  
Leg Press

The aim of this study was to evaluate the effect of palmitoylethanolamide (PEA), a cannabimimetic compound and lipid messenger, on recovery from muscle damaging exercise. Twenty-eight healthy young male participants attended the laboratory four times on subsequent days. In the first visit, baseline characteristics were recorded before participants were randomized to consume either liquid PEA (167.5 mg Levagen+ with 832.5 mg maltodextrin) or a matched placebo (1 g maltodextrin) drink. Leg press exercise consisted of four sets at 80% of one repetition maximum followed by a performance set. Muscle soreness, thigh circumference, blood lactate concentration, biomarkers of muscle damage and inflammation, and transcription factor pathways were measured pre- and immediately post-exercise and again at 1, 2, 3, 24, 48, and 72 h post-exercise. The leg press exercise increased (p < 0.05) blood lactate concentration and induced muscle damage as evidenced by increased muscle soreness, thigh circumference, biomarkers of muscle damage, and concentrations of tumor necrosis factor-α. PEA reduced (p < 0.05) myoglobin and blood lactate concentrations and increased protein kinase B phosphorylation following exercise. Taken together, these results indicate PEA supplementation may aid in muscle recovery from repeat bouts of exercise performed within a short duration by reducing myoglobin and lactate concentration.

Individual Muscle Adaptations in different Resistance Training Systems in Well-Trained Men

2021 ◽  
Author(s):  
Vitor Angleri ◽  
Carlos Ugrinowitsch ◽  
Cleiton Augusto Libardi
Keyword(s):  
Resistance Training ◽  
Cross Sectional ◽  
Leg Extension ◽  
Leg Press ◽  
Training Systems ◽  
Subject Design ◽  
Muscle Adaptations ◽  
Traditional Resistance Training ◽  
The Individual ◽  
Muscle Cross Sectional Area

AbstractUsing a within-subject design we compared the individual responses between drop-set (DS) vs. traditional resistance training (TRAD) (n=16) and crescent pyramid (CP) vs. TRAD (n=15). Muscle cross-sectional area (CSA), leg press and leg extension 1 repetition maximum (1-RM) were assessed pre and post training. At group level, CSA increased from pre to post (DS: 7.8% vs. TRAD: 7.5%, P=0.02; CP: 7.5% vs. TRAD: 7.8%, P=0.02). All protocols increased the 1-RM from pre to post for leg press (DS: 24.9% vs. TRAD: 26.8%, P < 0.0001; CP: 27.3% vs. TRAD:2 6.3%, P < 0.0001) and leg extension (DS: 17.1% vs. TRAD: 17.3%, P < 0.0001; CP: 17.0% vs. TRAD: 16.6%, P < 0.0001). Individual analysis for CSA demonstrated no differences between protocols in 15 subjects. For leg press 1-RM, 5 subjects responded more to TRAD, 2 to DS and 9 similarly between protocols. In TRAD vs. CP, 4 subjects responded more to CP, 1 to TRAD and 10 similarly between protocols. For leg extension 1-RM 2 subjects responded more to DS, 3 to TRAD and 11 similarly between protocols. Additionally, 2 subjects responded more to CP, 2 to TRAD and 11 similarly between protocols. In conclusion, all protocols induced similar individual responses for CSA. For 1-RM, some subjects experience greater gains for the protocol performed with higher loads, such as CP.

Prohormone supplement 3β-hydroxy-5α-androst-1-en-17-one enhances resistance training gains but impairs user health

2014 ◽  
Vol 116 (5) ◽  
pp. 560-569 ◽  
Author(s):  
Jorge Granados ◽  
Trevor L. Gillum ◽  
Kevin M. Christmas ◽  
Matthew R. Kuennen
Keyword(s):  
Body Composition ◽  
Resistance Training ◽  
Lean Body Mass ◽  
Body Mass ◽  
Muscular Strength ◽  
Fat Body ◽  
Resistance Training Program ◽  
Repetition Maximum ◽  
Back Squat ◽  
Fat Body Mass

Prohormone supplements (PS) are recognized not to impart anabolic or ergogenic effects in men, but the research supporting these conclusions is dated. The Anabolic Steroid Control Act was amended in 2004 to classify androstenedione and 17 additional anabolic compounds as controlled substances. The viability of PS that entered the market after that time have not been evaluated. Seventeen resistance-trained men (23 ± 1 yr; 13.1 ± 1.5% body fat) were randomly assigned to receive either 330 mg/day of 3β-hydroxy-5α-androst-1-en-17-one (Prohormone; n = 9) or sugar (Placebo; n = 8) per os and complete a 4-wk (16 session) structured resistance-training program. Body composition, muscular strength, circulating lipids, and markers of liver and kidney dysfunction were assessed at study onset and termination. Prohormone increased lean body mass by 6.3 ± 1.2%, decreased fat body mass by 24.6 ± 7.1%, and increased their back squat one repetition maximum and competition total by 14.3 ± 1.5 and 12.8 ± 1.1%, respectively. These improvements exceeded ( P < 0.05) Placebo, which increased lean body mass by 0.5 ± 0.8%, reduced fat body mass by 9.5 ± 3.6%, and increased back squat one repetition maximum and competition total by 5.7 ± 1.7 and 5.9 ± 1.7%, respectively. Prohormone also experienced multiple adverse effects. These included a 38.7 ± 4.0% reduction in HDL ( P < 0.01), a 32.8 ± 15.05% elevation in LDL ( P < 0.01), and elevations of 120.0 ± 22.6 and 77.4 ± 12.0% in LDL-to-HDL and cholesterol-to-HDL ratios, respectively (both P < 0.01). Prohormone also exhibited elevations in serum creatinine (19.6 ± 4.3%; P < 0.01) and aspartate transaminase (113.8 ± 61.1%; P = 0.05), as well as reductions in serum albumin (5.1 ± 1.9%; P = 0.04), alkaline phosphatase (16.4 ± 4.7%; P = 0.04), and glomerular filtration rate (18.0 ± 3.3%; P = 0.04). None of these values changed (all P > 0.05) in Placebo. The oral PS 3β-hydroxy-5α-androst-1-en-17-one improves body composition and muscular strength. However, these changes come at a significant cost. Cardiovascular health and liver function are particularly compromised. Given these findings, we feel the harm associated with this particular PS outweighs any potential benefit.

Planned Intensity Reduction to Maintain Repetitions Within Recommended Hypertrophy Range

2013 ◽  
Vol 8 (4) ◽  
pp. 384-390 ◽  
Author(s):  
Helio S. Medeiros ◽  
Rafael S. Mello ◽  
Mayara Z. Amorim ◽  
Alexander J. Koch ◽  
Marco Machado
Keyword(s):  
Resistance Exercise ◽  
Body Mass ◽  
Load Reduction ◽  
Repetition Maximum ◽  
Leg Press

Purpose:The authors tested different loading schemes for the number of repetitions completed during multiple sets of resistance exercise.Methods:Twenty-four resistance-trained men (age 24.0 ± 4.5 y, body mass 78.3 ± 10.2 kg, height 177 ± 7 cm) were tested over a 5-wk period. During week 1 a 10-repetition maximum (10RM) in the leg press was determined. During weeks 2–5 subjects completed 4 bouts of leg presses, in a randomized fashion, consisting of 4 sets with 60 s of interset rest. Set 1 of each bout was performed with 10RM, with differing intensity for sets 2–4 as follows: (1) 10RM load for all sets (CON), (2) 5% load reduction after each set (RED 5), (3) 10% load reduction after each set (RED 10), and (4) 15% load reduction after each set (RED 15).Results:Significant (P < .05) decreases in repetitions completed across sets were observed in CON (sets 2, 3, and 4) and RED 5 (sets 3 and 4). Significant increases in repetitions completed across sets (2, 3, and 4) were observed in RED 10 and RED 15 (P < .05). RED 5 (8.3 ± 0.9 repetitions) and RED 10 (12.0 ± 1.1 repetitions) allowed subjects to maintain the majority (>60%) of sets in the range of 8–12 repetitions, whereas both CON and RED 15 resulted in <50% of sets in the range of 8–12 repetitions, with the majority of sets performed <8 repetitions for CON and >12 repetitions for RED 15.Conclusion:Reducing load 5–10% in each set should allow maintenance of 8–12RM loads for most sets of resistance exercise.

scholarly journals Effects of Moderate-Volume, High-Load Lower-Body Resistance Training on Strength and Function in Persons with Parkinson's Disease: A Pilot Study

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Brian K. Schilling ◽  
Ronald F. Pfeiffer ◽  
Mark S. LeDoux ◽  
Robyn E. Karlage ◽  
Richard J. Bloomer ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Resistance Training ◽  
Body Mass ◽  
Training Group ◽  
High Load ◽  
Lower Body ◽  
Leg Press ◽  
Moderate Volume ◽  
And Function

Background. Resistance training research has demonstrated positive effects for persons with Parkinson's disease (PD), but the number of acute training variables that can be manipulated makes it difficult to determine the optimal resistance training program.Objective. The purpose of this investigation was to examine the effects of an 8-week resistance training intervention on strength and function in persons with PD.Methods. Eighteen men and women were randomized to training or standard care for the 8-week intervention. The training group performed 3 sets of 5–8 repetitions of the leg press, leg curl, and calf press twice weekly. Tests included leg press strength relative to body mass, timed up-and-go, six-minute walk, and Activities-specific Balance Confidence questionnaire.Results. There was a significant group-by-time effect for maximum leg press strength relative to body mass, with the training group significantly increasing their maximum relative strength (P<.05). No other significant interactions were noted (P>.05).Conclusions. Moderate volume, high-load weight training is effective for increasing lower-body strength in persons with PD.

scholarly journals Muscles adaptation to aging and training: Architectural changes - A randomised trial

2021 ◽  
Author(s):  
Adrien J. LÉTOCART ◽  
Franck Mabesoone ◽  
Fabrice Charleux ◽  
Christian Couppé ◽  
Rene B. Svensson ◽  
...  
Keyword(s):  
Resistance Training ◽  
Young Men ◽  
Cross Sectional Area ◽  
Muscle Volume ◽  
Triceps Surae ◽  
Moderate Intensity ◽  
Training Volume ◽  
Sectional Area ◽  
Cross Sectional ◽  
Repetition Maximum

Abstract Background: To investigate how anatomical cross-sectional area and volume of quadriceps and triceps surae muscles were affected by ageing, and by resistance training in older and younger men, in vivo. Methods: The old participants were randomly assigned to moderate (O55, n=13) or high-load (O80, n=14) resistance training intervention (12 weeks; 3 times/week) corresponding to 55% or 80% of one repetition maximum, respectively. Young men (Y55, n=11) were assigned to the moderate-intensity strengthening exercise program. Each group received the exact same training volume on triceps surae and quadriceps group (Reps x Sets x Intensity). The fitting polynomial regression equations for each of anatomical cross-sectional area-muscle length curves were used to calculate muscle volume (contractile content) before and after 12 weeks using magnetic resonance imaging scans.Results: Only Rectus femoris and medial gastrocnemius muscle showed a higher relative anatomical cross-sectional area in the young than the elderly on the proximal end. The old group displayed a higher absolute volume of non-contractile material than young men in triceps surae (+96%). After training, Y55, O55 and O80 showed an increase in total quadriceps (+4.3%; +6.7%; 4.2% respectively) and triceps surae (+2.8%; +7.5%; 4.3% respectively) volume. O55 demonstrated a greater increase on average gains compared to Y55, while no difference between O55 and O80 was observed.Conclusions: Muscle loss with aging is region-specific for some muscles and uniform for others. Equivalent strength training volume at moderate or high intensities increased muscle volume with no differences in muscle volume gains for old men. These data suggest that physical exercise at moderate intensity (55 to 60% of one repetition maximum) can reverse the aging related loss of muscle mass.Trial registration: NCT03079180 in ClinicalTrials.gov. Registration date: March 14, 2017.

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